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Certain Transactions - Other Transactions - Additional Information (Detail) - USD ($)
$ in Millions
 1 Months Ended 3 Months Ended 12 Months Ended
Jan. 08, 2018
May 12, 2017
Oct. 31, 2021
Aug. 31, 2021
Sep. 30, 2016
Mar. 31, 2022
Dec. 31, 2021
Sep. 30, 2021
Sep. 30, 2020
Mar. 31, 2020
Sep. 30, 2016
Dec. 31, 2018
Dec. 31, 2017
Alder [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
Upfront payment $ 25                        
Milestone payment                   $ 25      
Collaborative agreement milestone payments $ 150                        
Otsuka [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
Upfront payment   $ 50                      
Milestone payment               $ 35 $ 15        
Regeneron [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
Upfront payment                     $ 250    
Collaborative agreement milestone payments         $ 2,230             $ 120 $ 120
Research and development costs         $ 1,000                
Alvotech [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
Collaborative agreement milestone payments           $ 455              
MedinCell [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
Collaborative agreement milestone payments       $ 112                  
MODAG [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
License agreement potential aggregate milestone payments amount     $ 70                    
MODAG [Member] | Research and Development Expense [Member]                          
Noncash or Part Noncash Acquisitions [Line Items]                          
Milestone payment             $ 10