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Insider Trading Arrangements	12 Months Ended
	Dec. 31, 2024 shares
David R. McAvoy, EVP, Chief Legal Officer [Member]
Trading Arrangements, by Individual
Name	Richard D. Francis
Title	President and CEO
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	November 15, 2024
Expiration Date	March 6, 2025
Aggregate Available	279,109
Eli Kalif, EVP, Chief Financial Officer [Member]
Trading Arrangements, by Individual
Name	Richard Daniell, EVP
Title	Head of European Commercial
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	November 19, 2024
Expiration Date	March 7, 2025
Aggregate Available	287,741
Dr. Eric Hughes, EVP, Global RD and Chief Medical Officer [Member]
Trading Arrangements, by Individual
Name	Dr. Eric Hughes, EVP
Title	Global R&D and Chief Medical Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	November 15, 2024
Expiration Date	August 4, 2025
Aggregate Available	100,893
Richard Daniell, EVP, Head of European Commercial [Member]
Trading Arrangements, by Individual
Name	Eli Kalif, EVP
Title	Chief Financial Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	November 29, 2024
Expiration Date	June 13, 2025
Aggregate Available	111,525
Richard D. Francis, President and CEO [Member]
Trading Arrangements, by Individual
Name	David R. McAvoy, EVP
Title	Chief Legal Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	November 15, 2024
Expiration Date	March 6, 2025
Aggregate Available	16,741

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