_________ false

C002

אקס טי אל ביופרמסוטיקלס בע"מ

2

Public

X T L BIOPHARMACEUTICALS LTD

4313

Corporation no: 520039470

Stock Exchange/Market: אקס טי אל

1996

380

Hasapir 3 , Nes Ziona 76100 , ,

Tel: 08-9304444 , Fax: 08-9304445

E.mail address: rcohen@xtlbio.com

Date of transmission: 21/11/2007

              Time of broadcast: 10:40 10:34:58

Reference: 2007-02-450292

Israel Securities Authority		Tel Aviv Stock Exchange
www.isa.gov.il		www.tase.co.il

Immediate Report

Regulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

The corporation is a foreign private issuer as defined by U.S. Securities Laws.

Attached hereto is a report on A second amendment to the Company's registration statment on form F-3 was filed with the Securities and Exchange Commission.

vsecondamendmentF3_isa.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):

Previous names of reporting entity: XENOGRAFT TECHNOLOGIES LTD

Date of revision of form structure: 31/10/2007

Name of the Signatory: : Kantor Ronen , , Position of Signatory in the reporting corporation: Legal Consultant & Corporate Secretary

Abba Hillel Silver Telephone: 03-6133371 , Facsimile: 03-6133372 , E-mail: rkantor@kantor-law.com 2