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v3.26.1

Segments - Schedule of Significant Segment Expenses Regularly Provided to the CODM (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2026 | Mar. 31, 2026 | Jun. 30, 2025 | Mar. 31, 2025 | Jun. 30, 2026 | Jun. 30, 2025
Research and development expenses: |  |  |  |  |  |  |
Preclinical and early discovery assets |  | $ 1,411 |  | $ 967 |  | $ 2,354 | $ 1,790
Personnel-related (including non-cash stock-based compensation expense of $0.9 million and $0.6 million for three months ended June 30, 2026 and 2025. respectively and $1.8 million and $1.1 million for six months ended June 30, 2026 and 2025, respectively) |  | 4,732 |  | 3,715 |  | 9,331 | 6,870
Other indirect research and development expenses |  | 585 |  | 413 |  | 1,100 | 805
Total research and development expenses |  | 24,619 |  | 13,409 |  | 46,049 | 23,944
General and administrative expenses: |  |  |  |  |  |  |
Personnel-related (including non-cash stock-based compensation expense of $36.0 million and $1.2 million for three months ended June 30, 2026 and 2025. respectively and $37.6 million and $2.3 million for six months ended June 30, 2026 and 2025, respectively) |  | 38,168 |  | 3,239 |  | 42,292 | 6,262
Other general and administrative expenses | [1] | 3,021 |  | 1,822 |  | 5,010 | 4,449
Total general and administrative expenses |  | 41,189 |  | 5,061 |  | 47,302 | 10,711
Other segment items | [2] | (3,208) |  | (3,393) |  | (5,343) | (6,453)
Net loss |  | 62,600 | $ 25,408 | 15,077 | $ 13,125 | 88,008 | 28,202
GlyphAllo Direct Research and Development Expenses |  |  |  |  |  |  |
Research and development expenses: |  |  |  |  |  |  |
Total research and development expenses |  | 12,796 |  | 4,751 |  | 21,093 | 8,060
GlyphAgo Direct Research and Development Expenses |  |  |  |  |  |  |
Research and development expenses: |  |  |  |  |  |  |
Total research and development expenses |  | 3,478 |  | 2,011 |  | 9,972 | 3,971
Glyph2BLSD Direct Research and Development Expenses |  |  |  |  |  |  |
Research and development expenses: |  |  |  |  |  |  |
Total research and development expenses |  | $ 1,617 |  | $ 1,552 |  | $ 2,199 | $ 2,448
[1] | Other general and administrative expenses include professional fees, facilities, depreciation, IT, and other expenses.
[2] | Other segment items include interest income, net, research and development tax credit, income tax provision, and other expense, net.

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