<?xml version="1.0" encoding="utf-8"?>
<schema targetNamespace="https://www.marinomed.com/xbrl/2022-12-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:MARI="https://www.marinomed.com/xbrl/2022-12-31" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns="http://www.w3.org/2001/XMLSchema">
  <annotation>
    <appinfo>
      <link:linkbaseRef xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-gen-de.xml" xlink:role="http://www.xbrl.org/2003/role/linkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:linkbaseRef xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-lab-de.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:linkbaseRef xlink:href="529900GN3B1EN80XF405-2022-12-31_lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:linkbaseRef xlink:href="529900GN3B1EN80XF405-2022-12-31_lab-de.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:linkbaseRef xlink:href="529900GN3B1EN80XF405-2022-12-31_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:linkbaseRef xlink:href="529900GN3B1EN80XF405-2022-12-31_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:linkbaseRef xlink:href="529900GN3B1EN80XF405-2022-12-31_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:type="simple" />
      <link:roleType id="GeneralInformation" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/GeneralInformation">
        <link:definition>Mandatory elements that must be applied if corresponding information is present</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Anchoring" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/Anchoring">
        <link:definition>Anchoring</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="balance-sheet-assets" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/balance-sheet-assets">
        <link:definition>Statement of financial position Assets</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType id="balance-sheet-equity" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/balance-sheet-equity">
        <link:definition>Statement of financial position Equity</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType id="equity-changes" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/equity-changes">
        <link:definition>Statement of changes in equity</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType id="cash-flow" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/cash-flow">
        <link:definition>Statement of cash flows</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
      <link:roleType id="comprehensive-income" roleURI="https://www.marinomed.com/xbrl/2022-12-31/role/comprehensive-income">
        <link:definition>Statement of profit or loss</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
    </appinfo>
  </annotation>
  <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <import namespace="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor" schemaLocation="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor.xsd" />
  <element name="Adjustmentsforgainsondisposalofnoncurrentassets" id="marinomed_Adjustmentsforgainsondisposalofnoncurrentassets" type="xbrli:monetaryItemType" xbrli:periodType="duration" abstract="false" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" />
  <element name="Adjustmentsforlossesondisposalofnoncurrentassets" id="marinomed_Adjustmentsforlossesondisposalofnoncurrentassets" type="xbrli:monetaryItemType" xbrli:periodType="duration" abstract="false" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" />
  <element name="CashOuflowFromCapitalExpenditureForPlantAndEquipmentAndIntangibleAssets" id="marinomed_CashOuflowFromCapitalExpenditureForPlantAndEquipmentAndIntangibleAssets" type="xbrli:monetaryItemType" xbrli:periodType="duration" abstract="false" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" />
</schema>