For filings with the FCA include the annexFor filings with issuer exclude the annexTR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi1. Identity of the issuer or the underlying issuerof existing shares to which voting rights are PHSC plcattached:ii2 Reason for the notification (please tick the appropriate box or boxes):An acquisition or disposal of voting rights xAn acquisition or disposal of qualifying financial instruments which may resultin the acquisition of shares already issued to which voting rights are attachedAn acquisition or disposal of instruments with similar economic effect toqualifying financial instrumentsAn event changing the breakdown of voting rightsOther (please specify):3. Full name of person(s) subject to the Downing LLPnotification obligation:iii4. Full name of shareholder(s) Downing ONE VCT plc (if different from 3.):iv5. Date of the transaction and date onwhich the threshold is crossed or 20/04/2015reached: v6. Date on which issuer notified: 20/04/20157. Threshold(s) that is/are crossed or 4% to 3%reached: vi, vii8. Notified details:A: Voting rights attached to shares viii, ixClass/ Situation previous Resulting situation after the triggering transactiontype of to the triggeringshares transactionif Number Number Number Number of voting % of voting rightspossible of of of shares rights xusing Shares Votingthe ISIN RightsCODE Indirect Direct Direct xi xii Direct Indirect 576,509 576,509 441,509 441,509 3.48%OrdinarysharesB: Qualifying Financial InstrumentsResulting situation after the triggering transactionType of Expiration Exercise/ Number of voting % of votingfinancial date xiii Conversion Period xiv rights that may be rightsinstrument acquired if the instrument is exercised/ converted.C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xviResulting situation after the triggering transactionType of Exercise Expiration Exercise/ Number of voting rights % of voting rightsfinancial price date xvii Conversion instrument refers to xix, xxinstrument period xviii Nominal DeltaTotal (A+B+C)Number of voting rights Percentage of voting rights441,509 3.48%9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxiProxy Voting:10. Name of the proxy holder:11. Number of voting rights proxy holder will ceaseto hold:12. Date on which proxy holder will cease to holdvoting rights:13. Additional information:14. Contact name: Grant Whitehouse, Company Secretary15. Contact telephone number: 0207 416 7780