0001209191-17-015962 4 1 20170228 20170301 20170301 Castle Brands Inc 0001311538 2080 000000000 FL 0331 122 EAST 42ND STREET SUITE 4700 NEW YORK NY 10168 646-356-0200 122 EAST 42ND STREET SUITE 4700 NEW YORK NY 10168 Rubin Steven D 0001381874 4 34 001-32849 17655246 OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI FL 33137 4 1 doc4.xml FORM 4 SUBMISSION