<SUBMISSION>
<ACCESSION-NUMBER>0001686485-18-000005
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20180810
<FILING-DATE>20180814
<DATE-OF-FILING-DATE-CHANGE>20180814
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Cramer Michael John
<CIK>0001686485
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>001-37540
<FILM-NUMBER>181019150
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>1 EAST ARMOUR BOULEVARD
<CITY>KANSAS CITY
<STATE>MO
<ZIP>64111
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>Hostess Brands, Inc.
<CIK>0001644406
<ASSIGNED-SIC>2050
<IRS-NUMBER>000000000
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>1 EAST ARMOUR BOULEVARD
<CITY>KANSAS CITY
<STATE>MO
<ZIP>64111
<PHONE>816-701-4600
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>1 EAST ARMOUR BOULEVARD
<CITY>KANSAS CITY
<STATE>MO
<ZIP>64111
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>Gores Holdings, Inc.
<DATE-CHANGED>20150608
</FORMER-COMPANY>
</ISSUER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wf-form4_153428314305224.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2018-08-10</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001644406</issuerCik>
        <issuerName>Hostess Brands, Inc.</issuerName>
        <issuerTradingSymbol>TWNK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001686485</rptOwnerCik>
            <rptOwnerName>Cramer Michael John</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O HOSTESS BRANDS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1 EAST ARMOUR BOULEVARD</rptOwnerStreet2>
            <rptOwnerCity>KANSAS CITY</rptOwnerCity>
            <rptOwnerState>MO</rptOwnerState>
            <rptOwnerZipCode>64111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2018-08-10</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11.95</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>24410</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Individual Retirement Account</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Reflects the weighted average price of purchases on August 10, 2018. The shares were purchased in multiple transactions at prices ranging from $11.76 to $12.10, inclusive. The reporting person undertakes to provide to Hostess Brands, Inc., any security holder of Hostess Brands, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within such range.</footnote>
    </footnotes>

    <remarks>Executive Vice President, Chief Administrative Officer and Assistant Secretary</remarks>

    <ownerSignature>
        <signatureName>/s/ Jolyn J. Sebree, Attorney-in-Fact</signatureName>
        <signatureDate>2018-08-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
