<SUBMISSION>
<ACCESSION-NUMBER>0001864086-23-000006
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20230605
<FILING-DATE>20230607
<DATE-OF-FILING-DATE-CHANGE>20230607
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>O'Leary Daniel James
<CIK>0001864086
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>001-37540
<FILM-NUMBER>23999597
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>7905 QUIVIRA ROAD
<CITY>LENEXA
<STATE>KS
<ZIP>66215
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>Hostess Brands, Inc.
<CIK>0001644406
<ASSIGNED-SIC>2050
<IRS-NUMBER>000000000
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>7905 QUIVIRA ROAD
<CITY>LENEXA
<STATE>KS
<ZIP>66215
<PHONE>816-701-4600
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>7905 QUIVIRA ROAD
<CITY>LENEXA
<STATE>KS
<ZIP>66215
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>Gores Holdings, Inc.
<DATE-CHANGED>20150608
</FORMER-COMPANY>
</ISSUER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1686170992.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0407</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2023-06-05</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001644406</issuerCik>
        <issuerName>Hostess Brands, Inc.</issuerName>
        <issuerTradingSymbol>TWNK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001864086</rptOwnerCik>
            <rptOwnerName>O'Leary Daniel James</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O HOSTESS BRANDS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>7905 QUIVIRA ROAD</rptOwnerStreet2>
            <rptOwnerCity>LENEXA</rptOwnerCity>
            <rptOwnerState>KS</rptOwnerState>
            <rptOwnerZipCode>66215</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2023-06-05</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1901</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>26.24</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>14120</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
                <footnoteId id="F2"/>
            </securityTitle>
            <transactionDate>
                <value>2023-06-05</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4277</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>26.24</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>19496</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Restricted Stock Units</value>
                <footnoteId id="F3"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>24846</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">On June 5, 2023, the Company withheld 1,901 shares of Class A common stock to satisfy withholding taxes due in connection with the vesting of 4,290 shares of Class A common stock underlying an award of restricted stock units previously granted to the reporting person. Such shares had a market value of $26.24 per share, the closing price of the Class A common stock on June 2, 2023, the vesting date.</footnote>
        <footnote id="F2">On June 5, 2023, the Company withheld 4,277 shares of Class A common stock to satisfy withholding taxes due in connection with the vesting of 9,653 shares of Class A common stock underlying an award of restricted stock units previously granted to the reporting person. Such shares had a market value of $26.24 per share, the closing price of the Class A common stock on June 2, 2023, the vesting date.</footnote>
        <footnote id="F3">Consists of previously disclosed restricted stock units that remained subject to time-based vesting criteria.</footnote>
    </footnotes>

    <remarks>Executive Vice President, Chief Growth Officer</remarks>

    <ownerSignature>
        <signatureName>/s/ Jolyn J Sebree, Attorney-in-Fact</signatureName>
        <signatureDate>2023-06-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
