<SUBMISSION>
<ACCESSION-NUMBER>0001209191-14-023602
<TYPE>3
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20140327
<FILING-DATE>20140327
<DATE-OF-FILING-DATE-CHANGE>20140327
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>2U, Inc.
<CIK>0001459417
<ASSIGNED-SIC>7372
<IRS-NUMBER>262335939
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>8201 CORPORATE DRIVE, SUITE 110
<CITY>LANDOVER
<STATE>MD
<ZIP>20785
<PHONE>240-487-3991
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>8201 CORPORATE DRIVE, SUITE 110
<CITY>LANDOVER
<STATE>MD
<ZIP>20785
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>2tor, Inc.
<DATE-CHANGED>20090324
</FORMER-COMPANY>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Redpoint Associates III, LLC
<CIK>0001441299
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>001-36376
<FILM-NUMBER>14723083
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>3000 SAND HILL ROAD
<STREET2>BUILDING 2 SUITE 290
<CITY>MENLO PARK
<STATE>CA
<ZIP>94025
<PHONE>(650) 926-5600
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>3000 SAND HILL ROAD
<STREET2>BUILDING 2 SUITE 290
<CITY>MENLO PARK
<STATE>CA
<ZIP>94025
</MAIL-ADDRESS>
</REPORTING-OWNER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>REDPOINT VENTURES III LP
<CIK>0001353575
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>001-36376
<FILM-NUMBER>14723084
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>REDPOINT VENTURES
<STREET2>3000 SAND HILL ROAD BLDG 2 STE 290
<CITY>MENLO PARK
<STATE>CA
<ZIP>94025
<PHONE>6509265600
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>REDPOINT VENTURES
<STREET2>3000 SAND HILL ROAD BLDG 2 STE 290
<CITY>MENLO PARK
<STATE>CA
<ZIP>94025
</MAIL-ADDRESS>
</REPORTING-OWNER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Redpoint Ventures III, LLC
<CIK>0001441297
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>001-36376
<FILM-NUMBER>14723085
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>3000 SAND HILL ROAD
<STREET2>BUILDING 2 SUITE 290
<CITY>MENLO PARK
<STATE>CA
<ZIP>94025
<PHONE>(650) 926-5600
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>3000 SAND HILL ROAD
<STREET2>BUILDING 2 SUITE 290
<CITY>MENLO PARK
<STATE>CA
<ZIP>94025
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<DESCRIPTION>FORM 3 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2014-03-27</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001459417</issuerCik>
        <issuerName>2U, Inc.</issuerName>
        <issuerTradingSymbol>TWOU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001441297</rptOwnerCik>
            <rptOwnerName>Redpoint Ventures III, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3000 SAND HILL ROAD</rptOwnerStreet1>
            <rptOwnerStreet2>BUILDING 2, SUITE 290</rptOwnerStreet2>
            <rptOwnerCity>MENLO PARK</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94025</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001353575</rptOwnerCik>
            <rptOwnerName>REDPOINT VENTURES III LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3000 SAND HILL ROAD</rptOwnerStreet1>
            <rptOwnerStreet2>BUILDING 2, SUITE 290</rptOwnerStreet2>
            <rptOwnerCity>MENLO PARK</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94025</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001441299</rptOwnerCik>
            <rptOwnerName>Redpoint Associates III, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>3000 SAND HILL ROAD</rptOwnerStreet1>
            <rptOwnerStreet2>BUILDING 2, SUITE 290</rptOwnerStreet2>
            <rptOwnerCity>MENLO PARK</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94025</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series A Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>4728505</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1185498</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series C Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>681075</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series D Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>639828</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Each share of preferred stock is convertible, at any time, at the holder's election, into the issuer's common stock on a 1-for-1 basis. In addition, effective immediately prior to the closing of the issuer's initial public offering of its common stock, each share of preferred stock will automatically convert into one share of the issuer's common stock. The preferred stock has no expiration date.</footnote>
        <footnote id="F2">These shares consist of (i) 4,551,186 shares held by Redpoint Ventures III, L.P. (&quot;Redpoint Ventures&quot;) and (ii) 177,319 shares held by Redpoint Associates III, LLC (&quot;Redpoint Associates&quot;).</footnote>
        <footnote id="F3">The shares held by Redpoint Ventures are indirectly held by Redpoint Ventures III, LLC (&quot;RV III LLC&quot;), the general partner of Redpoint Ventures. Redpoint Associates is under common control with RV III LLC. As such, RV III LLC has voting and investment control over the shares owned by Redpoint Ventures and Redpoint Associates, and may be deemed to beneficially own the shares held by Redpoint Ventures and Redpoint Associates. RV III LLC owns no securities of the issuer directly. RV III LLC disclaims beneficial ownership of the shares reported herein, except to the extent of its pecuniary interest therein.</footnote>
        <footnote id="F4">These shares consist of (i) 1,141,042 shares held by Redpoint Ventures and (ii) 44,456 shares held by Redpoint Associates.</footnote>
        <footnote id="F5">These shares consist of (i) 655,535 shares held by Redpoint Ventures and (ii) 25,540 shares held by Redpoint Associates.</footnote>
        <footnote id="F6">These shares consist of (i) 615,835 shares held by Redpoint Ventures and (ii) 23,993 shares held by Redpoint Associates.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>REDPOINT VENTURES III, LLC
By: /s/ Timothy M. Haley, Managing Director

REDPOINT VENTURES III, L.P.
By: Redpoint Ventures III, LLC, its GP
By: /s/ Timothy M. Haley, Managing Director

REDPOINT ASSOCIATES III, LLC
By: /s/ Timothy M. Haley, Manager</signatureName>
        <signatureDate>2014-03-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
