<SUBMISSION>
<ACCESSION-NUMBER>0001209191-14-069740
<TYPE>3/A
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20141104
<FILING-DATE>20141118
<DATE-OF-FILING-DATE-CHANGE>20141118
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>2U, Inc.
<CIK>0001459417
<ASSIGNED-SIC>7372
<IRS-NUMBER>262335939
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>8201 CORPORATE DRIVE, SUITE 110
<CITY>LANDOVER
<STATE>MD
<ZIP>20785
<PHONE>240-487-3991
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>8201 CORPORATE DRIVE, SUITE 110
<CITY>LANDOVER
<STATE>MD
<ZIP>20785
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>2tor, Inc.
<DATE-CHANGED>20090324
</FORMER-COMPANY>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Macias Edward S.
<CIK>0001625679
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3/A
<ACT>34
<FILE-NUMBER>001-36376
<FILM-NUMBER>141233008
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>C/O 2U, INC.
<STREET2>8201 CORPORATE DRIVE, SUITE 900
<CITY>LANDOVER
<STATE>MD
<ZIP>20785
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>3/A
<SEQUENCE>1
<FILENAME>doc3a.xml
<DESCRIPTION>FORM 3/A SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3/A</documentType>

    <periodOfReport>2014-11-04</periodOfReport>

    <dateOfOriginalSubmission>2014-11-17</dateOfOriginalSubmission>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001459417</issuerCik>
        <issuerName>2U, Inc.</issuerName>
        <issuerTradingSymbol>TWOU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001625679</rptOwnerCik>
            <rptOwnerName>Macias Edward S.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 2U, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>8201 CORPORATE DRIVE, SUITE 900</rptOwnerStreet2>
            <rptOwnerCity>LANDOVER</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20785</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3220</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares were omitted from the reporting person's original Form 3 due to the ownership of those shares being disclosed to the Company on November 18, 2014. The shares are held in an IRA.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Matthew J. Norden, attorney-in-fact</signatureName>
        <signatureDate>2014-11-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
