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<!--Created on: 2/26/2018 12:11:47 PM-->
<!--Modified on: 2/26/2018 12:11:47 PM-->
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  <element id="twou_AdvancesFromToCustomers" name="AdvancesFromToCustomers" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_FlatironSchoolIncMember" name="FlatironSchoolIncMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_RepaymentOfSecurityDepositFromRelatedParty" name="RepaymentOfSecurityDepositFromRelatedParty" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_AdvancesRepaidByCustomers" name="AdvancesRepaidByCustomers" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_DeferredTaxLiabilitiesPrepaidExpensesAndOther" name="DeferredTaxLiabilitiesPrepaidExpensesAndOther" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SoftwareLicenseAndServicesAgreementMember" name="SoftwareLicenseAndServicesAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_NonCashCapitalExpenditure" name="NonCashCapitalExpenditure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_MarketingAndSalesCostsAbstract" name="MarketingAndSalesCostsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_NonCashLongLivedAssetAdditionsPolicyTextBlock" name="NonCashLongLivedAssetAdditionsPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_TaxCutsAndJobsActOf2017TransitionTaxForAccumulatedForeignEarningsIncomeTaxExpense" name="TaxCutsAndJobsActOf2017TransitionTaxForAccumulatedForeignEarningsIncomeTaxExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_CommonStockCapitalSharesReservedForFutureIssuanceAvailableForFutureIssuanceUnderStockPurchasePlan" name="CommonStockCapitalSharesReservedForFutureIssuanceAvailableForFutureIssuanceUnderStockPurchasePlan" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_ProfitLossFromSegmentOperations" name="ProfitLossFromSegmentOperations" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_GoodwillDecreaseInPeriodOffsettingInOtherCurrentLiabilitiesRelatedToContingentConsideration" name="GoodwillDecreaseInPeriodOffsettingInOtherCurrentLiabilitiesRelatedToContingentConsideration" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SegmentProfitabilityMarginAbstract" name="SegmentProfitabilityMarginAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_PercentageOfProfitLossFromSegmentOperations" name="PercentageOfProfitLossFromSegmentOperations" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SegmentReportingInformationAdjustmentsToNetIncomeLossAbstract" name="SegmentReportingInformationAdjustmentsToNetIncomeLossAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_AdjustmentsToNetIncomeLoss" name="AdjustmentsToNetIncomeLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
</XBRL>
