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<!-- Created by Merrill Corporation -->
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<!--Based on XBRL 2.1-->
<!--Created on: 8/2/2018 10:06:13 AM-->
<!--Modified on: 8/2/2018 10:06:13 AM-->
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  <element id="twou_IncreaseDecreaseInRefundsPayable" name="IncreaseDecreaseInRefundsPayable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <xsd:element name="DocumentAndEntityInformationAbstract" id="twou_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <element id="twou_IncreaseDecreaseInAccruedCompensationAndRelatedBenefits" name="IncreaseDecreaseInAccruedCompensationAndRelatedBenefits" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_EquityIncentivePlan2014Member" name="EquityIncentivePlan2014Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_NumberOfClients" name="NumberOfClients" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_LandlordFundedLeaseholdImprovementsMember" name="LandlordFundedLeaseholdImprovementsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_GetEducatedInternationalProprietaryLimitedMember" name="GetEducatedInternationalProprietaryLimitedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_DeferredGovernmentGrantObligationsNoncurrent" name="DeferredGovernmentGrantObligationsNoncurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_PrinceGeorgesCountyMarylandMember" name="PrinceGeorgesCountyMarylandMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_DepartmentOfCommerceMember" name="DepartmentOfCommerceMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_NumberOfGovernmentGrants" name="NumberOfGovernmentGrants" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_GovernmentGrantsAbstract" name="GovernmentGrantsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_PercentagePurchasePriceFairMarketValue" name="PercentagePurchasePriceFairMarketValue" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_CurriculumAndTeachingCosts" name="CurriculumAndTeachingCosts" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_CurriculumAndTeachingMember" name="CurriculumAndTeachingMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_GraduateProgramSegmentMember" name="GraduateProgramSegmentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_ShortCourseSegmentMember" name="ShortCourseSegmentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SegmentReportingInformationAssetsAbstract" name="SegmentReportingInformationAssetsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_RevolvingWorkingCapitalFacilityMember" name="RevolvingWorkingCapitalFacilityMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_BasicAndDilutedEarningsPerShareProforma" name="BasicAndDilutedEarningsPerShareProforma" nillable="true" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_InProcessCapitalizedTechnologyAndContentDevelopmentMember" name="InProcessCapitalizedTechnologyAndContentDevelopmentMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
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  <element id="twou_RevenueAndEbitdaLossBySegmentTableTextBlock" name="RevenueAndEbitdaLossBySegmentTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_TotalAssetsBySegmentTableTextBlock" name="TotalAssetsBySegmentTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_UniversityClientOneMember" name="UniversityClientOneMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_UniversityClientTwoMember" name="UniversityClientTwoMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_UniversityClientThreeMember" name="UniversityClientThreeMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_UniversityClientFourMember" name="UniversityClientFourMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_DefinedContributionPlanAnnualContributionsPerEmployeePercent" name="DefinedContributionPlanAnnualContributionsPerEmployeePercent" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_AdvancesFromToCustomers" name="AdvancesFromToCustomers" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_FlatironSchoolIncMember" name="FlatironSchoolIncMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_NonCashCapitalExpenditure" name="NonCashCapitalExpenditure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_MarketingAndSalesCostsAbstract" name="MarketingAndSalesCostsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_NonCashLongLivedAssetAdditionsPolicyTextBlock" name="NonCashLongLivedAssetAdditionsPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_CommonStockCapitalSharesReservedForFutureIssuanceAvailableForFutureIssuanceUnderStockPurchasePlan" name="CommonStockCapitalSharesReservedForFutureIssuanceAvailableForFutureIssuanceUnderStockPurchasePlan" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SegmentReportingInformationAdjustmentsToNetIncomeLossAbstract" name="SegmentReportingInformationAdjustmentsToNetIncomeLossAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_AdjustmentsToNetIncomeLoss" name="AdjustmentsToNetIncomeLoss" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_StockholdersEquityCompensationAbstract" name="StockholdersEquityCompensationAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SegmentReportingInformationIncomeLossAfterAdjustedEarningsBeforeInterestIncomeExpenseTaxesDepreciationAndAmortizationAbstract" name="SegmentReportingInformationIncomeLossAfterAdjustedEarningsBeforeInterestIncomeExpenseTaxesDepreciationAndAmortizationAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_IncomeLossAfterAdjustedEarningsBeforeInterestIncomeExpenseTaxesDepreciationAndAmortization" name="IncomeLossAfterAdjustedEarningsBeforeInterestIncomeExpenseTaxesDepreciationAndAmortization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_PaymentsForWebsite" name="PaymentsForWebsite" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_OutstandingConsiderationLicenseAndSoftwareServices" name="OutstandingConsiderationLicenseAndSoftwareServices" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SegmentProfitabilityMarginAbstract" name="SegmentProfitabilityMarginAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_ContractAssetsAbstract" name="ContractAssetsAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_ContractLiabilitiesAbstract" name="ContractLiabilitiesAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_PercentageOfProfitLossFromSegmentOperations" name="PercentageOfProfitLossFromSegmentOperations" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_IncreaseDecreaseInCustomerLiability" name="IncreaseDecreaseInCustomerLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_TechnologyAndContentDevelopmentCost" name="TechnologyAndContentDevelopmentCost" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_RevenueTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicyPolicyTextBlock" name="RevenueTradeAndOtherAccountsReceivableAllowanceForDoubtfulAccountsPolicyPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_WeworkCompaniesInc.Member" name="WeworkCompaniesInc.Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_CostOfServicesLicensesOfSourceCodeAndSoftwareDevelopment" name="CostOfServicesLicensesOfSourceCodeAndSoftwareDevelopment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_AgreementToOfferScholarships" name="AgreementToOfferScholarships" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SoftwareDevelopmentLicenseAndServicesAgreementMember" name="SoftwareDevelopmentLicenseAndServicesAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_SalesRevenueSegmentRevenueMember" name="SalesRevenueSegmentRevenueMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_LeaseRelatedAndOtherLiabilitiesNonCurrent" name="LeaseRelatedAndOtherLiabilitiesNonCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_IncomeTaxExpenseBenefitRelatedToIntangibleAssetsAndOtherLosses" name="IncomeTaxExpenseBenefitRelatedToIntangibleAssetsAndOtherLosses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="twou_CapitalizedContractCostsNet" name="CapitalizedContractCostsNet" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
</XBRL>
