NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIALRESPONSIBILITY OR CONNECTED PERSONSThis form is intended for use by an issuer to make a RIS notification requiredby DR 3.1.4R(1).(1) An issuer making a notification in respect of a transaction relating to the shares or debentures of the issuer should complete boxes 1 to 16, 23 and 24.(2) An issuer making a notification in respect of a derivative relating to the shares of the issuer should complete boxes 1 to 4, 6, 8, 13, 14, 16, 23 and 24.(3) An issuer making a notification in respect of options granted to a director/person discharging managerial responsibilities should complete boxes 1 to 3 and 17 to 24.(4) An issuer making a notification in respect of a financial instrument relating to the shares of the issuer (other than a debenture) should complete boxes 1 to 4, 6, 8, 9, 11, 13, 14, 16, 23 and 24.PLEASE COMPLETE ALL RELEVANT BOXES IN BLOCK CAPITAL LETTERS.1. Name of the issuer:THE BIOTECH GROWTH TRUST PLC2. State whether the notification relates to: (i) a transaction notified in accordance with DR 3.1.2R; or (ii) a disclosure made in accordance with LR9.8.6R(1); or(iii) a disclosure made in accordance with section 793 of the Companies Act2006(i)3. Name of person discharging managerial responsibilities/director:PETER KEEN (DIRECTOR)4. State whether notification relates to a person connected with a persondischarging managerial responsibilities/director named in 3 and identify theconnected person:AS ABOVE5. Indicate whether the notification is in respect of a holding of the personreferred to in 3 or 4 above or in respect of a non-beneficial interest:AS IN 3 ABOVE6. Description of shares (including class), debentures or derivatives orfinancial instruments relating to shares:ORDINARY 25p SHARES7. Name of registered shareholders(s) and, if more than one, the number ofshares held by each of them:NOT STATED8. State the nature of the transaction:ACQUISITION9. Number of shares, debentures or financial instruments relating to sharesacquired:5000 ORDINARY SHARES10. Percentage of issued class acquired (treasury shares of that class shouldnot be taken into account when calculating percentage):0.007%11. Number of shares, debentures or financial instruments relating to sharesdisposed:NOT APPLICABLE12. Percentage of issued class disposed (treasury shares of that class shouldnot be taken into account when calculating percentage):NOT APPLICABLE13. Price per share or value of transaction:514.29p PER SHARE14. Date and place of transaction:20 FEBRUARY 2014 - LONDON15. Total holding following notification and total percentage holding followingnotification (any treasury shares should not be taken into account whencalculating percentage):55,000 ORDINARY SHARES0.08%16. Date issuer informed of transaction:20 FEBRUARY 2014If a person discharging managerial responsibilities has been granted options bythe issuer complete the following boxes17. Date of grant:-18. Period during which or date on which it can be exercised:-19. Total amount paid (if any) for grant of the option:-20. Description of shares or debentures involved (class and number):-21. Exercise price (if fixed at time of grant) or indication that price is tobe fixed at the time of exercise:-22. Total number of shares or debentures over which options held followingnotification:-23. Any additional information:24. Name of contact and telephone number for queries:MARK POPE, COMPANY SECRETARYTEL: 020 3 008 4913Name and signature of duly authorised officer of issuer responsible for makingnotification: MARK POPEDate of notification:21 FEBRUARY 2014 - END -