For filings with the FCA include the annexFor filings with issuer exclude the annexTR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi1. Identity of the issuer or the underlying issuer of existing shares The Biotech Growthto which voting rights are attached:ii Trust PLC2 Reason for the notification (please tick the appropriate box or boxes):An acquisition or disposal of voting rights YesAn acquisition or disposal of qualifying financial instruments which may result Noin the acquisition of shares already issued to which voting rights are attachedAn acquisition or disposal of instruments with similar economic effect to Noqualifying financial instrumentsAn event changing the breakdown of voting rights NoOther (please specify): No3. Full name of person(s) subject to the notification Reliance Mutual Insuranceobligation:iii Society Limited4. Full name of shareholder(s) (if different from 3.):iv5. Date of the transaction and date on which the threshold 24 February 2014is crossed or reached: v6. Date on which issuer notified: 28 February 20147. Threshold(s) that is/are crossed or reached: vi, vii 5%8. Notified details:A: Voting rights attached to shares viii, ixClass/type of Situation previous Resulting situation aftershares to the triggering the triggering transaction transactionif possible using Number Number % of votingthe ISIN CODE Number of Number of rights x of Voting of voting Shares Rights shares rights Direct Direct xi Indirect xii Direct Indirect Ordinary 3,454,450 3,454,450 3,454,450 3,454,450 n/a 5.01% n/aGB0000385517B: Qualifying Financial InstrumentsResulting situation after the triggering transactionType of financial Expiration Exercise/ Number of voting % of voting instrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted.C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xviResulting situation after the triggering transactionType of financial Exercise Expiration Exercise/ Number of voting % of voting instrument price date xvii Conversion rights instrument rights xix, xx period xviii refers to Nominal DeltaTotal (A+B+C) Number of voting rights Percentage of voting rights 3,454,450 5.01%9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxiProxy Voting:10. Name of the proxy holder: n/a11. Number of voting rights proxy holder will cease to hold: n/a12. Date on which proxy holder will cease to hold voting rights: n/a13. Additional information: Voting rights based on 68,886,347 shares in issue14. Contact name: Ebru Smith15. Contact telephone number: 01892 773 219