For filings with the FCA include the annexFor filings with issuer exclude the annexTR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi1. Identity of the issuer or the underlying issuer The Biotech Growth Trustof existing shares to which voting rights are Plcattached:ii2 Reason for the notification (please tick the appropriate box or boxes):An acquisition or disposal of voting rights XAn acquisition or disposal of qualifying financial instruments which may resultin the acquisition of shares already issued to which voting rights are attachedAn acquisition or disposal of instruments with similar economic effect toqualifying financial instrumentsAn event changing the breakdown of voting rightsOther (please specify):3. Full name of person(s) subject to the Newton Investment Managementnotification obligation:iii Ltd.4. Full name of shareholder(s) (if different from 3.):iv N/A5. Date of the transaction and date onwhich the threshold is crossed or 25 July 2014reached: v6. Date on which issuer notified: 28 July 20147. Threshold(s) that is/are crossed or Falling below 5%reached: vi, vii8. Notified details: GB0000385517A: Voting rights attached to shares viii, ixClass/type Situation previous Resulting situation after the triggering transactionof to the triggeringshares transactionif possible Number Number Number Number of voting % of voting rights xusing of of of shares rightsthe ISIN Shares VotingCODE Rights Direct Direct xi Indirect xii Direct IndirectClosed-EndFund 3,580,174 3,580,174 3,080,174 3,080,174 N/A 4.57% N/AGB0000385517B: Qualifying Financial InstrumentsResulting situation after the triggering transactionType of financial Expiration Exercise/ Number of voting % of votinginstrument date xiii Conversion Period xiv rights that may be rights acquired if the instrument is exercised/ converted.N/AC: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xviResulting situation after the triggering transactionType of Exercise price Expiration Exercise/ Number of voting % of voting rights xix, xxfinancial date Conversion rights instrumentinstrument xvii period xviii refers to Nominal DeltaN/ATotal (A+B+C)Number of voting rights Percentage of voting rights3,080,174 4.57%9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxiNewton Investment Management Ltd. holds these shares as a discretionary fundmanager.Proxy Voting:10. Name of the proxy holder: N/A11. Number of voting rights proxy holder will cease N/Ato hold:12. Date on which proxy holder will cease to hold N/Avoting rights:13. Additional information: N/A14. Contact name: Ivan Arias 516-338-337015. Contact telephone number: