TR-1 (i) NOTIFICATION OF MAJOR INTERESTS IN SHARES1. Identity of the issuer or the underlying issuer of existing shares to whichvoting rights are attached (ii):THE BIOTECH GROWTH TRUST PLC2. Reason for the notification State Yes/NoAn acquisition or disposal of voting rights YESAn acquisition or disposal of financial instruments Nowhich may result in the acquisition of shares alreadyissued to which voting rights are attachedAn event changing the breakdown of voting rights NoOther (please specify): No3. Full name of person(s) subject to the notification EAST RIDING OF YORKSHIREobligation (iii): COUNCIL4. Full name of shareholder(s) (if different from 3.) STATE STREET NOMINEES(iv): LIMITED5. Date of the transaction (and date on which the 29 AUGUST 2014threshold is crossed or reached if different) (v):6. Date on which issuer notified: 29 AUGUST 20147. Threshold(s) that is/are crossed or reached: 8.00%8. Notified details:A: Voting rights attached to sharesClass/type of Situation previous Resulting situation after the triggering shares to transaction (vii) if possible the Triggering using the transaction (vi) ISIN CODE Number Number Number Number of voting % of voting of of of rights (ix) rights Shares Voting shares Rights (viii) Direct Direct Indirect Direct Indirect (x) (xi) ORDINARY 5,200,000 5,200,000 5,100,000 5,100,000 N/A 7.90% N/A GB000385517B: Financial InstrumentsResulting situation after the triggering transaction (xii) Type of Expiration Exercise/ Number of voting % of financial date (xiii) Conversion rights that may be voting instrument Period/ Date (xiv) acquired if the rights instrument is exercised/ convertedTotal (A+B)Number of voting rights % of voting rights5,100,000 7.90%9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable (xv):N/AProxy Voting:10. Name of the proxy holder: N/A11. Number of voting rights proxy holder will cease to hold: N/A12. Date on which proxy holder will cease to hold voting N/Arights:13. Additional information: VOTING RIGHTS RIGHTS (BOX A) BASED ON 64,592,843 SHARES IN ISSUE14. Contact name: JOANNA NOTTINGHAM15. Contact telephone number: 01482 394149Annex Notification Of Major Interests In Shares (xvi)A: Identity of the person or legal entity subject to thenotification obligationFull name (including legal form for legal entities) EAST RIDING OF YORKSHIRE COUNCILContact address (registered office for legal entities) INVESTMNT SECTION PO BOX 164 CHURCH STREET GOOLE DN14 5YZPhone number 01482 394149Other useful information (at least legal representative forlegal persons)B: Identity of the notifier, if applicable (xvii)Full nameContact addressPhone numberOther useful information (e.g. functional relationship withthe personor legal entity subject to the notification obligation)C: Additional informationNotesi. This form is to be sent to the issuer or underlying issuer and to be filedwith the competent authority.ii. Either the full name of the legal entity or another method for identifyingthe issuer or underlying issuer, provided it is reliable and accurate.iii. This should be the full name of (a) the shareholder; (b) the personacquiring, disposing of or exercising voting rights in the cases provided forin DTR5.2.1 (b) to (h); (c) all the parties to the agreement referred to inDTR5.2.1 (a), or (d) the direct or indirect holder of financial instrumentsentitled to acquire shares already issued to which voting rights are attached,as appropriate.In relation to the transactions referred to in points DTR5.2.1 (b) to (h), thefollowing list is provided as indication of the persons who should bementioned:- in the circumstances foreseen in DTR5.2.1 (b), the person that acquires thevoting rights and is entitled to exercise them under the agreement and thenatural person or legal entity who is transferring temporarily forconsideration the voting rights;- in the circumstances foreseen in DTR 5.2.1 (c), the person holding thecollateral, provided the person or entity controls the voting rights anddeclares its intention of exercising them, and person lodging the collateralunder these conditions;- in the circumstances foreseen in DTR5.2.1(d), the person who has a lifeinterest in shares if that person is entitled to exercise the voting rightsattached to the shares and the person who is disposing of the voting rightswhen the life interest is created;- in the circumstances foreseen in DTR5.2.1 (e), the parent undertaking and,provided it has a notification duty at an individual level under DTR 5.1, underDTR5.2.1 (a) to (d) or under a combination of any of those situations, thecontrolled undertaking;- in the circumstances foreseen in DTR5.2.1 (f), the deposit taker of theshares, if he can exercise the voting rights attached to the shares depositedwith him at his discretion, and the depositor of the shares allowing thedeposit taker to exercise the voting rights at his discretion;- in the circumstances foreseen in DTR5.2.1 (g), the person that controls thevoting rights;- in the circumstances foreseen in DTR5.2.1 (h), the proxy holder, if he canexercise the voting rights at his discretion, and the shareholder who has givenhis proxy to the proxy holder allowing the latter to exercise the voting rightsat his discretion.iv. Applicable in the cases provided for in DTR 5.2.1 (b) to (h). This shouldbe the full name of the shareholder or holder of financial instruments who isthe counterparty to the natural person or legal entity referred to in DTR5.2.v. The date of the transaction should normally be, in the case of an onexchange transaction, the date on which the matching of orders occurs; in thecase of an off exchange transaction, date of the entering into an agreement.The date on which threshold is crossed should normally be the date on which theacquisition, disposal or possibility to exercise voting rights takes effect(see DTR 5.1.1R (3)). For passive crossings, the date when the corporate eventtook effect.These dates will usually be the same unless the transaction is subject to acondition beyond the control of the parties.vi. Please refer to the situation disclosed in the previous notification, Incase the situation previous to the triggering transaction was below 3%, pleasestate `below 3%'.vii. If the holding has fallen below the minimum threshold , the notifyingparty should not be obliged to disclose the extent of the holding, only thatthe new holding is less than 3%.For the case provided for in DTR5.2.1(a), there should be no disclosure ofindividual holdings per party to the agreement unless a party individuallycrosses or reaches an Article 9 threshold. This applies upon entering into,introducing changes to or terminating an agreement.viii. Direct and indirectix In case of combined holdings of shares with voting rights attached `directholding' and voting rights `indirect holdings', please split the voting rightsnumber and percentage into the direct and indirect columns-if there is nocombined holdings, please leave the relevant box blank.x Voting rights attached to shares in respect of which the notifying party is adirect shareholder (DTR 5.1)xi. Voting rights held by the notifying party as an indirect shareholder (DTR5.2.1)xii If the holding has fallen below the minimum threshold, the notifying partyshould not be obliged to disclose the extent of the holding, only that the newholding is below 3%.xiii date of maturity / expiration of the finical instrument i.e. the date whenthe right to acquire shares ends.xiv If the financial instrument has such a period-please specify the period-for example once every three months starting from the [date]xv. The notification should include the name(s) of the controlled undertakingsthrough which the voting rights are held. The notification should also includethe amount of voting rights and the percentage held by each controlledundertaking, insofar as individually the controlled undertaking holds 3% ormore, and insofar as the notification by the parent undertaking is intended tocover the notification obligations of the controlled undertaking.xvi. This annex is only to be filed with the competent authority.xvii. Whenever another person makes the notification on behalf of theshareholder or the natural person/legal entity referred to in DTR5.2 andDTR5.3.