For filings with the FSA include the annexFor filings with issuer exclude the annexTR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi1. Identity of the issuer or the underlying issuer THE BIOTECH GROWTHof existing shares to which voting rights are TRUST PLCattached:ii2 Reason for the notification (please tick the appropriate box or boxes):An acquisition or disposal of voting rights XAn acquisition or disposal of qualifying financial instruments which may resultin the acquisition of shares already issued to which voting rights are attachedAn acquisition or disposal of instruments with similar economic effect toqualifying financial instrumentsAn event changing the breakdown of voting rightsOther (please specify):3. Full name of person(s) subject to the EAST RIDING OF YORKSHIREnotification obligation:iii COUNCIL4. Full name of shareholder(s) STATE STREET NOMINEES LIMITED (if different from 3.):iv5. Date of the transaction and date onwhich the threshold is crossed or 04/11/2014reached: v6. Date on which issuer notified: 05/11/20147. Threshold(s) that is/are crossed or 8 %reached: vi, vii8. Notified details:A: Voting rights attached to shares viii, ixClass/type Situation previous Resulting situation after the triggering transactionof to the triggeringshares transactionif possible Number Number Number Number of voting % of voting rightsusing of of of shares rights xthe ISIN Shares VotingCODE Rights Direct Direct xi Indirect xii Direct Indirect ORDINARY 5,100,000 5,100,000 5,070,000 5,070,000 N/A 7.95 % N/AGB0000385517B: Qualifying Financial InstrumentsResulting situation after the triggering transactionType of Expiration Exercise/ Number of voting % of votingfinancial date xiii Conversion Period xiv rights that may be rightsinstrument acquired if the instrument is exercised/ converted.C: Financial Instruments with similar economic effect to Qualifying FinancialInstruments xv, xviResulting situation after the triggering transactionType of Exercise price Expiration Exercise/ Number of voting rights % of votingfinancial date xvii Conversion instrument refers to rights xix, xxinstrument period xviii Nominal DeltaTotal (A+B+C)Number of voting rights Percentage of voting rights 5,070,000 7.95 %9. Chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held, if applicable: xxi N/AProxy Voting:10. Name of the proxy holder:11. Number of voting rights proxy holder will ceaseto hold:12. Date on which proxy holder will cease to holdvoting rights:13. Additional information: CALCULATION BASED ON 63,778,516 SHARES IN ISSUE14. Contact name: JOANNA NOTTINGHAM15. Contact telephone number: 01482 394149