<SEC-DOCUMENT>0001171843-18-000682.txt : 20180126
<SEC-HEADER>0001171843-18-000682.hdr.sgml : 20180126
<ACCEPTANCE-DATETIME>20180126155320
ACCESSION NUMBER:		0001171843-18-000682
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20180126
FILED AS OF DATE:		20180126
DATE AS OF CHANGE:		20180126

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NOVARTIS AG
		CENTRAL INDEX KEY:			0001114448
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15024
		FILM NUMBER:		18551774

	BUSINESS ADDRESS:	
		STREET 1:		LICHTSTRASSE 35
		CITY:			BASEL
		STATE:			V8
		ZIP:			CH 4056
		BUSINESS PHONE:		01141613241111

	MAIL ADDRESS:	
		STREET 1:		LICHTSTRASSE 35
		CITY:			BASEL
		STATE:			V8
		ZIP:			CH 4056
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<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>UNITED STATES</B></P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Washington, D.C. 20549</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>FORM 6-K</B></P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>REPORT OF FOREIGN PRIVATE ISSUER</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>PURSUANT TO RULE 13a-16 or 15d-16 OF</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>THE SECURITIES EXCHANGE ACT OF 1934</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Report on Form 6-K dated January  26, 2018</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(Commission File No. 1-15024)</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">____________________</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>Novartis AG</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">(Name of Registrant)</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Lichtstrasse 35</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>4056 Basel</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Switzerland</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">(Address of Principal Executive Offices)</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">____________________</P>

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<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark whether the registrant files or will file annual reports under
cover of Form 20-F or Form 40-F:</P>

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    <TD STYLE="width: 50%; text-align: right; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Form 20-F:&nbsp;&#9746;</B></FONT></TD>
    <TD STYLE="width: 3%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 47%; font-size: 10pt"><FONT STYLE="font-size: 10pt">Form 40-F:&nbsp;&#9744;</FONT></TD></TR>
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<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted
by Regulation S-T Rule 101(b)(1):</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right"><FONT STYLE="font-size: 10pt">Yes:&nbsp;&#9744;</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt"><B>No</B>:&nbsp;<B>&#9746;</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted
by Regulation S-T Rule 101(b)(7):&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right"><FONT STYLE="font-size: 10pt">Yes:&nbsp;&#9744;</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt"><B>No</B>:&nbsp;<B>&#9746;</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark whether the registrant by furnishing the information contained
in this form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange
Act of 1934.&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right"><FONT STYLE="font-size: 10pt">Yes:&nbsp;&#9744;</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt"><B>No</B>:&nbsp;<B>&#9746;</B></FONT></TD></TR>
</TABLE>


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<P STYLE="color: rgb(0, 0, 0); font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt; text-indent: 0px"><FONT STYLE="font-size: 10pt"></FONT></P>

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<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%"><FONT STYLE="font-size: 8pt"><IMG SRC="logo.jpg" ALT=""></FONT></TD>
    <TD STYLE="width: 34%"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 33%"><P STYLE="color: #0460A9; font-size: 10pt; font-weight: bold; margin: 0pt 0"><FONT STYLE="font-size: 8pt">Novartis&nbsp;International&nbsp;AG</FONT><BR>
                           <FONT STYLE="font-size: 8pt">Novartis Global Communications</FONT></P>
<P STYLE="color: #0460A9; font-size: 10pt; font-weight: bold; margin: 0pt 0"><FONT STYLE="font-size: 8pt"><FONT STYLE="font-weight: normal; color: windowtext"></FONT></FONT></P>
<P STYLE="color: #0460A9; font-size: 10pt; font-weight: bold; margin: 0pt 0"><FONT STYLE="font-size: 8pt"><FONT STYLE="font-weight: normal; color: windowtext">CH-4002 Basel</FONT><BR>
                           <FONT STYLE="font-weight: normal; color: windowtext">Switzerland</FONT></FONT></P>
<P STYLE="color: #0460A9; font-size: 10pt; font-weight: bold; margin: 0pt 0"><FONT STYLE="font-size: 8pt"><FONT STYLE="font-weight: normal; color: windowtext">&nbsp;</FONT></FONT></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0"><FONT STYLE="font-size: 8pt">http://www.novartis.com</FONT></P>



</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; background-color: #999999; color: white"><FONT STYLE="color: Black"><B>MEDIA
RELEASE &bull; COMMUNIQUE AUX MEDIAS &bull; MEDIENMITTEILUNG</B></FONT></P>



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<P STYLE="text-align: center"><FONT STYLE="font-size: 12pt"><B>Advanced Accelerator Applications Receives FDA Approval for Lutathera&#174;
for Treatment of Gastroenteropancreatic Neuroendocrine Tumors</B></FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD><I>Lutathera marks
                                         first FDA Approval for a Peptide Receptor Radionuclide Therapy (PRRT)</I></TD></TR></TABLE>
<P STYLE="text-align: center"><FONT STYLE="font-size: 12pt"><B></B></FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD><I>Advanced Accelerator
                                         Applications is a newly established subsidiary of Novartis</I></TD></TR></TABLE>
<P STYLE="text-align: center"><FONT STYLE="font-size: 12pt"><B></B></FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD><I>Lutathera expands
                                         Novartis' neuroendocrine tumor portfolio, building on long heritage and leadership</I></TD></TR></TABLE>

<P>&nbsp;<BR>
<FONT STYLE="font-size: 10pt"><B>Basel, January 26, 2018 - </B>Novartis AG (NYSE: NVS) today announced that Advanced
Accelerator Applications, a subsidiary of Novartis Groupe S.A., has received US Food and Drug Administration (FDA) approval of
its new drug application (NDA) for Lutathera<SUP>&#174; </SUP>(lutetium Lu 177 dotatate*) for the treatment of somatostatin receptor
positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors,
in adults. Lutathera, which received orphan drug designation from the FDA, is a first-in-class drug and the first available FDA-approved
Peptide Receptor Radionuclide Therapy (PRRT), a form of treatment comprising of a targeting molecule that carries a radioactive
component. The approval was based on a Phase 3 study which demonstrated a 79% reduction in the risk of disease progression or
death within the Lutathera plus best standard of care arm (octreotide LAR 30mg every four weeks) compared to 60 mg of octreotide
LAR alone (hazard ratio 0.21, 95% CI; 0.13-0.32; p&lt;00.001). Novartis recently completed a successful tender offer for Advanced
Accelerator Applications to become a subsidiary within the Novartis Group.</FONT></P>

<P><FONT STYLE="font-size: 10pt">"The approval of Lutathera marks an important achievement and an innovation greatly needed for
the NET cancer community," said Susanne Schaffert, Ph.D., Chairperson and President, Advanced Accelerator Applications. "For 30
years, Novartis has supported the NET community with the development of therapeutics in NET and carcinoid syndrome. I cannot think
of a better way to commemorate the joining of two organizations and our future together as we advance new nuclear medicine therapeutics
in NET as well as across other tumor types."</FONT></P>

<P><FONT STYLE="font-size: 10pt">NETs are rare tumors originating in the neuroendocrine cells of numerous organs, including the
gastrointestinal tract, pancreas and lung. Some patients develop symptoms arising from the excessive production of hormones by
neuroendocrine tumor cells, while others remain clinically silent for years. The estimated incidence, or rate of new cases, of
NETs in the United States is approximately 6.98/100,000 per year, while the estimated prevalence for 2014, based on the National
Cancer Institute's Surveillance, Epidemiology, and End Results&#160;(SEER)&#160;database, was 171,321.[1] Patient survival with
advanced GEP-NETs depends on stage and histology. Patients with well- and moderately-differentiated tumors and distant metastases
have a 5-year survival probability of 35%.[2]</FONT></P>

<P><FONT STYLE="font-size: 10pt">The approval of Lutathera is based on results of a randomized pivotal Phase 3 study, NETTER-1
that compared treatment using Lutathera plus best standard of care (octreotide LAR 30mg every four weeks) to 60 mg of octreotide
LAR, also dosed every four weeks, in patients with inoperable midgut NETs progressing under standard dose octreotide LAR treatment
and overexpressing somatostatin receptors, as well as a subset of efficacy and safety data from an international, single-institution,
single-arm, open-label trial conducted by Erasmus Medical Center in Rotterdam, Netherlands in more than 1,200 patients with somatostatin
receptor positive tumors.</FONT></P>

<P><FONT STYLE="font-size: 10pt"></FONT></P>

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<P><FONT STYLE="font-size: 10pt">The NETTER-1 study met its primary endpoint, showing a 79% reduction in risk of disease progression
or death using Lutathera compared to 60 mg octreotide LAR (hazard ratio 0.21, 95% CI: 0.13-0.32; p&lt;0.0001).[3] Median PFS was
not reached in the Lutathera arm compared to 8.5 months for the 60 mg octreotide LAR arm.[3] A pre-planned interim overall survival
analysis determined that Lutathera treatment lead to a 48% reduction in the estimated risk of death (hazard ratio 0.52, 95% CI:
0.32-0.84) compared to treatment with 60 mg octreotide LAR.[3] The objective response rate, composed of complete and partial responses,
was 13% for the Lutathera arm compared to 4% in the Octreotide LAR 60mg arm (p&lt;0.0148).[3]</FONT></P>

<P ALIGN="JUSTIFY"><FONT STYLE="font-size: 10pt">The most common Grade 3-4 adverse reactions occurring with a greater frequency
among patients in the NETTER-1 study receiving Lutathera with octreotide compared to patients receiving high-dose octreotide include:
lymphopenia (44%), increased gamma-glutamyl transferase&#160;(20%), vomiting (7%), nausea and elevated aspartate aminotransferase
(5% each), and increased alanine aminotransferase, hyperglycemia and hypokalemia (4% each).[3]<BR />&#160;&#160;<BR /><B>Lutathera<SUP>&#174;</SUP>&#160;(lutetium
Lu 177 dotatate) Important Safety information</B>[3]</FONT></P>

<P><FONT STYLE="font-size: 10pt"><B>INDICATION</B><BR />Lutathera<SUP>&#174;</SUP> is a radiolabeled somatostatin analog indicated
for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut,
midgut and hindgut neuroendocrine tumors in adults.</FONT></P>

<P><FONT STYLE="font-size: 10pt"><B>WARNINGS AND PRECAUTIONS</B></FONT><BR /><FONT STYLE="font-size: 10pt"><B>Radiation exposure:
</B>Treatment with Lutathera contributes to a patient's overall long-term radiation exposure and is associated with an increased
risk for cancer. Radiation can be detected in the urine for up to 30 days following Lutathera administration. Minimize radiation
exposure to patients, medical personnel, and household contacts during and after treatment with Lutathera consistent with institutional
good radiation safety practices and patient management procedures.</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Myelosuppression:</B> Due to potential hematological adverse reactions such as anemia, thrombocytopenia,
leukopenia, lymphopenia, and neutropenia, blood cell counts must be monitored prior to, during, and after treatment. Dose modification
or cessation of treatment may be necessary.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Secondary Myelodysplastic Syndrome and Leukemia: </B>With a median follow-up time of 24 months,
myelodysplastic syndrome (MDS) was reported in 2.7% of patients receiving Lutathera with long-acting octreotide compared to no
patients receiving high-dose long-acting octreotide. In a Phase I/II clinical study, 15 patients (1.8%) developed MDS and 4 (0.5%)
developed acute leukemia. The median time to the development of MDS was 28 months (9 to 41 months) and 55 months (32 to 155 months)
for acute leukemia.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Renal toxicity:</B> Treatment with Lutathera will expose kidneys to radiation, which may
impair renal function. Monitor serum creatinine and creatinine clearance to assess changes in renal function. A concomitant intravenous
infusion of amino acids during Lutathera administration is mandatory for renal protection. Patients with baseline renal impairment
may be at greater risk of toxicity. Perform more frequent assessments of renal function in patients with mild or moderate impairment.
Withhold, reduce dose, or permanently discontinue based on severity of reaction.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 7%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
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    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Hepatotoxicity:</B> In Lutathera clinical trials, &lt;1% of patients were reported to have
hepatic tumor hemorrhage, edema, or necrosis, with one patient experiencing intrahepatic congestion and cholestasis. Patients
with hepatic metastasis may be at increased risk of hepatotoxicity due to radiation exposure. Monitor transaminases, bilirubin,
and serum albumin during treatment. Withhold, reduce dose, or permanently discontinue based on severity of reaction.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Neuroendocrine hormonal crises</B>, manifesting with flushing, diarrhea, bronchospasm and
hypotension, occurred in 1% of patients and typically occurred during or within 24 hours following the initial Lutathera dose.
Monitor patients for flushing, diarrhea, hypotension, bronchoconstriction or other signs and symptoms of tumor-related hormonal
release. Administer intravenous somatostatin analogs, fluids, corticosteroids, and electrolytes as indicated.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Embryo-Fetal Toxicity:</B> Lutathera can cause fetal harm. Advise females and males of reproductive
potential of the potential risk to a fetus. Advise females and males of reproductive potential to use effective contraception
during treatment and after. Verify pregnancy status of females of reproductive potential prior to initiating Lutathera.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center">&bull;</TD>
    <TD COLSPAN="2"><B>Temporary Infertility: </B>Radiation absorbed by testis and ovaries from the recommended
cumulative Lutathera dose falls within the range in which temporary or permanent infertility can be expected following external
beam radiotherapy.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 7%; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 60%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
</TABLE>
<P><FONT STYLE="font-size: 10pt"></FONT></P>

<P><FONT STYLE="font-size: 10pt"><B>ADVERSE REACTIONS</B><BR />The most common Grade 3-4 adverse reactions observed in Lutathera
clinical trials were lymphopenia (44%), increased GGT (20%), vomiting (7%), nausea (5%), elevated AST (5%), increased ALT (4%),
hyperglycemia (4%), and hypokalemia (4%).</FONT></P>

<P><FONT STYLE="font-size: 10pt">The following serious adverse reactions are rare but have been observed with a median follow-up
time of more than 4 years after treatment with Lutathera: myelodysplastic syndrome (2%), acute leukemia (1%), renal failure (2%),
hypotension (1%), cardiac failure (2%), myocardial infarction (1%), and neuroendocrine hormonal crisis (1%). Patients should be
counseled and monitored in accordance with the Lutathera prescribing information.</FONT></P>

<P><FONT STYLE="font-size: 10pt"><B>DRUG INTERACTIONS</B><BR />Somatostatin and its analogs competitively bind to somatostatin
receptors and may interfere with the efficacy of Lutathera. Discontinue long-acting somatostatin analogs at least 4 weeks and
short-acting octreotide at least 24 hours prior to each Lutathera dose. Administer short- and long-acting octreotide during Lutathera
treatment as recommended.</FONT></P>

<P><FONT STYLE="font-size: 10pt"><B>Please see full Prescribing Information at:&#160;</B>http://www.adacap.com/wp-content/uploads/2018/01/Lutathera_lutetium_Lu_-177_dotatate_PI_2018_01.pdf</FONT></P>

<P><FONT STYLE="font-size: 10pt">To report SUSPECTED ADVERSE REACTIONS, contact Advanced Accelerator Applications USA, Inc. at
1-844-863-1930, or us-pharmacovigilance@adacap.com, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.</FONT></P>

<P><FONT STYLE="font-size: 10pt"><B>Disclaimer</B><BR />This press release contains forward-looking statements within the meaning
of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified
by words such as "potential," "can," "will," "plan," "expect," "anticipate," "look forward," "believe," "committed," "investigational,"
"pipeline," "launch," or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications
or labeling for the investigational or approved products described in this press release, or regarding potential future revenues
from such products. You should not place undue reliance on these statements. Such forward-looking statements are based on our
current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties.
Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results
may vary materially from those set forth in the forward-looking statements. There can be no guarantee that the investigational
or approved products described in this press release will be submitted or approved for sale or for any additional indications
or labeling in any market, or at any particular time. Nor can there be any guarantee that such products will be commercially successful
in the future. In particular, our expectations regarding such products could be affected by, among other things, the uncertainties
inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory
actions or delays or government regulation generally; our ability to obtain or maintain proprietary intellectual property protection;
the particular prescribing preferences of physicians and patients; global trends toward health care cost containment, including
government, payor and general public pricing and reimbursement pressures; general economic and industry conditions, including
the effects of the persistently weak economic and financial environment in many countries; safety, quality or manufacturing issues,
and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission.
Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any
forward-looking statements contained in this press release as a result of new information, future events or otherwise.</FONT></P>

<P><FONT STYLE="font-size: 10pt"><B></B></FONT></P>

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<P><FONT STYLE="font-size: 10pt"><B>About Novartis</B><BR />Novartis provides innovative healthcare solutions that address the
evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best
meet these needs: innovative medicines, cost-saving generic and biosimilar pharmaceuticals and eye care. Novartis has leading
positions globally in each of these areas. In 2017, the Group achieved net sales of USD 49.1 billion, while R&amp;D throughout
the Group amounted to approximately USD 9.0 billion. Novartis Group companies employ approximately 122,000 full-time-equivalent
associates. Novartis products are sold in approximately 155 countries around the world. For more information, please visit http://www.novartis.com.</FONT></P>

<P><FONT STYLE="font-size: 10pt">Novartis is on Twitter. Sign up to follow @Novartis at http://twitter.com/novartis and @NovartisCancer
at https://twitter.com/novartiscancer</FONT></P>

<P><FONT STYLE="font-size: 10pt">For Novartis multimedia content, please visit www.novartis.com/news/media-library<BR />For questions
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<P><FONT STYLE="font-size: 10pt"><B>References</B><BR />[1] Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC.
Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol.
2017; 3(10):1335-1342.<BR />[2] Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic
factors for neuroendocrine tumors in 35,825 cases in the United States.&#160;J Clin Oncol.&#160;2008;26:3063-3072.<BR />[3] LUTATHERA<SUP>&#174;</SUP>&#160;[prescribing
information]. Millburn, NJ: Advanced Accelerator Applications USA, Inc.; January 2018.&#160;http://www.adacap.com/wp-content/uploads/2018/01/Lutathera_lutetium_Lu_-177_dotatate_PI_2018_01.pdf</FONT></P>

<P><FONT STYLE="font-size: 10pt">* USAN: lutetium Lu 177 dotatate/INN: lutetium (177Lu) oxodotreotide</FONT></P>

<P ALIGN="CENTER"><FONT STYLE="font-size: 10pt"># # #</FONT></P>

<P><FONT STYLE="font-size: 10pt"></FONT></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="font-weight: bold; vertical-align: middle; width: 50%">Novartis Media Relations</TD>
    <TD STYLE="vertical-align: bottom; width: 50%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: middle">Central media line: +41 61 324 2200</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>E-mail: media.relations@novartis.com</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: middle">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD>Eric Althoff</TD>
    <TD>Kristen Klasey</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD>Novartis Global Media Relations&nbsp; &nbsp; &nbsp;</TD>
    <TD>Novartis Division Communications</TD></TR>
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    <TD>+41 61 324 7999 (direct)</TD>
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    778 4763 (direct)</TD></TR>
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    <TD>+41 79 593 4202 (mobile)</TD>
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    <TD>eric.althoff@novartis.com</TD>
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<P><FONT STYLE="font-size: 10pt"><B>Novartis Investor Relations</B><BR />Central investor relations line: +41 61 324 7944<BR />E-mail:
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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SIGNATURES</B></FONT></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pursuant to
the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</FONT></P>

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    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Novartis AG</B></FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
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    <TD STYLE="width: 52%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 7%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 25%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
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<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: January 26, 2018</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ PAUL
    PENEPENT</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name:&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Paul Penepent</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Title:</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Head Group Financial Reporting and
    Accounting</FONT></TD></TR>
</TABLE>


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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
