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Transaction with related parties (Details 1) $ in Millions | 12 Months Ended
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Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
Disclosure of transactions between related parties [line items] |  |  |
Net sales to third parties from continuing operations | $ 48,659 | $ 47,445 | $ 44,751
Executive Commitee members | 13 | 15 | 17
Non-executive directors | 14 | 13 | 13
Roche Holding AG [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Proportion of voting rights held in associate | 33.30% | 33.30% | 33.30%
Genentech / Roche [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Net expense, royalties cost sharing and profit sharing | $ (217) | $ (101) | $ (34)
Number of contracts with related parties | 2 |  |
Genentech / Roche [member] | Lucentis [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Net sales to third parties from continuing operations | $ 1,900 | 2,100 | 2,000
Genentech / Roche [member] | Xolair [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Net sales to third parties from continuing operations | $ 1,300 | $ 1,200 | $ 1,000
Spark Therapeutics, Inc. [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Number of contracts with related parties | 1 |  |

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