<SEC-DOCUMENT>0001171843-21-007500.txt : 20211104
<SEC-HEADER>0001171843-21-007500.hdr.sgml : 20211104
<ACCEPTANCE-DATETIME>20211104064311
ACCESSION NUMBER:		0001171843-21-007500
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20211104
FILED AS OF DATE:		20211104
DATE AS OF CHANGE:		20211104

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NOVARTIS AG
		CENTRAL INDEX KEY:			0001114448
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15024
		FILM NUMBER:		211377873

	BUSINESS ADDRESS:	
		STREET 1:		LICHTSTRASSE 35
		CITY:			BASEL
		STATE:			V8
		ZIP:			CH 4056
		BUSINESS PHONE:		01141613241111

	MAIL ADDRESS:	
		STREET 1:		LICHTSTRASSE 35
		CITY:			BASEL
		STATE:			V8
		ZIP:			CH 4056
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>f6k_110421.htm
<DESCRIPTION>FORM 6-K
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<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>UNITED STATES</B></P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Washington, D.C. 20549</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>FORM 6-K</B></P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>REPORT OF FOREIGN PRIVATE ISSUER</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>PURSUANT TO RULE 13a-16 or 15d-16 OF</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>THE SECURITIES EXCHANGE ACT OF 1934</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><b>Report on Form 6-K dated November 4, 2021</b></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(Commission File No. 1-15024)</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">____________________</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>Novartis AG</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">(Name of Registrant)</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Lichtstrasse 35</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>4056 Basel</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>Switzerland</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">(Address of Principal Executive Offices)</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">____________________</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark whether the registrant files or will file annual reports under
cover of Form 20-F or Form 40-F:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font-size: 10pt; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Form 20-F:&nbsp;&#9746;</B></FONT></TD>
    <TD STYLE="width: 3%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 47%; font-size: 10pt"><FONT STYLE="font-size: 10pt">Form 40-F:&nbsp;&#9744;</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted
by Regulation S-T Rule 101(b)(1):</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right"><FONT STYLE="font-size: 10pt">Yes:&nbsp;&#9744;</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt"><B>No</B>:&nbsp;<B>&#9746;</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted
by Regulation S-T Rule 101(b)(7):&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right"><FONT STYLE="font-size: 10pt">Yes:&nbsp;&#9744;</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt"><B>No</B>:&nbsp;<B>&#9746;</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 3pt">Indicate by check mark whether the registrant by furnishing the information contained
in this form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange
Act of 1934.&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; text-align: right"><FONT STYLE="font-size: 10pt">Yes:&nbsp;&#9744;</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 47%"><FONT STYLE="font-size: 10pt"><B>No</B>:&nbsp;<B>&#9746;</B></FONT></TD></TR>
</TABLE>


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<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%"><IMG SRC="logo.jpg" ALT=""></TD>
    <TD STYLE="width: 34%"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 33%"><p style="color: rgb(4,96,169); font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0"><b>Novartis&nbsp;International&nbsp;AG<BR>
                           Novartis&nbsp;Global Communications</b><BR>
                           <font style="color: windowtext">CH-4002 Basel</font><BR>
                           <font style="color: windowtext">Switzerland</font></P>

<p style="color: #0460A9; font: bold 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">&nbsp;</P>

<p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">http://www.novartis.com</P>
<P STYLE="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0">https://twitter.com/novartisnews</P>



</TD></TR>
</TABLE>
<P STYLE="color: rgb(0, 0, 0); font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt; text-indent: 0px"><FONT STYLE="font-size: 10pt">&nbsp;</font></p>

<p style="color: rgb(0, 0, 0); font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt; text-indent: 0px"><font style="font-size: 10pt">&nbsp;</font></p>

<p style="font: 14pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: rgb(141,31,27)"><b>MEDIA &amp; INVESTOR RELEASE</b></p>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt"><font style="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-align: left; font-size: 10pt; font-weight: bold; margin-top: 4.45pt; margin-right: 0pt; margin-bottom: 0pt"></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt"><FONT STYLE="font-size: 12pt"><B>Novartis to sell
its Roche stake in a bilateral transaction to Roche</B></FONT></P>

<P STYLE="font-size: 10pt; margin: 0.5pt 0 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt"><B>Ad hoc announcement pursuant to Art. 53 LR</B></P>

<P STYLE="font-size: 10pt; margin: 0.55pt 0 0"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1%"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="padding-right: 45.05pt"><I>Novartis and Roche agree a bilateral transaction for the sale of Roche bearer shares held by Novartis
for a total consideration of USD 20.7 billion</I></TD></TR></TABLE>

<P STYLE="font-size: 10pt; margin: 0.1pt 0 0"><I>&nbsp;</I></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1%"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="padding-right: 18.3pt"><I>Price of USD 388.99 per share (CHF 356.93 per share) reflects the volume- weighted average price
of the Roche non-voting equity certificates (Genussschein) over the last 20 trading days ending on November 2, 2021</I></TD></TR></TABLE>

<P STYLE="font-size: 10pt; margin: 0.5pt 0 0"><I>&nbsp;</I></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1%"></TD><TD STYLE="width: 18pt">&bull;</TD><TD><I>Monetization consistent with Novartis strategy as a focused medicines company</I></TD></TR></TABLE>

<P STYLE="font-size: 10pt; margin: 0"><I>&nbsp;</I></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font-size: 10pt; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 1%"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="padding-right: 31.55pt"><I>Use of proceeds will be in line with capital allocation priorities to enhance strong returns to
shareholders</I></TD></TR></TABLE>

<P STYLE="font-size: 10pt; margin: 0.45pt 0 0"><I>&nbsp;</I></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt"><B>Basel, November 4, 2021 </B>&mdash; Novartis has agreed to sell 53.3 million (approximately
33%) Roche bearer shares in a bilateral transaction to Roche for a total consideration of USD 20.7 billion.</P>

<P STYLE="font-size: 10pt; margin: 0.4pt 0 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">Vas Narasimhan, CEO of Novartis, said: &ldquo;After more than 20 years as a shareholder
of Roche, we concluded that now is the right time to monetize our investment. Today&rsquo;s announcement is consistent with our strategic
focus and we intend to deploy the proceeds from the transaction in line with our capital allocation priorities to maximize shareholder
value and continue to reimagine medicine.&rdquo;</P>

<P STYLE="font-size: 10pt; margin: 0.15pt 0 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">Novartis has been a shareholder of Roche since May, 2001 and currently holds 53.3
million bearer shares of Roche&rsquo;s common stock, representing approximately 33% of aggregate outstanding bearer shares. Novartis
acquired the stake between 2001 and 2003 for a total consideration of approximately USD 5 billion as a long-term financial investment
which delivered significant, recurring earnings contribution and cumulative dividends in excess of USD 6 billion. Over the holding period
of the stake, this resulted in an annualized return of 10.2 % in USD (and 6.6% in CHF). Today, Novartis does not consider the financial
investment in Roche as part of its core business and therefore not a strategic asset.</P>

<P STYLE="font-size: 10pt; margin: 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">Novartis will report a gain from the sale of the stake in income from associated
companies of approximately USD 14 billion, which will be core adjusted.</P>

<P STYLE="font-size: 10pt; margin: 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">The transaction is subject to the approval by the shareholders of Roche, at
the Extraordinary General Meeting (&ldquo;EGM&rdquo;) of Shareholders of Roche to be held on November 26, 2021.</P>

<P STYLE="margin: 0; font-size: 10pt">&nbsp;</P>

<P STYLE="margin: 0; font-size: 10pt"><B></B></P>

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<P STYLE="margin: 0; font-size: 10pt"><B>&nbsp;</B></P>

<P STYLE="margin: 0; font-size: 10pt"><B></B></P>

<P STYLE="margin: 0; font-size: 10pt"><B>Disclaimer</B></P>

<P STYLE="font-size: 10pt; margin: 0.4pt 0 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">This press release contains forward-looking statements
within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be
identified by words such as &ldquo;potential,&rdquo; &ldquo;can,&rdquo; &ldquo;will,&rdquo; &ldquo;plan,&rdquo; &ldquo;may,&rdquo; &ldquo;could,&rdquo;
&ldquo;would,&rdquo; &ldquo;expect,&rdquo; &ldquo;anticipate,&rdquo; &ldquo;seek,&rdquo; &ldquo;look forward,&rdquo; &ldquo;believe,&rdquo;
&ldquo;committed,&rdquo; &ldquo;investigational,&rdquo; &ldquo;pipeline,&rdquo; &ldquo;launch,&rdquo; &ldquo;to sell,&rdquo; &ldquo;strategy,&rdquo;
&ldquo;strategic focus,&rdquo; &ldquo;to enhance,&rdquo; or similar terms, or by express or implied discussions regarding the potential
completion of the announced transaction. You should not place undue reliance on these statements. Such forward-looking statements are
based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties.
Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may
vary materially from those set forth in the forward-looking statements. There can be no guarantee that the transaction described in this
press release will be completed in the expected time frame, or at all. Neither is there any guarantee that the expected benefits from
such transaction will be achieved in the expected timeframe, or at all. In particular, our expectations regarding the transaction described
in this press release could be affected by, among other things, an unexpected failure to obtain the approval by the shareholders of Roche
at the Extraordinary Meeting of Shareholders to be held on November 26, 2021 or to satisfy or waive all other closing conditions; the
uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data;
regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government,
payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain
or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general
political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases such as COVID-19; safety,
quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information
technology systems, and other risks and factors referred to in Novartis AG&rsquo;s current Form 20-F on file with the US Securities and
Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation
to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.</P>

<P STYLE="font-size: 10pt; margin: 0.2pt 0 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0pt; margin-bottom: 0pt"><B>About Novartis</B></P>

<P STYLE="font-size: 10pt; margin: 0.5pt 0 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">Novartis is reimagining medicine to improve and
extend people&rsquo;s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative
treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world&rsquo;s top companies
investing in research and development. Novartis products reach nearly 800 million people globally and <FONT STYLE="color: Black">we are
finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis
around the world. Find out more at https://www.novartis.com.</FONT></P>

<P STYLE="font-size: 10pt; margin: 0.5pt 0 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">Novartis is on Twitter. Sign up to follow @Novartis at <B>https://twitter.com/novartisnews
</B>.</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">For Novartis multimedia content, please visit <B>https://www.novartis.com/news/media-library</B> .</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0.3in; margin-bottom: 0pt">For questions about the site or required registration, please contact media.relations@novartis.com</P>

<P STYLE="font-size: 10pt; margin: 0.45pt 0 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0 210.85pt 0 3.25in"># # #</P>

<P STYLE="text-align: left; font-size: 10pt; font-weight: bold; margin-top: 4.45pt; margin-right: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 12pt">&nbsp;</FONT></P>

<P STYLE="text-align: left; font-size: 10pt; font-weight: bold; margin-top: 4.45pt; margin-right: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 12pt"></FONT></P>

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<P STYLE="margin: 0; font-size: 10pt"><B>&nbsp;</B></P>

<P STYLE="margin: 0; font-size: 10pt"><B></B></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-right: 0pt; margin-bottom: 0pt"><B>Novartis Media Relations</B></P>

<P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">E-mail: media.relations@novartis.com</P>

<P STYLE="font-size: 10pt; margin: 0.2pt 0 0">&nbsp;</P>

<TABLE STYLE="width: 100%; border-collapse: collapse; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">
    <P STYLE="font-size: 10pt; margin: 0 0 0 2.5pt">Richard Jarvis</P>
    <P STYLE="font-size: 10pt; margin: 0.5pt 51.1pt 0 2.5pt">Novartis Strategy &amp; Financial Communications</P>
    <P STYLE="font-size: 10pt; margin: 0.05pt 0 0 2.5pt">+41 79 584 23 26 (mobile)</P>
    <P STYLE="margin: 0.05pt 0 0 2.5pt; font-size: 10pt">richard.jarvis@novartis.com</P>
    <P STYLE="font-size: 10pt; margin: 0">&nbsp;</P>
    <P STYLE="font-size: 10pt; margin: 0.05pt 0 0 2.5pt">Julie Masow</P>
    <P STYLE="font-size: 10pt; margin: 0.5pt 0 0 2.5pt">Novartis US External Engagement</P>
    <P STYLE="font-size: 10pt; margin: 0.5pt 0 0 2.5pt">+1 862 579 8456</P>
    <P STYLE="font-size: 10pt; margin: 0.5pt 0 0 2.5pt">julie.masow@novartis.com</P></TD>
    <TD STYLE="width: 50%">
    <P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">Satoshi Sugimoto</P>
    <P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">Novartis Communications Switzerland</P>
    <P STYLE="font-size: 10pt; margin: 0.4pt 0 0"></P>
    <P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">+41 79 619 20 35 (mobile)</P>
    <P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">satoshi.sugimoto@novartis.com</P></TD></TR>
  </TABLE>
<P STYLE="font-size: 10pt; margin: 0.45pt 0 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt"><B>Novartis Investor Relations</B></P>

<P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">Central investor relations line: +41 61 324 7944</P>

<P STYLE="font-size: 10pt; margin-top: 0.5pt; margin-right: 0pt; margin-bottom: 0pt">E-mail: investor.relations@novartis.com</P>

<P STYLE="font-size: 10pt; margin: 0.35pt 0 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">Central</FONT></TD>
    <TD STYLE="width: 25%">&nbsp;</TD>
    <TD STYLE="width: 25%"><FONT STYLE="font-size: 10pt">North America</FONT></TD>
    <TD STYLE="width: 25%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Samir Shah</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">+41 61 324 7944</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Sloan Simpson</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">+1 862 345 4440</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Thomas Hungerbuehler</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">+41 61 324 8425</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Alina Levchuk</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">+1 862 778 3372</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Isabella Zinck</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">+41 61 324 7188</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">Parag Mahanti</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">+1 973-876-4912</FONT></TD></TR>
  </TABLE>
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<p style="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SIGNATURES</B></FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Pursuant to
the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned, thereunto duly authorized.</FONT></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; background-color: white; font-size: 10pt">
<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Novartis AG</B></FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="width: 52%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 7%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 25%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 16%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD><font style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Date: November 4, 2021</font></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ PAUL
    PENEPENT</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Name:&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Paul Penepent</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Title:</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Head Group Financial Reporting and
    Accounting</FONT></TD></TR>
</TABLE>


<P STYLE="margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="margin: 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;</FONT></P>

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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
