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Transaction with related parties (Details) $ in Millions | 12 Months Ended
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Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($)
Disclosure of transactions between related parties [line items] |  |  |
Net sales to third parties | $ 50,545 | $ 51,626 | $ 48,659
Executive Committee members | 11 | 12 | 13
Related parties, number of executive committee members who stepped down | 5 | 3 |
Non-executive directors | 15 | 14 | 14
Roche Holding AG [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Proportion of voting rights held in associate |  | 33.30% | 33.30%
Genentech / Roche [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Net expense, royalties cost sharing and profit sharing |  | $ (188) | $ (217)
Number of contracts with related parties | 2 |  |
Genentech / Roche [member] | Lucentis [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Net sales to third parties |  | 2,000 | 1,900
Genentech / Roche [member] | Xolair [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Net sales to third parties |  | $ 1,300 | $ 1,300
Spark Therapeutics, Inc. [member] |  |  |
Disclosure of transactions between related parties [line items] |  |  |
Number of contracts with related parties | 1 |  |

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