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Transaction with related parties (Details)
$ in Millions
 12 Months Ended
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Disclosure of transactions between related parties [line items]      
Net sales to third parties $ 50,545 $ 51,626 $ 48,659
Executive Committee members 11 12 13
Related parties, number of executive committee members who stepped down 5 3  
Non-executive directors 15 14 14
Roche Holding AG [member]      
Disclosure of transactions between related parties [line items]      
Proportion of voting rights held in associate   33.30% 33.30%
Genentech / Roche [member]      
Disclosure of transactions between related parties [line items]      
Net expense, royalties cost sharing and profit sharing   $ (188) $ (217)
Number of contracts with related parties 2    
Genentech / Roche [member] | Lucentis [member]      
Disclosure of transactions between related parties [line items]      
Net sales to third parties   2,000 1,900
Genentech / Roche [member] | Xolair [member]      
Disclosure of transactions between related parties [line items]      
Net sales to third parties   $ 1,300 $ 1,300
Spark Therapeutics, Inc. [member]      
Disclosure of transactions between related parties [line items]      
Number of contracts with related parties 1