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Goodwill and intangible assets (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | $ 63,777 |  |
Additions | 2,093 | $ 1,736 |
Intangible assets and goodwill at end of period | 60,945 | 63,777 |
Goodwill |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 29,595 | 29,999 |
Impact of business combinations | 161 | 238 |
Disposals and derecognitions | (28) |  |
Currency translation effects | (427) | (642) |
Intangible assets and goodwill at end of period | 29,301 | 29,595 | $ 29,999
Intangible Assets other than Goodwill |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 34,182 | 36,809 |
Impact of business combinations | 1,209 | 652 |
Additions | 2,093 | 1,736 |
Disposals and derecognitions | (100) | (37) |
Amortization charge | (3,982) | (3,903) |
Impairment charge | (1,326) | (403) | (914)
Currency translation effects | (432) | (672) |
Intangible assets and goodwill at end of period | 31,644 | 34,182 | 36,809
Acquired research and development [member] |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 5,499 | 4,700 |
Impact of business combinations | 1,209 | 262 |
Reclassifications | (1,429) | (20) |
Additions | 330 | 958 |
Disposals and derecognitions | (95) |  |
Impairment charge | (917) | (350) |
Currency translation effects | (176) | (51) |
Intangible assets and goodwill at end of period | 4,421 | 5,499 | 4,700
Technologies |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 177 | 230 |
Reclassifications | 2 | 15 |
Amortization charge | (37) | (41) |
Impairment charge | (15) | (17) |
Currency translation effects | (6) | (10) |
Intangible assets and goodwill at end of period | 121 | 177 | 230
Currently marketed products |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 27,106 | 30,767 |
Impact of business combinations |  | 292 |
Reclassifications | 1,403 | 5 |
Additions | 1,175 | 270 |
Disposals and derecognitions | (3) | (36) |
Amortization charge | (3,603) | (3,607) |
Impairment charge | (322) | (1) |
Currency translation effects | (243) | (584) |
Intangible assets and goodwill at end of period | 25,513 | 27,106 | 30,767
Other intangible assets |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 1,400 | 1,112 |
Impact of business combinations |  | 98 |
Reclassifications | 24 |  |
Additions | 588 | 508 |
Disposals and derecognitions | (2) | (1) |
Amortization charge | (342) | (255) |
Impairment charge | (72) | (35) |
Currency translation effects | (7) | (27) |
Intangible assets and goodwill at end of period | 1,589 | 1,400 | 1,112
Gross carrying amount | Goodwill |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 29,900 | 30,321 |
Intangible assets and goodwill at end of period | 29,596 | 29,900 | 30,321
Gross carrying amount | Intangible Assets other than Goodwill |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 68,211 | 67,725 |
Intangible assets and goodwill at end of period | 69,684 | 68,211 | 67,725
Gross carrying amount | Acquired research and development [member] |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 8,013 | 6,893 |
Intangible assets and goodwill at end of period | 7,092 | 8,013 | 6,893
Gross carrying amount | Technologies |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 1,080 | 1,115 |
Intangible assets and goodwill at end of period | 1,038 | 1,080 | 1,115
Gross carrying amount | Currently marketed products |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 56,213 | 57,333 |
Intangible assets and goodwill at end of period | 58,249 | 56,213 | 57,333
Gross carrying amount | Other intangible assets |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | 2,905 | 2,384 |
Intangible assets and goodwill at end of period | 3,305 | 2,905 | 2,384
Accumulated depreciation, amortisation and impairment | Goodwill |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | (305) | (322) |
Intangible assets and goodwill at end of period | (295) | (305) | (322)
Accumulated depreciation, amortisation and impairment | Intangible Assets other than Goodwill |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | (34,029) | (30,916) |
Intangible assets and goodwill at end of period | (38,040) | (34,029) | (30,916)
Accumulated depreciation, amortisation and impairment | Acquired research and development [member] |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | (2,514) | (2,193) |
Intangible assets and goodwill at end of period | (2,671) | (2,514) | (2,193)
Accumulated depreciation, amortisation and impairment | Technologies |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | (903) | (885) |
Intangible assets and goodwill at end of period | (917) | (903) | (885)
Accumulated depreciation, amortisation and impairment | Currently marketed products |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | (29,107) | (26,566) |
Intangible assets and goodwill at end of period | (32,736) | (29,107) | (26,566)
Accumulated depreciation, amortisation and impairment | Other intangible assets |  |  |
Disclosure of detailed information about intangible assets [line items] |  |  |
Intangible assets and goodwill at beginning of period | (1,505) | (1,272) |
Intangible assets and goodwill at end of period | $ (1,716) | $ (1,505) | $ (1,272)

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