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<PAGE>   1


                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549


                                    FORM 8-K


                                 CURRENT REPORT

     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of earliest reported)      April 20, 2001
                                           --------------------------


                           Advanced Biotherapy, Inc.
-----------------------------------------------------------------------------
             (Exact name of registrant as specified in its chapter)


          Delaware                        0-26323             51-0402415
----------------------------            -----------       -------------------
(State or other jurisdiction            (Commission          (IRS Employer
      of incorporation                  File Number)      Identification No.)


6355 Topanga Canyon Blvd., Suite 510
Woodland Hills, CA                                        91367
----------------------------------------            --------------------
(Address of principal executive offices)               (Zip Code)



Registrant's telephone number, including area code      (818) 883-6716
                                                   -------------------------


                         5950 La Place Court, Suite 210
                               Carlsbad, CA 92008
         -------------------------------------------------------------
         (Former name or former address, if changed since last report)






<PAGE>   2


ITEM 5.    OTHER EVENTS.

     Advanced Biotherapy, Inc. recently issued a press release regarding certain
executive officer resignations and appointments. A copy of such press release is
filed as an Exhibit to this Form 8-K.


ITEM 7.    FINANCIAL STATEMENTS AND EXHIBITS.

(c)   Exhibits


Designation                                  Description of Exhibit
  99.1                                       Press release, dated April 20, 2001



<PAGE>   3


Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                   ADVANCED BIOGRAPHY, INC.
                                   -------------------------------------
                                               (Registrant)

                                   By:  /s/ Edmond Buccellato
                                      ----------------------------------
                                        Edmond Buccellato
                                        Chief Executive Officer


Date  April 24, 2001
      -------------------


<PAGE>   4



                               INDEX TO EXHIBITS



     Exhibit                   Description
     -------                   -----------

     99.1                      Text of Press Release, dated April 20, 2001
</TEXT>
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<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>v71836ex99-1.txt
<DESCRIPTION>EXHIBIT 99.1
<TEXT>

<PAGE>   1
                                                                    EXHIBIT 99.1


ADVANCED BIOTHERAPY INC. ANNOUNCES RESIGNATIONS OF
PAUL J. MARANGOS, PH.D.
AND MARGO J. DOCKENDORF, ESQ.


WOODLAND HILLS, Calif. -- (BUSINESS WIRE)--April 20, 2001--Advance Biotherapy
Inc. (OTCBB:ADVB), today announced that Paul J. Marangos, Ph.D., the company's
chief executive officer and chairman of the board of directors, and Margo
Dockendorf, Esq., director of operations, general counsel and corporate
secretary and treasurer, have resigned to pursue other business interests and
opportunities.

Alexander L. Cappello, chairman and chief executive officer of Cappello Group
Inc., a member of the company's board of directors, has been appointed as the
company's chairman, and Edmond F. Buccellato, a member of the board of
directors, and chief executive officer of the company between 1995 and Aug. 31,
2000, will resume the role of chief executive officer. William M. Finkelstein,
certified public accountant, will become chief financial officer.

Commenting on Dr. Marangos' resignation, Cappello stated, "The company
appreciates and recognizes Dr. Marangos' contributions to the advancement of
our company over the past year and we are pleased that he will remain a member
of our board of directors."

Dr. Marangos commented, "I wish the company well in its endeavors as it moves
forward with the development of its therapeutic strategies for autoimmune
disorders."

The company develops drugs that may effectively treat a range of autoimmune
diseases.

In four randomized, placebo-controlled, double blind trials conducted in
Russia, the company has demonstrated efficacy of its anti-cytokine strategy in
both RA and MS. These studies have permitted the company to determine which
cytokines are most active in the autoimmune disease process, and therefore,
which need to be reduced to treat the disorder.

With a five day treatment course, statistically significant and clinically
relevant responses were obtained that persisted for as long as one year after
treatment termination in the MS studies and for one month in the RA studies.

The business strategy of the company involves the engagement of a corporate
partner to assist in the clinical development of its drug treatments for
autoimmune disorders. This will involve, upon the identification of such a

<PAGE>   2


partner, the filing of the necessary documents with the FDA, conducting clinical
trials and obtaining the necessary regulatory approvals (New Drug Applications
(NDA) or a 510K device approval).

The company does not intend to market its drug products if they are approved by
the FDA, but will instead seek a licensing and royalty arrangement with a
corporate partner who will market the products when and if they are approved.

Statements made in this news release, other than statements of historical fact,
are forward-looking statements and are subject to a number of uncertainties
that could cause actual results of differ materially from the statements made,
including risks associated with the success of clinical trials, the progress of
research and product development programs, the regulatory approval process,
competitive products, future capital requirements and the extent and breadth of
the company's patent portfolio. See the company's public filings with the
Securities and Exchange Commission for information about risks that may affect
the company.


CONTACT:

Advanced Biotherapy Inc.

Edmond F. Buccellato/Lisa McEntyre, 818/883-6716

KEYWORD: CALIFORNIA RUSSIA INTERNATIONAL EUROPE




BW0404 APR 20, 2001

17:47 PACIFIC

20:47 EASTERN

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