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                                                                    EXHIBIT 23.1

                         INDEPENDENT AUDITORS' CONSENT

  We consent to the inclusion in the Registration Statement on Form S-1 of our
reports dated February 25, 2000, on our audits of the financial statements and
Schedule II of 3-Dimensional Pharmaceuticals, Inc. as of December 31, 1999
(consolidated) and 1998 and for each of the years in the three year period
ended December 31, 1999, and to the reference to our firm under the captions
"Selected Financial Information" and "Experts" included in the Prospectus.

                                          Richard A. Eisner & Company, LLP

New York, New York
May 17, 2000
