<SUBMISSION>
<ACCESSION-NUMBER>0000950133-03-000450
<TYPE>SC 13G/A
<PUBLIC-DOCUMENT-COUNT>1
<FILING-DATE>20030214
<GROUP-MEMBERS>BIOTECH GROWTH N.V.
<SUBJECT-COMPANY>
<COMPANY-DATA>
<CONFORMED-NAME>3 DIMENSIONAL PHARMACEUTICALS INC
<CIK>0000914201
<ASSIGNED-SIC>2834
<IRS-NUMBER>232716487
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>SC 13G/A
<ACT>34
<FILE-NUMBER>005-59449
<FILM-NUMBER>03565958
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>665 STOCKTON DRIVE
<STREET2>SUITE 104
<CITY>EXTON
<STATE>PA
<ZIP>19341
<PHONE>6104588959
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>665 STOCKTON DRIVE
<STREET2>SUITE 104
<CITY>EXTON
<STATE>PA
<ZIP>19341
</MAIL-ADDRESS>
</SUBJECT-COMPANY>
<FILED-BY>
<COMPANY-DATA>
<CONFORMED-NAME>BB BIOTECH AG
<CIK>0000924223
<ASSIGNED-SIC>0000
<STATE-OF-INCORPORATION>V8
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>SC 13G/A
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>VODERGASSE 3
<STREET2>SWITZERLAND
<CITY>SCHAFFHAUSEN
<STATE>V8
<ZIP>CH-8300
<PHONE>411724 59 59
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>VODERGASSE 3
<STREET2>SWITZERLAND
<CITY>SCHAFFHAUSEN
<STATE>V8
<ZIP>CH-8300
</MAIL-ADDRESS>
</FILED-BY>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>w83576dsc13gza.htm
<DESCRIPTION>3 DIMENSIONAL PHARMACEUTICALS INC. SCHEDULE 13G
<TEXT>
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<HEAD>
<TITLE>sc13gza</TITLE>
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<TABLE align="right" width="160" border="1" cellspacing="0" cellpadding="1">
<TR><TD align="center" nowrap><FONT size="2">OMB APPROVAL</FONT></TD></TR>
<TR><TD nowrap><FONT size="2">OMB Number: 3235-0145</FONT></TD></TR>
<TR><TD nowrap><FONT size="2">Expires: December 31, 2005</FONT></TD></TR>
<TR><TD nowrap><FONT size="2">Estimated average burden<BR>
hours per response...11</FONT></TD></TR></TABLE>

<BR clear="right">
<BR clear="right">

<P align="center"><FONT size="4">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION</FONT><BR>
<FONT size="3">Washington, D.C. 20549</FONT>

<P align="center"><FONT size="5">SCHEDULE 13G</FONT>

<P align="center"><FONT size="2">Under the Securities Exchange Act of 1934<BR>
(Amendment No. 2)*</FONT>

<P align="center"><FONT size="2">3-Dimensional Pharmaceuticals Inc.</FONT><BR>
<HR size="1" noshade>
<CENTER><FONT size="2">(Name of Issuer)</FONT></CENTER>

<P align="center"><FONT size="2">Common Stock</FONT><BR>
<HR size="1" noshade>
<CENTER><FONT size="2">(Title of Class of Securities)</FONT></CENTER>

<P align="center"><FONT size="2">88554W104</FONT><BR>
<HR size="1" noshade>
<CENTER><FONT size="2">(Cusip Number)</FONT></CENTER>

<P align="center"><FONT size="2"></FONT><BR>
<HR size="1" noshade>
<CENTER><FONT size="2">(Date of Event Which Requires Filing of this
Statement)</FONT></CENTER>

<P><FONT size="2">Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
face="wingdings">&#111;</FONT><FONT size="2">&nbsp;Rule&nbsp;13d-1 (b)</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
face="wingdings">&#120;</FONT><FONT size="2">&nbsp;Rule&nbsp;13d-1 (c)</FONT>

<P><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT
face="wingdings">&#111;</FONT><FONT size="2">&nbsp;Rule&nbsp;13d-1 (d)</FONT>

<P><FONT size="2">*The remainder of this cover page shall be filled out for a
reporting person&#146;s initial filing on this form with respect to the subject
class of securities, and for any subsequent amendment containing information
which would alter the disclosures provided in a prior cover page.</FONT>

<P><FONT size="2">The information required in the remainder of this cover page
shall not be deemed to be &#147;filed&#148; for the purpose of Section&nbsp;18
of the Securities Exchange Act of 1934 or otherwise subject to the liabilities
of that section of the Act but shall be subject to all other provisions of the
Act (however, see the notes).</FONT>

<P align="center"><FONT size="2">&nbsp;</FONT>

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<TABLE width="100%" border="0" cellspacing="0" cellpadding="4">
<TR>
<TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="28%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="14%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="45%"><FONT size="2">&nbsp;</FONT></TD>
</TR>


<TR>
<TD colspan="7"><FONT size="2">CUSIP No. 88554W104</FONT> </TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">1.</FONT></TD>
<TD valign=top colspan=3><FONT size="2">Name of Reporting Person:<BR>BB Biotech
AG</FONT></TD>
<TD valign=top colspan=2><FONT size="2">I.R.S. Identification Nos. of above
persons (entities only):<BR>
N/A</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">2.</FONT></TD>
<TD valign=top colspan=5><FONT size="2">Check the Appropriate Box if a Member of
a Group:</FONT></TD>
</TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(a)</FONT></TD>
<TD valign=top><FONT face="wingdings">&#120;</FONT></TD>
<TD valign=top colspan=3><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(b)</FONT></TD>
<TD valign=top><FONT face="wingdings">&#111;</FONT></TD>
<TD valign=top colspan=3><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">3.</FONT></TD>
<TD valign=top colspan=5><FONT size="2">SEC Use Only:</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">4.</FONT></TD>
<TD valign=top colspan=5><FONT size="2">Citizenship or Place of
Organization:<BR>Switzerland</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR><TD colspan="3" rowspan="8" align="center"><FONT size="2">Number
of<BR>Shares<BR>Beneficially<BR>Owned by<BR> Each Reporting<BR>Person
With</FONT></TD></TR>

<TR><TD valign=top><FONT size="2">5.</FONT></TD>
<TD valign=top colspan=3><FONT size="2">Sole Voting Power:<BR>0</FONT></TD></TR>

<TR><TD colspan=4><hr noshade></TD></TR>

<TR><TD valign=top><FONT size="2">6.</FONT></TD><TD valign=top colspan=3> <FONT
size="2">Shared Voting Power:<BR>2,850,485</FONT></TD></TR>

<TR><TD colspan=4><hr noshade></TD></TR>

<TR><TD valign=top><FONT size="2">7.</FONT></TD><TD valign=top colspan=3> <FONT
size="2">Sole Dispositive Power:<BR>0</FONT></TD></TR>

<TR><TD colspan=4><hr noshade></TD></TR>

<TR><TD valign=top><FONT size="2">8.</FONT></TD><TD valign=top colspan=3><FONT
size="2">Shared Dispositive Power:<BR>2,850,485</FONT></TD></TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">9.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Aggregate Amount Beneficially Owned by Each Reporting Person:
<BR>2,850,485</FONT></TD>
</TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">10.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Check if the Aggregate Amount in Row (9) Excludes Certain
Shares:<BR><FONT face="wingdings">&#111;</FONT></FONT></TD>
</TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">11.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Percent of Class Represented by Amount in Row
(9):<BR>12.6%</FONT></TD></TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">12.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Type of Reporting Person:<BR>HC, CO</FONT></TD></TR>

<TR><TD colspan=7><hr noshade></TD></TR>
</TABLE>


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<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>

<TABLE width="100%" border="0" cellspacing="0" cellpadding="4">
<TR>
<TD width="4%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="3%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="28%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="14%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="45%"><FONT size="2">&nbsp;</FONT></TD>
</TR>


<TR>
<TD colspan="7"><FONT size="2">CUSIP No. 88554W104</FONT> </TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">1.</FONT></TD>
<TD valign=top colspan=3><FONT size="2">Name of Reporting Person:<BR>Biotech
Growth N.V.</FONT></TD>
<TD valign=top colspan=2><FONT size="2">I.R.S. Identification Nos. of above
persons (entities only):<BR>
N/A</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">2.</FONT></TD>
<TD valign=top colspan=5><FONT size="2">Check the Appropriate Box if a Member of
a Group:</FONT></TD>
</TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(a)</FONT></TD>
<TD valign=top><FONT face="wingdings">&#120;</FONT></TD>
<TD valign=top colspan=3><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(b)</FONT></TD>
<TD valign=top><FONT face="wingdings">&#111;</FONT></TD>
<TD valign=top colspan=3><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">3.</FONT></TD>
<TD valign=top colspan=5><FONT size="2">SEC Use Only:</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">4.</FONT></TD>
<TD valign=top colspan=5><FONT size="2">Citizenship or Place of
Organization:<BR>Netherlands Antilles</FONT></TD>
</TR>

<TR><TD colspan=7><HR noshade></TD></TR>

<TR><TD colspan="3" rowspan="8" align="center"><FONT size="2">Number
of<BR>Shares<BR>Beneficially<BR>Owned by<BR> Each Reporting<BR>Person
With</FONT></TD></TR>

<TR><TD valign=top><FONT size="2">5.</FONT></TD>
<TD valign=top colspan=3><FONT size="2">Sole Voting Power:<BR>0</FONT></TD></TR>

<TR><TD colspan=4><hr noshade></TD></TR>

<TR><TD valign=top><FONT size="2">6.</FONT></TD><TD valign=top colspan=3> <FONT
size="2">Shared Voting Power:<BR>2,850,485</FONT></TD></TR>

<TR><TD colspan=4><hr noshade></TD></TR>

<TR><TD valign=top><FONT size="2">7.</FONT></TD><TD valign=top colspan=3> <FONT
size="2">Sole Dispositive Power:<BR>0</FONT></TD></TR>

<TR><TD colspan=4><hr noshade></TD></TR>

<TR><TD valign=top><FONT size="2">8.</FONT></TD><TD valign=top colspan=3><FONT
size="2">Shared Dispositive Power:<BR>2,850,485</FONT></TD></TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">9.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Aggregate Amount Beneficially Owned by Each Reporting Person:
<BR>2,850,485</FONT></TD>
</TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">10.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Check if the Aggregate Amount in Row (9) Excludes Certain
Shares:<BR><FONT face="wingdings">&#111;</FONT></FONT></TD>
</TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">11.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Percent of Class Represented by Amount in Row
(9):<BR>12.6%</FONT></TD></TR>

<TR><TD colspan=7><hr noshade></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">12.</FONT></TD><TD valign=top colspan=5><FONT
size="2">Type of Reporting Person:<BR>CO</FONT></TD></TR>

<TR><TD colspan=7><hr noshade></TD></TR>
</TABLE>


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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>


<TABLE width="100%" border=0 cellspacing=0 cellpadding=4>

<TR>
<TD width="10%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="80%"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2"><BR><BR><BR></FONT></TD>
</TR>

<TR><TD colspan=4><FONT size="2">&nbsp;</FONT></TD></TR>

<TR><TD colspan=4 nowrap><FONT size="2"><B>
<!-- link2 "ITEM 2. Name of Person Filing:" -->
Item 2.</B></FONT></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(a)</FONT></TD>
<TD colspan=2><FONT size="2">Name of Person Filing:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">BB Biotech AG (&#147;BB Biotech&#148;), on behalf of Biotech
Growth N.V. (&#147;BioGrowth&#148;), its wholly-owned subsidiary and record owner of the
securities.</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(b)</FONT></TD>
<TD colspan=2><FONT size="2">Address of Principal Business Office or, if none,
Residence:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">BB Biotech AG: Vodergasse 3, CH-8300 Schaffhausen,
Switzerland<BR>Biotech Growth N.V.: De Ruyterkade 62, Willemstad, Curacao,
Netherlands Antilles<BR><BR></FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(c)</FONT></TD><TD colspan=2><FONT
size="2">Citizenship:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">See Item No. 4 of cover pages</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(d)</FONT></TD>
<TD colspan=2><FONT size="2">Title of Class of Securities:</FONT></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">Common Stock</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(e)</FONT></TD> <TD colspan=2><FONT size="2">CUSIP
Number:</FONT></TD></TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">88554W104</FONT></TD>
</TR>
</table>



<TABLE width="100%" border=0 cellspacing=0 cellpadding=4>

<TR>
<TD width="10%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="80%"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR><TD nowrap><FONT size="2"><B>
<!-- link2 "ITEM 4. Ownership." -->
Item 4.</B></FONT></TD><TD colspan=3><FONT size="2"><B>
Ownership.</B></FONT></TD>
</TR>

<tr>
<TD valign=top colspan=4><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Provide the following
information regarding the aggregate number and percentage of the
class of securities of the issuer identified in Item 1.</FONT></TD>
</TR>


<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(a)</FONT></TD>
<TD valign=top colspan=2><FONT size="2">Amount beneficially owned:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">2,850,485</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(b)</FONT></TD>
<TD valign=top colspan=2><FONT size="2">Percent of class:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD colspan=2><FONT size="2">12.6%</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(c)</FONT></TD>
<TD valign=top colspan=2><FONT size="2">Number of shares as to which the person
has:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(i)</FONT></TD>
<TD><FONT size="2">Sole power to vote or to direct the vote:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">0</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(ii)</FONT></TD>
<TD valign=top><FONT size="2">Shared power to vote or to direct the
vote:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">2,850,485</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(iii)</FONT></TD>
<TD valign=top><FONT size="2">Sole power to dispose or to direct the disposition
of:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">0</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">(iv)</FONT></TD>
<TD valign=top><FONT size="2">Shared power to dispose or to direct the
disposition of:</FONT></TD>
</TR>

<TR><TD><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD valign=top><FONT size="2">&nbsp;</FONT></TD>
<TD><FONT size="2">2,850,485</FONT></TD>
</TR>

<TR><TD colspan=4><FONT size="2">&nbsp;</FONT></TD></TR>
</TABLE>




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<P><HR noshade><P>
<H5 align="left" style="page-break-before:always">&nbsp;</H5><P>


<TABLE width="100%" border="0" cellspacing="0" cellpadding="4">

<TR>
<TD width="10%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="5%"><FONT size="2">&nbsp;</FONT></TD>
<TD width="80%"><FONT size="2">&nbsp;</FONT></TD>
</TR>

<TR><TD><FONT size="2"><B>
<!-- link2 "ITEM 10. Certification." -->
Item 10.</B></FONT></TD><TD colspan=3><FONT
size="2"><B>Certification.</B></FONT></TD></TR>

<TR><TD colspan=4><FONT size="2">&nbsp;</FONT></TD></TR>

<TR><TD colspan=4><FONT size="2"><P> By signing below I certify that, to the
best of my knowledge and belief, the securities referred to above were not
acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction
having that purpose or effect.</FONT></TD>
</TR>
</TABLE>

<P>
<P align="left"><FONT size="2"><B>
<!-- link1 "SIGNATURES" -->
SIGNATURES</B></FONT>
<P><FONT size="2">After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true,
complete and correct.</FONT>


<P align="left"><FONT size="2"><B>BB BIOTECH AG</B>
</FONT>

<CENTER>
<TABLE cellspacing="0" border="0" cellpadding="0" width="100%">
<TR valign="bottom">
    <TD width="45%">&nbsp;</TD>
    <TD width="10%">&nbsp;</TD>
    <TD width="45%">&nbsp;</TD>
</TR>
<TR valign="bottom">
    <TD valign="top" align="left"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ ANDERS HOVE<BR>
</FONT><HR size="1" noshade><FONT size="2">
By:        Anders Hove<BR>
Its:       Authorized Signatory<BR>
Date:      February 14, 2003</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ ADRIAN BRUENGGER<BR>
</FONT><HR size="1" noshade><FONT size="2">
By:        Adrian Bruengger<BR>
Its:       Authorized Signatory<BR>
Date:      February 14, 2003</FONT></TD>
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<P align="left"><FONT size="2"><B>BIOTECH GROWTH N.V.</B>
</FONT>

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    <TD width="5%">&nbsp;</TD>
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    <TD valign="top"><FONT size="2">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ ANDERS HOVE<BR>
</FONT><HR size="1" noshade><FONT size="2">
By:        Anders Hove<BR>
Its:       Authorized Signatory<BR>
Date:      February 14, 2003</FONT></TD>
    <TD><FONT size="2">&nbsp;</FONT></TD>
    <TD align="left" valign="top"><FONT size="2">
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ ADRIAN BRUENGGER<BR>
</FONT><HR size="1" noshade><FONT size="2">
By:        Adrian Bruengger<BR>
Its:       Authorized Signatory<BR>
Date:      February 14, 2003</FONT></TD>
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<P align="center"><font size="2"><B>EXHIBIT INDEX</B></font>


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  <TD nowrap><font size="2">Exhibit 1:</font></TD>
  <TD>&nbsp;</TD>
  <TD><font size="2">Agreement by and between BB Biotech and BioGrowth with respect to
the filing of this disclosure statement.*</font></TD>
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<P>&nbsp;
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<font size="2">* Previously filed.</font>



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