<SUBMISSION>
<ACCESSION-NUMBER>0001013594-09-000433
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>2
<PERIOD>20090225
<FILING-DATE>20090227
<DATE-OF-FILING-DATE-CHANGE>20090227
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Kaufman Michael A
<CIK>0001426157
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>000-27188
<FILM-NUMBER>09643499
</FILING-VALUES>
<BUSINESS-ADDRESS>
<PHONE>212-486-3211
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>590 MADISON AVENUE, 9TH FLOOR
<CITY>NEW YORK
<STATE>NY
<ZIP>10022
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>ACCELRYS, INC.
<CIK>0001002388
<ASSIGNED-SIC>7372
<IRS-NUMBER>330557266
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0331
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
<PHONE>(858) 799-5000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>PHARMACOPEIA INC
<DATE-CHANGED>19951018
</FORMER-COMPANY>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>MAK CAPITAL ONE LLC
<CIK>0001385702
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
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<FILE-NUMBER>000-27188
<FILM-NUMBER>09643498
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>590 MADISON AVENUE, 9TH FLOOR
<CITY>NEW YORK
<STATE>NY
<ZIP>10022
<PHONE>212-486-3211
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>590 MADISON AVENUE, 9TH FLOOR
<CITY>NEW YORK
<STATE>NY
<ZIP>10022
</MAIL-ADDRESS>
<FORMER-NAME>
<FORMER-CONFORMED-NAME>MAK Capital
<DATE-CHANGED>20070109
</FORMER-NAME>
</REPORTING-OWNER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>SUSSMAN S DONALD
<CIK>0001044734
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>000-27188
<FILM-NUMBER>09643496
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>6100 RED HOOK QUARTER
<STREET2>18B, SUITES C, 1-6
<CITY>ST. THOMAS
<STATE>VI
<ZIP>00802
<PHONE>2038628000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>6100 RED HOOK QUARTER, 18B
<STREET2>SUITES C, 1-6
<CITY>ST. THOMAS
<STATE>VI
<ZIP>00802
</MAIL-ADDRESS>
</REPORTING-OWNER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>MAK Capital Fund LP
<CIK>0001426156
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>000-27188
<FILM-NUMBER>09643497
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>590 MADISON AVENUE, 9TH FLOOR
<CITY>NEW YORK
<STATE>NY
<ZIP>10022
<PHONE>212-486-3211
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>590 MADISON AVENUE, 9TH FLOOR
<CITY>NEW YORK
<STATE>NY
<ZIP>10022
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>accelrysfm4-022709_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

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    <documentType>4</documentType>

    <periodOfReport>2009-02-25</periodOfReport>

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    <issuer>
        <issuerCik>0001002388</issuerCik>
        <issuerName>ACCELRYS, INC.</issuerName>
        <issuerTradingSymbol>ACCL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001385702</rptOwnerCik>
            <rptOwnerName>MAK CAPITAL ONE LLC</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>590 MADISON AVENUE, 9TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
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    <reportingOwner>
        <reportingOwnerId>
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            <rptOwnerName>MAK Capital Fund LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>590 MADISON AVENUE, 9TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001426157</rptOwnerCik>
            <rptOwnerName>Kaufman Michael A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>590 MADISON AVENUE, 9TH FLOOR</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001044734</rptOwnerCik>
            <rptOwnerName>SUSSMAN S DONALD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>6100 RED HOOK QUARTER, 18B</rptOwnerStreet1>
            <rptOwnerStreet2>SUITES C, 1-6</rptOwnerStreet2>
            <rptOwnerCity>ST. THOMAS</rptOwnerCity>
            <rptOwnerState>VI</rptOwnerState>
            <rptOwnerZipCode>00802</rptOwnerZipCode>
            <rptOwnerStateDescription>VIRGIN ISLANDS, U.S.</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
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    </reportingOwner>

    <nonDerivativeTable>
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            <securityTitle>
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            <transactionDate>
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            </transactionDate>
            <transactionCoding>
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                <transactionCode>S</transactionCode>
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            <transactionAmounts>
                <transactionShares>
                    <value>17100</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>3.9260</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
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            </transactionDate>
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                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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                </transactionPricePerShare>
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                </transactionAcquiredDisposedCode>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
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            </securityTitle>
            <transactionDate>
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            </transactionDate>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>16800</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>3.5319</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
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        </nonDerivativeTransaction>
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                <transactionCode>S</transactionCode>
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                <transactionPricePerShare>
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                </transactionPricePerShare>
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                    <value>1526380</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
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                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See</value>
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                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
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            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
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            </transactionDate>
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                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>9955</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>3.6098</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1516425</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
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                <directOrIndirectOwnership>
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                </directOrIndirectOwnership>
                <natureOfOwnership>
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                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-02-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>8200</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>3.5319</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
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                <sharesOwnedFollowingTransaction>
                    <value>1508225</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See</value>
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                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Reflects the transactions of securities owned directly by MAK Capital Fund LP (&quot;MAK Capital Fund&quot;).</footnote>
        <footnote id="F2">Reflects the transactions of securities owned indirectly by Paloma International L.P. (&quot;Paloma&quot;) through its subsidiary,
 Sunrise Partners Limited Partnership.</footnote>
        <footnote id="F3">MAK Capital One LLC (&quot;MAK Capital One&quot;) acts as the investment manager of MAK Capital Fund and Paloma with respect to the
 securities reported herein.  Michael A. Kaufman is the managing member of MAK Capital One and the controlling person of MAK
 Capital Fund.  S. Donald Sussman is the controlling person of Paloma.</footnote>
        <footnote id="F4">MAK Capital One and Mr. Kaufman may each be deemed to indirectly beneficially own the shares of common stock held by MAK
 Capital Fund and Paloma.  Mr. Sussman may be deemed to beneficially own the shares of common stock held by Paloma.  For
 purposes of this Form 4, MAK Capital One, Mr. Kaufman and Mr. Sussman each disclaims ownership of the shares of common stock
 owned by MAK Capital Fund and Paloma, except to the extent of their pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Michael A. Kaufman, Managing Member of MAK CAPITAL ONE LLC</signatureName>
        <signatureDate>2009-02-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>accelrysex99-022709.txt
<DESCRIPTION>JOINT FILER INFORMATION
<TEXT>
                             Joint Filer Information

Title of Security:      Common Stock

Issuer & Ticker Symbol: Accelrys, Inc. (ACCL)

Designated Filer:       MAK Capital One LLC

Other Joint Filers:     MAK Capital Fund LP (the "MAK Capital Fund");
                        Michael A. Kaufman;
                        Paloma International L.P. ("Paloma"); and
                        S. Donald Sussman

Addresses:              The address of each of MAK Capital Fund and Mr. Kaufman
                        is 590 Madison Ave, 9th Floor, New York, New York 10022.

                        The address of Paloma is Two American Lane, Greenwich,
                        Connecticut 06836.

                        The address of Mr. Sussman is 6100 Red Hook Quarter,
                        18B Suites C, 1-6, St. Thomas, United States Virgin
                        Islands 00802.


Signatures:


Dated:  February 27, 2009

                  MAK CAPITAL FUND LP
                  By: MAK GP LLC, as General Partner


                           By: /s/ Michael A. Kaufman
                                ----------------------
                                   Michael A. Kaufman,
                                   Managing Member



                  /s/ Michael A. Kaufman
                  ----------------------
                      Michael A. Kaufman


                  PALOMA INTERNATIONAL L.P.
                  By: Paloma Partners Company L.L.C., general partner


                           By:  /s/ Douglas W. Ambrose
                                ----------------------
                                    Douglas W. Ambrose,
                                    Vice President


                  S. DONALD SUSSMAN


                  By:      /s/ Douglas W. Ambrose
                           ----------------------
                               Douglas W. Ambrose,
                               Attorney-in-Fact


<PAGE>


                                POWER OF ATTORNEY

     The undersigned hereby makes, constitutes and appoints each of Michael J.
Berner and Douglas W. Ambrose as the undersigned's true and lawful authorized
representative, attorney-in-fact and agent, each with the power individually to
execute for and on behalf of the undersigned and to file with and deliver to the
United States Securities and Exchange Commission and any other authority or
party required or entitled to receive the same: (a) any Forms 3, 4 and 5, and
any amendments thereto, in accordance with Section 16(a) of the Securities
Exchange Act of 1934, as amended (the "1934 Act"), and the rules promulgated
thereunder; and (b) any Schedule 13D or Schedule 13G, and any amendments
thereto, on behalf of the undersigned in accordance with Section 13 of the 1934
Act and the rules promulgated thereunder.

     The undersigned also hereby grants to each such attorney-in-fact the full
power and authority to do and perform all and every act and thing whatsoever
requisite, necessary and proper to be done in the exercise of any of the rights
and powers herein granted, hereby ratifying and confirming all that such
attorney-in-fact shall lawfully do or cause to be done by virtue of this power
of attorney and the rights and powers herein granted. The undersigned
acknowledges that each of the foregoing attorneys-in-fact, in serving in such
capacity at the request of the undersigned, is not assuming any of the
undersigned's responsibilities to comply with Section 16 or Section 13 or any
other provision of the 1934 Act or the rules promulgated thereunder.

     This Power of Attorney shall remain in full force and effect until earlier
revoked by the undersigned in a signed writing delivered to the foregoing
attorneys-in-fact.

     IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of May 9, 2006.

/s/  S. Donald Sussman
----------------------
     S. Donald Sussman


                        ACKNOWLEDGEMENT IN NEW YORK STATE

STATE OF CONNECTICUT, COUNTY OF FAIRFIELD ss.:


     On May 9, 2006, before me, the undersigned personally appeared, S. Donald
Sussman, personally known to me or proved to me on the basis of satisfactory
evidence to be the individual whose name is subscribed to the within instrument
and acknowledged to me that he executed the same in his capacity, and that by
his signature on the instrument, the individual, or the person upon behalf of
which the individual acted, executed the instrument. /s/ Diane R. Erickson Diane
R. Erickson, Notary Public (signature and office of individual taking
acknowledgement)



                                 /s/ Diane R. Erickson
                                 ----------------------
                                     Diane R. Erickson, Notary Public
                                     (signature and office of individual taking
                                     acknowledgement)


</TEXT>
</DOCUMENT>
</SUBMISSION>
