<SUBMISSION>
<ACCESSION-NUMBER>0001181431-10-036653
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20100701
<FILING-DATE>20100706
<DATE-OF-FILING-DATE-CHANGE>20100706
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>GOLDBY STEVEN D
<CIK>0001216626
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>000-27188
<FILM-NUMBER>10940886
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>C/O SYMYX TECHNOLOGIES, INC.
<STREET2>3100 CENTRAL EXPRESSWAY
<CITY>SANTA CLARA
<STATE>CA
<ZIP>95051
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>ACCELRYS, INC.
<CIK>0001002388
<ASSIGNED-SIC>7372
<IRS-NUMBER>330557266
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0331
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
<PHONE>(858) 799-5000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>PHARMACOPEIA INC
<DATE-CHANGED>19951018
</FORMER-COMPANY>
</ISSUER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd280916.xml
<DESCRIPTION>FORM 4
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                    <value>D</value>
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            <transactionAmounts>
                <transactionShares>
                    <value>109458</value>
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                <transactionPricePerShare>
                    <footnoteId id="F14"/>
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                    <value>A</value>
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                <value>2013-03-03</value>
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    <footnotes>
        <footnote id="F1">Received in exchange for 62,345 shares of Symyx Technologies, Inc. (&quot;Symyx&quot;) common stock in connection with the merger of Alto Merger Sub, Inc., a wholly-owned subsidiary of Accelrys, Inc. (&quot;Accelrys&quot;), with and into Symyx, with Symyx surviving as a wholly-owned subsidiary of Accelrys (the &quot;Merger&quot;).  On the effective date of the Merger, the closing price of Symyx's common stock was $5.01 per share, and the closing price of Accelrys's common stock was $6.66 per share.</footnote>
        <footnote id="F2">Received in exchange for 2,500 shares of Symyx common stock in connection with the Merger.  On the effective date of the Merger, the closing price of Symyx's common stock was $5.01 per share and the closing price of Accelrys's common stock was $6.66 per share.</footnote>
        <footnote id="F3">Held in the name of the Steven Goldby and Florence Goldby Trust, of which Mr. and Mrs. Goldby are trustees.</footnote>
        <footnote id="F4">This option was received in the Merger in exchange for an incentive stock option to acquire 4,963 shares of Symyx common stock at an exercise price of $25.50 per share.</footnote>
        <footnote id="F5">This option was received in the Merger in exchange for a non-qualified stock option to acquire 50,000 shares of Symyx common stock at an exercise price of $25.00 per share.</footnote>
        <footnote id="F6">This option was received in the Merger in exchange for a non-qualified stock option to acquire 50,000 shares of Symyx common stock at an exercise price of $16.70 per share.</footnote>
        <footnote id="F7">This option was received in the Merger in exchange for an incentive stock option to acquire 9,705 shares of Symyx common stock at an exercise price of $13.26 per share.</footnote>
        <footnote id="F8">This option was received in the Merger in exchange for a non-qualified stock option to acquire 12,500 shares of Symyx common stock at an exercise price of $26.70 per share.</footnote>
        <footnote id="F9">This option was received in the Merger in exchange for a non-qualified stock option to acquire 12,500 shares of Symyx common stock at an exercise price of $24.09 per share.</footnote>
        <footnote id="F10">This option was received in the Merger in exchange for a non-qualified stock option to acquire 12,500 shares of Symyx common stock at an exercise price of $18.95 per share.</footnote>
        <footnote id="F11">This option was received in the Merger in exchange for a non-qualified stock option to acquire 12,500 shares of Symyx common stock at an exercise price of $31.53 per share.</footnote>
        <footnote id="F12">This option was received in the Merger in exchange for a non-qualified stock option to acquire 50,000 shares of Symyx common stock at an exercise price of $27.89 per share.</footnote>
        <footnote id="F13">This option was received in the Merger in exchange for a non-qualified stock option to acquire 45,037 shares of Symyx common stock at an exercise price of $25.50 per share.</footnote>
        <footnote id="F14">This option was received in the Merger in exchange for a non-qualified stock option to acquire 140,295 shares of Symyx common stock at an exercise price of $13.26 per share.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Shannon Catalano, Attorney-In-Fact</signatureName>
        <signatureDate>2010-07-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
