<SUBMISSION>
<ACCESSION-NUMBER>0001193125-10-077574
<TYPE>8-K
<PUBLIC-DOCUMENT-COUNT>4
<PERIOD>20100405
<ITEMS>1.01
<ITEMS>9.01
<FILING-DATE>20100406
<DATE-OF-FILING-DATE-CHANGE>20100406
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>ACCELRYS, INC.
<CIK>0001002388
<ASSIGNED-SIC>7372
<IRS-NUMBER>330557266
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0331
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>8-K
<ACT>34
<FILE-NUMBER>000-27188
<FILM-NUMBER>10735205
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
<PHONE>(858) 799-5000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>PHARMACOPEIA INC
<DATE-CHANGED>19951018
</FORMER-COMPANY>
</FILER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>d8k.htm
<DESCRIPTION>FORM 8-K
<TEXT>
<HTML><HEAD>
<TITLE>Form 8-K</TITLE>
</HEAD>
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 <P STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P
STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P STYLE="margin-top:4px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>UNITED STATES </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>SECURITIES AND EXCHANGE COMMISSION </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="3"><B>Washington, D.C. 20549 </B></FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P
STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>FORM 8-K </B>
</FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P
STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>CURRENT REPORT </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman"
SIZE="3"><B>PURSUANT TO SECTION 13 OR 15(d) OF THE </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>SECURITIES EXCHANGE ACT OF 1934 </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>Date of Report (Date of earliest event reported): April&nbsp;5, 2010 </B></FONT></P> <P
STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:6px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="6"><B>ACCELRYS, INC. </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(Exact Name of Registrant as
Specified in Charter) </B></FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P
STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Delaware</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>0-27188</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>33-0557266</B></FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(State or Other Jurisdiction</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>of Incorporation)</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Commission File Number</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(I.R.S. Employer</B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="1"><B>Identification Number)</B></FONT></P></TD></TR></TABLE> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10188 Telesis Court, San Diego,
California 92121-4779 </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Address of Principal Executive Offices) (Zip Code) </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Registrant&#146;s telephone number, including area code: (858)&nbsp;799-5000 </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>N/A </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Former Name, or Former Address, if Changed
Since Last Report) </B></FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P
STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the
following provisions: </FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#120;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) </FONT></TD></TR></TABLE> <P
STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) </FONT></TD></TR></TABLE> <P
STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) </FONT></TD></TR></TABLE> <P
STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) </FONT></TD></TR></TABLE> <P
STYLE="font-size:8px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="line-height:3px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P
STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P>

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<TD WIDTH="10%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;1.01.</B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Entry into a Material Definitive Agreement. </B></FONT></TD></TR></TABLE> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B><I>Merger Agreement </I></B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">On April&nbsp;5, 2010, Accelrys, Inc., a Delaware corporation (<B><I>&#147;we&#148;</I></B> or the
<B><I>&#147;Company&#148;</I></B>), Symyx Technologies, Inc., a Delaware corporation (<B><I>&#147;Symyx&#148;</I></B>), and Alto Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of the Company, entered into an Agreement and
Plan of Merger and Reorganization (the <B><I>&#147;Merger Agreement&#148;</I></B>). Pursuant to the terms and subject to the conditions set forth in the Merger Agreement, Merger Sub will merge with and into Symyx, and Symyx will continue as the
surviving corporation and as a wholly-owned subsidiary of the Company (the <B><I>&#147;Merger&#148;</I></B>). The boards of directors of the Company and Symyx have approved the Merger Agreement and the transactions contemplated thereby. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">At the effective time of the Merger (the <B><I>&#147;Effective Time&#148;</I></B>), by virtue of the Merger and without any action on the part of the
holders of any shares of the capital stock of Symyx, each outstanding share of Symyx common stock will be converted into the right to receive 0.7802 shares of the Company&#146;s common stock (the <B><I>&#147;Exchange Ratio&#148;</I></B>). In
addition, at the Effective Time: (i)&nbsp;all outstanding options to purchase Symyx common stock will be assumed by the Company and converted into options to purchase Company common stock, in each case appropriately adjusted based on the Exchange
Ratio; and (ii)&nbsp;all outstanding restricted stock units representing rights to receive Symyx common stock will vest in full and will entitle the holders thereof to receive shares of Company common stock in accordance with the Exchange Ratio. No
fractional shares of Company common stock will be issued in the Merger. The Merger is intended to qualify as a &#147;reorganization&#148; within the meaning of Section&nbsp;368(a) of the Internal Revenue Code of 1986, as amended. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Merger Agreement specifies that, as of the Effective Time, the board of directors of the Company will be reconstituted such that: (i)&nbsp;Steven
Goldby, a current director of Symyx, will join Jeffrey Rodeck and Larry Ferguson as a Class I director of the Company; (ii)&nbsp;Timothy Harkness, a current director of Symyx, will join Max Carnecchia and Christopher Steffen as a Class II director
of the Company; and (iii)&nbsp;Chris van Ingen and Bruce Pasternack, current directors of Symyx, will join Ken Coleman and Ricardo Levy as Class III directors of the Company. In addition, the Merger Agreement further provides that following the
Effective Time, Max Carnecchia and Michael Piraino will continue to serve as the Company&#146;s Chief Executive Officer and Senior Vice President and Chief Financial Officer, respectively. In connection with the Merger, the Company will also seek
stockholder approval to amend its certificate of incorporation, as amended, to increase the number of authorized shares of Company common stock from 60,000,000 to 100,000,000. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Completion of the Merger is subject to various customary conditions, including, among other things: (i)&nbsp;the approval of the stockholders of the Company and Symyx; (ii)&nbsp;subject to certain
materiality exceptions, the accuracy of the representations and warranties made by each of the Company and Symyx and the compliance by each of the Company and Symyx with their respective obligations under the Merger Agreement; (iii)&nbsp;obtaining
clearance under the Hart-Scott-Rodino Antitrust Improvements Act, as amended; and (iv)&nbsp;the declaration of the effectiveness by the Securities and Exchange Commission (the <B><I>&#147;SEC&#148;</I></B>) of the Registration Statement on Form S-4
to be filed by the Company. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Merger Agreement contains customary representations, warranties and covenants, including covenants obligating
the Company and Symyx to continue to conduct their respective businesses in the ordinary course and to cooperate on seeking regulatory approvals and providing access to each other&#146;s information. The Merger Agreement also contains a customary
&#147;no solicitation&#148; provision pursuant to which, prior to the completion of the Merger, neither the Company nor Symyx is permitted to solicit or engage in discussions with any third party regarding another acquisition proposal unless it has
received an unsolicited bona fide written proposal or offer that the recipient&#146;s board of directors determines is or would reasonably be expected to result in a &#147;Superior Proposal&#148;. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Merger Agreement contains certain termination rights in favor of each of the Company and Symyx, including each party&#146;s right to terminate the
Merger Agreement under certain circumstances in connection with the acceptance of a &#147;Superior Proposal&#148; In addition, the Merger Agreement provides that in connection with certain terminations of the Merger Agreement, depending on the
circumstances surrounding the termination, one party may be required to pay the other a termination fee of $7,500,000. </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The foregoing summary of the Merger Agreement and the Merger does not purport to be complete and is subject
to, and qualified in its entirety by, the full text of the Merger Agreement, a copy of which is attached hereto as Exhibit 2.1 and the terms of which are incorporated herein by reference. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Merger Agreement has been provided pursuant to applicable rules and regulations of the SEC in order to provide investors and stockholders with
information regarding its terms. However, it is not intended to provide any other factual information about the Company, Symyx, their respective subsidiaries and affiliates, or any other party. In particular, the representations, warranties and
covenants contained in the Merger Agreement have been made only for the purpose of the Merger Agreement and, as such, are intended solely for the benefit of the parties to the Merger Agreement. In many cases, these representations, warranties and
covenants are subject to limitations agreed upon by the parties and are qualified by certain disclosures exchanged by the parties in connection with the execution of the Merger Agreement. Furthermore, many of the representations and warranties in
the Merger Agreement are the result of a negotiated allocation of contractual risk among the parties and, taken in isolation, do not necessarily reflect facts about the Company, Symyx, their respective subsidiaries and affiliates or any other party.
Likewise, any references to materiality contained in the representations and warranties may not correspond to concepts of materiality applicable to investors or stockholders. Finally, information concerning the subject matter of the representations
and warranties may change after the date of the Merger Agreement and these changes may not be fully reflected in the Company&#146;s public disclosures. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">AS A RESULT OF THE FOREGOING, INVESTORS AND STOCKHOLDERS ARE STRONGLY ENCOURAGED NOT TO RELY ON THE REPRESENTATIONS, WARRANTIES AND COVENANTS CONTAINED IN THE MERGER AGREEMENT, OR ON ANY DESCRIPTIONS
THEREOF, AS ACCURATE CHARACTERIZATIONS OF THE STATE OF FACTS OR CONDITION OF THE COMPANY OR ANY OTHER PARTY. INVESTORS AND STOCKHOLDERS ARE LIKEWISE CAUTIONED THAT THEY ARE NOT THIRD-PARTY BENEFICIARIES UNDER THE MERGER AGREEMENT AND DO NOT HAVE ANY
DIRECT RIGHTS OR REMEDIES PURSUANT TO THE MERGER AGREEMENT. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Accelrys Voting Agreement with Key Symyx Stockholders </I></B></FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Concurrently with the execution and delivery of the Merger Agreement, all of the directors and certain executive officers of Symyx (collectively, the
<B><I>&#147;Key Symyx Stockholders&#148;</I></B>) entered into voting agreements in favor of the Company (collectively, the <B><I>&#147;Accelrys Voting Agreements&#148;</I></B>). The shares of Symyx common stock beneficially owned by the Key Symyx
Stockholders (including all shares of Symyx common stock underlying options and restricted stock units) and thus subject to the Accelrys Voting Agreements constitutes approximately 5.1% of the total issued and outstanding shares of Symyx common
stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pursuant to the Accelrys Voting Agreements, the Key Symyx Stockholders have agreed to vote, or cause to be voted, all shares of Symyx
common stock beneficially owned by them in favor of the adoption of the Merger Agreement. In addition, the Key Symyx Stockholders have agreed to vote all such shares of Symyx common stock against any acquisition proposal related to Symyx or any
other action involving Symyx that would in any manner interfere with or impede the Merger or the Merger Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Accelrys Voting
Agreements also provide that the Key Symyx Stockholders will not, among other things, sell, pledge, encumber, transfer or otherwise dispose of, or enter into any contract, option or other agreement with respect to the transfer of, any shares of
Symyx common stock beneficially owned by them, or grant any proxies with respect to such shares. The Key Symyx Stockholders have also agreed not to take any actions that Symyx is prohibited from taking pursuant to the &#147;no solicitation&#148;
provisions contained in the Merger Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Accelrys Voting Agreements will terminate upon the earliest to occur of: (i)&nbsp;the
termination of the Merger Agreement in accordance with its terms; (ii)&nbsp;the date on which the Merger becomes effective; and (iii)&nbsp;the date on which an amendment to the Merger Agreement is effected without the consent of the Key Symyx
Stockholders that decreases the Exchange Ratio or materially and adversely effects such Key Symyx Stockholders. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The foregoing description of
the Accelrys Voting Agreements and the transactions contemplated thereby does not purport to be complete and is subject to, and qualified in its entirety by, the full text of the form of Accelrys Voting Agreement, a copy of which is attached hereto
as Exhibit 10.1 and the terms of which are incorporated herein by reference. </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Rights Amendment </I></B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">In connection with the Merger, the Company and American Stock Transfer&nbsp;&amp; Trust Co. (the <B><I>&#147;Rights Agent&#148;</I></B>) entered into an amendment (the <B><I>&#147;Rights
Amendment&#148;</I></B>) to the Rights Agreement, dated as of September&nbsp;6, 2002 (the <B><I>&#147;Rights Agreement&#148;</I></B>), by and between the Company and the Rights Agent, a copy of which was filed as Exhibit 4.1 to the Company&#146;s
Current Report on Form 8-K filed with the SEC on September&nbsp;10, 2002. Pursuant to the Rights Amendment, the Rights Agreement has been amended to provide that neither the execution and delivery of the Merger Agreement or the Voting Agreements,
nor the completion of the Merger or the transactions contemplated by the Merger Agreement, will be deemed to result in the occurrence of a &#147;Stock Acquisition Date&#148; (as defined in the Rights Agreement) or the classification of Symyx, any
Symyx stockholder or any of their respective affiliates or associates as an &#147;Acquiring Person&#148; (as defined in the Rights Agreement). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2">The foregoing summary of the Rights Amendment does not purport to be complete and is subject to, and qualified in its entirety by, the full text of the Rights Amendment, a copy of which is attached hereto as Exhibit 4.1 and the terms of
which are incorporated herein by reference. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Additional Ancillary Agreements </I></B></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Concurrently with the execution of the Merger Agreement, all of the directors and certain executive officers of the Company entered into voting agreements
with Symyx. The shares of Company common stock beneficially owned by the directors and executive officers of the Company who entered into these voting agreements (including all shares of Company common stock underlying options and restricted stock
units) and thus subject to such voting agreements constitutes approximately 5.2% of the total issued and outstanding shares of Company common stock. The terms of such voting agreements are substantially similar to the terms of the Accelrys Voting
Agreements. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">In addition, certain employees of Symyx, including but not limited to Isy Goldwasser, the Chief Executive Officer of Symyx, and
Rex Jackson, the Executive Vice President and Chief Financial Officer of Symyx, entered into short-term employment letter agreements with the Company that will become effective upon the closing of the Merger. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Forward-Looking Statements </I></B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certain
statements in this Current Report on Form 8-K may constitute &#147;forward-looking statements&#148; within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements relate to a variety of matters, including but not limited
to: the timing and anticipated completion of the proposed merger; the benefits and synergies expected to result from the proposed merger; the anticipated customer base for the Company and Symyx following the completion of the proposed merger; and
other statements that are not purely statements of historical fact. These forward-looking statements are made on the basis of the current beliefs, expectations and assumptions of the management of the Company and Symyx and are subject to significant
risks and uncertainty. Investors are cautioned not to place undue reliance on any such forward-looking statements. All such forward-looking statements speak only as of the date they are made, and neither the Company nor Symyx undertakes any
obligation to update or revise these statements, whether as a result of new information, future events or otherwise. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Factors that could cause
actual results to differ materially from the forward-looking statements contained herein include, but are not limited to: any operational or cultural difficulties associated with the integration of the businesses of the Company and Symyx; potential
adverse reactions or changes to business relationships resulting from the announcement or completion of the proposed merger; unexpected costs, charges or expenses resulting from the proposed merger; litigation or adverse judgments relating to the
proposed merger; risks relating to the consummation of the contemplated merger, including the risk that the required stockholder approval might not be obtained in timely manner or at all or that other closing conditions will not be satisfied; the
failure to realize synergies and cost savings from the transaction or delay in realization thereof; any difficulties associated with requests or directions from governmental authorities resulting from their reviews of the transaction; and any
changes in general economic and/or industry-specific conditions. Additional factors that could cause actual results to differ materially from those described in the forward-looking statements are set forth in the Annual Report on Form 10-K of the
Company for the year ended March&nbsp;31, 2009, which was filed with the SEC on May&nbsp;26, 2009, under the heading &#147;Item 1A&#151;Risk Factors&#148; and in the Annual Report on Form 10-K of Symyx for the year ended December&nbsp;31, 2009,
which was filed with the SEC on February&nbsp;26, 2010, under the heading &#147;Item 1A&#151;Risk Factors,&#148; and in subsequent reports on Forms 10-Q and 8-K and other filings made with the SEC by each of the Company and Symyx. </FONT></P>

<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Company and Symyx also note that a preliminary, draft press release relating to their transaction was
inadvertently disseminated on April&nbsp;2, 2010. The companies retract the errant April&nbsp;2 release, which was issued in error. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B><I>Important Merger Information and Additional Information and Where to Find It </I></B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">This press release does not constitute an
offer to sell or the solicitation of an offer to buy any securities or a solicitation of any vote or approval. In connection with the proposed merger, the Company and Symyx will file relevant materials with the SEC, including the filing by the
Company of a Registration Statement on Form S-4 containing a joint proxy statement/prospectus. <B>Investors are strongly urged to read the joint proxy statement/prospectus when it becomes available and other documents filed with the SEC by the
Company and Symyx, because they will contain important information about the Company, Symyx and the proposed merger.</B> The joint proxy statement/prospectus and other documents that will be filed by the Company and Symyx with the SEC will be
available free of charge at the SEC&#146;s website, www.sec.gov, by directing a request when such a filing is made to the Company, Inc., 10188 Telesis Court, San Diego, California 92121-1761, Attention: Corporate Secretary or by directing a request
when such a filing is made to Symyx Technologies, Inc., 1263 East Arques Avenue, Sunnyvale, CA 94085, Attention: Corporate Secretary. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The
Company, Symyx and their respective directors and certain of their executive officers may be considered participants in the solicitation of proxies in connection with the proposed merger. <B>Information about the directors and executive officers of
the Company is set forth in the Company&#146;s most recent definitive proxy statement, which was filed with the SEC on July&nbsp;21, 2009. Information about the directors and executive officers of Symyx is set forth in Symyx&#146;s most recent
definitive proxy statement, which was filed with the SEC on April&nbsp;29, 2009.</B> Certain directors and executive officers of the Company and Symyx may have direct or indirect interests in the proposed merger due to securities holdings,
pre-existing or future indemnification arrangements, vesting of options or rights to severance payments if their employment is terminated following the proposed merger. Investors may obtain additional information regarding the interests of such
participants by reading the joint proxy statement/prospectus the Company and Symyx will file with the SEC when it becomes available. </FONT></P> <P STYLE="font-size:18px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="10%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;9.01.</B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Financial Statements and Exhibits. </B></FONT></TD></TR></TABLE> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="92%" BORDER="0" ALIGN="center">

<TR>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD WIDTH="6%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="87%"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d)</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><I>Exhibits.</I></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom"></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Agreement and Plan of Merger and Reorganization, dated as of April 5, 2010, by and among Accelrys, Inc., Alto Merger Sub, Inc. and Symyx Technologies, Inc.</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;4.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">First Amendment to Rights Agreement, dated as of April 5, 2010, by and between Accelrys, Inc. and American Stock Transfer &amp; Trust Co.</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">10.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Form of Voting Agreement, dated April 5, 2010, by and between Accelrys, Inc. and the directors and certain executive officers of Symyx Technologies, Inc.</FONT></TD></TR></TABLE>

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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SIGNATURES </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </FONT></P> <P
STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0">

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<TD WIDTH="6%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="92%"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ACCELRYS, INC.</B></FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/&nbsp;&nbsp;&nbsp;&nbsp;D<SMALL>AVID</SMALL> R.
M<SMALL>ERSTEN&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</SMALL></FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>David R. Mersten</B></FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Senior Vice President, General Counsel &amp; Secretary</B></FONT></TD></TR></TABLE></DIV> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Date: April&nbsp;5, 2010 </FONT></P>
</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-2.1
<SEQUENCE>2
<FILENAME>dex21.htm
<DESCRIPTION>AGREEMENT AND PLAN OF MERGER AND REORGANIZATION
<TEXT>
<HTML><HEAD>
<TITLE>Agreement and Plan of Merger and Reorganization</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 2.1 </B></FONT></P> <P
STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="font-size:180px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P
STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P
STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>AGREEMENT AND PLAN OF MERGER AND REORGANIZATION </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2">by and among: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>A<SMALL>CCELRYS</SMALL> I<SMALL>NC</SMALL>., </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">a Delaware corporation; </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman"
SIZE="3"><B>A<SMALL>LTO</SMALL> M<SMALL>ERGER</SMALL> S<SMALL>UB</SMALL>, I<SMALL>NC</SMALL>., </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">a Delaware corporation; and
</FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>S<SMALL>YMYX</SMALL> T<SMALL>ECHNOLOGIES</SMALL>, I<SMALL>NC</SMALL>., </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">a Delaware corporation </FONT></P> <P STYLE="font-size:24px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P
STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dated as of
April&nbsp;5, 2010 </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P
STYLE="font-size:48px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P
STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="font-size:180px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>

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<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>T<SMALL>ABLE</SMALL> <SMALL>OF</SMALL> C<SMALL>ONTENTS</SMALL> </B></FONT></P> <P
STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TR>
<TD WIDTH="13%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="83%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD></TR>
<TR>
<TD VALIGN="bottom">&nbsp;<FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>P<SMALL>AGE</SMALL></B></FONT></TD></TR>
<TR>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 1.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">DESCRIPTION OF TRANSACTION</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">1</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Merger of Merger Sub into the Company</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">1</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Effects of the Merger</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">1</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Closing; Effective Time</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">1</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certificate of Incorporation and Bylaws; Directors and Officers</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">2</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Conversion of Shares</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">2</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Closing of the Company&#146;s Transfer Books</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">3</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Exchange of Certificates</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">3</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Tax Consequences</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">4</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Further Action</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">4</FONT></TD></TR>
<TR>
<TD VALIGN="top"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 2.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">REPRESENTATIONS AND WARRANTIES OF THE COMPANY</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">4</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Subsidiaries; Due Organization; Etc</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">5</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certificate of Incorporation and Bylaws</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">5</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Capitalization, Etc</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">5</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">SEC Filings; Financial Statements</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">7</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Absence of Changes</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">8</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title to Assets</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">9</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Loans; Customers</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">10</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Equipment; Real Property; Leasehold</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">10</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Intellectual Property</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">11</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.10</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Contracts</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">13</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.11</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Liabilities</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">15</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.12</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Compliance with Legal Requirements</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">15</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.13</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certain Business Practices</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">15</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.14</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Governmental Authorizations</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">15</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.15</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Tax Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">16</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.16</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee and Labor Matters; Benefit Plans</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">17</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.17</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Environmental Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">20</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.18</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Insurance</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">20</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.19</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Transactions with Affiliates</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">20</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.20</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Legal Proceedings; Orders</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">20</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.21</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Authority; Binding Nature of Agreement</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">21</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.22</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Inapplicability of Section 203 of the DGCL and Other Anti-takeover Statutes</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">21</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.23</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Vote Required</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">21</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.24</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Non-Contravention; Consents</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">21</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.25</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Opinion of Financial Advisor</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">22</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.26</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Brokers</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">22</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.27</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Disclosure</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">22</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;2.28</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Acknowledgement by the Company</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">23</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">i </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>T<SMALL>ABLE</SMALL> <SMALL>OF</SMALL> C<SMALL>ONTENTS</SMALL> </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(<SMALL>CONTINUED</SMALL>) </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" ALIGN="center">

<TR>
<TD WIDTH="13%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="83%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD></TR>

<TR>
<TD VALIGN="bottom">&nbsp;<FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>P<SMALL>AGE</SMALL></B></FONT></TD></TR>


<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 3.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUB</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">23</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Subsidiaries; Due Organization; Etc</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">23</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certificate of Incorporation and Bylaws</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">23</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Capitalization, Etc</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">24</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">SEC Filings; Financial Statements</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">25</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Absence of Changes</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">27</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title to Assets</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">28</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Loans; Customers</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">28</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Equipment; Real Property; Leasehold</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">28</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Intellectual Property</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">29</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.10</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Contracts</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">31</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.11</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Liabilities</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">33</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.12</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Compliance with Legal Requirements</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">33</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.13</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certain Business Practices</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">33</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.14</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Governmental Authorizations</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">34</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.15</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Tax Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">34</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.16</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee and Labor Matters; Benefit Plans</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">35</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.17</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Environmental Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">38</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.18</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Insurance</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">38</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.19</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Transactions with Affiliates</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">39</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.20</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Legal Proceedings; Orders</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">39</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.21</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Authority; Binding Nature of Agreement</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">39</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.22</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Inapplicability of Section 203 of the DGCL and Other Anti-takeover Statutes</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">39</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.23</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Vote Required</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">40</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.24</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Non-Contravention; Consents</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">40</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.25</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Opinion of Financial Advisor</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">41</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.26</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Brokers</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">41</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.27</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Valid Issuance</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">41</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.28</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Rights Agreement</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">41</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.29</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Disclosure</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">41</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.30</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Acknowledgement by Parent</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">42</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;3.31</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Merger Sub</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">42</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 4.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">CERTAIN COVENANTS OF THE PARTIES REGARDING OPERATIONS DURING THE PRE-CLOSING PERIOD</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">42</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">4.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Access and Investigation</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">42</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">4.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Operation of the Business of the Symyx Corporations</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">42</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">4.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Operation of the Business of the Accelrys Corporations</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">45</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">4.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Solicitation</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">48</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">ii </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>T<SMALL>ABLE</SMALL> <SMALL>OF</SMALL> C<SMALL>ONTENTS</SMALL> </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(<SMALL>CONTINUED</SMALL>) </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" ALIGN="center">

<TR>
<TD WIDTH="13%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="83%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD></TR>

<TR>
<TD VALIGN="bottom">&nbsp;<FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>P<SMALL>AGE</SMALL></B></FONT></TD></TR>


<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 5.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">ADDITIONAL COVENANTS OF THE PARTIES</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">50</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Registration Statement; Joint Proxy Statement/Prospectus</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">50</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Company Stockholders&#146; Meeting</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">51</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Parent Stockholders&#146; Meeting</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">53</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Stock Options and Company ESPP</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">54</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee Benefits</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">56</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Indemnification of Officers and Directors</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">57</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Regulatory Approvals and Related Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">57</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Disclosure</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">58</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Tax Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">59</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;5.10</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Listing</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">59</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;5.11</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Resignation of Officers and Directors</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">59</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;5.12</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Board of Directors of the Combined Company; Management of the Combined Company</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">59</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;5.13</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Section 16 Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">59</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;5.14</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Affiliates</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">60</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;5.15</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Obligations of Merger Sub</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">60</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 6.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">CONDITIONS PRECEDENT TO OBLIGATIONS OF PARENT AND MERGER SUB</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">60</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accuracy of Representations</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">60</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Performance of Covenants</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Effectiveness of Registration Statement</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Stockholder Approval</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Documents</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Company Material Adverse Effect</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Governmental Approvals</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Listing</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Restraints</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">61</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;6.10</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Governmental Litigation</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">62</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;6.11</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Current SEC Reports</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">62</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;6.12</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">FIRPTA Matters</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">62</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 7.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">CONDITIONS PRECEDENT TO OBLIGATION OF THE COMPANY</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">62</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accuracy of Representations</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">62</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Performance of Covenants</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">62</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Effectiveness of Registration Statement</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Stockholder Approval</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Documents</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Parent Material Adverse Effect</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Governmental Approvals</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">iii </FONT></P>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>T<SMALL>ABLE</SMALL> <SMALL>OF</SMALL> C<SMALL>ONTENTS</SMALL> </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(<SMALL>CONTINUED</SMALL>) </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" ALIGN="center">

<TR>
<TD WIDTH="13%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="83%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD></TR>

<TR>
<TD VALIGN="bottom">&nbsp;<FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>P<SMALL>AGE</SMALL></B></FONT></TD></TR>


<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Listing</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Restraints</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;7.10</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Governmental Litigation</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">63</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;7.11</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Current SEC Reports</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">64</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 8.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">TERMINATION</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">64</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">8.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Termination</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">64</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">8.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Effect of Termination</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">65</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">8.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Expenses; Termination Fees</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">65</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">SECTION 9.</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">MISCELLANEOUS PROVISIONS</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">67</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.1</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Amendment</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">67</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.2</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Waiver</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">67</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.3</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">No Survival of Representations and Warranties</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">67</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.4</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Entire Agreement; Counterparts; Exchanges by Facsimile</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">67</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.5</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Applicable Law; Jurisdiction; Specific Performance; Remedies</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">67</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.6</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Disclosure Schedules</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">68</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.7</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attorneys&#146; Fees</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">68</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.8</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Assignability; No Third Party Rights</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">68</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9.9</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Notices</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">68</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;9.10</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Cooperation</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">69</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;9.11</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Severability</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">69</FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-left:1.00em; text-indent:-1.00em" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;&nbsp;9.12</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-left:1.00em; text-indent:-1.00em"><FONT STYLE="font-family:Times New Roman" SIZE="2">Construction</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2">69</FONT></TD></TR></TABLE> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">iv </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>AGREEMENT AND PLAN OF MERGER AND REORGANIZATION </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>T<SMALL>HIS</SMALL> A<SMALL>GREEMENT</SMALL> <SMALL>AND</SMALL> P<SMALL>LAN</SMALL> <SMALL>OF</SMALL> M<SMALL>ERGER</SMALL>
<SMALL>AND</SMALL> R<SMALL>EORGANIZATION</SMALL> </B>(&#147;<B>Agreement</B>&#148;) is made and entered into as of April&nbsp;5, 2010, by and among: <B>A<SMALL>CCELRYS</SMALL>, I<SMALL>NC</SMALL>.</B>, a Delaware corporation
(&#147;<B>Parent</B>&#148;);<B> A<SMALL>LTO</SMALL> M<SMALL>ERGER</SMALL> S<SMALL>UB</SMALL>, I<SMALL>NC</SMALL></B><SMALL></SMALL>., a Delaware corporation and a wholly-owned subsidiary of Parent (&#147;<B>Merger Sub</B>&#148;); and
<B>S<SMALL>YMYX</SMALL> T<SMALL>ECHNOLOGIES</SMALL>, I<SMALL>NC</SMALL>.</B>, a Delaware corporation (the &#147;<B>Company</B>&#148;). Certain capitalized terms used in this Agreement are defined in <B>Exhibit A</B>. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>R<SMALL>ECITALS</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>A.</B> Parent, Merger Sub and the Company intend to effect a merger of Merger Sub into the Company in accordance with this Agreement and the DGCL (the &#147;<B>Merger</B>&#148;). Upon consummation of
the Merger, Merger Sub will cease to exist, and the Company will become a wholly-owned subsidiary of Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>B.</B> It is
intended that the Merger qualify as a reorganization within the meaning of Section&nbsp;368(a) of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>C. </B>The
respective boards of directors of Parent, Merger Sub and the Company have approved this Agreement and the Merger. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B></B><B>D.</B> In order to induce Parent to enter into this Agreement and cause the Merger to be consummated, certain stockholders of the Company are executing voting agreements in favor of Parent concurrently with the execution of this
Agreement (the &#147;<B>Company Stockholder Voting Agreements</B>&#148;). <B> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>E. </B>In order to induce the Company to
enter into this Agreement and consummate the Merger, certain stockholders of Parent are executing voting agreements in favor of the Company concurrently with the execution of this Agreement (the &#147;<B>Parent Stockholder Voting
Agreements</B>&#148;). </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A<SMALL>GREEMENT</SMALL></B><SMALL></SMALL> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The parties to this Agreement, intending to be legally bound, agree as follows: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;1. D<SMALL>ESCRIPTION</SMALL> <SMALL>OF</SMALL> T<SMALL>RANSACTION</SMALL> </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.1 Merger of Merger Sub into the Company.</B> Upon the terms and subject to the conditions set forth in this Agreement, at the Effective
Time (as defined in Section&nbsp;1.3), Merger Sub shall be merged with and into the Company. By virtue of the Merger, at the Effective Time, the separate existence of Merger Sub shall cease and the Company shall continue as the surviving corporation
in the Merger (the &#147;<B>Surviving Corporation</B>&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.2 Effects of the Merger</B><B>.</B> The Merger shall have
the effects set forth in this Agreement and in the applicable provisions of the DGCL. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.3 Closing; Effective
Time</B><B>.</B> The consummation of the Merger (the &#147;<B>Closing</B>&#148;) shall take place at the offices of Cooley Godward Kronish <SMALL>LLP</SMALL>, 3175 Hanover Street, Palo Alto, California, on a date to be designated jointly by Parent
and the Company, which shall be no later than the second business day after the satisfaction or waiver of the last to be satisfied or waived of the conditions set forth in Sections 6 and 7 (other than the conditions, which by their nature are to be
satisfied at the Closing, but subject to the satisfaction or waiver of each of such conditions). The date on which the Closing actually takes place is referred to as the &#147;<B>Closing Date</B>.&#148; Subject to the provisions of this Agreement, a
certificate of merger satisfying the applicable requirements of the DGCL shall be duly executed by the Company and concurrently with or as soon as practicable following the Closing shall be filed with the Secretary of State of the State of Delaware.
The Merger shall become effective at the time of the filing of such certificate of merger with the Secretary of State of the State of Delaware or at such later time as may be designated jointly by Parent and the Company and specified in such
certificate of merger (the time as of which the Merger becomes effective being referred to as the &#147;<B>Effective Time</B>&#148;). </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.4 Certificate of Incorporation and Bylaws; Directors and Officers</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Certificate of Incorporation of the Surviving Corporation shall be amended and restated immediately after the Effective Time
to read as set forth on <B><U>Exhibit B</U></B>; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The Bylaws of the Surviving Corporation shall be amended and
restated as of the Effective Time to conform to read as set forth on <B><U>Exhibit C</U></B>; and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The directors
and officers of the Surviving Corporation immediately after the Effective Time shall be the respective individuals who are directors and officers of Merger Sub immediately prior to the Effective Time. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.5 Conversion of Shares</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Subject to the terms and conditions of this Agreement, at the Effective Time, by virtue of the Merger and without any further action on the part of Parent, Merger Sub, the Company or any
stockholder of the Company: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>any shares of Company Common Stock held by any wholly-owned Subsidiary of the Company
immediately prior to the Effective Time (or held in the Company&#146;s treasury) shall be canceled and retired and shall cease to exist, and no consideration shall be delivered in exchange therefor; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>any shares of Company Common Stock held by Parent, Merger Sub or any other wholly-owned Subsidiary of Parent immediately prior
to the Effective Time shall be canceled and retired and shall cease to exist, and no consideration shall be delivered in exchange therefor; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>except as provided in clauses &#147;(i)&#148; and &#147;(ii)&#148; above and subject to Sections 1.5(c) and 1.5(d), each share of Company Common Stock outstanding immediately prior to the
Effective Time shall be converted into the right to receive 0.7802 of a share of Parent Common Stock (such number as may be adjusted in accordance with Section&nbsp;1.5(b), the &#147;<B>Exchange Ratio</B>&#148;); and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>each share of the Common Stock, $0.001 par value per share, of Merger Sub outstanding immediately prior to the Effective Time
shall be converted into one share of common stock of the Surviving Corporation. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>If, during the period from the
date of this Agreement through the Effective Time, the outstanding shares of Company Common Stock or Parent Common Stock are changed into a different number or class of shares by reason of any stock split, division or subdivision of shares, stock
dividend, reverse stock split, consolidation of shares, reclassification, recapitalization or other similar transaction, or if a stock dividend is declared by the Company or Parent during such period, then the Exchange Ratio shall be adjusted to the
extent appropriate to provide the same economic effect as contemplated by this Agreement prior to such action. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>If
any shares of Company Common Stock outstanding immediately prior to the Effective Time are unvested or are subject to a repurchase option, risk of forfeiture or other condition under any applicable restricted stock purchase agreement or other
Contract with the Company or under which the Company has any rights, then (except to the extent provided in any binding agreement between the Company and the holder thereof): (i)&nbsp;the shares of Parent Common Stock issued in exchange for such
shares of Company Common Stock will also be unvested and subject to the same repurchase option, risk of forfeiture or other condition; and (ii)&nbsp;the certificates representing such shares of Parent Common Stock may accordingly be marked with
appropriate legends. Prior to the Effective Time, the Company shall use commercially reasonable efforts to ensure that, from and after the Effective Time, Parent is entitled to exercise any such repurchase option or other right set forth in any such
restricted stock purchase agreement or other Contract. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>No fractional shares of Parent Common Stock shall be issued in connection with
the Merger, and no certificates or scrip for any such fractional shares shall be issued. Any holder of Company Common Stock who would otherwise be entitled to receive a fraction of a share of Parent Common Stock (after aggregating all fractional
shares of Parent Common Stock issuable to such holder) shall, in lieu of such fraction of a share and upon surrender of such holder&#146;s Company Stock Certificate(s) (as defined in Section&nbsp;1.6), or non-certificated shares of Company Common
Stock represented by book entry (&#147;<B>Book Entry Shares</B>&#148;) be paid in cash the dollar amount (rounded to the nearest whole cent), without interest, determined by multiplying such fraction by the closing price of a share of Parent Common
Stock on the NASDAQ Global Market on the Closing Date. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.6 Closing of the Company&#146;s Transfer Books</B><B>.</B> At the
Effective Time: (a)&nbsp;all shares of Company Common Stock outstanding immediately prior to the Effective Time shall automatically be canceled and retired and shall cease to exist, and all holders of Book Entry Shares or of certificates
representing shares of Company Common Stock that were outstanding immediately prior to the Effective Time shall cease to have any rights as stockholders of the Company, except the right to receive shares of Parent Common Stock as contemplated by
Section&nbsp;1.5, cash in lieu of any fractional share of Parent Common Stock pursuant to Section&nbsp;1.5(d) and any dividends or other distributions pursuant to Section&nbsp;1.7(c); and (b)&nbsp;the stock transfer books of the Company shall be
closed with respect to all shares of Company Common Stock outstanding immediately prior to the Effective Time. No further transfer of any such shares of Company Common Stock shall be made on such stock transfer books after the Effective Time. If,
after the Effective Time, a valid certificate previously representing any shares of Company Common Stock outstanding immediately prior to the Effective Time (a &#147;<B>Company Stock Certificate</B>&#148;) or a Book Entry Share is presented to the
Exchange Agent (as defined in Section&nbsp;1.7) or to the Surviving Corporation or Parent, such Company Stock Certificate or Book Entry Share shall be canceled and shall be exchanged as provided in Section&nbsp;1.7. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.7 Exchange of Certificates</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>On or prior to the Closing Date, Parent shall select a reputable bank or trust company reasonably satisfactory to the Company to act as exchange agent in the Merger (the &#147;<B>Exchange
Agent</B>&#148;). Promptly after the Effective Time, Parent shall cause to be deposited with the Exchange Agent: (i)&nbsp;certificates representing the shares of Parent Common Stock issuable pursuant to Section&nbsp;1.5; and (ii)&nbsp;cash
sufficient to make payments in lieu of fractional shares in accordance with Section&nbsp;1.5(d). The shares of Parent Common Stock and cash amounts so deposited with the Exchange Agent, together with any dividends or distributions received by the
Exchange Agent with respect to such shares of Parent Common Stock, are referred to collectively as the &#147;<B>Exchange Fund</B>.&#148; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Promptly after the Effective Time, the Exchange Agent will mail to the Persons who were record holders of Company Stock Certificates or Book Entry Shares immediately prior to the Effective
Time: (i)&nbsp;a letter of transmittal in customary form and containing such provisions as Parent may reasonably specify and the Company shall reasonably approve prior to the Effective Time (including a provision confirming that delivery of Company
Stock Certificates or Book Entry Shares shall be effected, and risk of loss and title to Company Stock Certificates or Book Entry Shares shall pass, only upon delivery of such Company Stock Certificates or Book Entry Shares to the Exchange Agent);
and (ii)&nbsp;instructions for use in effecting the surrender of Company Stock Certificates or Book Entry Shares in exchange for certificates representing Parent Common Stock. Upon surrender of a Company Stock Certificate or Book Entry Shares to the
Exchange Agent for exchange, together with a duly executed letter of transmittal and such other documents as may be reasonably required by the Exchange Agent or Parent: (A)&nbsp;the holder of such Company Stock Certificate or Book Entry Shares shall
be entitled to receive in exchange therefor a certificate representing the number of whole shares of Parent Common Stock that such holder has the right to receive pursuant to the provisions of Section&nbsp;1.5 (and cash in lieu of any fractional
share of Parent Common Stock pursuant to Section&nbsp;1.5(d) and any dividends or other distributions pursuant to Section&nbsp;1.7(c)); and (B)&nbsp;the Company Stock Certificate or Book Entry Shares so surrendered shall be canceled. Until
surrendered as contemplated by this Section&nbsp;1.7(b), each Company Stock Certificate and Book Entry Share shall be deemed, from and after the Effective Time, to represent only the right
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
to receive shares of Parent Common Stock (and cash in lieu of any fractional share of Parent Common Stock) as contemplated by Section&nbsp;1.5. If any Company Stock Certificate shall have been
lost, stolen or destroyed, Parent may, in its reasonable discretion and as a condition to the issuance of any certificate representing Parent Common Stock, require the owner of such lost, stolen or destroyed Company Stock Certificate to provide an
appropriate affidavit and indemnification obligation against any claim that may be made against the Exchange Agent, Parent or the Surviving Corporation with respect to such Company Stock Certificate. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>No dividends or other distributions declared or made with respect to Parent Common Stock with a record date after the Effective
Time shall be paid or otherwise delivered to the holder of any unsurrendered Company Stock Certificate or Book Entry Share with respect to the shares of Parent Common Stock that such holder has the right to receive in the Merger until such holder
surrenders such Company Stock Certificate or Book Entry Share in accordance with this Section&nbsp;1.7 (at which time such holder shall be entitled, subject to the effect of applicable abandoned property, escheat or similar laws, to receive all such
dividends and distributions, without interest). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Any portion of the Exchange Fund that remains undistributed to
holders of Company Stock Certificates and Book Entry Shares as of the date that is one year after the date on which the Merger becomes effective shall be delivered to Parent upon demand, and any holders of Company Stock Certificates or Book Entry
Shares who have not theretofore surrendered their Company Stock Certificates or Book Entry Shares in accordance with this Section&nbsp;1.7 shall thereafter look only to Parent for satisfaction of their claims for Parent Common Stock, cash in lieu of
fractional shares of Parent Common Stock and any dividends or distributions with respect to shares of Parent Common Stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(e) </B>Each of the Exchange Agent, Parent and the Surviving Corporation shall be entitled to deduct and withhold from any consideration payable or otherwise deliverable pursuant to this Agreement to any holder or former holder of
Company Common Stock such amounts as may be required to be deducted or withheld from such consideration under the Code or any provision of state, local or foreign tax law or under any other applicable Legal Requirement. To the extent such amounts
are so deducted or withheld and timely paid to the appropriate Governmental Body, such amounts shall be treated for all purposes under this Agreement as having been paid to the Person to whom such amounts would otherwise have been paid. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>Neither Parent nor the Surviving Corporation shall be liable to any holder or former holder of Company Common Stock or to any
other Person with respect to any shares of Parent Common Stock (or dividends or distributions with respect thereto), or for any cash amounts, delivered to any public official pursuant to any applicable abandoned property law, escheat law or other
Legal Requirement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.8 Tax Consequences</B><B>.</B> For U.S. federal income tax purposes, the Merger is intended to
constitute a reorganization within the meaning of Section&nbsp;368(a) of the Code. The parties to this Agreement adopt this Agreement as a &#147;plan of reorganization&#148; within the meaning of Sections 1.368-2(g) and 1.368-3(a) of the
United&nbsp;States Treasury Regulations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1.9 Further Action</B><B>.</B> If, at any time after the Effective Time, any
further action is determined by Parent or the Surviving Corporation to be necessary or desirable to carry out the purposes of this Agreement or to vest the Surviving Corporation with full right, title and possession of and to all rights and property
of Merger Sub and the Company, the officers and directors of the Surviving Corporation and Parent shall be fully authorized (in the name of Merger Sub, in the name of the Company and otherwise) to take such action. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;2. R<SMALL>EPRESENTATIONS</SMALL> <SMALL>AND</SMALL> W<SMALL>ARRANTIES</SMALL> <SMALL>OF</SMALL> <SMALL>THE</SMALL>
C<SMALL>OMPANY</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Company represents and warrants to Parent and Merger Sub as follows (it being understood that
each representation and warranty contained in this Section&nbsp;2 is subject to: (a)&nbsp;the exceptions and disclosures set forth in the part or subpart of the Company Disclosure Schedule corresponding to the particular Section or subsection
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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in this Section&nbsp;2 in which such representation and warranty appears; and (b)&nbsp;any exception or disclosure set forth in any other part or subpart of the Company Disclosure Schedule to the
extent it is reasonably apparent from the wording of such exception or disclosure that such exception or disclosure is intended to qualify such representation and warranty): </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.1 Subsidiaries; Due Organization; Etc</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Exhibit 21 to the Company&#146;s Annual Report on Form 10-K for the fiscal year ended December&nbsp;31, 2009 identifies each Subsidiary of the Company and indicates its jurisdiction of
organization. Neither the Company nor any of the Entities identified in Exhibit 21 of the Company&#146;s Annual Report on Form&nbsp;10-K for the fiscal year ended December&nbsp;31, 2009 owns any capital stock of, or any equity interest of any nature
in, any other Entity, other than the Entities identified in said Exhibit 21 and the other Entities identified in Part 2.1(a) of the Company Disclosure Schedule. No Symyx Corporation has agreed or is obligated to make, or is bound by any Contract
under which it may become obligated to make, any future investment in or capital contribution to any other Entity. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)
</B>Each of the Symyx Corporations is a corporation duly organized, validly existing and in good standing (to the extent that the laws of the jurisdiction of its formation recognize the concept of good standing) under the laws of the jurisdiction of
its incorporation and has all necessary power and authority: (i)&nbsp;to conduct its business in the manner in which its business is currently being conducted; (ii)&nbsp;to own and use its assets in the manner in which its assets are currently owned
and used; and (iii)&nbsp;to perform its obligations under all Contracts by which it is bound. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Each of the Symyx
Corporations is qualified to do business as a foreign corporation, and is in good standing, under the laws of all jurisdictions where the nature of its business requires such qualification, except for jurisdictions in which the failure to be so
qualified, individually or in the aggregate, would not have a Company Material Adverse Effect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.2 Certificate of
Incorporation and Bylaws.</B> The Company has delivered or Made Available to Parent accurate and complete copies of the certificate of incorporation, bylaws, memorandum of association and articles of association or equivalent governing documents of
each of the Symyx Corporations, including all amendments thereto. The Company has delivered or Made Available to Parent accurate and complete copies of: (a)&nbsp;the charters of all committees of the Company Board; and (b)&nbsp;any code of conduct,
corporate governance policies or principles, related party transaction policy, stock ownership guidelines, whistleblower policy, disclosure committee charter or similar codes, policies, or guidelines adopted by any of the Symyx Corporations or by
the board of directors, or any committee of the board of directors, of any of the Symyx Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.3 Capitalization,
Etc</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The authorized capital stock of the Company consists of: (i)&nbsp;60,000,000 shares of Company Common
Stock, of which 34,791,879 shares have been issued and are outstanding as of the date of this Agreement; and (ii)&nbsp;10,000,000 shares of Company Preferred Stock, of which no shares have been issued or are outstanding. All of the outstanding
shares of Company Common Stock have been duly authorized and validly issued, and are fully paid and nonassessable. None of the Symyx Corporations (other than the Company) holds any shares of Company Common Stock or any rights to acquire shares of
Company Common Stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part 2.3(b) of the Company Disclosure Schedule: (i)&nbsp;none of the
outstanding shares of Company Common Stock is entitled or subject to any preemptive right, right of repurchase or forfeiture, right of participation, right of maintenance or any similar right; (ii)&nbsp;none of the outstanding shares of Company
Common Stock is subject to any right of first refusal in favor of the Company; and (iii)&nbsp;there is no Company Contract relating to the voting or registration of, or restricting any Person from purchasing, selling, pledging or otherwise disposing
of (or from granting any option or similar right with respect to), any shares of
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Company Common Stock. None of the Symyx Corporations is under any obligation, or is bound by any Contract pursuant to which it may become obligated, to repurchase, redeem or otherwise acquire any
outstanding shares of Company Common Stock or other securities, except for the Company&#146;s right to repurchase or reacquire restricted shares of Company Common Stock held by an employee of the Company upon termination of such employee&#146;s
employment or upon any other forfeiture of a vesting condition. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>As of the date of this Agreement:
(i)&nbsp;3,655,668 shares of Company Common Stock are subject to issuance pursuant to Company Options; (ii)&nbsp;1,879,110 shares of Company Common Stock are reserved for future issuance pursuant to the 1999 Employee Stock Purchase Plan (the
&#147;<B>Company ESPP</B>&#148;); (iii)&nbsp;300,675 shares of Company Common Stock are reserved for future issuance pursuant to Company RSUs; and (iv)&nbsp;6,039,772 shares of Company Common Stock are reserved for future issuance pursuant to
Company Equity Awards not yet granted under the Company Option Plans. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>The Company has Made Available to Parent a
complete and accurate list that sets forth with respect to each Company Equity Award outstanding as of the date of this Agreement the following information: (i)&nbsp;the particular plan (if any) pursuant to which such Company Equity Award was
granted; (ii)&nbsp;the name of the holder of such Company Equity Award; (iii)&nbsp;the type of Company Equity&nbsp;Award (whether a Company Option, a Company RSU, or another type of Company Equity Award); (iv)&nbsp;the number of shares of Company
Common Stock subject to such Company Equity Award; (v)&nbsp;the per share exercise price (if any) of such Company Equity Award; (vi)&nbsp;the applicable vesting schedule (including a description of any acceleration provisions), and the extent to
which such Company Equity Award is vested and exercisable, if applicable; (vii)&nbsp;the date on which such Company Equity Award was granted; (viii)&nbsp;the date on which such Company Equity Award expires (if applicable); (ix)&nbsp;if such Company
Equity Award is a Company Option, whether such Company Option is intended to be an &#147;incentive stock option&#148; (as defined in the Code) or a non-qualified stock option; and (x)&nbsp;if such Company Equity Award is in the form of Company RSUs,
the dates on which shares of Company Common Stock are scheduled to be delivered, if different from the applicable vesting schedule. The Company has Made Available to Parent accurate and complete copies of all equity plans pursuant to which any
outstanding Company Equity Awards were granted by the Company, and the forms of all agreements evidencing such Company Equity Awards. The exercise price of each Company Option is not less than the fair market value of a share of Company Common Stock
as determined on the date of grant of such Company Option. All grants of Company Equity Awards were recorded on the Company&#146;s financial statements (including, any related notes thereto) contained in the Company SEC Documents (as defined in
Section&nbsp;2.4(a)) in accordance with GAAP, and no such grants involved any &#147;back dating&#148; or similar practices with respect to the effective date of grant (whether intentionally or otherwise). There are no outstanding or authorized stock
appreciation, phantom stock, profit participation or similar rights or equity-based awards with respect to any of the Symyx Corporations. Each Company Equity Award was granted in accordance with the terms of the Company Employee Plan applicable
thereto. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Except as set forth in Sections 2.3(a) and 2.3(c), there is no: (i)&nbsp;outstanding subscription,
option, call, warrant or right (whether or not currently exercisable) to acquire any shares of the capital stock or other securities of any of the Symyx Corporations; (ii)&nbsp;outstanding security, instrument or obligation that is or may become
convertible into or exchangeable for any shares of the capital stock or other securities of any of the Symyx Corporations; (iii)&nbsp;stockholder rights plan (or similar plan commonly referred to as a &#147;poison pill&#148;) or Contract under which
any of the Symyx Corporations is or may become obligated to sell or otherwise issue any shares of its capital stock or any other securities; or (iv)&nbsp;condition or circumstance that would reasonably be expected to give rise to or provide a basis
for the assertion of a claim by any Person to the effect that such Person is entitled to acquire or receive any shares of capital stock or other securities of any of the Symyx Corporations. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>All outstanding shares of Company Common Stock, and all Company Equity Awards and other securities of the Symyx Corporations,
have been issued and granted in compliance with: (i)&nbsp;all applicable securities laws and other applicable Legal Requirements; and (ii)&nbsp;all requirements set forth in applicable Contracts. </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>All of the outstanding shares of capital stock of each of the Company&#146;s
Subsidiaries have been duly authorized and validly issued, are fully paid and nonassessable and free of preemptive rights, with no personal liability attaching to the ownership thereof, and are owned beneficially and of record by the Company, free
and clear of any Encumbrances. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.4 SEC Filings; Financial Statements.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Company has Made Available (or made available on the SEC website) to Parent accurate and complete copies of all registration
statements, proxy statements, Company Certifications (as defined below) and other statements, reports, schedules, forms, exhibits and other documents filed by the Company with the SEC, including all amendments thereto since January&nbsp;1, 2008
(collectively, the &#147;<B>Company SEC Documents</B>&#148;). All statements, reports, schedules, forms, exhibits and other documents required to have been filed by the Company or its officers with the SEC since January&nbsp;1, 2008 have been so
filed on a timely basis. None of the Company&#146;s Subsidiaries is required to file any documents with the SEC. As of the time filed with the SEC (or, if amended or superseded by a filing prior to the date of this Agreement, then on the date of
such filing): (i)&nbsp;each of the Company SEC Documents complied in all material respects with the applicable requirements of the Securities Act or the Exchange Act (as the case may be); and (ii)&nbsp;none of the Company SEC Documents contained any
untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. Each of the
certifications and statements relating to the Company SEC Documents required by: (A)&nbsp;Rule 13a-14 or Rule 15d-14 under the Exchange Act; (B)&nbsp;18 U.S.C. &#167;1350 (Section 906 of the Sarbanes-Oxley Act); or (C)&nbsp;any other rule or
regulation promulgated by the SEC or applicable to the Company SEC Documents (collectively, the &#147;<B>Company Certifications</B>&#148;) is accurate and complete, and complies as to form and content with all applicable Legal Requirements. As used
in Section&nbsp;2.4, the term &#147;<B>file</B>&#148; and variations thereof shall be broadly construed to include any manner in which a document or information is filed, furnished, submitted, supplied or otherwise made available to the SEC or any
member of its staff in accordance with the applicable requirements of the Securities Act or the Exchange Act (as the case may be). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(b) </B>The Company maintains, and at all times since January&nbsp;1, 2008 has maintained, disclosure controls and procedures as required by Rule 13a-15 or 15d-15 under the Exchange Act. Such disclosure controls and procedures are
designed to ensure that all material information concerning the Symyx Corporations required to be disclosed by the Company in the reports that it is required to file, submit or furnish under the Exchange Act is recorded, processed, summarized and
reported within the time periods specified in the SEC&#146;s rules and forms. The Company has delivered or Made Available to Parent accurate and complete copies of all written descriptions of, and all policies, manuals and other documents
promulgating, such disclosure controls and procedures. The Company is, and has been at all times since January&nbsp;1, 2008, in compliance in all material respects with the applicable listing requirements of the NASDAQ Global Market, and has not
since January&nbsp;1, 2008 received any notice asserting any non-compliance with the listing requirements of the NASDAQ Global Market. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The financial statements (including any related notes) contained or incorporated by reference in the Company SEC Documents: (i)&nbsp;complied as to form in all material respects with the
published rules and regulations of the SEC applicable thereto; (ii)&nbsp;were prepared in accordance with GAAP applied on a consistent basis throughout the periods covered (except as may be indicated in the notes to such financial statements or, in
the case of unaudited financial statements, as permitted by Form 10-Q, Form 8-K or any successor form under the Exchange Act, and except that the unaudited financial statements may not contain footnotes and are subject to normal and recurring
year-end adjustments, none of which were or will be material); and (iii)&nbsp;fairly present, in all material respects, the consolidated financial position of the Company and its consolidated Subsidiaries as of the respective dates thereof and the
consolidated results of operations and cash flows of the Company and its consolidated Subsidiaries for the periods covered thereby. No financial statements of any Person other than the Symyx Corporations are required by GAAP to be included in the
consolidated financial statements of the Company. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>The Company&#146;s auditor has at all times since the date of
enactment of the Sarbanes-Oxley Act been: (i)&nbsp;a registered public accounting firm (as defined in Section&nbsp;2(a)(12) of the Sarbanes-Oxley Act);
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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(ii)&nbsp;&#147;independent&#148; with respect to the Company within the meaning of Regulation S-X under the Exchange Act; and (iii)&nbsp;to the knowledge of the Company, in compliance with
subsections (g)&nbsp;through (l)&nbsp;of Section&nbsp;10A of the Exchange Act and the rules and regulations promulgated by the SEC and the Public Company Accounting Oversight Board thereunder. All non-audit services performed by the Company&#146;s
auditors for the Symyx Corporations that were required to be approved in accordance with Section&nbsp;202 of the Sarbanes-Oxley Act were so approved. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>The Company maintains, and at all times since January&nbsp;1, 2008 has maintained, a system of internal controls over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the
Exchange Act) which is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with GAAP, and includes those policies and procedures
that: (i)&nbsp;pertain to the maintenance of records that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Symyx Corporations; (ii)&nbsp;provide reasonable assurance that transactions are
recorded as necessary to permit preparation of financial statements in conformity with GAAP and that receipts and expenditures are being made only in accordance with authorizations of management and directors of the Company; and (iii)&nbsp;provide
reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the assets of the Symyx Corporations that could have a material effect on the financial statements. The Company has delivered or Made
Available to Parent accurate and complete copies of all written descriptions of, and all policies, manuals and other documents promulgating, such internal accounting controls. The Company&#146;s management has completed an assessment of the
effectiveness of the Company&#146;s system of internal controls over financial reporting in compliance with the requirements of Section&nbsp;404 of the Sarbanes-Oxley Act for the fiscal years ended December&nbsp;31, 2008 and December&nbsp;31, 2009,
and, except as set forth in the Company SEC Documents filed prior to the date of this Agreement, such assessment concluded that such controls were effective and the Company&#146;s independent registered accountant has issued (and not subsequently
withdrawn or qualified) an attestation report concluding that the Company maintained effective internal control over financial reporting as of December&nbsp;31, 2008 and December&nbsp;31, 2009, respectively. To the knowledge of the Company, except
as set forth in the Company SEC Documents filed prior to the date of this Agreement, since January&nbsp;1, 2008, neither the Company nor any of its Subsidiaries nor the Company&#146;s independent registered accountant has identified or been made
aware of: (A)&nbsp;any significant deficiency or material weakness in the design or operation of internal control over financial reporting utilized by the Symyx Corporations; (B)&nbsp;any illegal act or fraud, whether or not material, that involves
the Company&#146;s management or other employees; or (C)&nbsp;any claim or allegation regarding any of the foregoing. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f)
</B>Part 2.4(f) of the Company Disclosure Schedule lists, and the Company has delivered or Made Available to Parent accurate and complete copies of the documentation creating or governing, all securitization transactions and &#147;off-balance sheet
arrangements&#148; (as defined in Item&nbsp;303(c) of Regulation S-K under the Exchange Act) currently in effect or effected by any of the Symyx Corporations since January&nbsp;1, 2008. None of the Symyx Corporations has any obligation or other
commitment to become a party to any such &#147;off-balance sheet arrangements&#148; in the future. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.5 Absence of
Changes.</B> Except as set forth in Part 2.5 of the Company Disclosure Schedule, since December&nbsp;31, 2009 through the date of this Agreement: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>there has not been any Company Material Adverse Effect, and no event has occurred or circumstance has arisen that, in combination with any other events or circumstances, would reasonably be
expected to result in a Company Material Adverse Effect; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>there has not been any material loss, damage or
destruction to, or any material interruption in the use of, any of the material assets of any of the Symyx Corporations (whether or not covered by insurance); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>none of the Symyx Corporations has: (i)&nbsp;declared, accrued, set aside or paid any dividend or made any other distribution in respect of any shares of capital stock; or
(ii)&nbsp;repurchased, redeemed or otherwise
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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reacquired any shares of capital stock or other securities (other than repurchase of restricted Company Common Stock in connection with termination of employment of the previous holder of such
Company Common Stock that were made in the ordinary course of business and consistent with past practices); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>none
of the Symyx Corporations has sold, issued or granted, or authorized the issuance of: (i)&nbsp;any capital stock or other security (except for Company Common Stock issued upon the valid exercise of outstanding Company Options or Company RSUs);
(ii)&nbsp;any option, warrant or right to acquire any capital stock or any other security (except for Company Options and Company RSUs identified in Part 2.5(d) of the Company Disclosure Schedule); or (iii)&nbsp;any instrument convertible into or
exchangeable for any capital stock or other security; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>the Company has not amended or waived any of its rights
under, or permitted the acceleration of vesting under: (i)&nbsp;any provision of any of the Company Option Plans; or (ii)&nbsp;any provision of any Contract evidencing any outstanding Company Equity Award; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>there has been no amendment to the certificate of incorporation or bylaws of the Company, and none of the Symyx Corporations has
effected or been a party to any merger, consolidation, share exchange, business combination, recapitalization, reclassification of shares, stock split, reverse stock split or similar transaction; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>the Symyx Corporations have not made any capital expenditures that in the aggregate exceeded $1,000,000; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>none of the Symyx Corporations has written off as uncollectible, or established any extraordinary reserve with respect to, any
material account receivable or other material indebtedness; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>none of the Symyx Corporations has: (i)&nbsp;lent
money to any Person (other than routine travel advances made to employees in the ordinary course of business); or (ii)&nbsp;incurred or guaranteed any indebtedness for borrowed money; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(j) </B>none of the Symyx Corporations has: (i)&nbsp;adopted, established or entered into any Company Employee Plan or Company Employee
Agreement; (ii)&nbsp;caused or permitted any Company Employee Plan or Company Employee Agreement to be amended in any material respect; or (iii)&nbsp;materially increased the amount of the wages, salary, commissions, fringe benefits or other
compensation or remuneration payable to any of its directors, officers or other employees; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>none of the Symyx
Corporations has changed any of its methods of accounting or accounting practices in any material respect except as required by concurrent changes in GAAP or SEC rules and regulations; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(l) </B>none of the Symyx Corporations has made any material Tax election; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(m) </B>none of the Symyx Corporations has commenced or settled any Legal Proceeding; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(n) </B>none of the Symyx Corporations has entered into any material transaction or taken any other material action other than in the
ordinary course of business and consistent with past practices; and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(o) </B>none of the Symyx Corporations has agreed or
committed to take any of the actions referred to in clauses &#147;(c)&#148; through &#147;(n)&#148; above. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.6 Title to
Assets.</B> The Symyx Corporations own, and have good and valid title to, all assets purported to be owned by them, including: (a)&nbsp;all assets reflected on the Company Audited Balance Sheet (except for
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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inventory sold or otherwise disposed of in the ordinary course of business since the date of the Company Audited Balance Sheet); and (b)&nbsp;all other assets reflected in the books and records
of the Symyx Corporations as being owned by the Symyx Corporations. All of said assets are owned by the Symyx Corporations free and clear of any Encumbrances, except for: (i)&nbsp;any liens for current Taxes not yet due and payable; (ii)&nbsp;minor
liens that have arisen in the ordinary course of business and that do not (in any case or in the aggregate) materially detract from the value of the assets subject thereto or materially impair the operations of any of the Symyx Corporations; and
(iii)&nbsp;liens described in Part 2.6 of the Company Disclosure Schedule. The Symyx Corporations are the lessees of, and hold valid leasehold interests in, all assets purported to have been leased by them, including: (A)&nbsp;all assets reflected
as leased on the Company Audited Balance Sheet; and (B)&nbsp;all other assets reflected in the books and records of the Symyx Corporations as being leased to the Symyx Corporations,&nbsp;and the Symyx Corporations enjoy undisturbed possession of
such leased assets. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.7 Loans; Customers.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Part 2.7(a) of the Company Disclosure Schedule contains an accurate and complete list as of the date of this Agreement of all
outstanding loans and advances made by any of the Symyx Corporations to any Company Associate, other than routine travel advances made to directors or officers or other employees in the ordinary course of business. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Part 2.7(b) of the Company Disclosure Schedule accurately identifies Symyx Corporations&#146; top 25 customers in each of the
fiscal years ended in December&nbsp;31, 2008 and December&nbsp;31, 2009 based on the revenues received by Symyx Corporations in these years (excluding revenues received from customers that are solely customers of the HPR Business). The Company has
not received any notice or other communication, and has not received any other information, indicating that any customer or other Person identified or required to be identified in Part 2.7(b) of the Company Disclosure Schedule may cease dealing with
or materially reduce its orders from any of the Symyx Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.8 Equipment; Real Property; Leasehold</B>.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>All material items of equipment and other tangible assets owned by or leased to the Symyx Corporations (except
for the assets related solely to the HPR Business) are adequate for the uses to which they are being put, are in good and safe condition and repair (ordinary wear and tear excepted) and are adequate for the conduct of the businesses of the Symyx
Corporations in the manner in which such businesses are currently being conducted. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part
2.8(b) of the Disclosure Schedule, no Symyx Corporation owns any real property. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Part 2.8(c) of the Company
Disclosure Schedule sets forth an accurate and complete list of each lease pursuant to which any of the Symyx Corporations leases real property from any other Person. All real property leased to the Symyx Corporations pursuant to the real property
leases identified or required to be identified in Part 2.8(c) of the Company Disclosure Schedule, including all buildings, structures, fixtures and other improvements leased to the Symyx Corporations, is referred to as the &#147;<B>Symyx Leased Real
Property</B>.&#148; To the knowledge of the Company, there is no existing plan or study by any Governmental Body or by any other Person that challenges or otherwise adversely affects the continuation of the use or operation of any Symyx Leased Real
Property. Part 2.8(c) of the Company Disclosure Schedule contains an accurate and complete list of all subleases, occupancy agreements and other Company Contracts granting to any Person (other than any Symyx Corporation) a right of use or occupancy
of any of the Symyx Leased Real Property. Except as set forth in the leases or subleases identified in Part 2.8(c) of the Company Disclosure Schedule, there is no Person in possession of any Symyx Leased Real Property other than a Symyx Corporation.
Since January&nbsp;1, 2008, none of the Symyx Corporations has received any written notice (or, to the knowledge of the Company, any other communication, whether written or otherwise) of a default, alleged failure to perform, or any offset or
counterclaim with respect to any occupancy agreement with respect to any Symyx Leased Real Property which has not been fully remedied and withdrawn. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.9 Intellectual Property.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Part 2.9(a) of the Company Disclosure Schedule accurately identifies: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>in Part 2.9(a)(i) of the Company Disclosure Schedule: (A)&nbsp;each material item of Registered IP in which any of the Symyx
Corporations has or purports to have an ownership interest of any nature (whether exclusively, jointly with another Person or otherwise) and that is either: (1)&nbsp;bundled, included, used in, licensed or distributed with any Active Company Product
or Active Company Product Software or part of any Active Company Product or Active Company Product Software; or (2)&nbsp;used to manufacture, develop, support, maintain or test any Active Company Product or Active Company Product Software and is not
generally available on standard terms (the &#147;<B>Symyx Material Registered IP</B>&#148;); (B)&nbsp;the jurisdiction in which such Symyx Material Registered IP has been registered or filed and the applicable registration or serial number; and
(C)&nbsp;any other Person that has an ownership interest in such item of Symyx Material Registered IP and the nature of such ownership interest; and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>in Part 2.9(a)(ii) of the Company Disclosure Schedule: (A)&nbsp;each Contract pursuant to which any material Intellectual Property Rights or material Intellectual Property is licensed to any
Symyx Corporation (other than software license agreements for any third-party non-customized software that is generally available to the public at a cost of less than $100,000 and that is not contained or included in or provided with any Active
Company Product (collectively, &#147;<B>Company Non-Customized Software Licenses</B>&#148;); and (B)&nbsp;whether these licenses are exclusive or nonexclusive (for purposes of this Agreement, a covenant not to sue or not to assert infringement
claims shall be deemed to be equivalent to a license). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The Company has delivered or Made Available to Parent an
accurate and complete copy of each standard form of the following documents and Contracts used by any Symyx Corporation at any time since January&nbsp;1, 2008: (i)&nbsp;terms and conditions with respect to the distribution, sale, lease, license or
provisioning of any Active Company Product or Active Company Product Software; (ii)&nbsp;Company Employee Agreement or similar Contract containing any assignment or license of Intellectual Property or Intellectual Property Rights or any
confidentiality provision (except for Intellectual Property, Intellectual Property Rights or confidentiality provisions which are solely related to the HPR Business); or (iii)&nbsp;consulting or independent contractor agreement or similar Contract
containing any assignment or license of Intellectual Property or Intellectual Property Rights or any confidentiality provision (except for Intellectual Property, Intellectual Property Rights or confidentiality provisions which are solely related to
the HPR Business). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The Symyx Corporations exclusively own all right, title and interest to and in the Company IP
(other than Intellectual Property Rights or Intellectual Property licensed to the Company, as identified in Part 2.9(a)(ii) of the Company Disclosure Schedule or pursuant to Company Non-Customized Software Licenses) free and clear of any
Encumbrances (other than non-exclusive licenses granted by any Symyx Corporation in connection with the sale or license of Company Products in the ordinary course of business). Without limiting the generality of the foregoing: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>all documents and instruments necessary to perfect the rights of the Symyx Corporations in the Company IP that is Symyx Material
Registered IP have been validly executed, delivered and filed in a timely manner with the appropriate Governmental Body; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(ii) </B>no Company Associate has any claim, right (whether or not currently exercisable) or interest to or in any Company IP and each Company Associate who is or was involved in the creation or development of any Company IP has signed a
valid, enforceable agreement containing an assignment of Intellectual Property Rights to the Symyx Corporations and confidentiality provisions protecting the Company IP; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>no funding, facilities or personnel of any Governmental Body or any university, college, research institute or other educational institution have been or are being, or are expected to be,
used, directly or indirectly, to develop or create, in whole or in part, any Company IP, Active Company Product or Active Company Product Software; </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>each Symyx Corporation has taken sufficient reasonable steps to maintain the
confidentiality of and otherwise protect and enforce its rights in all proprietary information held by any of the Symyx Corporations, or purported to be held by any of the Symyx Corporations, as a trade secret; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>none of the Symyx Corporations is now or has ever been a member or promoter of, or a contributor to, any industry standards body
or any similar organization that would reasonably be expected to require or obligate any of the Symyx Corporations to grant or offer to any other Person any license or right to any Company IP; and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vi) </B>the Symyx Corporations own or otherwise have, and after the Effective Time the Surviving Corporation will continue to have, all
Intellectual Property Rights needed to conduct the business of the Symyx Corporations as conducted as of the date of this Agreement and as currently planned by the Company to be conducted. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>All Company IP that is material to the business of any of the Symyx Corporations is valid, subsisting and enforceable.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Neither the execution, delivery or performance of this Agreement nor the consummation of any of the Contemplated
Transactions will, or would reasonably be expected to, with or without notice or the lapse of time, result in or give any other Person the right or option to cause, create, impose or declare: (i)&nbsp;a loss of, or Encumbrance on, any Company IP; or
(ii)&nbsp;the grant, assignment or transfer to any other Person of any license or other right or interest under, to or in any of the Company IP. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>To the knowledge of the Company, no Person has infringed, misappropriated or otherwise violated, and no Person is infringing, misappropriating or otherwise violating, any Company IP. Part
2.9(f) of the Company Disclosure Schedule: (i)&nbsp;accurately identifies (and the Company has provided to Parent an accurate and complete copy of) each letter or other written or electronic communication or correspondence that has been sent or
otherwise delivered by or to any of the Symyx Corporations or any Representative of any of the Symyx Corporations since January&nbsp;1, 2008 regarding any actual, alleged or suspected infringement or misappropriation of any Company IP; and
(ii)&nbsp;provides a brief description of the current status of the matter referred to in such letter, communication or correspondence. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>None of the Symyx Corporations and none of the Company IP, Company Products or Company Product Software has ever infringed (directly, contributorily, by inducement or otherwise),
misappropriated or otherwise violated any Intellectual Property Right of any other Person. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>No infringement,
misappropriation or similar claim or Legal Proceeding is or, since January&nbsp;1, 2008, has been pending and served or, to the knowledge of the Company, pending and not served or threatened against any Symyx Corporation or against any other Person
who is, or has asserted or would reasonably be expected to assert that it is, entitled to be indemnified, defended, held harmless or reimbursed by any Symyx Corporation with respect to such claim or Legal Proceeding (including any claim or Legal
Proceeding that has been settled, dismissed or otherwise concluded). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>Except as set forth in Part 2.9(i) of the
Company Disclosure Schedule, since January&nbsp;1, 2008, none of the Symyx Corporations has received any notice or other communication relating to any actual, alleged or suspected infringement, misappropriation or violation of any Intellectual
Property Right of another Person by any of the Symyx Corporations, the Company Products or the Company Product Software. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(j) </B>To the Company&#146;s knowledge, none of the Active Company Product Software: (i)&nbsp;contains any bug, defect or error (including any bug, defect or error relating to or resulting from the display, manipulation, processing,
storage, transmission or use of date data) that materially and adversely affects the use, functionality or performance of such Active Company Product Software or any Active Company Product containing or used in
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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conjunction with such Active Company Product Software; or (ii)&nbsp;fails to comply in any material respect with any applicable warranty or other contractual commitment made by any
Symyx&nbsp;Corporation relating to the use, functionality or performance of such software or any Active Company Product containing or used in conjunction with such Active Company Product Software. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>None of the Symyx Corporations has transferred title to, or granted any exclusive license with respect to, any material Company
IP. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(l) </B>Except as set forth in Part 2.9(l) of the Company Disclosure Schedule, none of the Active Company Product
Software contains any &#147;back door,&#148; &#147;drop dead device,&#148; &#147;time bomb,&#148; &#147;Trojan horse,&#148; &#147;virus&#148; or &#147;worm&#148; (as such terms are commonly understood in the software industry) or any other code
designed or intended to have, or capable of performing, any of the following functions: (i)&nbsp;disrupting, disabling, harming or otherwise impeding in any manner the operation of, or providing unauthorized access to, a computer system or network
or other device on which such code is stored or installed; or (ii)&nbsp;damaging or destroying any data or file without the user&#146;s consent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(m) </B>None of the Active Company Product Software is subject to any &#147;copyleft&#148; or other obligation or condition (including any obligation or condition under any &#147;open source&#148;
license such as the GNU&nbsp;Public License, Lesser GNU Public License or Mozilla Public License) that: (i)&nbsp;requires or would reasonably be expected to require, or conditions or would reasonably be expected to condition, the use or distribution
of such Company Product Software on, the disclosure, licensing or distribution of any Company Source Code for any portion of such Active Company Product Software; or (ii)&nbsp;otherwise imposes or would reasonably be expected to impose any material
limitation, restriction or condition on the right or ability of the Company to use or distribute any Active Company Product Software. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(n) </B>The Symyx Corporations own and possess source code for all Active Company Product Software owned or purported to be owned by the Symyx Corporations. No Company Source Code has been delivered, licensed or made available to any
escrow agent or other Person (other than employees of the Symyx&nbsp;Corporations). None of the Symyx Corporations has any duty or obligation (whether present, contingent or otherwise) to deliver, license or make available any Company Source Code to
any escrow agent or other Person. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.10 Contracts.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Part 2.10(a) of the Company Disclosure Schedule identifies each Company Contract that constitutes a Company Material Contract.
For purposes of this Agreement, each of the following Company Contracts shall be deemed to constitute a &#147;<B>Company Material Contract</B>&#148;: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>any Company Contract: (A)&nbsp;constituting a Company Employee Agreement; (B)&nbsp;pursuant to which any of the Symyx Corporations or any Company Affiliate is or may become obligated to make
any severance, termination or similar payment to any Company Associate or any spouse, heir or Representative of any Company Associate except for severance, termination or similar payments required by applicable Legal Requirements that does not
exceed $25,000 per beneficiary; (C)&nbsp;pursuant to which any of the Symyx&nbsp;Corporations or any Company Affiliate is or may become obligated to make any bonus or similar payment (other than payments constituting base salary or commissions paid
in the ordinary course of business) in excess of $50,000 to any Company Associate; or (D)&nbsp;pursuant to which any of the Symyx Corporations or any Company Affiliate is or may become obligated to grant or accelerate the vesting of, or otherwise
modify, any Company Equity Award; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>any Company Contract identified or required to be identified in Part 2.9 of
the Company Disclosure Schedule; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>any Company Contract with any distributor and any Company Contract with any
other reseller or sales representative, in each case that provides exclusivity rights to any third party; </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>any Company Contract with sole-source or single-source suppliers of tangible
products or services; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>any Company Contract that provides for: (A)&nbsp;reimbursement of any Company Associate
for, or advancement to any Company Associate of, legal fees or other expenses associated with any Legal Proceeding or the defense thereof; or (B)&nbsp;indemnification of any Company Associate; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vi) </B>any Company Contract imposing any restriction on the right or ability of any Symyx&nbsp;Corporation: (A)&nbsp;to compete with
any other Person; (B)&nbsp;to acquire any product or other asset or any services from any other Person; (C)&nbsp;to solicit, hire or retain any Person as a director, an officer or other employee, a consultant or an independent contractor other than
in the ordinary course of business; (D)&nbsp;to develop, sell, supply, distribute, offer, support or service any product or any technology or other asset to or for any other Person; (E)&nbsp;to perform services for any other Person; or (F)&nbsp;to
transact business with any other Person, in each case which restriction would or would reasonably be expected to materially and adversely affect: (x)&nbsp;the conduct of the business of the Symyx Corporations as currently conducted or as currently
is proposed to be conducted; or (y)&nbsp;the design, development, manufacturing, reproduction, marketing, licensing, sale, offer for sale, importation, distribution, performance, display, creation of derivative works with respect to and/or use of
any Company Product; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vii) </B>any Company Contract incorporating or relating to any guaranty, any warranty, any sharing
of liabilities or any indemnity (including any indemnity with respect to Intellectual Property or Intellectual Property Rights) or similar obligation, other than Contracts entered into in the ordinary course of business or that do not deviate in any
material respect from the standard forms of end-user licenses previously delivered or Made Available by the Company to Parent; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(viii) </B>any Company Contract relating to any currency hedging; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ix) </B>any Company Contract requiring
that any of the Symyx Corporations give any notice or provide any information to any Person prior to responding to or prior to accepting any Company Acquisition Proposal or similar proposal, or prior to entering into any discussions, agreement,
arrangement or understanding relating to any Company Acquisition Transaction; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(x) </B>any Company Contract relating to
the lease or sublease of Symyx Leased Real Property; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xi) </B>any Company Contract that: (A)&nbsp;involves orders
aggregated by customer in an amount in excess of $500,000 in the fiscal year ending December&nbsp;31, 2009 or the following fiscal years; (B)&nbsp;requires by its terms the payment or delivery of cash or other consideration by the Symyx Corporations
in an amount or having a value in excess of $500,000 in the fiscal year ending December&nbsp;31, 2009 or the following fiscal years; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(xii) </B>any Company Contract material to the business of the Symyx Corporation as currently conducted that has a term of more than one year and that may not be terminated by a Symyx Corporation (without penalty in excess of $50,000)
within 120 days after the delivery of a termination notice by such Symyx&nbsp;Corporation (other than confidentiality or nondisclosure agreements entered into by any Symyx Corporation in the ordinary course of business); and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xiii) </B>any Company Contract, the termination of which would reasonably be expected to have a Company Material Adverse Effect.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Company has delivered or Made Available to Parent an accurate and complete copy of each Company Material Contract. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Each Company Material Contract is valid and in full force and effect, and is enforceable in accordance with its terms, subject
to: (i)&nbsp;laws of general application relating to bankruptcy, insolvency and the relief of debtors; and (ii)&nbsp;rules of law governing specific performance, injunctive relief and other equitable remedies. </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Except as set forth in Part&nbsp;2.10(c) of the Company Disclosure Schedule:
(i)&nbsp;none of the Symyx&nbsp;Corporations has violated or breached in any material respect, or committed any default in any material respect under, any Company Material Contract; (ii)&nbsp;to the knowledge of the Company, no other Person has
violated or breached in any material respect, or committed any default in any material respect under, any Company Material Contract; (iii)&nbsp;to the knowledge of the Company, no event has occurred, and no circumstance or condition exists, that
(with or without notice or lapse of time) would reasonably be expected to: (A)&nbsp;result in a violation or breach in any material respect of any of the provisions of any Company Material Contract; (B)&nbsp;give any Person the right to declare a
default in any material respect under any Company Material Contract; (C)&nbsp;give any Person the right to receive or require a rebate, chargeback, penalty or change in delivery schedule under any Company Material Contract; (D)&nbsp;give any Person
the right to accelerate the maturity or performance of any Company Material Contract; (E)&nbsp;result in the disclosure, release or delivery of any Company Source Code; or (F)&nbsp;give any Person the right to cancel, terminate or modify any Company
Material Contract; and (iv)&nbsp;since January&nbsp;1, 2008, none of the Symyx Corporations has received any notice or other communication regarding any actual or possible violation or breach of, or default under, any Company Material Contract.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.11 Liabilities.</B> None of the Symyx Corporations has any accrued contingent or other liabilities of the type required
to be disclosed, accrued or reserved in the liabilities column of a balance sheet prepared in accordance with GAAP, except for: (a)&nbsp;liabilities identified as such, or specifically reserved against, in the Company Audited Balance Sheet;
(b)&nbsp;liabilities that have been incurred by the Symyx Corporations since the date of the Company Audited Balance Sheet in the ordinary course of business and consistent with past practices; (c)&nbsp;liabilities for performance of obligations of
the Symyx Corporations pursuant to the express terms of Company Contracts; (d)&nbsp;liabilities under this Agreement or incurred in connection with the Contemplated Transactions; and (e)&nbsp;liabilities described in Part 2.11 of the Company
Disclosure Schedule. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.12 Compliance with Legal Requirements.</B> Each of the Symyx Corporations is, and has at all times
since January&nbsp;1, 2008 been, in compliance in all material respects with all applicable Legal Requirements. Since January&nbsp;1, 2005, none of the Symyx Corporations has received any notice or other communication from any Governmental Body or
other Person regarding any actual or possible violation in any material respect of, or failure to comply in any material respect with, any Legal Requirement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>2.13 Certain Business Practices.</B> None of the Symyx Corporations, and (to the knowledge of the Company) no Representative of any of the Symyx Corporations with respect to any matter relating to any
of the Symyx Corporations, has: (a)&nbsp;used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses relating to political activity; (b)&nbsp;made any unlawful payment to foreign or domestic government officials or
employees or to foreign or domestic political parties or campaigns or violated any provision of the Foreign Corrupt Practices Act of 1977, as amended; or (c)&nbsp;made any other payment that violated any Legal Requirement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.14 Governmental Authorizations.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Symyx Corporations hold all material Governmental Authorizations necessary to enable the Symyx Corporations to conduct their respective businesses in the manner in which such businesses are
currently being conducted, including all Governmental Authorizations required under Environmental Laws. All such Governmental Authorizations are valid and in full force and effect. Each Symyx Corporation is, and at all times since January&nbsp;1,
2008 has been, in compliance in all material respects with the terms and requirements of such Governmental Authorizations. Since January&nbsp;1, 2008, none of the Symyx Corporations has received any notice or other communication from any
Governmental Body regarding: (i)&nbsp;any actual or possible violation of or failure to comply with any term or requirement of any material Governmental Authorization; or (ii)&nbsp;any actual or possible revocation, withdrawal, suspension,
cancellation, termination or modification of any material Governmental Authorization. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Part 2.14(b) of the Company
Disclosure Schedule describes the terms of each grant, incentive or subsidy provided or made available to or for the benefit of any of the Symyx Corporations by any U.S. federal,
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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state or local Governmental Body or any foreign Governmental Body or otherwise. Each of the Symyx&nbsp;Corporations is in full compliance with all of the terms and requirements of each grant,
incentive and subsidy identified or required to be identified in Part 2.14(b) of the Company Disclosure Schedule. Neither the execution, delivery or performance of this Agreement, nor the consummation of the Merger or any of the other Contemplated
Transactions, does, will or would reasonably be expected to (with or without notice or lapse of time) give any Person the right to revoke, withdraw, suspend, cancel, terminate or modify any grant, incentive or subsidy identified or required to be
identified in Part 2.14(b) of the Company Disclosure Schedule. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.15 Tax Matters.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Each of the Tax Returns required to be filed by or on behalf of the respective Symyx&nbsp;Corporations with any Governmental
Body with respect to any taxable period ending on or before the Closing Date (the &#147;<B>Symyx Corporation Returns</B>&#148;): (i)&nbsp;has been or will be filed on or before the applicable due date (including any extensions of such due date); and
(ii)&nbsp;has been, or will be when filed, prepared in all material respects in compliance with all applicable Legal Requirements. All amounts shown on the Symyx Corporation Returns to be due on or before the Closing Date have been or will be paid
on or before the Closing Date. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The Company Audited Balance Sheet fully accrues all actual and contingent
liabilities for Taxes with respect to all periods through the date of the Company Audited Balance Sheet. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Except
as set forth in Part 2.15(c) of the Company Disclosure Schedule, to the knowledge of the Symyx Corporation, no Symyx Corporation and no Symyx Corporation Return is subject to (or since January&nbsp;1, 2008 has been subject to) with an audit by any
Governmental Body. No extension or waiver of the limitation period applicable to any of the Symyx Corporation Returns has been granted (by the Company or any other Person), and no such extension or waiver has been requested from any Symyx
Corporation. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>No claim or Legal Proceeding is pending or, to the knowledge of the Company, has been threatened
against or with respect to any Symyx Corporation in respect of any material Tax. There are no unsatisfied liabilities for material Taxes with respect to any notice of deficiency or similar document received by any Symyx Corporation with respect to
any material Tax (other than liabilities for Taxes asserted under any such notice of deficiency or similar document which are being contested in good faith by the Symyx Corporations and with respect to which adequate reserves for payment have been
established on the Company Audited Balance Sheet). There are no liens for material Taxes upon any of the assets of any of the Symyx Corporations except liens for current Taxes not yet due and payable. None of the Symyx Corporations has been, and
none of the Symyx Corporations will be, required to include any adjustment in taxable income for U.S. federal income tax purposes for any tax period (or portion thereof) pursuant to Section&nbsp;481 or 263A of the Code as a result of transactions or
events occurring, or accounting methods employed, prior to the Closing. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>No written claim has ever been made by
any Governmental Body in a jurisdiction where a Symyx Corporation does not file a Tax Return that it is or may be subject to taxation by that jurisdiction which has resulted or would reasonably be expected to result in an obligation to pay material
Taxes. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>There are no Contracts relating to the allocating, sharing or indemnification of Taxes to which any Symyx
Corporation is a party, other than (i)&nbsp;commercially reasonable agreements providing for the allocation or payment of real property Taxes attributable to real property leased or occupied by any Symyx&nbsp;Corporation; (ii)&nbsp;commercially
reasonable agreements for the allocation or payment of personal property Taxes, sales or use Taxes or value added Taxes with respect to personal property leased, used, owned or sold in the ordinary course of business; and (iii)&nbsp;provisions of
Company Employee Plans compensating employees for any increase in taxation of such employee&#146;s income resulting from the performance of work for any of the Symyx Corporations outside of such employee&#146;s country of residence. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>No Symyx Corporation has constituted either a &#147;distributing corporation&#148; or a &#147;controlled corporation&#148;
within the meaning of Section&nbsp;355(a)(1)(A) of the Code. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>No Symyx Corporation is or has been a United States real property holding
corporation within the meaning of Section&nbsp;897(c)(2) of the Code during the applicable period specified in Section&nbsp;897(c)(1)(A)(ii) of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>No Symyx Corporation has been a member of an affiliated group of corporations within the meaning of Section&nbsp;1504 of the Code or within the meaning of any similar Legal Requirement to which
a Symyx&nbsp;Corporation may be subject, other than the affiliated group of which the Company is the common parent. No Symyx Corporation has any liability for taxes of a predecessor or transferor that became a liability of the successor or
transferee by operation of law. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(j) </B>The Company has disclosed on its federal income Tax Returns all positions that
could give rise to a material understatement penalty within the meaning of Section&nbsp;6662 of the Code or any similar Legal Requirement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>No Symyx Corporation has participated in, or is currently participating in, (i)&nbsp;a &#147;Reportable Transaction&#148; within the meaning of United States Treasury Regulation
Section&nbsp;1.6011-4(b)(1); or (ii)&nbsp;a &#147;Listed Transaction&#148; within the meaning of United States Treasury Regulation Section&nbsp;1.6011-4(b)(2). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>2.16 Employee and Labor Matters; Benefit Plans.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Except as set
forth in Part 2.16(a) of the Company Disclosure Schedule or as required by applicable Legal Requirements, the employment of each of the Symyx Corporations&#146; employees is terminable by the applicable Symyx Corporation at will. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part 2.16(b) of the Company Disclosure Schedule, none of the Symyx&nbsp;Corporations is a party to, or
has a duty to bargain for, any collective bargaining agreement or other Contract with a labor organization or works council representing any of its employees and there are no labor organizations or works councils representing, purporting to
represent or, to the knowledge of the Company, seeking to represent any employees of any of the Symyx Corporations. There has not been any strike, slowdown, work stoppage, lockout, job action, picketing, labor dispute, question concerning
representation, union organizing activity, or any threat thereof, or any similar activity or dispute, affecting any of the Symyx Corporations or any of their employees. There is not now pending, and, to the knowledge of the Company, no Person has
threatened to commence, any such strike, slowdown, work stoppage, lockout, job action, picketing, labor dispute, question regarding representation or union organizing activity or any similar activity or dispute. Except as set forth in Part 2.16(b)
of the Company Disclosure Schedule, there is no claim or grievance pending or, to the knowledge of the Company, threatened relating to any Company Employee Agreement, wages and hours, leave of absence, plant closing notification, employment statute
or regulation, privacy right, labor dispute, workers&#146; compensation policy or long-term disability policy, safety, retaliation, immigration or discrimination matters involving any Company Associate, including charges of unfair labor practices or
harassment complaints. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The Company has delivered or Made Available to Parent an accurate and complete list, by
country and as of the date hereof, of each Company Employee Plan and each Company Employee Agreement. None of the Symyx Corporations intends, and none of the Symyx Corporations has committed, to establish or enter into any new Company Employee Plan
or Company Employee Agreement, or to modify any Company Employee Plan or Company Employee Agreement (except to conform any such Company Employee Plan or Company Employee Agreement to the requirements of any applicable Legal Requirements, in each
case as previously disclosed to Parent in writing or as required by this Agreement). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>The Company has delivered or
Made Available to Parent accurate and complete copies of: (i)&nbsp;all documents setting forth the terms of each Company Employee Plan and each Company Employee Agreement, including all amendments thereto and all related trust documents;
(ii)&nbsp;the three most recent annual reports (Form Series 5500 and all schedules and financial statements attached thereto), if any, required under
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applicable Legal Requirements in connection with each Company Employee Plan; (iii)&nbsp;if the Company Employee Plan is subject to any minimum funding standards (including those of
Section&nbsp;302 of ERISA), the most recent annual and periodic accounting of Company Employee Plan assets, if any; (iv)&nbsp;the most recent summary plan description together with the summaries of material modifications thereto, if any, required
under ERISA or any similar Legal Requirement with respect to each Company Employee Plan; (v)&nbsp;all material written Contracts relating to each Company Employee Plan, including administrative service agreements and group insurance contracts;
(vi)&nbsp;all discrimination tests required under the Code for each Company Employee Plan intended to be qualified under Section&nbsp;401(a) of the Code for the three most recent plan years; and (vii)&nbsp;the most recent IRS determination or
opinion letter issued with respect to each Company Employee Plan intended to be qualified under Section&nbsp;401(a) of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(e) </B>Each of the Symyx Corporations and Company Affiliates has performed in all material respects all obligations required to be performed by it under each Company Employee Plan, and each Company Employee Plan has been established and
maintained in all material respects in accordance with its terms. Any Company Employee Plan intended to be qualified under Section&nbsp;401(a) of the Code has obtained a favorable determination letter (or opinion letter, if applicable) as to its
qualified status under the Code. All Company Employee Plans required to have been approved by any foreign Governmental Body have been so approved, no such approval has been revoked (or, to the knowledge of the Company, has revocation been
threatened) and no event has occurred since the date of the most recent approval or application therefor relating to any such Company Employee Plan that would reasonably be expected to materially affect any such approval relating thereto or
materially increase the costs relating thereto. Each Company Employee Plan intended to be tax qualified under applicable Legal Requirements is so tax qualified, and no event has occurred and no circumstance or condition exists that would reasonably
be expected to result in the disqualification of any such Company Employee Plan. No &#147;prohibited transaction,&#148; within the meaning of Section&nbsp;4975 of the Code or Sections 406 and 407 of ERISA, and not otherwise exempt under
Section&nbsp;408 of ERISA, has occurred with respect to any Company Employee Plan. Each Company Employee Plan (other than any Company Employee Plan to be terminated prior to the Effective Time in accordance with this Agreement) can be amended,
terminated or otherwise discontinued after the Closing in accordance with its terms, without liability to Parent, any of the Symyx Corporations or any Company Affiliate (other than any liability for ordinary administration expenses). There are no
audits or inquiries pending or, to the knowledge of the Company, threatened by the IRS, the DOL or any other Governmental Body with respect to any Company Employee Plan. Except as set forth in Part 2.16 of the Company Disclosure Schedule, there are
no pending or, to the knowledge of the Company, threatened claims or Legal Proceedings involving any Company Employee Plan other than routine claims for benefits. None of the Symyx Corporations, and no Company Affiliate, has ever incurred any
material penalty or Tax with respect to any Company Employee Plan under applicable Legal Requirements. Each of the Symyx Corporations and Company Affiliates has made all contributions and other payments required by and due under the terms of each
Company Employee Plan. Neither the terms nor the performance of any Company Employee Agreement or Company Employee Plan would reasonably be expected to result in gross income inclusion prior to, on or after the Effective Time pursuant to
Section&nbsp;409A(a)(1)(A) of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>None of the Symyx Corporations, and no Company Affiliate, has ever
maintained, established, sponsored, participated in or contributed to any: (i)&nbsp;Company Pension Plan subject to Title IV of ERISA; (ii)&nbsp;&#147;multiemployer plan&#148; within the meaning of Section (3)(37)&nbsp;of ERISA; or (iii)&nbsp;plan
described in Section&nbsp;413 of the Code. No Company Employee Plan is or has been funded by, associated with or related to a &#147;voluntary employees&#146; beneficiary association&#148; within the meaning of Section&nbsp;501(c)(9) of the Code.
None of the Symyx&nbsp;Corporations, and no Company Affiliate, has ever maintained, established, sponsored, participated in or contributed to any Company Pension Plan in which stock of any of the Symyx Corporations or any Company Affiliate is or was
held as a plan asset. The fair market value of the assets of each funded Company Foreign Plan, the liability of each insurer for any Company Foreign Plan funded through insurance, or the book reserve established for any Company Foreign Plan,
together with any accrued contributions, is sufficient to procure or provide in full for the accrued benefit obligations, with respect to all current and former participants in such Company Foreign Plan according to the reasonable actuarial
assumptions and valuations most recently used to
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determine employer contributions to and obligations under such Foreign Plan, and no Contemplated Transaction will cause any such assets or insurance obligations to be less than such benefit
obligations. There are no liabilities of the Symyx Corporations with respect to any Company Employee Plan that are not properly accrued and reflected in the financial statements of the Company in accordance with GAAP. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>No Company Employee Plan that is an employee welfare benefit plan (whether or not ERISA applies to such Company Employee Plan)
is, in whole or in part, self-funded or self-insured. No Company Employee Plan provides (except at no cost to the Symyx Corporations or any Company Affiliate), or reflects or represents any liability of any of the Symyx Corporations or any Company
Affiliate to provide, post-termination or retiree life insurance, post-termination or retiree health benefits or other post-termination or retiree employee welfare benefits to any Person for any reason, except as may be required by COBRA or other
applicable Legal Requirements. Other than commitments made that involve no future costs to any of the Symyx Corporations or any Company Affiliate, none of the Symyx Corporations nor any Company Affiliate has ever represented, promised or contracted
(whether in oral or written form) to any Company Associate (either individually or to Company Associates as a group) or any other Person that such Company Associate(s) or other Person would be provided with post-termination or retiree life
insurance, post-termination or retiree health benefit or other post-termination or retiree employee welfare benefits, except to the extent required by applicable Legal Requirements. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>Except as set forth in Part 2.16(h) of the Company Disclosure Schedule, and except as expressly required or provided by this
Agreement, neither the execution of this Agreement nor the consummation of the Contemplated Transactions will or would reasonably be expected to (either alone or upon the occurrence of termination of employment) constitute an event under any Company
Employee Plan, Company Employee Agreement, trust or loan that will or may result (either alone or in connection with any other circumstance or event) in any payment (whether of severance pay or otherwise), acceleration, forgiveness of indebtedness,
vesting, distribution, increase in benefits or obligation to fund benefits with respect to any Company Associate. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i)
</B>Except as set forth in Part 2.16(i) of the Company Disclosure Schedule, each of the Symyx&nbsp;Corporations and Company Affiliates: (i)&nbsp;is, and since January&nbsp;1, 2008 has been, in compliance in all material respects with all Legal
Requirements and any Order or arbitration award of any court, arbitrator or any Governmental Body respecting employment, employment practices, terms and conditions of employment, wages, hours or other labor related matters; (ii)&nbsp;has paid all
wages, salaries and other payments to Company Associates at the time required by all Legal Requirements and has withheld and reported all amounts required by applicable Legal Requirements or by Contract to be withheld and reported with respect to
wages, salaries and other payments to Company Associates; (iii)&nbsp;is not liable for any arrears of wages or any taxes or any interest or penalty for failure to comply with the Legal Requirements applicable of the foregoing; and (iv)&nbsp;is not
liable for any payment to any trust or other fund governed by or maintained by or on behalf of any Governmental Body with respect to unemployment compensation benefits, social security, social charges or other benefits or obligations for Company
Associates (other than routine payments to be made in the ordinary course of business and consistent with past practice). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(j) </B>There is no agreement, plan, arrangement or other Contract covering any Company Associate, and no payments have been made or will be made in connection with the Merger to any Company Associate, that, considered individually or
considered collectively with any other such Contracts or payments, will, or would reasonably be expected to, be characterized as a &#147;parachute payment&#148; within the meaning of Section&nbsp;280G(b)(2) of the Code or give rise directly or
indirectly to the payment of any amount that would not be deductible pursuant to Section&nbsp;162(m) of the Code (or any comparable provision under state or foreign Tax laws). No Symyx Corporation is a party to or has any obligation under any
Contract to compensate any Person for excise taxes payable pursuant to Section&nbsp;4999 of the Code or for additional taxes payable pursuant to Section&nbsp;409A of the Code. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>Each of the Symyx Corporations is, and has been at all times since January&nbsp;1, 2008, in compliance in all material respects
with the Worker Adjustment and Retraining Notification Act or any similar Legal Requirement. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(l) </B>Each of the Company Option Plans and the Company ESPP has been approved by the
Company&#146;s stockholders to the extent required by applicable Legal Requirements. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.17 Environmental Matters.</B>
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>None of the Symyx Corporations has received any notice or other communication, whether from a Governmental Body,
citizens group, Company Associate or otherwise, that alleges that any of the Symyx&nbsp;Corporations is not or might not be in compliance with any Environmental Law, and, to the knowledge of the Company, there are no circumstances that may prevent
or interfere with the compliance by any of the Symyx&nbsp;Corporations with any Environmental Law in the future. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)
</B>To the knowledge of the Company: (i)&nbsp;all Symyx Leased Real Property and any other property that was leased to or owned, controlled or used by any of the Symyx Corporations, and all surface water, groundwater and soil associated with or
adjacent to such property, is free of any Materials of Environmental Concern or material environmental contamination of any nature; (ii)&nbsp;none of the Symyx Leased Real Property or any other property that was leased to or owned, controlled or
used by any of the Symyx Corporations contains any underground storage tanks, asbestos, equipment using PCBs or underground injection wells; and (iii)&nbsp;none of the Symyx Leased Real Property or any other property that was leased to or owned,
controlled or used by any of the Symyx Corporations contains any septic tanks in which process wastewater or any Materials of Environmental Concern have been Released. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>No Symyx Corporation has ever sent or transported, or arranged to send or transport, any Materials of Environmental Concern to a site that, pursuant to any applicable Environmental Law:
(i)&nbsp;has been placed on the &#147;National Priorities List&#148; of hazardous waste sites or any similar state list; (ii)&nbsp;is otherwise designated or identified as a potential site for remediation, cleanup, closure or other environmental
remedial activity; or (iii)&nbsp;is subject to a Legal Requirement to take &#147;removal&#148; or &#147;remedial&#148; action as detailed in any applicable Environmental Law or to make payment for the cost of cleaning up any site. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>None of the Symyx Corporations has entered into any Company Contract that may require any of them to guarantee, reimburse,
defend, hold harmless or indemnify any other party with respect to liabilities arising out of Environmental Laws, or the activities of the Symyx Corporations or any other Person relating to Materials of Environmental Concern. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.18 Insurance</B><B>.</B> Each material insurance policy and self-insurance program and arrangement relating to the business, assets and
operations of the Symyx Corporations is in full force and effect. Since January&nbsp;1, 2008, none of the Symyx Corporations has received any notice or other communication regarding any actual or possible: (a)&nbsp;cancellation or invalidation of
any material insurance policy; (b)&nbsp;refusal of any coverage or rejection of any material claim under any insurance policy; or (c)&nbsp;material adjustment in the amount of the premiums payable with respect to any insurance policy. There is no
pending workers&#146; compensation or other claim under or based upon any insurance policy of any of the Symyx Corporations involving an amount in excess of $100,000 in any individual case or $500,000 in the aggregate. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.19 Transactions with Affiliates</B><B>.</B> Except as set forth in the Company SEC Documents , since the date of the Company&#146;s
last proxy statement filed with the SEC, no event has occurred that would be required to be reported by the Company pursuant to Item&nbsp;404 of Regulation S-K promulgated by the SEC. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.20 Legal Proceedings; Orders</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Except as set forth in Part 2.20(a) of the Company Disclosure Schedule, there is no pending and served Legal Proceeding, and (to the knowledge of the Company) there is no pending but not served
Legal Proceeding and no Person has threatened to commence any material Legal Proceeding: (i)&nbsp;that involves any of the Symyx Corporations, any business of any of the Symyx Corporations, any of the assets owned, leased or used by any of the Symyx
Corporations or, to the knowledge of the Company, any Company Associate; or (ii)&nbsp;that
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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challenges, or that may have the effect of preventing, delaying, making illegal or otherwise interfering with, the Merger or any of the other Contemplated Transactions. To the knowledge of the
Company, no event has occurred, and no claim, dispute or other condition or circumstance exists, that would reasonably be expected to give rise to or serve as a reasonable basis for the commencement of any Legal Proceeding of the type described in
clause &#147;(i)&#148; or clause &#147;(ii)&#148; of the first sentence of this Section&nbsp;2.20(a). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>There is no
Order to which any of the Symyx Corporations, or any of the material assets owned or used by any of the Symyx Corporations, is subject. To the knowledge of the Company, no officer or other key employee of any of the Symyx Corporations is subject to
any Order that prohibits such officer or other employee from engaging in or continuing any conduct, activity or practice relating to the business of any of the Symyx Corporations. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.21 Authority; Binding Nature of Agreement</B><B>.</B> The Company has the corporate right, power and authority to enter into and
subject to obtaining the Required Company Stockholder Vote (as defined in Section&nbsp;2.23) to perform its obligations under this Agreement. The Company had the corporate right, power and authority to enter into the HPR Agreement and had and has
the corporate right, power and authority to perform its obligations under the HPR Agreement. The Company Board (at a meeting duly called and held) has: (a)&nbsp;determined that the Merger is advisable and fair to, and in the best interests of, the
Company and its stockholders; (b)&nbsp;authorized and approved the execution, delivery and performance of this Agreement by the Company and approved the Merger; and (c)&nbsp;recommended the adoption of this Agreement by the holders of Company Common
Stock and directed that this Agreement and the Merger be submitted for consideration by the Company&#146;s stockholders at the Company Stockholders&#146; Meeting (as defined in Section&nbsp;5.2(a)). Assuming the due authorization, execution and
delivery of this Agreement by Parent and Merger Sub, this Agreement constitutes the legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, subject to: (i)&nbsp;laws of general application
relating to bankruptcy, insolvency, the relief of debtors and creditors&#146; rights generally; and (ii)&nbsp;rules of law governing specific performance, injunctive relief and other equitable remedies. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.22 Inapplicability of Section&nbsp;203 of the DGCL and Other Anti-takeover Statutes</B><B>.</B> The Company Board has taken, and during
the Pre-Closing Period (as defined in Section&nbsp;4.1) the Company Board will take, all actions necessary to ensure that the restrictions applicable to business combinations contained in Section&nbsp;203 of the DGCL are not, and will not be,
applicable to the execution, delivery or performance of this Agreement, the Company Stockholder Voting Agreements or to the consummation of the Merger or any of the other Contemplated Transactions. The Company Board (at a meeting duly called and
held) has,&nbsp;to the extent necessary, adopted a resolution having the effect of causing the Company not to be subject to any state takeover law or similar Legal Requirement that might otherwise apply to the Merger or any of the other Contemplated
Transactions. No state takeover statute or similar Legal Requirement applies or purports to apply to the Merger, this Agreement or any of the Contemplated Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>2.23 Vote Required</B><B>.</B> The affirmative vote of the holders of a majority of the voting power of the shares of Company Common Stock outstanding on the record date for the Company
Stockholders&#146; Meeting (the &#147;<B>Required Company Stockholder Vote</B>&#148;) is the only vote of the holders of any class or series of the Company&#146;s capital stock necessary to adopt this Agreement or otherwise authorize and approve the
Merger. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.24 Non-Contravention; Consents</B><B>.</B> Assuming compliance with the applicable provisions of the DGCL, the
HSR Act, if applicable, any applicable foreign antitrust Legal Requirements and the listing requirements of the NASDAQ Global Market, except as set forth in Part 2.24 of the Company Disclosure Schedule, neither (1)&nbsp;the execution, delivery or
performance of this Agreement by the Company, nor (2)&nbsp;the consummation of the Merger or any of the other Contemplated Transactions, will or would reasonably be expected to, directly or indirectly (with or without notice or lapse of time):
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>contravene, conflict with or result in a violation of: (i)&nbsp;any of the provisions of the certificate of
incorporation, bylaws or other charter or organizational documents of any of the Symyx Corporations; or (ii)&nbsp;any resolution adopted by the stockholders, the board of directors or any committee of the board of directors of any of the Symyx
Corporations; </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>contravene, conflict with or result in a violation of, any Legal Requirement or
any Order to which any of the Symyx Corporations, or any of the assets owned or used by any of the Symyx Corporations, is subject; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(c) </B>contravene, conflict with or result in a violation of any of the terms or requirements of, or give any Governmental Body the right to revoke, withdraw, suspend, cancel, terminate or modify, any Governmental Authorization that is
held by any of the Symyx Corporations or that otherwise relates to the business of any of the Symyx Corporations or to any of the assets owned or used by any of the Symyx Corporations; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>contravene, conflict with or result in a violation or breach of, or result in a default under, any provision of any Company
Material Contract, or give any Person the right to: (i)&nbsp;declare a default or exercise any remedy under any such Company Material Contract; (ii)&nbsp;a rebate, chargeback, penalty or change in delivery schedule under any such Company Material
Contract; (iii)&nbsp;accelerate the maturity or performance of any such Company Material Contract; or (iv)&nbsp;cancel, terminate or modify any right, benefit, obligation or other term of such Company Material Contract; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>result in the imposition or creation of any Encumbrance upon or with respect to any asset owned or used by any of the Symyx
Corporations (except for minor liens that will not, in any case or in the aggregate, materially detract from the value of the assets subject thereto or materially impair the operations of any of the Symyx Corporations); or </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>result in, or increase the likelihood of, the disclosure or delivery to any escrow holder or other Person of any Company IP
(including Company Source Code), or the transfer of any material asset of any of the Symyx Corporations to any Person. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Except
as may be required by the Securities Act, Exchange Act, the DGCL, the HSR Act, any applicable foreign antitrust Legal Requirement and the listing requirements of the NASDAQ Global Market, none of the Symyx Corporations was, is or will be required to
make any filing with or give any notice to, or to obtain any Consent from, any Person in connection with: (x)&nbsp;the execution, delivery or performance of this Agreement; or (y)&nbsp;the consummation of the Merger or any of the other Contemplated
Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.25 Opinion of Financial Advisor.</B> The Company Board has received the opinion of UBS Securities LLC (the
&#147;<B>Company Financial Advisor</B>&#148;), financial advisor to the Company, dated April&nbsp;4, 2010, to the effect that, as of the date of such opinion, the Exchange Ratio is fair, from a financial point of view, to the holders of the Company
Common Stock. The Company has furnished an accurate and complete copy of said written opinion to Parent solely for informational purposes after receipt thereof by the Company. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.26 Brokers.</B> Except for the Company Financial Advisor, no broker, finder or investment banker is entitled to any brokerage,
finder&#146;s or other fee or commission in connection with the Merger or any of the other Contemplated Transactions based upon arrangements made by or on behalf of any of the Symyx Corporations. The Company has furnished to Parent accurate and
complete copies of all agreements under which any such fees, commissions or other amounts have been paid or may become payable and all indemnification and other agreements related to the engagement of the Company Financial Advisor. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.27 Disclosure.</B> None of the information supplied or to be supplied by or on behalf of the Company for inclusion or incorporation by
reference in the Form S-4 Registration Statement will, at the time the Form S-4 Registration Statement is filed with the SEC or at the time it becomes effective under the Securities Act, contain any untrue statement of a material fact or omit to
state any material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they are made, not misleading. None of the information supplied or to be supplied by or on
behalf of the Company for inclusion or incorporation by reference in the Joint Proxy Statement/Prospectus will, at the time the Joint Proxy Statement/
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Prospectus is mailed to the stockholders of the Company or the stockholders of Parent or at the time of the Company Stockholders&#146; Meeting or the Parent Stockholders&#146; Meeting (or any
adjournment or postponement thereof), contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under
which they are made, not misleading. The Joint Proxy Statement/Prospectus will comply as to form in all material respects with the provisions of the Exchange Act and the rules and regulations promulgated by the SEC thereunder. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.28 Acknowledgement by the Company.</B> The Company is not relying and has not relied on any representations or warranties whatsoever
regarding the subject matter of this Agreement, express or implied, except for the representations and warranties in Section&nbsp;3, including the Parent Disclosure Schedule. Such representations and warranties by Parent constitute the sole and
exclusive representations and warranties of Parent in connection with the Contemplated Transactions and the Company understands, acknowledges and agrees that all other representations and warranties of any kind or nature whether express, implied or
statutory are specifically disclaimed by Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section 3. R<SMALL>EPRESENTATIONS</SMALL> <SMALL>AND</SMALL>
W<SMALL>ARRANTIES</SMALL> <SMALL>OF</SMALL> P<SMALL>ARENT</SMALL> <SMALL>AND</SMALL> M<SMALL>ERGER</SMALL> S<SMALL>UB</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">Parent and Merger Sub represent and warrant to the Company as follows (it being understood that each representation and warranty contained in this Section&nbsp;3 is subject to: (a)&nbsp;the exceptions and disclosures set forth in the part
or subpart of the Parent Disclosure Schedule corresponding to the particular Section or subsection in this Section&nbsp;3 in which such representation and warranty appears; and (b)&nbsp;any exception or disclosure set forth in any other part or
subpart of the Parent Disclosure Schedule to the extent it is reasonably apparent from the wording of such exception or disclosure that such exception or disclosure is intended to qualify such representation and warranty): </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.1 Subsidiaries; Due Organization; Etc. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Exhibit 21.1 to the Parent&#146;s Annual Report on Form 10-K for the fiscal year ended March&nbsp;31, 2009 identifies each Subsidiary of Parent and indicates its jurisdiction of organization.
Neither Parent nor any of the Entities identified in Exhibit 21.1 of Parent&#146;s Annual Report on Form 10-K for the fiscal year ended March&nbsp;31, 2009 owns any capital stock of, or any equity interest of any nature in, any other Entity, other
than the Entities identified in said Exhibit 21.1 and the other Entities identified in Part 3.1(a) of the Parent Disclosure Schedule. No Accelrys Corporation has agreed or is obligated to make, or is bound by any Contract under which it may become
obligated to make, any future investment in or capital contribution to any other Entity. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Each of the Accelrys
Corporations is a corporation duly organized, validly existing and in good standing (to the extent that the laws of the jurisdiction of its formation recognize the concept of good standing) under the laws of the jurisdiction of its incorporation and
has all necessary power and authority: (i)&nbsp;to conduct its business in the manner in which its business is currently being conducted; (ii)&nbsp;to own and use its assets in the manner in which its assets are currently owned and used; and
(iii)&nbsp;to perform its obligations under all Contracts by which it is bound. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Each of the Accelrys Corporations
is qualified to do business as a foreign corporation, and is in good standing, under the laws of all jurisdictions where the nature of its business requires such qualification, except for jurisdictions in which the failure to be so qualified,
individually or in the aggregate, would not have a Parent Material Adverse Effect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.2 Certificate of Incorporation and
Bylaws.</B> Parent has delivered or Made Available to the Company accurate and complete copies of the certificate of incorporation, bylaws, memorandum of association and articles of association or equivalent governing documents of each of the
Accelrys Corporations, including all amendments thereto. Parent has delivered or Made Available to the Company accurate and complete copies of: (a)&nbsp;the charters of all committees of the Parent Board; and (b)&nbsp;any code of conduct, corporate
governance policies
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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or principles, related party transaction policy, stock ownership guidelines, whistleblower policy, disclosure committee charter or similar codes policies, or guidelines adopted by any of the
Accelrys Corporations or by the board of directors, or any committee of the board of directors, of any of the Accelrys Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>3.3 Capitalization, Etc. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The authorized capital stock of Parent consists of: (i)&nbsp;60,000,000
shares of Parent Common Stock, of which 28,400,393 shares have been issued and 27,756,493 are outstanding as of the date of this Agreement; and (ii)&nbsp;2,000,000 shares of Parent Preferred Stock, of which no shares have been issued or are
outstanding. Parent holds 643,900 shares of its capital stock in its treasury as of the date of this Agreement. All of the outstanding shares of Parent Common Stock have been duly authorized and validly issued, and are fully paid and nonassessable.
None of the Accelrys Corporations (other than Parent) holds any shares of Parent Common Stock or any rights to acquire shares of Parent Common Stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part 3.3(b) of the Parent Disclosure Schedule: (i)&nbsp;none of the outstanding shares of Parent Common Stock is entitled or subject to any preemptive right, right of
repurchase or forfeiture, right of participation, right of maintenance or any similar right; (ii)&nbsp;none of the outstanding shares of Parent Common Stock is subject to any right of first refusal in favor of Parent; and (iii)&nbsp;there is no
Parent Contract relating to the voting or registration of, or restricting any Person from purchasing, selling, pledging or otherwise disposing of (or from granting any option or similar right with respect to), any shares of Parent Common Stock. None
of the Accelrys Corporations is under any obligation, or is bound by any Contract pursuant to which it may become obligated, to repurchase, redeem or otherwise acquire any outstanding shares of Parent Common Stock or other securities, except for the
Parent&#146;s right to repurchase or reacquire restricted shares of Parent Common Stock held by an employee of Parent upon termination of such employee&#146;s employment or upon any other forfeiture of a vesting condition. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>As of the date of this Agreement, 400,000 shares of Parent Preferred Stock, designated as Series A Junior Participating
Preferred Stock, are reserved for future issuance upon exercise of the rights (the &#147;<B>Rights</B>&#148;) issued pursuant to the Parent Rights Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>As of the date of this Agreement: (i)&nbsp;3,543,660 shares of Parent Common Stock are subject to issuance pursuant to Parent Options; (ii)&nbsp;494,900 shares of Parent Common Stock are
reserved for future issuance pursuant to the Parent ESPP; (iii)&nbsp;949,577 shares of Parent Common Stock are reserved for future issuance pursuant to Parent RSUs; and (iv)&nbsp;1,155,818 shares of Parent Common Stock are reserved for future
issuance pursuant to Parent Equity Awards not yet granted under the Parent Option Plans. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Parent has Made
Available to the Company a complete and accurate list that sets forth with respect to each Parent Equity Award outstanding as of the date of this Agreement the following information: (i)&nbsp;the particular plan (if any) pursuant to which such
Parent Equity Award was granted; (ii)&nbsp;the name of the holder of such Parent Equity Award; (iii)&nbsp;the type of Parent Equity Award (whether a Parent Option, a Parent RSU, or another type of Parent Equity Award); (iv)&nbsp;the number of shares
of Parent Common Stock subject to such Parent Equity Award; (v)&nbsp;the per share exercise price (if any) of such Parent Equity Award; (vi)&nbsp;the applicable vesting schedule (including a description of any acceleration provisions), and the
extent to which such Parent Equity Award is vested and exercisable, if applicable; (vii)&nbsp;the date on which such Parent Equity Award was granted; (viii)&nbsp;the date on which such Parent Equity Award expires (if applicable); (ix)&nbsp;if such
Parent Equity Award is a Parent Option, whether such Parent Option is intended to be an &#147;incentive stock option&#148; (as defined in the Code) or a non-qualified stock option; and (x)&nbsp;if such Parent Equity Award is in the form of Parent
RSUs, the dates on which shares of Parent Common Stock are scheduled to be delivered, if different from the applicable vesting schedule. Parent has Made Available to the Company accurate and complete copies of all equity plans pursuant to which any
outstanding Parent Equity Awards were granted by Parent, and the forms of all agreements evidencing such Parent Equity Awards. The exercise price of each Parent Option is not less than the fair market
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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value of a share of Parent Common Stock as determined on the date of grant of such Parent Option. All grants of Parent Equity Awards were recorded on the Parent&#146;s financial statements
(including, any related notes thereto) contained in the Parent SEC Documents (as defined in Section&nbsp;3.4(a)) in accordance with GAAP, and no such grants involved any &#147;back dating&#148; or similar practices with respect to the effective date
of grant (whether intentionally or otherwise). There are no outstanding or authorized stock appreciation, phantom stock, profit participation or similar rights or equity-based awards with respect to any of the Accelrys Corporations. Each Parent
Equity Award was granted in accordance with the terms of the Parent Employee Plan applicable thereto. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>Except as
set forth in Sections 3.3(a) and 3.3(d), there is no: (i)&nbsp;outstanding subscription, option, call, warrant or right (whether or not currently exercisable) to acquire any shares of the capital stock or other securities of any of the Accelrys
Corporations; (ii)&nbsp;outstanding security, instrument or obligation that is or may become convertible into or exchangeable for any shares of the capital stock or other securities of any of the Accelrys Corporations; (iii)&nbsp;stockholder rights
plan (or similar plan commonly referred to as a &#147;poison pill&#148;) or Contract under which any of the Accelrys Corporations is or may become obligated to sell or otherwise issue any shares of its capital stock or any other securities; or
(iv)&nbsp;condition or circumstance that would reasonably be expected to give rise to or provide a basis for the assertion of a claim by any Person to the effect that such Person is entitled to acquire or receive any shares of capital stock or other
securities of any of the Accelrys Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>All outstanding shares of Parent Common Stock, and all Parent
Equity Awards and other securities of the Accelrys Corporations, have been issued and granted in compliance with: (i)&nbsp;all applicable securities laws and other applicable Legal Requirements; and (ii)&nbsp;all requirements set forth in applicable
Contracts. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>All of the outstanding shares of capital stock of each of the Parent&#146;s Subsidiaries have been
duly authorized and validly issued, are fully paid and nonassessable and free of preemptive rights, with no personal liability attaching to the ownership thereof, and are owned beneficially and of record by Parent, free and clear of any
Encumbrances. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.4 SEC Filings; Financial Statements. </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Parent has Made Available (or made available on the SEC website) to Parent accurate and complete copies of all registration
statements, proxy statements, Parent Certifications (as defined below) and other statements, reports, schedules, forms, exhibits and other documents filed by Parent with the SEC, including all amendments thereto since January&nbsp;1, 2008
(collectively, the &#147;<B>Parent SEC Documents</B>&#148;). All statements, reports, schedules, forms, exhibits and other documents required to have been filed by Parent or its officers with the SEC since January&nbsp;1, 2008 have been so filed on
a timely basis. None of the Parent&#146;s Subsidiaries is required to file any documents with the SEC. As of the time filed with the SEC (or, if amended or superseded by a filing prior to the date of this Agreement, then on the date of such filing):
(i)&nbsp;each of the Parent SEC Documents complied in all material respects with the applicable requirements of the Securities Act or the Exchange Act (as the case may be); and (ii)&nbsp;none of the Parent SEC Documents contained any untrue
statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. Each of the
certifications and statements relating to the Parent SEC Documents required by: (A)&nbsp;Rule 13a-14 or Rule 15d-14 under the Exchange Act; (B)&nbsp;18 U.S.C. &#167;1350 (Section 906 of the Sarbanes-Oxley Act); or (C)&nbsp;any other rule or
regulation promulgated by the SEC or applicable to the Parent SEC Documents (collectively, the &#147;<B>Parent Certifications</B>&#148;) is accurate and complete, and complies as to form and content with all applicable Legal Requirements. As used in
Section&nbsp;3.4, the term &#147;<B>file</B>&#148; and variations thereof shall be broadly construed to include any manner in which a document or information is filed, furnished, submitted, supplied or otherwise made available to the SEC or any
member of its staff in accordance with the applicable requirements of the Securities Act or the Exchange Act (as the case may be). </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Parent maintains, and at all times since January&nbsp;1, 2008 has maintained,
disclosure controls and procedures as required by Rule 13a-15 or 15d-15 under the Exchange Act. Such disclosure controls and procedures are designed to ensure that all material information concerning the Accelrys Corporations required to be
disclosed by Parent in the reports that it is required to file, submit or furnish under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC&#146;s rules and forms. Parent has delivered or
Made Available to the Company accurate and complete copies of all written descriptions of, and all policies, manuals and other documents promulgating, such disclosure controls and procedures. Parent is, and has been at all times since
January&nbsp;1, 2008, in compliance in all material respects with the applicable listing requirements of the NASDAQ Global Market, and has not since January&nbsp;1, 2008 received any notice asserting any non-compliance with the listing requirements
of the NASDAQ Global Market. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The financial statements (including any related notes) contained or incorporated by
reference in the Parent SEC Documents: (i)&nbsp;complied as to form in all material respects with the published rules and regulations of the SEC applicable thereto; (ii)&nbsp;were prepared in accordance with GAAP applied on a consistent basis
throughout the periods covered (except as may be indicated in the notes to such financial statements or, in the case of unaudited financial statements, as permitted by Form 10-Q, Form 8-K or any successor form under the Exchange Act, and except that
the unaudited financial statements may not contain footnotes and are subject to normal and recurring year-end adjustments, none of which were or will be material); and (iii)&nbsp;fairly present, in all material respects, the consolidated financial
position of Parent and its consolidated Subsidiaries as of the respective dates thereof and the consolidated results of operations and cash flows of Parent and its consolidated Subsidiaries for the periods covered thereby. No financial statements of
any Person other than the Accelrys Corporations are required by GAAP to be included in the consolidated financial statements of Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Parent&#146;s auditor has at all times since the date of enactment of the Sarbanes-Oxley Act been: (i)&nbsp;a registered public accounting firm (as defined in Section&nbsp;2(a)(12) of the
Sarbanes-Oxley Act); (ii)&nbsp;&#147;independent&#148; with respect to Parent within the meaning of Regulation S-X under the Exchange Act; and (iii)&nbsp;to the knowledge of Parent, in compliance with subsections (g)&nbsp;through (l)&nbsp;of
Section&nbsp;10A of the Exchange Act and the rules and regulations promulgated by the SEC and the Public Company Accounting Oversight Board thereunder. All non-audit services performed by Parent&#146;s auditors for the Accelrys Corporations that
were required to be approved in accordance with Section&nbsp;202 of the Sarbanes-Oxley Act were so approved. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e)
</B>Parent maintains, and at all times since January&nbsp;1, 2008 has maintained, a system of internal controls over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) which is designed to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with GAAP, and includes those policies and procedures that: (i)&nbsp;pertain to the maintenance of records
that in reasonable detail accurately and fairly reflect the transactions and dispositions of the assets of the Accelrys Corporations; (ii)&nbsp;provide reasonable assurance that transactions are recorded as necessary to permit preparation of
financial statements in conformity with GAAP and that receipts and expenditures are being made only in accordance with authorizations of management and directors of Parent; and (iii)&nbsp;provide reasonable assurance regarding prevention or timely
detection of unauthorized acquisition, use or disposition of the assets of the Accelrys Corporations that could have a material effect on the financial statements. Parent has delivered or Made Available to the Company accurate and complete copies of
all written descriptions of, and all policies, manuals and other documents promulgating, such internal accounting controls. Parent&#146;s management has completed an assessment of the effectiveness of the Parent&#146;s system of internal controls
over financial reporting in compliance with the requirements of Section&nbsp;404 of the Sarbanes-Oxley Act for the fiscal years ended March&nbsp;31, 2008 and March&nbsp;31, 2009, and, except as set forth in the Parent SEC Documents filed prior to
the date of this Agreement, such assessment concluded that such controls were effective and Parent&#146;s independent registered accountant has issued (and not subsequently withdrawn or qualified) an attestation report concluding that Parent
maintained effective internal control over financial reporting as of March&nbsp;31, 2008 and March&nbsp;31, 2009, respectively. To the knowledge of Parent, except as set forth in the Parent SEC Documents filed prior to the date of this Agreement,
since January&nbsp;1, 2008, neither Parent nor any of its Subsidiaries nor Parent&#146;s independent registered accountant has identified or been made aware of: (A)&nbsp;any significant deficiency or material weakness in the design
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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or operation of internal control over financial reporting utilized by the Accelrys Corporations; (B)&nbsp;any illegal act or fraud, whether or not material, that involves Parent&#146;s management
or other employees; or (C)&nbsp;any claim or allegation regarding any of the foregoing. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>Part 3.4(f) of the Parent
Disclosure Schedule lists, and Parent has delivered or Made Available to the Company accurate and complete copies of the documentation creating or governing, all securitization transactions and &#147;off-balance sheet arrangements&#148; (as defined
in Item&nbsp;303(c) of Regulation S-K under the Exchange Act) currently in effect or effected by any of the Accelrys Corporations since January&nbsp;1, 2008. None of the Accelrys Corporations has any obligation or other commitment to become a party
to any such &#147;off-balance sheet arrangements&#148; in the future. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.5 Absence of Changes.</B> Except as set forth in
Part 3.5 of the Parent Disclosure Schedule, since December&nbsp;31, 2009 through the date of this Agreement: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a)
</B>there has not been any Parent Material Adverse Effect, and no event has occurred or circumstance has arisen that, in combination with any other events or circumstances, would reasonably be expected to result in a Parent Material Adverse Effect;
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>there has not been any material loss, damage or destruction to, or any material interruption in the use of, any
of the material assets of any of the Accelrys Corporations (whether or not covered by insurance); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>none of the
Accelrys Corporations has: (i)&nbsp;declared, accrued, set aside or paid any dividend or made any other distribution in respect of any shares of capital stock; or (ii)&nbsp;repurchased, redeemed or otherwise reacquired any shares of capital stock or
other securities (other than repurchase of restricted Parent Common Stock in connection with termination of employment of the previous holder of such Parent Common Stock that were made in the ordinary course of business and consistent with past
practices); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>none of the Accelrys Corporations has sold, issued or granted, or authorized the issuance of:
(i)&nbsp;any capital stock or other security (except for Parent Common Stock issued upon the valid exercise of outstanding Parent Options or Parent RSUs); (ii)&nbsp;any option, warrant or right to acquire any capital stock or any other security
(except for Parent Options and Parent RSUs identified in Part 3.5(d) of the Parent Disclosure Schedule); or (iii)&nbsp;any instrument convertible into or exchangeable for any capital stock or other security; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Parent has not amended or waived any of its rights under, or permitted the acceleration of vesting under: (i)&nbsp;any provision
of any of Parent Option Plans; or (ii)&nbsp;any provision of any Contract evidencing any outstanding Parent Equity Award; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(f) </B>there has been no amendment to the certificate of incorporation or bylaws of Parent, and none of the Accelrys Corporations has effected or been a party to any merger, consolidation, share exchange, business combination,
recapitalization, reclassification of shares, stock split, reverse stock split or similar transaction; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>the
Accelrys Corporations have not made any capital expenditures that in the aggregate exceeded $1,000,000; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>none of
the Accelrys Corporations has written off as uncollectible, or established any extraordinary reserve with respect to, any material account receivable or other material indebtedness; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>none of the Accelrys Corporations has: (i)&nbsp;lent money to any Person (other than routine travel advances made to employees
in the ordinary course of business); or (ii)&nbsp;incurred or guaranteed any indebtedness for borrowed money; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(j)
</B>none of the Accelrys Corporations has: (i)&nbsp;adopted, established or entered into any Parent Employee Plan or Parent Employee Agreement; (ii)&nbsp;caused or permitted any Parent Employee Plan or Parent
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Employee Agreement to be amended in any material respect; or (iii)&nbsp;materially increased the amount of the wages, salary, commissions, fringe benefits or other compensation or remuneration
payable to any of its directors, officers or other employees; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>none of the Accelrys Corporations has changed any
of its methods of accounting or accounting practices in any material respect except as required by concurrent changes in GAAP or SEC rules and regulations; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(l) </B>none of the Accelrys Corporations has made any material Tax election; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(m) </B>none of the Accelrys Corporations has commenced or settled any Legal Proceeding; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(n) </B>none of the
Accelrys Corporations has entered into any material transaction or taken any other material action other than in the ordinary course of business and consistent with past practices; and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(o) </B>none of the Accelrys Corporations has agreed or committed to take any of the actions referred to in clauses &#147;(c)&#148;
through &#147;(n)&#148; above. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.6 Title to Assets.</B> The Accelrys Corporations own, and have good and valid title to,
all assets purported to be owned by them, including: (a)&nbsp;all assets reflected on the Parent Unaudited Balance Sheet (except for inventory sold or otherwise disposed of in the ordinary course of business since the date of the Parent Unaudited
Balance Sheet); and (b)&nbsp;all other assets reflected in the books and records of the Accelrys Corporations as being owned by the Accelrys Corporations. All of said assets are owned by the Accelrys Corporations free and clear of any Encumbrances,
except for: (i)&nbsp;any liens for current Taxes not yet due and payable; (ii)&nbsp;minor liens that have arisen in the ordinary course of business and that do not (in any case or in the aggregate) materially detract from the value of the assets
subject thereto or materially impair the operations of any of the Accelrys Corporations; and (iii)&nbsp;liens described in Part 3.6 of the Parent Disclosure Schedule. The Accelrys Corporations are the lessees of, and hold valid leasehold interests
in, all assets purported to have been leased by them, including: (A)&nbsp;all assets reflected as leased on the Parent Unaudited Balance Sheet; and (B)&nbsp;all other assets reflected in the books and records of the Accelrys Corporations as being
leased to the Accelrys Corporations,&nbsp;and the Accelrys Corporations enjoy undisturbed possession of such leased assets. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>3.7 Loans; Customers.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Part 3.7(a) of the Parent Disclosure Schedule contains an accurate and
complete list as of the date of this Agreement of all outstanding loans and advances made by any of the Accelrys Corporations to any Parent Associate, other than routine travel advances made to directors or officers or other employees in the
ordinary course of business. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Part 3.7(b) of the Parent Disclosure Schedule accurately identifies Accelrys
Corporations&#146; top 25 customers in each of the fiscal years ended in March&nbsp;31, 2009 and March&nbsp;31, 2010 based on the orders received by Accelrys Corporations in these years. Parent has not received any notice or other communication, and
has not received any other information, indicating that any customer or other Person identified or required to be identified in Part 3.7(b) of the Parent Disclosure Schedule may cease dealing with or materially reduce its orders from any of the
Accelrys Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.8 Equipment; Real Property; Leasehold</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>All material items of equipment and other tangible assets owned by or leased to the Accelrys Corporations are adequate for the
uses to which they are being put, are in good and safe condition and repair (ordinary wear and tear excepted) and are adequate for the conduct of the businesses of the Accelrys Corporations in the manner in which such businesses are currently being
conducted. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part 3.8(b) of the Disclosure Schedule, no Accelrys
Corporation owns any real property. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Part 3.8(c) of the Parent Disclosure Schedule sets forth an accurate and
complete list of each lease pursuant to which any of the Accelrys Corporations leases real property from any other Person. All real property leased to the Accelrys Corporations pursuant to the real property leases identified or required to be
identified in Part 3.8(c) of the Parent Disclosure Schedule, including all buildings, structures, fixtures and other improvements leased to the Accelrys Corporations, is referred to as the &#147;<B>Alto Leased Real Property</B>.&#148; To the
knowledge of Parent, there is no existing plan or study by any Governmental Body or by any other Person that challenges or otherwise adversely affects the continuation of the use or operation of any Accelrys Leased Real Property. Part 3.8(c) of the
Parent Disclosure Schedule contains an accurate and complete list of all subleases, occupancy agreements and other Parent Contracts granting to any Person (other than any Accelrys Corporation) a right of use or occupancy of any of the Accelrys
Leased Real Property. Except as set forth in the leases or subleases identified in Part 3.8(c) of the Parent Disclosure Schedule, there is no Person in possession of any Accelrys Leased Real Property other than an Accelrys Corporation. Since
January&nbsp;1, 2008, none of the Accelrys Corporations has received any written notice (or, to the knowledge of Parent, any other communication, whether written or otherwise) of a default, alleged failure to perform, or any offset or counterclaim
with respect to any occupancy agreement with respect to any Accelrys Leased Real Property which has not been fully remedied and withdrawn. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>3.9 Intellectual Property. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Part 3.9(a) of the Parent
Disclosure Schedule accurately identifies: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>in Part 3.9(a)(i) of the Parent Disclosure Schedule: (A)&nbsp;each
material item of Registered IP in which any of the Accelrys Corporations has or purports to have an ownership interest of any nature (whether exclusively, jointly with another Person or otherwise) and that is either: (1)&nbsp;bundled, included, used
in, licensed or distributed with any Parent Product or Parent Product Software or part of any Parent Product or Parent Product Software; or (2)&nbsp;used to manufacture, develop, support, maintain or test any Parent Product or Parent Product
Software and is not generally available on standard terms (the &#147;<B>Accelrys Material Registered IP</B>&#148;); (B)&nbsp;the jurisdiction in which such Accelrys Material Registered IP has been registered or filed and the applicable registration
or serial number; and (C)&nbsp;any other Person that has an ownership interest in such item of Accelrys Material Registered IP and the nature of such ownership interest; and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>in Part 3.9(a)(ii) of the Parent Disclosure Schedule: (A)&nbsp;each Contract pursuant to which any material Intellectual
Property Rights or material Intellectual Property is licensed to any Accelrys Corporation (other than software license agreements for any third-party non-customized software that is generally available to the public at a cost of less than $100,000
and that is not contained or included in or provided with any Parent Product (collectively, &#147;<B>Parent Non-Customized Software Licenses</B>&#148;); and (B)&nbsp;whether these licenses are exclusive or nonexclusive (for purposes of this
Agreement, a covenant not to sue or not to assert infringement claims shall be deemed to be equivalent to a license). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)
</B>Parent has delivered or Made Available to the Company an accurate and complete copy of each standard form of the following documents and Contracts used by any Accelrys Corporation at any time since January&nbsp;1, 2008: (i)&nbsp;terms and
conditions with respect to the distribution, sale, lease, license or provisioning of any Parent Product or Parent Product Software; (ii)&nbsp;Parent Employee Agreement or similar Contract containing any assignment or license of Intellectual Property
or Intellectual Property Rights or any confidentiality provision; or (iii)&nbsp;consulting or independent contractor agreement or similar Contract containing any assignment or license of Intellectual Property or Intellectual Property Rights or any
confidentiality provision. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>The Accelrys Corporations exclusively own all right, title and interest to and in the
Parent IP (other than Intellectual Property Rights or Intellectual Property licensed to Parent, as identified in Part 3.9(a)(ii)
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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of the Parent Disclosure Schedule or pursuant to Parent Non-Customized Software Licenses) free and clear of any Encumbrances (other than non-exclusive licenses granted by any Accelrys Corporation
in connection with the sale or license of Parent Products in the ordinary course of business). Without limiting the generality of the foregoing: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>all documents and instruments necessary to perfect the rights of the Accelrys Corporations in the Parent IP that is Accelrys Material Registered IP have been validly executed, delivered and
filed in a timely manner with the appropriate Governmental Body; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>no Parent Associate has any claim, right
(whether or not currently exercisable) or interest to or in any Parent IP and each Parent Associate who is or was involved in the creation or development of any Parent IP has signed a valid, enforceable agreement containing an assignment of
Intellectual Property Rights to the Accelrys Corporations and confidentiality provisions protecting the Parent IP; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii)
</B>no funding, facilities or personnel of any Governmental Body or any university, college, research institute or other educational institution have been or are being, or are expected to be, used, directly or indirectly, to develop or create, in
whole or in part, any Parent IP, Parent Product or Parent Product Software; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>each Accelrys Corporation has taken
sufficient reasonable steps to maintain the confidentiality of and otherwise protect and enforce its rights in all proprietary information held by any of the Accelrys Corporations, or purported to be held by any of the Accelrys Corporations, as a
trade secret; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>none of the Accelrys Corporations is now or has ever been a member or promoter of, or a contributor
to, any industry standards body or any similar organization that would reasonably be expected to require or obligate any of the Accelrys Corporations to grant or offer to any other Person any license or right to any Parent IP; and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vi) </B>the Accelrys Corporations own or otherwise have, and after the Effective Time the Surviving Corporation will continue to have,
all Intellectual Property Rights needed to conduct the business of the Accelrys Corporations as conducted as of the date of this Agreement and as currently planned by Parent to be conducted. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>All Parent IP that is material to the business of any of the Accelrys Corporations is valid, subsisting and enforceable.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Neither the execution, delivery or performance of this Agreement nor the consummation of any of the Contemplated
Transactions will, or would reasonably be expected to, with or without notice or the lapse of time, result in or give any other Person the right or option to cause, create, impose or declare: (i)&nbsp;a loss of, or Encumbrance on, any Parent IP; or
(ii)&nbsp;the grant, assignment or transfer to any other Person of any license or other right or interest under, to or in any of the Parent IP. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>To the knowledge of Parent, no Person has infringed, misappropriated or otherwise violated, and no Person is infringing, misappropriating or otherwise violating, any Parent IP. Part 3.9(f) of
the Parent Disclosure Schedule: (i)&nbsp;accurately identifies (and Parent has provided to the Company an accurate and complete copy of) each letter or other written or electronic communication or correspondence that has been sent or otherwise
delivered by or to any of the Accelrys Corporations or any Representative of any of the Accelrys Corporations since January&nbsp;1, 2008 regarding any actual, alleged or suspected infringement or misappropriation of any Parent IP; and
(ii)&nbsp;provides a brief description of the current status of the matter referred to in such letter, communication or correspondence. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>None of the Accelrys Corporations and none of the Parent IP, Parent Products or Parent Product Software has ever infringed (directly, contributorily, by inducement or otherwise),
misappropriated or otherwise violated any Intellectual Property Right of any other Person. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>No infringement, misappropriation or similar claim or Legal Proceeding is or,
since January&nbsp;1, 2008, has been pending and served or, to the knowledge of Parent, pending and not served or threatened against any Accelrys Corporation or against any other Person who is, or has asserted or would reasonably be expected to
assert that it is, entitled to be indemnified, defended, held harmless or reimbursed by any Accelrys Corporation with respect to such claim or Legal Proceeding (including any claim or Legal Proceeding that has been settled, dismissed or otherwise
concluded). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>Except as set forth in Part 3.9(i) of the Parent Disclosure Schedule, since January&nbsp;1, 2008,
none of the Accelrys Corporations has received any notice or other communication relating to any actual, alleged or suspected infringement, misappropriation or violation of any Intellectual Property Right of another Person by any of the Accelrys
Corporations, the Parent Products or the Parent Product Software. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(j) </B>To Parent&#146;s knowledge, none of the Parent
Product Software: (i)&nbsp;contains any bug, defect or error (including any bug, defect or error relating to or resulting from the display, manipulation, processing, storage, transmission or use of date data) that materially and adversely affects
the use, functionality or performance of such Parent Product Software or any Parent Product containing or used in conjunction with such Parent Product Software; or (ii)&nbsp;fails to comply in any material respect with any applicable warranty or
other contractual commitment made by any Accelrys Corporation relating to the use, functionality or performance of such software or any Parent Product containing or used in conjunction with such Parent Product Software. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>None of the Accelrys Corporations has transferred title to, or granted any exclusive license with respect to, any material
Parent IP. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(l) </B>Except as set forth in Part 3.9(l) of the Parent Disclosure Schedule, none of the Parent Product
Software contains any &#147;back door,&#148; &#147;drop dead device,&#148; &#147;time bomb,&#148; &#147;Trojan horse,&#148; &#147;virus&#148; or &#147;worm&#148; (as such terms are commonly understood in the software industry) or any other code
designed or intended to have, or capable of performing, any of the following functions: (i)&nbsp;disrupting, disabling, harming or otherwise impeding in any manner the operation of, or providing unauthorized access to, a computer system or network
or other device on which such code is stored or installed; or (ii)&nbsp;damaging or destroying any data or file without the user&#146;s consent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(m) </B>None of the Parent Product Software is subject to any &#147;copyleft&#148; or other obligation or condition (including any obligation or condition under any &#147;open source&#148; license such
as the GNU Public License, Lesser GNU Public License or Mozilla Public License) that: (i)&nbsp;requires or would reasonably be expected to require, or conditions or would reasonably be expected to condition, the use or distribution of such Parent
Product Software on, the disclosure, licensing or distribution of any Parent Source Code for any portion of such Parent Product Software; or (ii)&nbsp;otherwise imposes or would reasonably be expected to impose any material limitation, restriction
or condition on the right or ability of Parent to use or distribute any Parent Product Software. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(n) </B>The Accelrys
Corporations own and possess source code for all Parent Product Software owned or purported to be owned by the Accelrys Corporations. No Parent Source Code has been delivered, licensed or made available to any escrow agent or other Person (other
than employees of the Accelrys Corporations). None of the Accelrys Corporations has any duty or obligation (whether present, contingent or otherwise) to deliver, license or make available any Parent Source Code to any escrow agent or other Person.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.10 Contracts</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Part 3.10(a) of the Parent Disclosure Schedule identifies each Parent Contract that constitutes a Parent Material Contract. For purposes of this Agreement, each of the following Parent
Contracts shall be deemed to constitute a &#147;<B>Parent Material Contract</B>&#148;: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>any Parent Contract:
(A)&nbsp;constituting a Parent Employee Agreement; (B)&nbsp;pursuant to which any of the Accelrys Corporations or any Parent Affiliate is or may become obligated to make any severance,
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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termination or similar payment to any Parent Associate or any spouse, heir or Representative of any Parent Associate except for severance, termination or similar payments required by applicable
Legal Requirements that does not exceed $25,000 per beneficiary; (C)&nbsp;pursuant to which any of the Accelrys Corporations or any Parent Affiliate is or may become obligated to make any bonus or similar payment (other than payments constituting
base salary or commissions paid in the ordinary course of business) in excess of $50,000 to any Parent Associate; or (D)&nbsp;pursuant to which any of the Accelrys Corporations or any Parent Affiliate is or may become obligated to grant or
accelerate the vesting of, or otherwise modify, any Parent Equity Award; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>any Parent Contract identified or
required to be identified in Part 3.9 of the Parent Disclosure Schedule; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>any Parent Contract with any
distributor and any Parent Contract with any other reseller or sales representative, in each case that provides exclusivity rights to any third party; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>any Parent Contract with sole-source or single-source suppliers of tangible products or services; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>any Parent Contract that provides for: (A)&nbsp;reimbursement of any Parent Associate for, or advancement to any Parent Associate of, legal fees or other expenses associated with any Legal
Proceeding or the defense thereof; or (B)&nbsp;indemnification of any Parent Associate; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vi) </B>any Parent Contract
imposing any restriction on the right or ability of any Accelrys Corporation: (A)&nbsp;to compete with any other Person; (B)&nbsp;to acquire any product or other asset or any services from any other Person; (C)&nbsp;to solicit, hire or retain any
Person as a director, an officer or other employee, a consultant or an independent contractor other than in the ordinary course of business; (D)&nbsp;to develop, sell, supply, distribute, offer, support or service any product or any technology or
other asset to or for any other Person; (E)&nbsp;to perform services for any other Person; or (F)&nbsp;to transact business with any other Person, in each case which restriction would or would reasonably be expected to materially and adversely
affect: (x)&nbsp;the conduct of the business of the Accelrys Corporations as currently conducted or as currently is proposed to be conducted; or (y)&nbsp;the design, development, manufacturing, reproduction, marketing, licensing, sale, offer for
sale, importation, distribution, performance, display, creation of derivative works with respect to and/or use of any Parent Product; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(vii) </B>any Parent Contract incorporating or relating to any guaranty, any warranty, any sharing of liabilities or any indemnity (including any indemnity with respect to Intellectual Property or Intellectual Property Rights) or similar
obligation, other than Contracts entered into in the ordinary course of business or that do not deviate in any material respect from the standard forms of end-user licenses previously delivered or Made Available by Parent to the Company; </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(viii) </B>any Parent Contract relating to any currency hedging; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ix) </B>any Parent Contract requiring that any of the Accelrys Corporations give any notice or provide any information to any Person
prior to responding to or prior to accepting any Parent Acquisition Proposal or similar proposal, or prior to entering into any discussions, agreement, arrangement or understanding relating to any Parent Acquisition Transaction; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(x) </B>any Parent Contract relating to the lease or sublease of Accelrys Leased Real Property; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xi) </B>any Parent Contract that: (A)&nbsp;involves orders aggregated by customer in an amount in excess of $500,000 in the fiscal year
ending March&nbsp;31, 2009 or the following fiscal years; (B)&nbsp;requires by its terms the payment or delivery of cash or other consideration by the Accelrys Corporations in an amount or having a value in excess of $500,000 in the fiscal year
ending March&nbsp;31, 2009 or the following fiscal years; </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xii) </B>any Parent Contract material to the business of the Accelrys Corporation as
currently conducted that has a term of more than one year and that may not be terminated by an Accelrys Corporation (without penalty in excess of $50,000) within 120 days after the delivery of a termination notice by such Accelrys Corporation (other
than confidentiality or nondisclosure agreements entered into by any Accelrys Corporation in the ordinary course of business); and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(xiii) </B>any Parent Contract, the termination of which would reasonably be expected to have a Parent Material Adverse Effect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2">Parent has delivered or Made Available to the Company an accurate and complete copy of each Parent Material Contract. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(b) </B>Each Parent Material Contract is valid and in full force and effect, and is enforceable in accordance with its terms, subject to: (i)&nbsp;laws of general application relating to bankruptcy, insolvency and the relief of debtors;
and (ii)&nbsp;rules of law governing specific performance, injunctive relief and other equitable remedies. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Except
as set forth in Part&nbsp;3.10(c) of the Parent Disclosure Schedule: (i)&nbsp;none of the Accelrys Corporations has violated or breached in any material respect, or committed any default in any material respect under, any Parent Material Contract;
(ii)&nbsp;to the knowledge of Parent, no other Person has violated or breached in any material respect, or committed any default in any material respect under, any Parent Material Contract; (iii)&nbsp;to the knowledge of Parent, no event has
occurred, and no circumstance or condition exists, that (with or without notice or lapse of time) would reasonably be expected to: (A)&nbsp;result in a violation or breach in any material respect of any of the provisions of any Parent Material
Contract; (B)&nbsp;give any Person the right to declare a default in any material respect under any Parent Material Contract; (C)&nbsp;give any Person the right to receive or require a rebate, chargeback, penalty or change in delivery schedule under
any Parent Material Contract; (D)&nbsp;give any Person the right to accelerate the maturity or performance of any Parent Material Contract; (E)&nbsp;result in the disclosure, release or delivery of any Parent Source Code; or (F)&nbsp;give any Person
the right to cancel, terminate or modify any Parent Material Contract; and (iv)&nbsp;since January&nbsp;1, 2008, none of the Accelrys Corporations has received any notice or other communication regarding any actual or possible violation or breach
of, or default under, any Parent Material Contract. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.11 Liabilities</B><B>.</B> None of the Accelrys Corporations has any
accrued contingent or other liabilities of the type required to be disclosed, accrued or reserved in the liabilities column of a balance sheet prepared in accordance with GAAP, except for: (a)&nbsp;liabilities identified as such, or specifically
reserved against, in the Parent Unaudited Balance Sheet; (b)&nbsp;liabilities that have been incurred by the Accelrys Corporations since the date of the Parent Unaudited Balance Sheet in the ordinary course of business and consistent with past
practices; (c)&nbsp;liabilities for performance of obligations of the Accelrys Corporations pursuant to the express terms of Parent Contracts; (d)&nbsp;liabilities under this Agreement or incurred in connection with the Contemplated Transactions;
and (e)&nbsp;liabilities described in Part 3.11 of the Parent Disclosure Schedule. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.12 Compliance with Legal
Requirements</B><B>.</B> Each of the Accelrys Corporations is, and has at all times since January&nbsp;1, 2008 been, in compliance in all material respects with all applicable Legal Requirements. Since January&nbsp;1, 2005, none of the Accelrys
Corporations has received any notice or other communication from any Governmental Body or other Person regarding any actual or possible violation in any material respect of, or failure to comply in any material respect with, any Legal Requirement.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.13 Certain Business Practices</B><B>.</B> None of the Accelrys Corporations, and (to the knowledge of Parent) no
Representative of any of the Accelrys Corporations with respect to any matter relating to any of the Accelrys Corporations, has: (a)&nbsp;used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses relating to
political activity; (b)&nbsp;made any unlawful payment to foreign or domestic government officials or employees or to foreign or domestic political parties or campaigns or violated any provision of the Foreign Corrupt Practices Act of 1977, as
amended; or (c)&nbsp;made any other payment that violated any Legal Requirement. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.14 Governmental Authorizations</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Accelrys Corporations hold all material Governmental Authorizations necessary to enable the Accelrys Corporations to conduct
their respective businesses in the manner in which such businesses are currently being conducted, including all Governmental Authorizations required under Environmental Laws. All such Governmental Authorizations are valid and in full force and
effect. Each Accelrys Corporation is, and at all times since January&nbsp;1, 2008 has been, in compliance in all material respects with the terms and requirements of such Governmental Authorizations. Since January&nbsp;1, 2008, none of the Accelrys
Corporations has received any notice or other communication from any Governmental Body regarding: (i)&nbsp;any actual or possible violation of or failure to comply with any term or requirement of any material Governmental Authorization; or
(ii)&nbsp;any actual or possible revocation, withdrawal, suspension, cancellation, termination or modification of any material Governmental Authorization. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Part 3.14(b) of the Parent Disclosure Schedule describes the terms of each grant, incentive or subsidy provided or made available to or for the benefit of any of the Accelrys Corporations by
any U.S. federal, state or local Governmental Body or any foreign Governmental Body or otherwise. Each of the Accelrys Corporations is in full compliance with all of the terms and requirements of each grant, incentive and subsidy identified or
required to be identified in Part 3.14(b) of the Parent Disclosure Schedule. Neither the execution, delivery or performance of this Agreement, nor the consummation of the Merger or any of the other Contemplated Transactions, does, will or would
reasonably be expected to (with or without notice or lapse of time) give any Person the right to revoke, withdraw, suspend, cancel, terminate or modify any grant, incentive or subsidy identified or required to be identified in Part 3.14(b) of the
Parent Disclosure Schedule. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.15 Tax Matters</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Each of the Tax Returns required to be filed by or on behalf of the respective Accelrys Corporations with any Governmental Body
with respect to any taxable period ending on or before the Closing Date (the &#147;<B>Accelrys Corporation Returns</B>&#148;): (i)&nbsp;has been or will be filed on or before the applicable due date (including any extensions of such due date); and
(ii)&nbsp;has been, or will be when filed, prepared in all material respects in compliance with all applicable Legal Requirements. All amounts shown on the Accelrys Corporation Returns to be due on or before the Closing Date have been or will be
paid on or before the Closing Date. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The Parent Unaudited Balance Sheet fully accrues all actual and contingent
liabilities for Taxes with respect to all periods through the date of the Parent Unaudited Balance Sheet. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Except
as set forth in Part 3.15(c) of the Parent Disclosure Schedule, to the knowledge of the Accelrys Corporation, no Accelrys Corporation and no Accelrys Corporation Return is subject to (or since January&nbsp;1, 2008 has been subject to) with an audit
by any Governmental Body. No extension or waiver of the limitation period applicable to any of the Accelrys Corporation Returns has been granted (by Parent or any other Person), and no such extension or waiver has been requested from any Accelrys
Corporation. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>No claim or Legal Proceeding is pending or, to the knowledge of Parent, has been threatened against
or with respect to any Accelrys Corporation in respect of any material Tax. There are no unsatisfied liabilities for material Taxes with respect to any notice of deficiency or similar document received by any Accelrys Corporation with respect to any
material Tax (other than liabilities for Taxes asserted under any such notice of deficiency or similar document which are being contested in good faith by the Accelrys Corporations and with respect to which adequate reserves for payment have been
established on the Parent Unaudited Balance Sheet). There are no liens for material Taxes upon any of the assets of any of the Accelrys Corporations except liens for current Taxes not yet due and payable. None of the Accelrys Corporations has been,
and none of the Accelrys Corporations will be, required to include any adjustment in taxable income for U.S. federal income tax purposes for any tax period (or portion thereof) pursuant to Section&nbsp;481 or 263A of the Code as a result of
transactions or events occurring, or accounting methods employed, prior to the Closing. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>No written claim has ever been made by any Governmental Body in a jurisdiction
where an Accelrys Corporation does not file a Tax Return that it is or may be subject to taxation by that jurisdiction which has resulted or would reasonably be expected to result in an obligation to pay material Taxes. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>There are no Contracts relating to the allocating, sharing or indemnification of Taxes to which any Accelrys Corporation is a
party, other than (i)&nbsp;commercially reasonable agreements providing for the allocation or payment of real property Taxes attributable to real property leased or occupied by any Accelrys Corporation; (ii)&nbsp;commercially reasonable agreements
for the allocation or payment of personal property Taxes, sales or use Taxes or value added Taxes with respect to personal property leased, used, owned or sold in the ordinary course of business; and (iii)&nbsp;provisions of Parent Employee Plans
compensating employees for any increase in taxation of such employee&#146;s income resulting from the performance of work for any of the Accelrys Corporations outside of such employee&#146;s country of residence. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>No Accelrys Corporation has constituted either a &#147;distributing corporation&#148; or a &#147;controlled corporation&#148;
within the meaning of Section&nbsp;355(a)(1)(A) of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>No Accelrys Corporation is or has been a United
States real property holding corporation within the meaning of Section&nbsp;897(c)(2) of the Code during the applicable period specified in Section&nbsp;897(c)(1)(A)(ii) of the Code. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>No Accelrys Corporation has been a member of an affiliated group of corporations within the meaning of Section&nbsp;1504 of the
Code or within the meaning of any similar Legal Requirement to which an Accelrys Corporation may be subject, other than the affiliated group of which Parent is the common parent. No Accelrys Corporation has any liability for taxes of a predecessor
or transferor that became a liability of the successor or transferee by operation of law. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(j) </B>Parent has disclosed on
its federal income Tax Returns all positions that could give rise to a material understatement penalty within the meaning of Section&nbsp;6662 of the Code or any similar Legal Requirement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>No Accelrys Corporation has participated in, or is currently participating in, (i)&nbsp;a &#147;Reportable Transaction&#148;
within the meaning of United States Treasury Regulation Section&nbsp;1.6011-4(b)(1); or (ii)&nbsp;a &#147;Listed Transaction&#148; within the meaning of United States Treasury Regulation Section&nbsp;1.6011-4(b)(2). </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.16 Employee and Labor Matters; Benefit Plans</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Except as set forth in Part 3.16(a) of the Parent Disclosure Schedule or as required by applicable Legal Requirements, the employment of each of the Accelrys Corporations&#146; employees is
terminable by the applicable Accelrys Corporation at will. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part 3.16(b) of the Parent
Disclosure Schedule, none of the Accelrys Corporations is a party to, or has a duty to bargain for, any collective bargaining agreement or other Contract with a labor organization or works council representing any of its employees and there are no
labor organizations or works councils representing, purporting to represent or, to the knowledge of Parent, seeking to represent any employees of any of the Accelrys Corporations. There has not been any strike, slowdown, work stoppage, lockout, job
action, picketing, labor dispute, question concerning representation, union organizing activity, or any threat thereof, or any similar activity or dispute, affecting any of the Accelrys Corporations or any of their employees. There is not now
pending, and, to the knowledge of Parent, no Person has threatened to commence, any such strike, slowdown, work stoppage, lockout, job action, picketing, labor dispute, question regarding representation or union organizing activity or any similar
activity or dispute. Except as set forth in Part 3.16(b) of the Parent Disclosure Schedule, there is no claim or grievance pending or, to the knowledge of Parent, threatened relating to any Parent Employee Agreement, wages and hours, leave of
absence, plant closing notification,
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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employment statute or regulation, privacy right, labor dispute, workers&#146; compensation policy or long-term disability policy, safety, retaliation, immigration or discrimination matters
involving any Parent Associate, including charges of unfair labor practices or harassment complaints. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Parent has
delivered or Made Available to the Company an accurate and complete list, by country and as of the date hereof, of each Parent Employee Plan and each Parent Employee Agreement. None of the Accelrys Corporations intends, and none of the Accelrys
Corporations has committed, to establish or enter into any new Parent Employee Plan or Parent Employee Agreement, or to modify any Parent Employee Plan or Parent Employee Agreement (except to conform any such Parent Employee Plan or Parent Employee
Agreement to the requirements of any applicable Legal Requirements, in each case as previously disclosed to Parent in writing or as required by this Agreement). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Parent has delivered or Made Available to the Company accurate and complete copies of: (i)&nbsp;all documents setting forth the terms of each Parent Employee Plan and each Parent Employee
Agreement, including all amendments thereto and all related trust documents; (ii)&nbsp;the three most recent annual reports (Form Series 5500 and all schedules and financial statements attached thereto), if any, required under applicable Legal
Requirements in connection with each Parent Employee Plan; (iii)&nbsp;if the Parent Employee Plan is subject to any minimum funding standards (including those of Section&nbsp;302 of ERISA), the most recent annual and periodic accounting of Parent
Employee Plan assets, if any; (iv)&nbsp;the most recent summary plan description together with the summaries of material modifications thereto, if any, required under ERISA or any similar Legal Requirement with respect to each Parent Employee Plan;
(v)&nbsp;all material written Contracts relating to each Parent Employee Plan, including administrative service agreements and group insurance contracts; (vi)&nbsp;all discrimination tests required under the Code for each Parent Employee Plan
intended to be qualified under Section&nbsp;401(a) of the Code for the three most recent plan years; and (vii)&nbsp;the most recent IRS determination or opinion letter issued with respect to each Parent Employee Plan intended to be qualified under
Section&nbsp;401(a) of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Each of the Accelrys Corporations and Parent Affiliates has performed in all
material respects all obligations required to be performed by it under each Parent Employee Plan, and each Parent Employee Plan has been established and maintained in all material respects in accordance with its terms. Any Parent Employee Plan
intended to be qualified under Section&nbsp;401(a) of the Code has obtained a favorable determination letter (or opinion letter, if applicable) as to its qualified status under the Code. All Parent Employee Plans required to have been approved by
any foreign Governmental Body have been so approved, no such approval has been revoked (or, to the knowledge of Parent, has revocation been threatened) and no event has occurred since the date of the most recent approval or application therefor
relating to any such Parent Employee Plan that would reasonably be expected to materially affect any such approval relating thereto or materially increase the costs relating thereto. Each Parent Employee Plan intended to be tax qualified under
applicable Legal Requirements is so tax qualified, and no event has occurred and no circumstance or condition exists that would reasonably be expected to result in the disqualification of any such Parent Employee Plan. No &#147;prohibited
transaction,&#148; within the meaning of Section&nbsp;4975 of the Code or Sections 406 and 407 of ERISA, and not otherwise exempt under Section&nbsp;408 of ERISA, has occurred with respect to any Parent Employee Plan. Each Parent Employee Plan
(other than any Parent Employee Plan to be terminated prior to the Effective Time in accordance with this Agreement) can be amended, terminated or otherwise discontinued after the Closing in accordance with its terms, without liability to Parent,
any of the Accelrys Corporations or any Parent Affiliate (other than any liability for ordinary administration expenses). There are no audits or inquiries pending or, to the knowledge of Parent, threatened by the IRS, the DOL or any other
Governmental Body with respect to any Parent Employee Plan. Except as set forth in Part 3.16 of the Parent Disclosure Schedule, there are no pending or, to the knowledge of Parent, threatened claims or Legal Proceedings involving any Parent Employee
Plan other than routine claims for benefits. None of the Accelrys Corporations, and no Parent Affiliate, has ever incurred any material penalty or Tax with respect to any Parent Employee Plan under applicable Legal Requirements. Each of the Accelrys
Corporations and Parent Affiliates has made all contributions and other payments required by and due under the terms of each Parent Employee Plan. Neither the terms nor the performance of any Parent Employee Agreement or Parent Employee Plan would
reasonably be expected to result in gross income inclusion prior to, on or after the Effective Time pursuant to Section&nbsp;409A(a)(1)(A) of the Code. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>None of the Accelrys Corporations, and no Parent Affiliate, has ever maintained,
established, sponsored, participated in or contributed to any: (i)&nbsp;Parent Pension Plan subject to Title IV of ERISA; (ii)&nbsp;&#147;multiemployer plan&#148; within the meaning of Section (3)(37)&nbsp;of ERISA; or (iii)&nbsp;plan described in
Section&nbsp;413 of the Code. No Parent Employee Plan is or has been funded by, associated with or related to a &#147;voluntary employees&#146; beneficiary association&#148; within the meaning of Section&nbsp;501(c)(9) of the Code. None of the
Accelrys Corporations, and no Parent Affiliate, has ever maintained, established, sponsored, participated in or contributed to any Parent Pension Plan in which stock of any of the Accelrys Corporations or any Parent Affiliate is or was held as a
plan asset. The fair market value of the assets of each funded Parent Foreign Plan, the liability of each insurer for any Parent Foreign Plan funded through insurance, or the book reserve established for any Parent Foreign Plan, together with any
accrued contributions, is sufficient to procure or provide in full for the accrued benefit obligations, with respect to all current and former participants in such Parent Foreign Plan according to the reasonable actuarial assumptions and valuations
most recently used to determine employer contributions to and obligations under such Foreign Plan, and no Contemplated Transaction will cause any such assets or insurance obligations to be less than such benefit obligations. There are no liabilities
of the Accelrys Corporations with respect to any Parent Employee Plan that are not properly accrued and reflected in the financial statements of Parent in accordance with GAAP. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>No Parent Employee Plan that is an employee welfare benefit plan (whether or not ERISA applies to such Parent Employee Plan) is,
in whole or in part, self-funded or self-insured. No Parent Employee Plan provides (except at no cost to the Accelrys Corporations or any Parent Affiliate), or reflects or represents any liability of any of the Accelrys Corporations or any Parent
Affiliate to provide, post-termination or retiree life insurance, post-termination or retiree health benefits or other post-termination or retiree employee welfare benefits to any Person for any reason, except as may be required by COBRA or other
applicable Legal Requirements. Other than commitments made that involve no future costs to any of the Accelrys Corporations or any Parent Affiliate, none of the Accelrys Corporations nor any Parent Affiliate has ever represented, promised or
contracted (whether in oral or written form) to any Parent Associate (either individually or to Parent Associates as a group) or any other Person that such Parent Associate(s) or other Person would be provided with post-termination or retiree life
insurance, post-termination or retiree health benefit or other post-termination or retiree employee welfare benefits, except to the extent required by applicable Legal Requirements. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>Except as set forth in Part 3.16(h) of the Parent Disclosure Schedule, and except as expressly required or provided by this
Agreement, neither the execution of this Agreement nor the consummation of the Contemplated Transactions will or would reasonably be expected to (either alone or upon the occurrence of termination of employment) constitute an event under any Parent
Employee Plan, Parent Employee Agreement, trust or loan that will or may result (either alone or in connection with any other circumstance or event) in any payment (whether of severance pay or otherwise), acceleration, forgiveness of indebtedness,
vesting, distribution, increase in benefits or obligation to fund benefits with respect to any Parent Associate. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i)
</B>Except as set forth in Part 3.16(i) of the Parent Disclosure Schedule, each of the Accelrys Corporations and Parent Affiliates: (i)&nbsp;is, and since January&nbsp;1, 2008 has been, in compliance in all material respects with all Legal
Requirements and any Order or arbitration award of any court, arbitrator or any Governmental Body respecting employment, employment practices, terms and conditions of employment, wages, hours or other labor related matters; (ii)&nbsp;has paid all
wages, salaries and other payments to Parent Associates at the time required by all Legal Requirements and has withheld and reported all amounts required by applicable Legal Requirements or by Contract to be withheld and reported with respect to
wages, salaries and other payments to Parent Associates; (iii)&nbsp;is not liable for any arrears of wages or any taxes or any interest or penalty for failure to comply with the Legal Requirements applicable of the foregoing; and (iv)&nbsp;is not
liable for any payment to any trust or other fund governed by or maintained by or on behalf of any Governmental Body with respect to unemployment compensation benefits, social security, social charges or other benefits or obligations for Parent
Associates (other than routine payments to be made in the ordinary course of business and consistent with past practice). </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(j) </B>There is no agreement, plan, arrangement or other Contract covering any Parent
Associate, and no payments have been made or will be made in connection with the Merger to any Parent Associate, that, considered individually or considered collectively with any other such Contracts or payments, will, or would reasonably be
expected to, be characterized as a &#147;parachute payment&#148; within the meaning of Section&nbsp;280G(b)(2) of the Code or give rise directly or indirectly to the payment of any amount that would not be deductible pursuant to Section&nbsp;162(m)
of the Code (or any comparable provision under state or foreign Tax laws). No Accelrys Corporation is a party to or has any obligation under any Contract to compensate any Person for excise taxes payable pursuant to Section&nbsp;4999 of the Code or
for additional taxes payable pursuant to Section&nbsp;409A of the Code. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(k) </B>Each of the Accelrys Corporations is, and
has been at all times since January&nbsp;1, 2008, in compliance in all material respects with the Worker Adjustment and Retraining Notification Act or any similar Legal Requirement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(l) </B>Each of the Parent Option Plans and the Parent ESPP has been approved by the Parent&#146;s stockholders to the extent required
by applicable Legal Requirements. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.17 Environmental Matters</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>None of the Accelrys Corporations has received any notice or other communication, whether from a Governmental Body, citizens
group, Parent Associate or otherwise, that alleges that any of the Accelrys Corporations is not or might not be in compliance with any Environmental Law, and, to the knowledge of Parent, there are no circumstances that may prevent or interfere with
the compliance by any of the Accelrys Corporations with any Environmental Law in the future. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>To the knowledge of
Parent: (i)&nbsp;all Accelrys Leased Real Property and any other property that was leased to or owned, controlled or used by any of the Accelrys Corporations, and all surface water, groundwater and soil associated with or adjacent to such property,
is free of any Materials of Environmental Concern or material environmental contamination of any nature; (ii)&nbsp;none of the Accelrys Leased Real Property or any other property that was leased to or owned, controlled or used by any of the Accelrys
Corporations contains any underground storage tanks, asbestos, equipment using PCBs or underground injection wells; and (iii)&nbsp;none of the Accelrys Leased Real Property or any other property that was leased to or owned, controlled or used by any
of the Accelrys Corporations contains any septic tanks in which process wastewater or any Materials of Environmental Concern have been Released. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>No Accelrys Corporation has ever sent or transported, or arranged to send or transport, any Materials of Environmental Concern to a site that, pursuant to any applicable Environmental Law:
(i)&nbsp;has been placed on the &#147;National Priorities List&#148; of hazardous waste sites or any similar state list; (ii)&nbsp;is otherwise designated or identified as a potential site for remediation, cleanup, closure or other environmental
remedial activity; or (iii)&nbsp;is subject to a Legal Requirement to take &#147;removal&#148; or &#147;remedial&#148; action as detailed in any applicable Environmental Law or to make payment for the cost of cleaning up any site. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>None of the Accelrys Corporations has entered into any Parent Contract that may require any of them to guarantee, reimburse,
defend, hold harmless or indemnify any other party with respect to liabilities arising out of Environmental Laws, or the activities of the Accelrys Corporations or any other Person relating to Materials of Environmental Concern. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.18 Insurance</B><B>.</B> Each material insurance policy and self-insurance program and arrangement relating to the business, assets and
operations of the Accelrys Corporations is in full force and effect. Since January&nbsp;1, 2008, none of the Accelrys Corporations has received any notice or other communication regarding any actual or possible: (a)&nbsp;cancellation or invalidation
of any material insurance policy; (b)&nbsp;refusal of any coverage or rejection of any material claim under any insurance policy; or (c)&nbsp;material adjustment in the amount of the premiums
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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payable with respect to any insurance policy. There is no pending workers&#146; compensation or other claim under or based upon any insurance policy of any of the Accelrys Corporations involving
an amount in excess of $100,000 in any individual case or $500,000 in the aggregate. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.19 Transactions with
Affiliates</B><B>.</B> Except as set forth in the Parent SEC Documents , since the date of the Parent&#146;s last proxy statement filed with the SEC, no event has occurred that would be required to be reported by Parent pursuant to Item&nbsp;404 of
Regulation S-K promulgated by the SEC. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.20 Legal Proceedings; Orders</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Except as set forth in Part 3.20(a) of the Parent Disclosure Schedule, there is no pending and served Legal Proceeding, and (to
the knowledge of Parent) there is no pending but not served Legal Proceeding and no Person has threatened to commence any material Legal Proceeding: (i)&nbsp;that involves any of the Accelrys Corporations, any business of any of the Accelrys
Corporations, any of the assets owned, leased or used by any of the Accelrys Corporations or, to the knowledge of Parent, any Parent Associate; or (ii)&nbsp;that challenges, or that may have the effect of preventing, delaying, making illegal or
otherwise interfering with, the Merger or any of the other Contemplated Transactions. To the knowledge of Parent, no event has occurred, and no claim, dispute or other condition or circumstance exists, that would reasonably be expected to give rise
to or serve as a reasonable basis for the commencement of any Legal Proceeding of the type described in clause &#147;(i)&#148; or clause &#147;(ii)&#148; of the first sentence of this Section&nbsp;3.20(a). </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>There is no Order to which any of the Accelrys Corporations, or any of the material assets owned or used by any of the Accelrys
Corporations, is subject. To the knowledge of Parent, no officer or other key employee of any of the Accelrys Corporations is subject to any Order that prohibits such officer or other employee from engaging in or continuing any conduct, activity or
practice relating to the business of any of the Accelrys Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.21 Authority; Binding Nature of
Agreement</B><B>.</B> Parent and Merger Sub have the corporate right, power and authority to enter into and subject to obtaining the Required Parent Stockholder Vote and the Required Merger Sub Stockholder Vote (as such terms are defined in
Section&nbsp;3.23) to perform their respective obligations under this Agreement. Parent Board (at a meeting duly called and held) has: (a)&nbsp;authorized and approved the execution, delivery and performance of this Agreement by Parent;
(b)&nbsp;authorized and approved the execution and delivery of the Rights Agreement Amendment (as defined in Section&nbsp;3.28); (c)&nbsp;authorized and approved the execution, delivery and performance of this Agreement by Parent and the issuance of
shares of Parent Common Stock pursuant to this Agreement; (d)&nbsp;authorized and approved Parent&#146;s Amendment Certificate (as defined in Section&nbsp;5.3); and (e)&nbsp;recommended the approval of the issuance of the Parent Common Stock
pursuant to this Agreement and the approval of Parent&#146;s Amendment Certificate by the holders of Parent Common Stock and directed that the issuance of such shares and Parent&#146;s Amendment Certificate be submitted for consideration by the
Parent&#146;s stockholders at the Parent Stockholders&#146; Meeting (as defined in Section&nbsp;5.3). Assuming the due authorization, execution and delivery of this Agreement by the Company, this Agreement constitutes the legal, valid and binding
obligation of each of Parent and Merger Sub, enforceable against each of Parent and Merger Sub in accordance with its terms, subject to: (i)&nbsp;laws of general application relating to bankruptcy, insolvency, the relief of debtors and
creditors&#146; rights generally; and (ii)&nbsp;rules of law governing specific performance, injunctive relief and other equitable remedies. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>3.22 Inapplicability of Section&nbsp;203 of the DGCL and Other Anti-takeover Statutes</B><B>.</B> Parent Board has taken, and during the Pre-Closing Period (as defined in Section&nbsp;4.1) the Parent
Board will take, all actions necessary to ensure that the restrictions applicable to business combinations contained in Section&nbsp;203 of the DGCL are not, and will not be, applicable to the execution, delivery or performance of this Agreement,
the Parent Stockholder Voting Agreements, the Rights Agreement Amendment or to the consummation of the Merger or any of the other Contemplated Transactions. The Parent Board (at a meeting duly called and held) has,&nbsp;to the extent necessary,
adopted a resolution having the effect of causing Parent not to be subject to any state
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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takeover law or similar Legal Requirement that might otherwise apply to the Merger or any of the other Contemplated Transactions. No state takeover statute or similar Legal Requirement applies or
purports to apply to the Merger, the Rights Agreement Amendment, this Agreement or any of the Contemplated Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>3.23 Vote Required</B><B>.</B> The only vote of Parent&#146;s stockholders required to: (a)&nbsp;approve the issuance of the Parent Common Stock pursuant to this Agreement is the affirmative vote of the holders of a majority of the
shares of Parent Common Stock voting on such item at the Parent Stockholders&#146; Meeting; and (b)&nbsp;approve the adoption of the Parent&#146;s Amendment Certificate (as defined in Section&nbsp;5.3(a) below) is the affirmative vote of the holders
of a majority of the voting power of the shares of the Parent Common Stock (the &#147;<B>Required Parent Stockholder Vote</B>&#148;). The affirmative vote of the holders of a majority of the voting power of the shares of common stock of Merger Sub
(the &#147;<B>Required Merger Sub Stockholder Vote</B>&#148;) is the only vote of the holders of any class or series of Merger Sub&#146;s capital stock necessary to adopt this Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.24 Non-Contravention; Consents</B><B>.</B> Assuming compliance with the applicable provisions of the DGCL, the HSR Act, if applicable,
any applicable foreign antitrust Legal Requirements and the listing requirements of the NASDAQ Global Market, except as set forth in Part 3.24 of the Parent Disclosure Schedule, neither (1)&nbsp;the execution, delivery or performance of this
Agreement by the Parent and Merger Sub, nor (2)&nbsp;the consummation of the Merger or any of the other Contemplated Transactions, will or would reasonably be expected to, directly or indirectly (with or without notice or lapse of time): </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>contravene, conflict with or result in a violation of: (i)&nbsp;any of the provisions of the certificate of incorporation,
bylaws or other charter or organizational documents of any of the Accelrys Corporations; or (ii)&nbsp;any resolution adopted by the stockholders, the board of directors or any committee of the board of directors of any of the Accelrys Corporations;
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>contravene, conflict with or result in a violation of, any Legal Requirement or any Order to which any of the
Accelrys Corporations, or any of the assets owned or used by any of the Accelrys Corporations, is subject; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c)
</B>contravene, conflict with or result in a violation of any of the terms or requirements of, or give any Governmental Body the right to revoke, withdraw, suspend, cancel, terminate or modify, any Governmental Authorization that is held by any of
the Accelrys Corporations or that otherwise relates to the business of any of the Accelrys Corporations or to any of the assets owned or used by any of the Accelrys Corporations; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>contravene, conflict with or result in a violation or breach of, or result in a default under, any provision of any Parent
Material Contract, or give any Person the right to: (i)&nbsp;declare a default or exercise any remedy under any such Parent Material Contract; (ii)&nbsp;a rebate, chargeback, penalty or change in delivery schedule under any such Parent Material
Contract; (iii)&nbsp;accelerate the maturity or performance of any such Parent Material Contract; or (iv)&nbsp;cancel, terminate or modify any right, benefit, obligation or other term of such Parent Material Contract; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>result in the imposition or creation of any Encumbrance upon or with respect to any asset owned or used by any of the Accelrys
Corporations (except for minor liens that will not, in any case or in the aggregate, materially detract from the value of the assets subject thereto or materially impair the operations of any of the Accelrys Corporations); or </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>result in, or increase the likelihood of, the disclosure or delivery to any escrow holder or other Person of any Parent IP
(including Parent Source Code), or the transfer of any material asset of any of the Accelrys Corporations to any Person. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Except as may be
required by the Securities Act, Exchange Act, the DGCL, the HSR Act, any applicable foreign antitrust Legal Requirement and the listing requirements of the NASDAQ Global Market, none of the Accelrys
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Corporations was, is or will be required to make any filing with or give any notice to, or to obtain any Consent from, any Person in connection with: (x)&nbsp;the execution, delivery or
performance of this Agreement; or (y)&nbsp;the consummation of the Merger or any of the other Contemplated Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>3.25 Opinion of Financial Advisor</B><B>.</B> The Parent Board has received the written opinion of Jefferies&nbsp;&amp; Company, Inc. (the &#147;<B>Parent Financial Advisor</B>&#148;), financial advisor to Parent, dated April&nbsp;4,
2010, to the effect that, as of the date of such opinion, the Exchange Ratio is fair, from a financial point of view, to Parent. Parent has furnished an accurate and complete copy of said written opinion to the Company solely for informational
purposes after receipt thereof by Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.26 Brokers</B><B>.</B> Except for the Parent Financial Advisor, no broker,
finder or investment banker is entitled to any brokerage, finder&#146;s or other fee or commission in connection with the Merger or any of the other Contemplated Transactions based upon arrangements made by or on behalf of any of the Accelrys
Corporations. Parent has furnished to the Company accurate and complete copies of all agreements under which any such fees, commissions or other amounts have been paid or may become payable and all indemnification and other agreements related to the
engagement of the Parent Financial Advisor. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.27 Valid Issuance</B><B>.</B> The Parent Common Stock to be issued in the
Merger including the Parent Common Stock to be issued upon the exercise of assumed and converted Company Options, has been duly authorized and will, when issued in accordance with the provisions of this Agreement, be validly issued, fully paid and
nonassessable and will not be subject to any restriction on resale under the Securities Act, other than restrictions imposed by Rules 144 and 145 under the Securities Act. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.28 Rights Agreement</B><B>.</B> Parent has amended the Rights Agreement to provide that : (i)&nbsp;none of the Company, any of its
stockholders nor any of their respective Affiliates or Associates (as such terms are defined in the Rights Agreement), shall be deemed to be an Acquiring Person (as defined in the Rights Agreement) as a result of the execution, delivery or
performance of this Agreement, the Parent Voting Agreement or the Company Stockholder Voting Agreements or the consummation of the Merger or any of the other Contemplated Transactions; (ii)&nbsp;neither a Stock Acquisition Date (as defined in the
Rights Agreement) nor a Distribution Date (as defined in the Rights Agreement) shall be deemed to occur as a result of the execution, delivery or performance of this Agreement, the Parent Voting Agreement or the Company Stockholder Voting Agreements
or the consummation of the Merger or any of the other Contemplated Transactions; and (iii)&nbsp;the Rights will not separate from the Parent Common Stock as a result of the execution, delivery or performance of this Agreement, the Parent Voting
Agreement or the Company Stockholder Voting Agreements or the consummation of the Merger or any of the other Contemplated Transactions (such amendment to the Parent Rights Agreement being referred to as the &#147;<B>Rights Agreement
Amendment</B>&#148;). Each of the shares of Parent Common Stock to be issued in the Merger (including the Parent Common Stock to be issued upon the exercise of assumed and converted Company Options will be entitled to one Right pursuant to the
Rights Agreement and all other rights to which other holders of Parent Common Stock are entitled to receive. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.29
Disclosure</B><B>.</B> None of the information supplied or to be supplied by or on behalf of Parent for inclusion or incorporation by reference in the Form S-4 Registration Statement will, at the time the Form S-4 Registration Statement is filed
with the SEC or at the time it becomes effective under the Securities Act, contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in the
light of the circumstances under which they are made, not misleading. None of the information supplied or to be supplied by or on behalf of Parent for inclusion or incorporation by reference in the Joint Proxy Statement/Prospectus will, at the time
the Joint Proxy Statement/Prospectus is mailed to the stockholders of the Company or the stockholders of Parent or at the time of the Company Stockholders&#146; Meeting or the Parent Stockholders&#146; Meeting (or any adjournment or postponement
thereof), contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they are made, not
misleading. The Joint Proxy Statement/Prospectus will comply as to form in all material respects
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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with the provisions of the Exchange Act and the rules and regulations promulgated by the SEC thereunder, except that no representation or warranty is made by Parent with respect to statements
made or incorporated by reference therein based on information supplied by the Company for inclusion or incorporation by reference in the Joint Proxy Statement/Prospectus. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.30 Acknowledgement by Parent</B><B>.</B> Neither Parent nor Merger Sub is relying and neither Parent nor Merger Sub has relied on any
representations or warranties whatsoever regarding the subject matter of this Agreement, express or implied, except for the representations and warranties in Section&nbsp;2, including the Company Disclosure Schedule. Such representations and
warranties by the Company constitute the sole and exclusive representations and warranties of the Company in connection with the Contemplated Transactions and each of Parent and Merger Sub understands, acknowledges and agrees that all other
representations and warranties of any kind or nature whether express, implied or statutory are specifically disclaimed by the Company. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>3.31 Merger Sub</B><B>.</B> Merger Sub was formed solely for the purpose of engaging in the Contemplated Transactions and has not engaged in any business activities or conducted any operations other than in connection with the
Contemplated Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;4. C<SMALL>ERTAIN</SMALL> C<SMALL>OVENANTS</SMALL> <SMALL>OF</SMALL>
<SMALL>THE</SMALL> P<SMALL>ARTIES</SMALL> R<SMALL>EGARDING</SMALL> O<SMALL>PERATIONS</SMALL> <SMALL>DURING</SMALL> <SMALL>THE</SMALL> P<SMALL>RE</SMALL>-C<SMALL>LOSING</SMALL> P<SMALL>ERIOD</SMALL> </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.1 Access and Investigation</B><B>.</B> During the period commencing on the date of this Agreement and ending as of the earlier of the
termination of this Agreement or the Effective Time (the &#147;<B>Pre-Closing Period</B>&#148;), subject to applicable Legal Requirements and the terms of any confidentiality restrictions under Contracts of a party as of the date hereof, upon
reasonable notice the Company and Parent shall each, and shall cause each of their respective Subsidiaries to: (a)&nbsp;provide the Representatives of the other party with reasonable access during normal business hours to its Representatives and
assets and to all existing Contracts (subject to confidentiality obligations), books, records, Tax Returns, work papers and other documents and information relating to such Entity or any of its Subsidiaries, in each case as reasonably requested by
Parent or the Company, as the case may be; and (b)&nbsp;provide the Representatives of the other party with such copies of the existing Contracts (subject to confidentiality obligations), books, records, Tax Returns, work papers and other documents
and information relating to such Entity and its Subsidiaries as reasonably requested by Parent or the Company, as the case may be. During the Pre-Closing Period, the Company shall, and shall cause the Representatives of each of the Symyx
Corporations to, permit Parent&#146;s senior officers to meet, upon reasonable notice and during normal business hours, with the chief financial officer and other officers of the Company responsible for the Company&#146;s financial statements and
the internal controls of the Symyx Corporations to discuss such matters as Parent may deem necessary or appropriate in order to enable Parent to satisfy its post-Closing obligations under the Sarbanes-Oxley Act and the rules and regulations relating
thereto. Without limiting the generality of any of the foregoing, and subject to Section&nbsp;5.7(b), during the Pre-Closing Period, the Company and Parent shall each, at least two business days prior to the filing thereof, provide the other with
copies of any notice, report or other document proposed to be filed with or sent to any Governmental Body on behalf of any of the Symyx Corporations or Parent or Merger Sub in connection with the Merger or any of the other Contemplated Transactions.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.2 Operation of the Business of the Symyx Corporations</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>During the Pre-Closing Period, except as set forth in Part 4.2(a) of the Company Disclosure Schedule, as otherwise expressly
permitted by this Agreement, as required by Legal Requirements or to the extent that Parent shall otherwise consent in writing: (i)&nbsp;the Company shall ensure that each of the Symyx Corporations conducts its business and operations in the
ordinary course and consistent with past practices; (ii)&nbsp;the Company shall use commercially reasonable efforts to attempt to ensure that each of the Symyx Corporations preserves intact the material components of its current business
organization, keeps available the services of its current officers and key employees and maintains its relations and goodwill with all material
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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suppliers, material customers, material licensors and Governmental Bodies; and (iii)&nbsp;the Company shall promptly notify Parent of any claim asserted or Legal Proceeding commenced, or, to the
Company&#146;s knowledge, either: (A)&nbsp;with respect to a Governmental Body, overtly threatened; or (B)&nbsp;with respect to any other Person, threatened in writing, against, relating to, involving or otherwise affecting any of the Symyx
Corporations that relates to any of the Contemplated Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Except as set forth in Part 4.2(b) of the
Company Disclosure Schedule, during the Pre-Closing Period, the Company shall not (without the prior written consent of Parent, which consent shall not be unreasonably withheld or delayed), and the Company shall ensure that each of the other Symyx
Corporations does not (without the prior written consent of Parent, which consent shall not be unreasonably withheld or delayed): </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(i) </B>declare, accrue, set aside or pay any dividend or make any other distribution in respect of any shares of capital stock, or repurchase, redeem or otherwise reacquire any shares of capital stock or other securities, other than:
(A)&nbsp;dividends or distributions between or among any of the Symyx Corporations to the extent consistent with past practices; or (B)&nbsp;pursuant to the Company&#146;s right to purchase restricted shares of Company Common Stock held by an
employee of the Company upon termination of such employee&#146;s employment; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>sell, issue, grant or authorize the
sale, issuance or grant of: (A)&nbsp;any capital stock or other security; (B)&nbsp;any option, call, warrant or right to acquire any capital stock or other security; or (C)&nbsp;any instrument convertible into or exchangeable for any capital stock
or other security (except that: (1)&nbsp;the Company may issue shares of Company Common Stock: (aa) upon the valid exercise of Company Options, Company Warrants or upon the vesting of Company RSUs, in each case outstanding as of the date of this
Agreement; and (bb) pursuant to the Company ESPP; and (2)&nbsp;the Company may, in the ordinary course of business and consistent with past practices grant Company Equity Awards to any employee of a Symyx Corporation under the Company Option Plans
commensurate with his or her position with such Symyx Corporation and consistent with past practices; provided that such Company Equity Awards: (aa) if in the form of Company Options, shall have an exercise price equal to the fair market value of
the Company Common Stock covered by such options determined as of the time of the grant of such options; (bb) shall be granted pursuant to the Company&#146;s standard agreement and in any event shall not contain any &#147;single-trigger,&#148;
&#147;double-trigger&#148; or other vesting acceleration provisions and shall not otherwise be subject to acceleration (in whole or in part) as a result of the Merger or any of the other Contemplated Transactions (whether alone or in combination
with any termination of employment or other event); (cc) shall contain the Company&#146;s standard vesting schedule; (dd) shall not be &#147;non-plan&#148; options; and (ee) shall be limited such that no single Company Equity Award represents the
right to purchase or receive in excess of 10,000 shares of Company Common Stock and all such Company Equity Awards collectively represent the right to purchase or receive not more than 100,000 shares of Company Common Stock; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>amend or waive any of its rights under, or accelerate the vesting under, any provision of any of the Company Option Plans, any
provision of any agreement evidencing any outstanding Company Equity Award, or otherwise modify any of the terms of any outstanding Company Equity Award or other security or any related Contract; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>amend, terminate or grant any waiver under any standstill agreements (except as permitted in Section&nbsp;4.4(a)); </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>amend or permit the adoption of any amendment to its certificate of incorporation or bylaws or other charter or
organizational documents; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vi)</B>(A) except in the ordinary course of business and consistent with past practices,
acquire any equity interest or other interest in any other Entity; (B)&nbsp;except in the ordinary course of business and consistent with past practices, form any Subsidiary; or (C)&nbsp;effect or become a party to any merger, consolidation, share
exchange, business combination, amalgamation, recapitalization, reclassification of shares, stock split, reverse stock split, division or subdivision of shares, consolidation of shares or similar transaction; </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vii) </B>make any capital expenditure (except that the Symyx Corporations may make any
capital expenditure that: (A)&nbsp;is provided for in the Company&#146;s capital expense budget delivered or Made Available to Parent prior to the date of this Agreement; or (B)&nbsp;when added to all other capital expenditures made on behalf of all
of the Symyx Corporations since the date of this Agreement but not provided for in the Company&#146;s capital expense budget delivered or Made Available to Parent prior to the date of this Agreement, does not exceed $100,000 in the aggregate);
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(viii) </B>other than in the ordinary course of business and consistent with past practices: (A)&nbsp;enter into or
become bound by, or permit any of the assets owned or used by it to become bound by, any Company Material Contract or any other Contract that is material to the Symyx Corporations (taken as a whole); or (B)&nbsp;amend, terminate, or waive any
material right or remedy under, any Company Material Contract or any other Contract that is material to the Symyx Corporations (taken as a whole); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(ix) </B>acquire, lease or license any right or other asset from any other Person or sell or otherwise dispose of, or lease or license, any right or other asset to any other Person (except in each case
for assets: (A)&nbsp;acquired, leased, licensed or disposed of by the Company in the ordinary course of business and consistent with past practices; or (B)&nbsp;that are immaterial to the business of the Symyx Corporations); </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(x) </B>make any pledge of any of its material assets or permit any of its material assets to become subject to any Encumbrances, except
for Encumbrances that do not materially detract from the value of such assets or that do not materially impair the operations of any of the Symyx Corporations; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(xi) </B>lend money to any Person (other than routine travel and business expense advances made to directors or employees in the ordinary course of business and consistent with past practices), or,
except in the ordinary course of business and consistent with past practices, incur or guarantee any indebtedness; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xii)
</B>establish, adopt, enter into or amend any Company Employee Plan or Company Employee Agreement, pay any bonus or make any profit-sharing or similar payment to, or increase the amount of the wages, salary, commissions, fringe benefits or other
compensation (including equity-based compensation, whether payable in stock, cash or other property) or remuneration payable to, any Company Associate (except that the Company: (A)&nbsp;may provide routine, reasonable salary increases to non-officer
employees in the ordinary course of business and consistent with past practices in connection with the Company&#146;s customary employee review process, provided that such salary increases may not exceed 10%&nbsp;per Company Associate or 2% in the
aggregate for all Company Associates; (B)&nbsp;may amend the Company Employee Plans to the extent required by applicable Legal Requirements; and (C)&nbsp;may make customary bonus payments and profit sharing payments consistent with past practices in
accordance with bonus and profit sharing plans existing on the date of this Agreement); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xiii) </B>hire any employee with
annual non-equity compensation, including target bonuses, in excess of $200,000 or promote any employee to the level of Director or above (except in order to fill a position vacated after the date of this Agreement); </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xiv) </B>other than in the ordinary course of business and consistent with past practices or as required by concurrent changes in GAAP
or SEC rules and regulations, change any of its methods of accounting or accounting practices in any respect; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xv)
</B>make any material Tax election; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xvi) </B>commence any Legal Proceeding, except with respect to: (A)&nbsp;routine
matters in the ordinary course of business and consistent with past practices; (B)&nbsp;in such cases where the Company reasonably determines in good faith that the failure to commence suit would result in a material impairment of a valuable aspect
of its business (provided that the Company consults with Parent and considers the views and comments of Parent with respect to such Legal Proceedings prior to commencement thereof); or (C)&nbsp;in connection with a breach of this Agreement or the
other agreements listed in the definition of &#147;Contemplated Transactions;&#148; </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xvii) </B>settle any Legal Proceeding or other material claim, other than pursuant to a
settlement: (A)&nbsp;that results solely in monetary obligation involving payment by the Symyx Corporations of the amount specifically reserved in accordance with GAAP with respect to such Legal Proceedings or claim on the Company Audited Balance
Sheet; or (B)&nbsp;that results solely in monetary obligation involving only the payment of monies by the Symyx Corporations of not more than $200,000 in the aggregate; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(xviii) </B>enter into any Contract covering any Company Associate, or make any payment to any Company Associate, that, considered individually or considered collectively with any other such Contracts
or payments, will, or would reasonably be expected to, be characterized as a &#147;parachute payment&#148; within the meaning of Section&nbsp;280G(b)(2) of the Code in connection with the Contemplated Transactions or give rise directly or indirectly
to the payment of any amount that would not be deductible pursuant to Section&nbsp;162(m) of the Code (or any comparable provision under state or foreign Tax laws); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(xix) </B>take any action that would reasonably be expected to cause the Merger to fail to qualify as a &#147;reorganization&#148; under Section&nbsp;368(a) of the Code (whether or not otherwise
permitted by the provisions of this Section&nbsp;4) or fail to take any action reasonably necessary to cause the Merger to so qualify; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(xx) </B>terminate the employment of more than 5 Company Employees during any ninety-day period at any Employment Site of the Symyx Corporations; or </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xxi) </B>agree or commit to take any of the actions described in clauses&nbsp;&#147;(i)&#148; through &#147;(xx)&#148; of this
Section&nbsp;4.2(b). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>During the Pre-Closing Period, the Company shall promptly notify Parent in writing of any
event, condition, fact or circumstance that would reasonably be expected to make the timely satisfaction of any of the conditions set forth in Section&nbsp;6 impossible or unlikely or that has had or would reasonably be expected to have or result in
a Company Material Adverse Effect. Without limiting the generality of the foregoing, the Company shall promptly advise Parent in writing of any material Legal Proceeding or material claim threatened, commenced or asserted against or with respect to
any of the Symyx Corporations. No notification given to Parent pursuant to this Section&nbsp;4.2(c) shall limit or otherwise affect any of the representations, warranties, covenants or obligations of the Company contained in this Agreement.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.3 Operation of the Business of the Accelrys Corporations</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>During the Pre-Closing Period, except as set forth in Part 4.3(a) of the Parent Disclosure Schedule, as otherwise expressly
permitted by this Agreement, as required by Legal Requirements or to the extent that the Company shall otherwise consent in writing: (i)&nbsp;Parent shall ensure that each of the Accelrys Corporations conducts its business and operations in the
ordinary course and consistent with past practices; (ii)&nbsp;Parent shall use commercially reasonable efforts to attempt to ensure that each of the Accelrys Corporations preserves intact the material components of its current business organization,
keeps available the services of its current officers and key employees and maintains its relations and goodwill with all material suppliers, material customers, material licensors, and Governmental Bodies; and (iii)&nbsp;Parent shall promptly notify
Company of any claim asserted or Legal Proceeding commenced, or, to Parent&#146;s knowledge, either: (A)&nbsp;with respect to a Governmental Body, overtly threatened; or (B)&nbsp;with respect to any other Person, threatened in writing, against,
relating to, involving or otherwise affecting any of the Accelrys Corporations that relates to any of the Contemplated Transactions. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(b) </B>Except as set forth in Part 4.3(b) of the Parent Disclosure Schedule, during the Pre-Closing Period, Parent shall not (without the prior written consent of Company, which consent shall not be unreasonably withheld or delayed),
and Parent shall ensure that each of the other Accelrys Corporations does not (without the prior written consent of the Company, which consent shall not be unreasonably withheld or delayed): </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>declare, accrue, set aside or pay any dividend or make any other distribution in respect of any shares of capital stock, or
repurchase, redeem or otherwise reacquire any shares of capital stock or other
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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securities, other than: (A)&nbsp;dividends or distributions between or among any of the Accelrys Corporations to the extent consistent with past practices; or (B)&nbsp;pursuant to Parent&#146;s
right to purchase restricted shares of Parent Common Stock held by an employee of Parent upon termination of such employee&#146;s employment; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>sell, issue, grant or authorize the sale, issuance or grant of: (A)&nbsp;any capital stock or other security; (B)&nbsp;any option, call, warrant or right to acquire any capital stock or other
security; or (C)&nbsp;any instrument convertible into or exchangeable for any capital stock or other security (except that: (1)&nbsp;Parent may issue shares of Parent Common Stock: (aa) upon the valid exercise of Parent Options or upon the vesting
of any Parent RSUs, in each case outstanding as of the date of this Agreement; and (bb) pursuant to the Parent ESPP; and (2)&nbsp;Parent may, in the ordinary course of business and consistent with past practices grant Parent Equity Awards to any
employee of an Accelrys Corporation under the Parent Option Plans commensurate with his or her position with such Accelrys Corporation and consistent with past practices; provided that such Parent Equity Awards: (aa) if in the form of Parent Option,
shall have an exercise price equal to the fair market value of the Parent Common Stock covered by such options determined as of the time of the grant of such options; (bb) shall be granted pursuant to the Parent&#146;s standard form of agreement and
in any event shall not contain any &#147;single-trigger,&#148; &#147;double-trigger&#148; or other vesting acceleration provisions and shall not otherwise be subject to acceleration (in whole or in part) as a result of the Merger or any of the other
Contemplated Transactions (whether alone or in combination with any termination of employment or other event); (cc) shall contain Parent&#146;s standard vesting schedule; (dd) shall not be &#147;non-plan&#148; options; and (ee) shall be limited such
that no single Parent Equity Award represents the right to purchase or receive in excess of 10,000 shares of Parent Common Stock and all such Parent Equity Awards collectively represent the right to purchase or receive not more than 100,000 shares
of Parent Common Stock; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>amend or waive any of its rights under, or accelerate the vesting under, any provision
of any of the Parent Option Plans, any provision of any agreement evidencing any outstanding Parent Equity Award, or otherwise modify any of the terms of any outstanding Parent Equity Award or other security or any related Contract; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>amend, terminate or grant any waiver under the Parent Rights Agreement or any standstill agreements (except as permitted in
Section&nbsp;4.4(b)); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>amend or permit the adoption of any amendment to its certificate of incorporation or bylaws
or other charter or organizational documents; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vi)</B>(A) except in the ordinary course of business and consistent with
past practices, acquire any equity interest or other interest in any other Entity; (B)&nbsp;except in the ordinary course of business and consistent with past practices, form any Subsidiary; or (C)&nbsp;effect or become a party to any merger,
consolidation, share exchange, business combination, amalgamation, recapitalization, reclassification of shares, stock split, reverse stock split, division or subdivision of shares, consolidation of shares or similar transaction; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(vii) </B>make any capital expenditure (except that the Accelrys Corporations may make any capital expenditure that: (A)&nbsp;is
provided for in Parent&#146;s capital expense budget delivered or Made Available to the Company prior to the date of this Agreement; or (B)&nbsp;when added to all other capital expenditures made on behalf of all of the Accelrys Corporations since
the date of this Agreement but not provided for in Parent&#146;s capital expense budget delivered or Made Available to the Company prior to the date of this Agreement, does not exceed $100,000 in the aggregate); </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(viii) </B>other than in the ordinary course of business and consistent with past practices: (A)&nbsp;enter into or become bound by, or
permit any of the assets owned or used by it to become bound by, any Parent Material Contract or any other Contract that is material to the Accelrys Corporations (taken as a whole); or (B)&nbsp;amend, terminate, or waive any material right or remedy
under, any Parent Material Contract or any other Contract that is material to the Accelrys Corporations (taken as a whole); </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ix) </B>acquire, lease or license any right or other asset from any other Person or
sell or otherwise dispose of, or lease or license, any right or other asset to any other Person (except in each case for assets: (A)&nbsp;acquired, leased, licensed or disposed of by Parent in the ordinary course of business and consistent with past
practices; or (B)&nbsp;that are immaterial to the business of the Accelrys Corporations); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(x) </B>make any pledge of any
of its material assets or permit any of its material assets to become subject to any Encumbrances, except for Encumbrances that do not materially detract from the value of such assets or that do not materially impair the operations of any of the
Accelrys Corporations; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xi) </B>lend money to any Person (other than routine travel and business expense advances made to
directors or employees in the ordinary course of business and consistent with past practices), or, except in the ordinary course of business and consistent with past practices, incur or guarantee any indebtedness; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xii) </B>establish, adopt, enter into or amend any Parent Employee Plan or Parent Employee Agreement, pay any bonus or make any
profit-sharing or similar payment to, or increase the amount of the wages, salary, commissions, fringe benefits or other compensation (including equity-based compensation, whether payable in stock, cash or other property) or remuneration payable to,
any Parent Associate (except that Parent: (A)&nbsp;may provide routine, reasonable salary increases to non-officer employees in the ordinary course of business and consistent with past practices in connection with Parent&#146;s customary employee
review process, provided that such salary increases may not exceed 10%&nbsp;per Parent Associate or 2% in the aggregate for all Parent Associates; (B)&nbsp;may amend the Parent Employee Plans to the extent required by applicable Legal Requirements;
and (C)&nbsp;may make customary bonus payments and profit sharing payments consistent with past practices in accordance with bonus and profit sharing plans existing on the date of this Agreement); </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xiii) </B>hire any employee with annual non-equity compensation, including target bonuses, in excess of $200,000 or promote any
employee to the level of Director or above (except in order to fill a position vacated after the date of this Agreement); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(xiv) </B>other than in the ordinary course of business and consistent with past practices or as required by concurrent changes in GAAP or SEC rules and regulations, change any of its methods of accounting or accounting practices in any
respect; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xv) </B>make any material Tax election; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xvi) </B>commence any Legal Proceeding, except with respect to: (A)&nbsp;routine matters in the ordinary course of business and
consistent with past practices; (B)&nbsp;in such cases where Parent reasonably determines in good faith that the failure to commence suit would result in a material impairment of a valuable aspect of its business (provided that Parent consults with
the Company and considers the views and comments of the Company with respect to such Legal Proceedings prior to commencement thereof); or (C)&nbsp;in connection with a breach of this Agreement or the other agreements listed in the definition of
&#147;Contemplated Transactions;&#148; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xvii) </B>settle any Legal Proceeding or other material claim, other than
pursuant to a settlement: (A)&nbsp;that results solely in monetary obligation involving payment by the Accelrys Corporations of the amount specifically reserved in accordance with GAAP with respect to such Legal Proceedings or claim on the Parent
Unaudited Balance Sheet; or (B)&nbsp;that results solely in monetary obligation involving only the payment of monies by the Accelrys Corporations of not more than $200,000 in the aggregate; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xviii) </B>enter into any Contract covering any Parent Associate, or make any payment to any Parent Associate, that, considered
individually or considered collectively with any other such Contracts or payments, will, or would reasonably be expected to, be characterized as a &#147;parachute payment&#148; within the meaning of Section&nbsp;280G(b)(2) of the Code in connection
with the Contemplated Transactions or give rise directly or indirectly to the payment of any amount that would not be deductible pursuant to Section&nbsp;162(m) of the Code (or any comparable provision under state or foreign Tax laws); </FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xix) </B>take any action that would reasonably be expected to cause the Merger to fail
to qualify as a &#147;reorganization&#148; under Section&nbsp;368(a) of the Code (whether or not otherwise permitted by the provisions of this Section&nbsp;4) or fail to take any action reasonably necessary to cause the Merger to so qualify;
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xx) </B>terminate the employment of more than 5 Parent Employees during any ninety-day period at any Employment Site of
the Accelrys Corporations; or </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(xxi) </B>agree or commit to take any of the actions described in
clauses&nbsp;&#147;(i)&#148; through &#147;(xx)&#148; of this Section&nbsp;4.3(b). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>During the Pre-Closing Period,
Parent shall promptly notify the Company in writing of any event, condition, fact or circumstance that would reasonably be expected to make the timely satisfaction of any of the conditions set forth in Section&nbsp;7 impossible or unlikely or that
has had or would reasonably be expected to have or result in a Parent Material Adverse Effect. Without limiting the generality of the foregoing, Parent shall promptly advise the Company in writing of any material Legal Proceeding or material claim
threatened, commenced or asserted against or with respect to any of the Accelrys Corporations. No notification given to the Company pursuant to this Section&nbsp;4.3(c) shall limit or otherwise affect any of the representations, warranties,
covenants or obligations of Parent contained in this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.4 No Solicitation</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>During the Pre-Closing Period, Company shall not, directly or indirectly, and the Company shall use commercially reasonable
efforts to ensure that its Subsidiaries and the respective Representatives of the Symyx Corporations do not, directly or indirectly: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(i) </B>solicit, initiate, knowingly encourage or knowingly facilitate the making, submission or announcement of any Company Acquisition Proposal; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>furnish any information regarding any of the Symyx Corporations to any Person in connection with or in response to any Company Acquisition Proposal; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>engage in discussions or negotiations with any Person relating to, or that prior to such discussions or negotiations would
reasonably be expected to give rise to, any Company Acquisition Proposal; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>approve, endorse or recommend any
Company Acquisition Proposal; or </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>enter into any letter of intent or similar document or any Contract
contemplating or otherwise relating to any Company Acquisition Transaction; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><I>provided, however,</I> that prior to the adoption of this
Agreement by the Required Company Stockholder Vote, this Section&nbsp;4.4(a) shall not prohibit the Company from furnishing information regarding the Symyx&nbsp;Corporations to, or entering into discussions and negotiations with, any Person if:
(A)&nbsp;the Company shall have received from such Person a bona fide Company Acquisition Proposal that, after consultation with a financial advisor of nationally recognized reputation and outside legal counsel, the Company Board determines in good
faith is, or would reasonably be expected to result in, a Company Superior Offer (and such proposal has not been withdrawn); (B)&nbsp;such Company Acquisition Proposal did not result from any breach of, or any action inconsistent with, any of the
provisions set forth in this Section&nbsp;4.4(a); (C)&nbsp;the Company Board concludes in good faith, after having consulted with its outside legal counsel, that failure to take such action would reasonably be expected to constitute a breach of the
fiduciary duties of the Company Board to the Company&#146;s stockholders under applicable law; (D)&nbsp;at least four business days prior to furnishing any information to, or entering into discussions or negotiations with, such Person, the Company
gives Parent written notice of the identity of such Person and of the Company&#146;s intention to furnish information to, or enter into discussions with, such Person, and the Company
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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receives from such Person an executed confidentiality agreement containing provisions (including nondisclosure provisions, use restrictions and non-solicitation provisions) at least as favorable
to the Company as the provisions of the Confidentiality Agreement as in effect immediately prior to the execution of this Agreement (provided, however, that no such confidentiality agreement need include &#147;standstill&#148; provisions); and
(E)&nbsp;at least four business days prior to furnishing any information to such Person, the Company furnishes such information to Parent (to the extent such information has not been previously furnished by the Company to Parent or Made Available to
Parent). Without limiting the foregoing, any violation of the restrictions contained in this Section&nbsp;4.4(a) by any Subsidiary or Representative of the Company shall be deemed a breach of this Section&nbsp;4.4(a) by the Company. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b)</B> During the Pre-Closing Period, Parent shall not, directly or indirectly, and Parent shall use commercially reasonable efforts to
ensure that its Subsidiaries and the respective Representatives of the Accelrys&nbsp;Corporations do not, directly or indirectly: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(i) </B>solicit, initiate, knowingly encourage or knowingly facilitate the making, submission or announcement of any Parent Acquisition Proposal; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>furnish any information regarding any of the Accelrys Corporations to any Person in connection with or in response to any Parent Acquisition Proposal; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) </B>engage in discussions or negotiations with any Person relating to, or that prior to such discussions or negotiations would
reasonably be expected to give rise to, any Parent Acquisition Proposal; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iv) </B>approve, endorse or recommend any
Parent Acquisition Proposal; or </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(v) </B>enter into any letter of intent or similar document or any Contract contemplating
or otherwise relating to any Parent Acquisition Transaction; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><I>provided, however,</I> that prior to the approval of the Parent Proposals (as
defined in Section&nbsp;5.3(a)) by the Required Parent Stockholder Vote, this Section&nbsp;4.4(b) shall not prohibit Parent from furnishing information regarding the Accelrys Corporations to, or entering into discussions and negotiations with, any
Person if: (A)&nbsp;the Parent shall have received from such Person a bona fide Parent Acquisition Proposal that, after consultation with a financial advisor of nationally recognized reputation and outside legal counsel, the Parent Board determines
in good faith is, or would reasonably be expected to result in, a Parent Superior Offer (and such proposal has not been withdrawn); (B)&nbsp;such Parent Acquisition Proposal did not result from any breach of, or any action inconsistent with, any of
the provisions set forth in this Section&nbsp;4.4(b); (C)&nbsp;the Parent Board concludes in good faith, after having consulted with its outside legal counsel, that failure to take such action would reasonably be expected to constitute a breach of
the fiduciary duties of the Parent Board to Parent&#146;s stockholders under applicable law; (D)&nbsp;at least four business days prior to furnishing any information to, or entering into discussions or negotiations with, such Person, Parent gives
the Company written notice of the identity of such Person and of Parent&#146;s intention to furnish information to, or enter into discussions with, such Person, and Parent receives from such Person an executed confidentiality agreement containing
provisions (including nondisclosure provisions, use restrictions and non-solicitation provisions) at least as favorable to Parent as the provisions of the Confidentiality Agreement as in effect immediately prior to the execution of this Agreement
(<I>provided, however</I>, that no such confidentiality agreement need include &#147;standstill&#148; provisions); and (E)&nbsp;at least four business days prior to furnishing any information to such Person, Parent furnishes such information to the
Company (to the extent such information has not been previously furnished by Parent to the Company or Made Available to the Company). Without limiting the foregoing, any violation of the restrictions contained in this Section&nbsp;4.4(b) by any
Subsidiary or Representative of Parent shall be deemed a breach of this Section&nbsp;4.4(b) by Parent. <B> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c)
</B>During the Pre-Closing Period, the Company shall promptly (and in no event later than 24&nbsp;hours) after receipt of any Company Acquisition Proposal: (i)&nbsp;advise Parent orally and in writing of any such Company Acquisition Proposal
(including the identity of the Person making or submitting such Company
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Acquisition Proposal and the terms thereof) that is made or submitted by any Person during the Pre-Closing Period, and (ii)&nbsp;provide to Parent a copy of any written Company Acquisition
Proposal and a copy of all written materials (including copies of any written materials received via e-mail or other electronic medium) received by the Company in connection with such Company Acquisition Proposal. The Company shall keep Parent
reasonably informed with respect to: (A)&nbsp;the status of any such Company Acquisition Proposal, and (B)&nbsp;the status and terms of any material modification or proposed material modification thereto. The Company shall provide Parent with 48
hours prior notice (or such lesser notice as is provided to the members of the Company Board) of any meeting of the Company Board at which the Company Board is reasonably expected to consider any Company Acquisition Proposal. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>During the Pre-Closing Period, Parent shall promptly (and in no event later than 24 hours) after receipt of any Parent
Acquisition Proposal: (i)&nbsp;advise the Company orally and in writing of any such Parent Acquisition Proposal (including the identity of the Person making or submitting such Parent Acquisition Proposal and the terms thereof) that is made or
submitted by any Person during the Pre-Closing Period, and (ii)&nbsp;provide to the Company a copy of any written Parent Acquisition Proposal and a copy of all written materials (including copies of any written materials received via e-mail or other
electronic medium) received by Parent in connection with such Parent Acquisition Proposal. Parent shall keep the Company reasonably informed with respect to: (A)&nbsp;the status of any such Parent Acquisition Proposal, and (B)&nbsp;the status and
terms of any material modification or proposed material modification thereto. Parent shall provide the Company with 48 hours prior notice (or such lesser notice as is provided to the members of the Parent Board) of any meeting of the Parent Board at
which the Parent Board is reasonably expected to consider any Parent Acquisition Proposal. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>The Company shall, and
shall cause its Representatives to, immediately cease and cause to be terminated any discussions existing as of the date of this Agreement with any Person that relate to any Company Acquisition Proposal. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>Parent shall, and shall cause its Representatives to, immediately cease and cause to be terminated any discussions existing as
of the date of this Agreement with any Person that relate to any Parent Acquisition Proposal. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>Each of Parent and
the Company agrees not to release or permit the release of any Person from, or to waive or permit the waiver of any provision of, any confidentiality, non-solicitation, no hire, &#147;standstill&#148; or similar Contract to which any such party or
any of its Subsidiaries is a party or under which any such party or any of its Subsidiaries has any rights, and will use its commercially reasonable efforts to cause each such agreement to be enforced at the request of the other party to this
Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;5. A<SMALL>DDITIONAL</SMALL> C<SMALL>OVENANTS</SMALL> <SMALL>OF</SMALL> <SMALL>THE</SMALL>
P<SMALL>ARTIES</SMALL> </B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.1 Registration Statement; Joint Proxy Statement/Prospectus</B>. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>As promptly as practicable after the date of this Agreement, Parent and the Company shall prepare and cause to be filed with the
SEC the Joint Proxy Statement/Prospectus and Parent shall prepare and cause to be filed with the SEC the Form S-4 Registration Statement, in which the Joint Proxy Statement/Prospectus will be included as a prospectus. Each of Parent and the Company
shall use commercially reasonable efforts: (i)&nbsp;to cause the Form S-4 Registration Statement and the Joint Proxy Statement/Prospectus to comply with the applicable rules and regulations promulgated by the SEC; (ii)&nbsp;to promptly notify the
other of, cooperate with each other with respect to and respond promptly to any comments of the SEC or its staff; (iii)&nbsp;to have the Form S-4 Registration Statement declared effective under the Securities Act as promptly as practicable after it
is filed with the SEC; and (iv)&nbsp;to keep the Form S-4 Registration Statement effective through the Closing in order to permit the consummation of the Merger. Parent shall use commercially reasonable efforts to cause the Joint Proxy
Statement/Prospectus to be mailed to Parent&#146;s stockholders, and the Company shall use commercially reasonable efforts to cause the Joint Proxy Statement/Prospectus to be mailed to the Company&#146;s stockholders, as
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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promptly as practicable after the Form S-4 Registration Statement is declared effective under the Securities Act. Each of Parent and the Company shall promptly furnish the other party all
information concerning such party, its Subsidiaries and stockholders that may be required or reasonably requested in connection with any action contemplated by this Section&nbsp;5.1. If either Parent or the Company becomes aware of any information
that should be disclosed in an amendment or supplement to the Form S-4 Registration Statement or the Joint Proxy Statement/Prospectus, then such party: (i)&nbsp;shall promptly inform the other party thereof; (ii)&nbsp;shall provide the other party
(and its counsel) with a reasonable opportunity to review and comment on any amendment or supplement to the Form S-4 Registration Statement or the Joint Proxy Statement/Prospectus prior to it being filed with the SEC; (iii)&nbsp;shall provide the
other party with a copy of such amendment or supplement promptly after it is filed with the SEC; and (iv)&nbsp;shall cooperate, if appropriate, in mailing such amendment or supplement to the stockholders of the Company or Parent. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Prior to the Effective Time, Parent shall use commercially reasonable efforts to obtain all regulatory approvals needed to
ensure that the Parent Common Stock to be issued in the Merger will (to the extent required) be registered or qualified or exempt from registration or qualification under the securities law of every state of the United States in which any registered
holder of Company Common Stock has an address of record on the record date for determining the stockholders entitled to notice of and to vote at the Company Stockholders&#146; Meeting; <I>provided, however,</I> that Parent shall not be required:
(i)&nbsp;to qualify to do business as a foreign corporation in any jurisdiction in which it is not now qualified; or (ii)&nbsp;to file a general consent to service of process in any jurisdiction. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.2 Company Stockholders&#146; Meeting.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The Company: (i)&nbsp;shall take all action necessary under all applicable Legal Requirements to call, give notice of and hold a meeting of the holders of Company Common Stock to vote on a
proposal to adopt this Agreement (the &#147;<B>Company Stockholders&#146; Meeting</B>&#148;); and (ii)&nbsp;shall submit such proposal to such holders at the Company Stockholders&#146; Meeting and, except as otherwise contemplated by this Agreement,
shall not submit any other proposal to such holders in connection with the Company&#146;s Stockholders&#146; Meeting without the prior written consent of Parent. The Company, in consultation with Parent, shall set a record date for persons entitled
to notice of, and to vote at, the Company&#146;s Stockholders&#146; Meeting and shall not change such record date without the prior written consent of Parent. The Company Stockholders&#146; Meeting shall be held (on a date selected by the Company in
consultation with Parent) as promptly as practicable after the Form S-4 Registration Statement is declared effective under the Securities Act. The Company shall ensure that all proxies solicited in connection with the Company Stockholders&#146;
Meeting are solicited in compliance with all applicable Legal Requirements. Notwithstanding anything to the contrary contained in this Agreement, the Company may after consultation with Parent adjourn or postpone the Company&#146;s
Stockholders&#146; Meeting only: (A)&nbsp;to the extent necessary to ensure that any supplement or amendment to the Joint Proxy Statement/Prospectus that is required by applicable law is timely provided to the Company&#146;s stockholders;
(B)&nbsp;if as of the time for which the Company Stockholders&#146; Meeting is originally scheduled there are insufficient shares of Company Common Stock represented (either in person or by proxy) to constitute a quorum necessary to conduct the
business to be conducted at the Company&#146;s Stockholders&#146; Meeting; or (C)&nbsp;if additional time is reasonably required to solicit proxies in favor of the adoption of this Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Subject to Section&nbsp;5.2(c): (i)&nbsp;the Joint Proxy Statement/Prospectus shall include a statement to the effect that the
Company Board recommends that the Company&#146;s stockholders vote to adopt this Agreement at the Company Stockholders&#146; Meeting (the recommendation of the Company Board that the Company&#146;s stockholders vote to adopt this Agreement being
referred to as the &#147;<B>Company Board Recommendation</B>&#148;); (ii)&nbsp;the Company Board Recommendation shall not, directly or indirectly, be withdrawn or modified in a manner adverse to Parent; (iii)&nbsp;neither the Company Board nor any
committee thereof shall: (A)&nbsp;fail to reaffirm the Company Board Recommendation, or fail to publicly state that the Merger and this Agreement are in the best interest of the Company&#146;s stockholders, within ten business days after Parent
requests in writing that such action be taken; (B)&nbsp;fail to publicly announce, within ten business days after a tender offer or exchange offer relating to
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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the securities of the Company shall have been commenced, a statement disclosing that the Company Board recommends rejection of such tender or exchange offer; (C)&nbsp;fail to issue, within ten
business days after a Company Acquisition Proposal is publicly announced, a press release announcing its opposition to such Company Acquisition Proposal; or (D)&nbsp;recommend, adopt or approve a Company Acquisition Proposal; or (iv)&nbsp;resolve to
take any action described in clauses &#147;(ii)&#148; or &#147;(iii)&#148; of this sentence (each of the foregoing actions described in clauses &#147;(ii),&#148; &#147;(iii)&#148; and &#147;(iv)&#148; being referred to as a &#147;<B>Company Change
in Recommendation</B>&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Notwithstanding anything to the contrary contained in Section&nbsp;5.2(b) or
elsewhere in this Agreement, at any time prior to the adoption of this Agreement by the Required Company Stockholder Vote, the Company Board may effect, or cause the Company to effect, as the case may be, a Company Change in Recommendation:
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>if: (A)&nbsp;the Company has not breached its obligations under Section&nbsp;4.4(a) in connection with the
Company Acquisition Proposal referred to in the following clause &#147;(B);&#148; (B)&nbsp;after the date of this Agreement, an unsolicited Company Acquisition Proposal is made to the Company and is not withdrawn; (C)&nbsp;the Company Board
determines in its good faith judgment, after consulting with a financial advisor of nationally recognized reputation and outside legal counsel, that such Company Acquisition Proposal constitutes a Company Superior Offer; (D)&nbsp;the Company Board
does not effect, or cause the Company to effect, a Company Change in Recommendation at any time within four business days after Parent receives written notice from the Company confirming that the Company Board has determined that such Company
Acquisition Proposal is a Company Superior Offer; (E)&nbsp;during such four business day period, if requested by Parent, the Company engages in good faith negotiations with Parent to amend this Agreement in such a manner that the Company Acquisition
Proposal that was determined to constitute a Company Superior Offer no longer constitutes a Company Superior Offer; (F)&nbsp;at the end of such four business day period, such Company Acquisition Proposal has not been withdrawn and continues to
constitute a Company Superior Offer (taking into account any changes to the terms of this Agreement proposed by Parent as a result of the negotiations required by clause &#147;(E)&#148; or otherwise); and (G)&nbsp;the Company Board determines in
good faith, after having consulted with its outside legal counsel, that, in light of such Company Superior Offer, a failure to make a Company Change in Recommendation would reasonably be expected to constitute a breach of the fiduciary duties of the
Company Board to the Company&#146;s stockholders under applicable law; or </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>if: (A)&nbsp;other than the
development or circumstances contemplated by clause &#147;(i)&#148; of this Section&nbsp;5.2(c), a material development or change in circumstances occurs or arises after the date of this Agreement that was neither known to any Symyx Corporation or
any Representative of any Symyx Corporation nor reasonably foreseeable to any Symyx Corporation as of the date of this Agreement (such material development or change in circumstances being referred to as a &#147;<B>Company Intervening
Event</B>&#148;); <I>provided, however,</I> that (1)&nbsp;in no event shall the receipt, existence of or terms of a Company Acquisition Proposal or a Company Superior Offer or any inquiry relating thereto or the consequences thereof constitute a
Company Intervening Event and (2)&nbsp;in no event shall any event, occurrence, fact, condition, effect, change or development that has an adverse effect on the business, financial condition or results of operations of any Accelrys Corporation,
constitute a Company Intervening Event, unless such event, occurrence, fact, condition, effect, change or development has had or would reasonably be expected to have a Parent Material Adverse Effect; (B)&nbsp;at least four business days prior to any
meeting of the Company Board at which the Company Board will consider whether such Company Intervening Event requires the Company Board to effect, or cause the Company to effect, a Company Change in Recommendation, the Company provides Parent with a
written notice specifying the date and time of such meeting and the reasons for holding such meeting; (C)&nbsp;during such four business day period, if requested by Parent, the Company engages in good faith negotiations with Parent to amend this
Agreement in such a manner that obviates the need for the Company Board to effect, or cause the Company to effect, a Company Change in Recommendation as a result of such Company Intervening Event; and (D)&nbsp;the Company Board determines in good
faith, after having consulted with its outside legal counsel, that, in light of such Company Intervening Event, a failure to make a Company Change in Recommendation would reasonably be expected to constitute a breach of the fiduciary duties of the
Company Board to the Company&#146;s stockholders under applicable law. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Notwithstanding any Company Change in Recommendation, unless earlier terminated
in accordance with Section&nbsp;8.1, this Agreement shall be submitted to the holders of Company&#146;s Common Stock at the Company Stockholders&#146; Meeting for the purpose of voting on the adoption of this Agreement and nothing contained in this
Agreement shall be deemed to relieve the Company of such obligation. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.3 Parent Stockholders&#146; Meeting</B><B>.</B>
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Parent: (i)&nbsp;shall take all action necessary under all applicable Legal Requirements to call, give notice of
and hold a meeting of the holders of Parent Common Stock (the &#147;<B>Parent Stockholders&#146; Meeting</B>&#148;) to vote on proposals to approve (A)&nbsp;the issuance of shares of Parent Common Stock in the Merger; and (B)&nbsp;an amendment to
Parent&#146;s certificate of incorporation to increase the number of shares of Parent Common Stock authorized for issuance under the Parent&#146;s certificate of incorporation from 60,000,000 shares to 100,000,000 shares (the &#147;<B>Parent&#146;s
Amendment Certificate</B>&#148; and together with the proposal set forth in clause &#147;(A)&#148; the <B>&#147;Parent Proposals&#148;)</B>; and (ii)&nbsp;shall submit such Parent Proposals to such holders at the Parent Stockholders&#146; Meeting
and, except as otherwise contemplated by this Agreement, shall not submit any other proposal to such holders in connection with the Parent Stockholders&#146; Meeting without the prior written consent of the Company; <I>provided, however, </I>that
Parent may submit the Other Parent Proposals to its stockholders at the Parent Stockholders&#146; Meeting without the prior written consent of the Company. Parent, in consultation with the Company shall set a record date for persons entitled to
notice of, and to vote at, the Parent Stockholders&#146; Meeting and shall not change such record date without the prior written consent of the Company. The Parent Stockholders&#146; Meeting shall be held on the same date this Agreement would be
submitted to the Company&#146;s stockholders for adoption at the Company Stockholders&#146; Meeting (or, to the extent that Parent and the Company agree, as promptly as practicable thereafter). Parent shall ensure that all proxies solicited in
connection with the Parent Stockholders&#146; Meeting are solicited in compliance with all applicable Legal Requirements. Notwithstanding anything to the contrary contained in this Agreement, Parent may after consultation with the Company adjourn or
postpone the Parent Stockholders&#146; Meeting only: (i)&nbsp;to the extent necessary to ensure that any supplement or amendment to the Joint Proxy Statement/Prospectus that is required by applicable law is timely provided to Parent&#146;s
stockholders; (ii)&nbsp;if as of the time for which the Parent Stockholders&#146; Meeting is originally scheduled there are insufficient shares of Parent Common Stock represented (either in person or by proxy) to constitute a quorum necessary to
conduct the business to be conducted at the Parent Stockholders&#146; Meeting; or (iii)&nbsp;if additional time is reasonably required to solicit proxies in favor of the approval of the Parent Proposals. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Subject to Section&nbsp;5.3(c): (i)&nbsp;the Joint Proxy Statement/Prospectus shall include a statement to the effect that the
Parent Board recommends that Parent&#146;s stockholders vote to approve the Parent Proposals (the recommendation of the Parent Board that Parent&#146;s stockholders vote to approve the Parent Proposals being referred to as the &#147;<B>Parent Board
Recommendation</B>&#148;); (ii)&nbsp;the Parent Board Recommendation shall not, directly or indirectly, be withdrawn or modified in a manner adverse to the Company; (iii)&nbsp;neither the Parent Board nor any committee thereof shall: (A)&nbsp;fail
to reaffirm the Parent Board Recommendation, or fail to publicly state that the Merger and this Agreement are in the best interest of Parent&#146;s stockholders, within ten business days after the Company requests in writing that such action be
taken; (B)&nbsp;fail to publicly announce, within ten business days after a tender offer or exchange offer relating to the securities of Parent shall have been commenced, a statement disclosing that the Parent Board recommends rejection of such
tender or exchange offer; (C)&nbsp;fail to issue, within ten business days after a Parent Acquisition Proposal is publicly announced, a press release announcing its opposition to such Parent Acquisition Proposal; or (D)&nbsp;recommend, adopt or
approve a Parent Acquisition Proposal; or (iv)&nbsp;resolve to take any action described in clauses &#147;(ii)&#148; or &#147;(iii)&#148; of this sentence (each of the foregoing actions described in clauses &#147;(ii),&#148; &#147;(iii)&#148; and
&#147;(iv)&#148; being referred to as a &#147;<B>Parent Change in Recommendation</B>&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Notwithstanding
anything to the contrary contained in Section&nbsp;5.3(b) or elsewhere in this Agreement, at any time prior to the approval of the Parent Proposals by the Required Parent Stockholder Vote, the Parent Board may effect, or cause Parent to effect, as
the case may be, a Parent Change in Recommendation: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>if: (A)&nbsp;Parent has not breached its obligations under
Section&nbsp;4.4(b) in connection with the Parent Acquisition Proposal referred to in the following clause &#147;(B);&#148; (B)&nbsp;after the date of this Agreement, an
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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unsolicited Parent Acquisition Proposal is made to Parent and is not withdrawn; (C)&nbsp;the Parent Board determines in its good faith judgment, after consulting with a financial advisor of
nationally recognized reputation and outside legal counsel, that such Parent Acquisition Proposal constitutes a Parent Superior Offer; (D)&nbsp;the Parent Board does not effect, or cause Parent to effect, a Parent Change in Recommendation at any
time within four business days after the Company receives written notice from Parent confirming that the Parent Board has determined that such Parent Acquisition Proposal is a Parent Superior Offer; (E)&nbsp;during such four business day period, if
requested by the Company, Parent engages in good faith negotiations with the Company to amend this Agreement in such a manner that the Parent Acquisition Proposal that was determined to constitute a Parent Superior Offer no longer constitutes a
Parent Superior Offer; (F)&nbsp;at the end of such four business day period, such Parent Acquisition Proposal has not been withdrawn and continues to constitute a Parent Superior Offer (taking into account any changes to the terms of this Agreement
proposed by the Company as a result of the negotiations required by clause &#147;(E)&#148; or otherwise); and (G)&nbsp;the Parent Board determines in good faith, after having consulted with its outside legal counsel, that, in light of such Parent
Superior Offer, a failure to make a Parent Change in Recommendation would reasonably be expected to constitute a breach of the fiduciary duties of the Parent Board to Parent&#146;s stockholders under applicable law; or </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>if: (A)&nbsp;other than the development or circumstances contemplated by clause &#147;(i)&#148; of this Section&nbsp;5.3(c), a
material development or change in circumstances occurs or arises after the date of this Agreement that was neither known to any Accelrys Corporation or any Representative of any Accelrys Corporation nor reasonably foreseeable to any Accelrys
Corporation as of the date of this Agreement (such material development or change in circumstances being referred to as a &#147; <B>Parent Intervening Event</B>&#148;); <I>provided, however,</I> that (1)&nbsp;in no event shall the receipt, existence
of or terms of a Parent Acquisition Proposal or a Parent Superior Offer or any inquiry relating thereto or the consequences thereof constitute a Parent Intervening Event and (2)&nbsp;in no event shall any event, occurrence, fact, condition, effect,
change or development that has an adverse effect on the business, financial condition or results of operations of any Symyx Corporation, constitute a Parent Intervening Event, unless such event, occurrence, fact, condition, effect, change or
development has had or would reasonably be expected to have a Company Material Adverse Effect; (B)&nbsp;at least four business days prior to any meeting of the Parent Board at which the Parent Board will consider whether such Parent Intervening
Event requires the Parent Board to effect, or cause Parent to effect, a Parent Change in Recommendation, Parent provides the Company with a written notice specifying the date and time of such meeting and the reasons for holding such meeting;
(C)&nbsp;during such four business day period, if requested by the Company, Parent engages in good faith negotiations with the Company to amend this Agreement in such a manner that obviates the need for the Parent Board to effect, or cause Parent to
effect, a Parent Change in Recommendation as a result of such Parent Intervening Event; and (D)&nbsp;the Parent Board determines in good faith, after having consulted with its outside legal counsel, that, in light of such Parent Intervening Event,
the failure to make a Parent Change in Recommendation would reasonably be expected to constitute a breach of the fiduciary duties of the Parent Board to Parent&#146;s stockholders under applicable law. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Notwithstanding any Parent Change in Recommendation, unless earlier terminated in accordance with Section&nbsp;8.1, this
Agreement shall be submitted to the holders of Parent Common Stock at the Parent Stockholders&#146; Meeting for the purpose of voting on the Parent Proposals and nothing contained in this Agreement shall be deemed to relieve Parent of such
obligation. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.4 Stock Options and Company ESPP.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>At the Effective Time, each Company Option that is outstanding and unexercised immediately prior to the Effective Time, whether
or not vested, shall be converted into and become an option to purchase Parent Common Stock, and Parent shall assume such Company Option in accordance with the terms (as in effect as of the date of this Agreement) of the applicable Company Option
Plan and the terms of the Contract by which such Company Option is evidenced. All rights with respect to Company Common Stock under Company Options assumed by Parent shall thereupon be converted into rights with respect to Parent Common Stock.
Accordingly, from and after the Effective Time: (A)&nbsp;each Company Option assumed by Parent may be exercised solely for shares of Parent Common Stock; (B)&nbsp;the number of shares of Parent Common Stock subject to each Company
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Option assumed by Parent shall be determined by multiplying the number of shares of Company Common Stock that were subject to such Company Option immediately prior to the Effective Time by the
Exchange Ratio, and rounding the resulting number down to the nearest whole number of shares of Parent Common Stock; (C)&nbsp;the per share exercise price for the Parent Common Stock issuable upon exercise of each Company Option assumed by Parent
shall be determined by dividing the per share exercise price of Company Common Stock subject to such Company Option, as in effect immediately prior to the Effective Time, by the Exchange Ratio, and rounding the resulting exercise price up to the
nearest whole cent; and (D)&nbsp;any restriction on the exercise of any Company Option assumed by Parent shall continue in full force and effect and the term, exercisability, vesting schedule and other provisions of such Company Option shall
otherwise remain unchanged as a result of the assumption of such Company Option; <I>provided, however,</I> that Parent Board or a committee thereof shall succeed to the authority and responsibility of the Company Board or any committee thereof with
respect to each Company Option assumed by Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Parent shall file with the SEC, no later than 30 days after the
Closing Date, a registration statement on Form S-8, if available for use by Parent, relating to the shares of Parent Common Stock issuable with respect to the Company Options assumed by Parent in accordance with Section 5.4(a). </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>At the Effective Time, Parent may (if Parent determines that it desires to do so) assume any or all of the Company Option Plans.
If Parent elects to assume any Company Option Plan, then, under such Company Option Plan, Parent shall be entitled to grant stock awards, to the extent permissible under applicable Legal Requirements, using the share reserves of such Company Option
Plan as of the Effective Time (including any shares returned to such share reserves as a result of the termination of Company Options that are assumed by Parent pursuant to Section&nbsp;5.4(a)), except that: (i)&nbsp;stock covered by such awards
shall be shares of Parent Common Stock; (ii)&nbsp;all references in such Company Option Plan to a number of shares of Company Common Stock shall be deemed amended to refer instead to a number of shares of Parent Common Stock determined by
multiplying the number of referenced shares of Company Common Stock by the Exchange Ratio, and rounding the resulting number down to the nearest whole number of shares of Parent Common Stock; and (iii)&nbsp;the Parent Board or a committee thereof
shall succeed to the authority and responsibility of the Company Board or any committee thereof with respect to the administration of such Company Option Plan. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Prior to the Effective Time, the Company shall take all action that may be necessary (under the Company Option Plans and otherwise) to effectuate the provisions of this Section&nbsp;5.4 and to
ensure that, from and after the Effective Time, holders of Company Equity Awards have no rights with respect thereto other than those specifically provided in this Section&nbsp;5.4. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>Prior to the Designated Date, the Company shall take all action that may be necessary to: (i)&nbsp;cause any outstanding
offering period (or similar period during which Company Common Stock may be purchased) under the Company ESPP to be terminated as of the last business day prior to the Closing Date (the last business day prior to the Closing Date being referred to
as the &#147;<B>Designated Date</B>&#148;); (ii)&nbsp;make any pro-rata adjustments that may be necessary to reflect the shortened offering period (or similar period), but otherwise treat such shortened offering period (or similar period) as a fully
effective and completed offering period for all purposes under the Company ESPP; (iii)&nbsp;cause the exercise as of the Designated Date of each outstanding purchase right under the Company ESPP; and (iv)&nbsp;provide that no further offering period
(or similar period) or purchase period shall commence under the Company ESPP after the date of this Agreement;<I> provided, however</I>, that the actions described in clauses &#147;(i)&#148; through &#147;(iv)&#148; of this sentence shall be
conditioned upon the consummation of the Merger. On the Designated Date, the Company shall apply the funds credited as of such date under the Company ESPP within each participant&#146;s payroll withholding account to the purchase of whole shares of
Company Common Stock in accordance with the terms of the Company ESPP. Immediately prior to and effective as of the Designated Date (and subject to the consummation of the Merger), the Company shall terminate the Company ESPP. </FONT></P> <P
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.5 Employee Benefits</B><B>.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Parent agrees that, subject to any necessary transition period and subject to any applicable plan provisions, contractual
requirements or Legal Requirements: (i)&nbsp;all employees of the Symyx Corporations who continue employment with Parent, the Surviving Corporation or any Subsidiary of the Surviving Corporation after the Effective Time (&#147;<B>Continuing
Employees</B>&#148;) shall be eligible to participate in Parent&#146;s health, vacation and 401(k) plans, to substantially the same extent as similarly situated employees of Parent; and (ii)&nbsp;for purposes of determining a Continuing
Employee&#146;s eligibility to participate in such plans (but not for purposes of benefit accrual), such Continuing Employee shall receive credit under such plans for his or her years of continuous service with the Symyx Corporations prior to the
Effective Time. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Nothing in this Section&nbsp;5.5 or elsewhere in this Agreement shall be construed to create a
right in any Company Associate to employment with Parent, the Surviving Corporation or any other Subsidiary of Parent. No provision in this Agreement shall modify or amend any other agreement, plan, program of document (including any Company
Employee Plan or Company Option Plan) unless this Agreement explicitly states that agreement, plan, program of document (including any Company Employee Plan or Company Option Plan) shall be so modified or amended. Except for Company Indemnified
Persons (as defined in Section&nbsp;5.6(a)) to the extent of their respective rights pursuant to Section&nbsp;5.6, no Company Associate, and no Continuing Employee, shall be deemed to be a third party beneficiary of this Agreement. No Parent
Associate shall be deemed to be a third party beneficiary of this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>If requested in writing by Parent at
least five days prior to the Closing, the Company shall take (or cause to be taken) all actions necessary or appropriate to terminate, effective no later than the Designated Date, any Company Employee Plan that contains a cash or deferred
arrangement intended to qualify under Section&nbsp;401(k) of the Code (a &#147;<B>Company 401(k) Plan</B>&#148;). If the Company is required to terminate any Company 401(k) Plan, then the Company shall provide to Parent prior to the Closing Date
written evidence of the adoption by the Company Board of resolutions authorizing the termination of such Company 401(k) Plan (the form and substance of which resolutions shall be subject to the prior review and approval of Parent). The Company also
shall take, prior to the Effective Time, such other actions in furtherance of terminating such Company 401(k) Plan as Parent may reasonably request. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>With respect to each &#147;employee benefit plan&#148; as defined in Section&nbsp;3(3) of ERISA and each vacation and severance plan (that is not an &#147;employee benefit plan&#148; as defined
in Section&nbsp;3(3) of ERISA) maintained by Parent or any Subsidiary of Parent (collectively, the &#147;<B>Parent Benefit Plans</B>&#148;) in which any Continuing Employee will participate after the Effective Time, Parent shall use commercially
reasonable efforts to, or shall cause the Surviving Corporation to use commercially reasonable efforts to, recognize all service of the Continuing Employees with the Company or a Subsidiary, as the case may be, for purposes of eligibility, vesting
and participation (but not for benefit accrual purposes), in any such Parent Benefit Plan. In addition, Parent shall use commercially reasonable efforts to, or shall cause the Surviving Corporation to use commercially reasonable efforts to:
(i)&nbsp;waive all limitations as to preexisting conditions, exclusions and waiting periods with respect to participation and coverage requirements applicable to the Continuing Employees under any Parent Benefit Plan that is a welfare benefit plan
in which such Continuing Employees may be eligible to participate after the Effective Time, other than preexisting condition limitations, exclusions or waiting periods that are already in effect with respect to such Continuing Employees and that
have not been satisfied or waived as of the Effective Time under any welfare benefit plan maintained for the Continuing Employees immediately prior to the Effective Time; and (ii)&nbsp;provide each Continuing Employee with credit for any co-payments
and deductibles paid prior to the Effective Time in satisfying any applicable deductible or out-of-pocket requirements under any Parent Benefit Plan that is a welfare plans in which such Continuing Employees may be eligible to participate after the
Effective Time. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>To the extent any employee notification or consultation requirements are imposed by applicable
Legal Requirements with respect to any of the Contemplated Transactions, the Company shall
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cooperate with Parent to ensure that such requirements are complied with prior to the Effective Time. Prior to the Effective Time, the Company shall not, and shall ensure that its Subsidiaries
and the respective Representatives of the Symyx Corporations do not, communicate with any employees of the Symyx Corporations regarding post-Closing employment matters, including post-Closing employee benefits and compensation, without the prior
written approval of Parent, which approval shall not be unreasonably withheld. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.6 Indemnification of Officers and
Directors</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) Company Indemnified Person</B><B>.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>All rights to indemnification by the Company existing in favor of those Persons who are directors and officers of the Company as
of the date of this Agreement (the &#147;<B>Company Indemnified Persons</B>&#148;) for their acts and omissions as directors and officers of the Company occurring prior to the Effective Time, as provided in the Company&#146;s certificate of
incorporation or bylaws (as in effect as of the date of this Agreement) and as provided in any indemnification agreements between the Company and said Company Indemnified Persons (as in effect as of the date of this Agreement) identified in Part
2.10(a)(iv) of the Company Disclosure Schedule, shall survive the Merger and be observed by the Surviving Corporation to the fullest extent permitted by Delaware law for a period of six years from the date on which the Merger becomes effective.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) </B>From the Effective Time until the sixth anniversary of the date on which the Merger becomes effective, the
Surviving Corporation shall maintain in effect, for the benefit of the Company Indemnified Persons with respect to their acts and omissions as directors and officers of the Company occurring prior to the Effective Time, the existing policy of
directors&#146; and officers&#146; liability insurance maintained by the Company as of the date of this Agreement in the form delivered or Made Available by the Company to Parent prior to the date of this Agreement (the &#147;<B>Company Existing
D&amp;O Policy</B>&#148;), to the extent that directors&#146; and officers&#146; liability insurance coverage is commercially available; <I>provided, however,</I> that: (i)&nbsp;the Surviving Corporation may substitute for the Company Existing
D&amp;O Policy a policy or policies of comparable coverage; and (ii)&nbsp;the Surviving Corporation shall not be required to pay annual premiums for the Company Existing D&amp;O Policy (or for any substitute policies) in excess of $848,000 (the
&#147;<B>Company Maximum Premium</B>&#148;). In the event any future annual premiums for the Company Existing D&amp;O Policy (or any substitute policies) exceed the Company Maximum Premium, the Surviving Corporation shall be entitled to reduce the
amount of coverage of the Company Existing D&amp;O Policy (or any substitute policies) to the amount of coverage that can be obtained for a premium equal to the Company Maximum Premium. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>This Section&nbsp;5.6 is intended to be for the benefit of, and shall be enforceable by, the Company Indemnified Persons, their
heirs and personal representatives and shall be binding on the Parent, the Surviving Corporation and their successors and assigns, and may not be amended, altered or repealed after the Effective Time without the prior written consent of the affected
Company Indemnified Person (provided that such amendment, alteration or repeal prior to the Effective Time shall be governed by Section&nbsp;9.1). In the event that the Parent or the Surviving Corporation or any of their successors or assigns:
(i)&nbsp;consolidates with or merges into any other Person and shall not be the continuing or surviving corporation or entity in such consolidation or merger; or (ii)&nbsp;transfers all or substantially all of its properties and assets to any
person, then, and in each case, proper provision shall be made so that the successors and assigns of the Surviving Corporation or the Parent (as the case may be) honor the indemnification obligations set forth in this Section&nbsp;5.6. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.7 Regulatory Approvals and Related Matters</B><B>.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Each party shall use reasonable best efforts to file, as soon as practicable after the date of this Agreement, all notices,
reports and other documents required to be filed by such party with any Governmental Body with respect to the Merger and the other Contemplated Transactions, and to submit promptly any additional information requested by any such Governmental Body.
Without limiting the generality of the foregoing, the Company and Parent shall, promptly (and in any event within 10 days) after the date of this Agreement, prepare
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and file the notifications required under any Legal Requirement that is designed to prohibit, restrict or regulate actions having the purpose or effect of monopolization or restraint of trade
(collectively, &#147;<B>Antitrust Laws</B>&#148;) in connection with the Merger. The Company and Parent each shall promptly (i)&nbsp;supply the other party with any information which may be required in order to effectuate notices, reports, documents
or other filings with any Governmental Body required to be made pursuant to any Antitrust Laws (including the HSR Act) (the &#147;<B>Antitrust Filings</B>&#148;); and (ii)&nbsp;supply any additional information which reasonably may be required by
any Governmental Body in connection with Antitrust Filings or which the parties may reasonably deem appropriate. Each of the Company and Parent will notify the other party promptly upon the receipt of (A)&nbsp;any comments from any Governmental
Bodies in connection with any Antitrust Filings made pursuant hereto; and (B)&nbsp;any request by any Governmental Bodies for amendments or supplements to any Antitrust Filings made pursuant to, or information provided to comply in all material
respects with, any Legal Requirements, including the requirements of the HSR Act. Whenever any event occurs that is required to be set forth in an amendment or supplement to any Antitrust Filings, the Company or Parent, as the case may be, will
promptly inform the other party of such occurrence and cooperate in filing with the applicable Governmental Body such amendment or supplement. Each of the Company and Parent shall give the other party prompt notice of the commencement or known
threat of commencement of any Legal Proceeding by or before any Governmental Body with respect to the Merger or any of the other Contemplated Transactions, keep the other party reasonably informed as to the status of any such Legal Proceeding or
threat, and in connection with any such Legal Proceeding, each of the Company or Parent will permit authorized representatives of the other party to be present at each meeting or conference relating to any such Legal Proceeding and to have access to
and be consulted in connection with any document, opinion or proposal made or submitted to any Governmental Body in connection with any such Proceeding. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Subject to Section&nbsp;5.7(c), Parent and the Company shall each use its reasonable best efforts to take, or cause to be taken, all actions, and to do, or cause to be done, and to assist and
cooperate with the other in doing, all things necessary, proper or advisable to consummate the Merger and make effective the other Contemplated Transactions. Without limiting the generality of the foregoing, but subject to Section&nbsp;5.7(c), each
party to this Agreement: (i)&nbsp;shall make all filings (if any) and give all notices (if any) required to be made and given by such party in connection with the Merger and the other Contemplated Transactions; (ii)&nbsp;shall use best reasonable
efforts to obtain each Consent (if any) required to be obtained (pursuant to any applicable Legal Requirement or Contract, or otherwise) by such party in connection with the Merger or any of the other Contemplated Transactions; and (iii)&nbsp;shall
use reasonable best efforts to lift any restraint, injunction or other legal bar to the Merger. The Company and Parent shall each furnish to the other party such necessary information and reasonable assistance as such other party may reasonably
request in connection with the foregoing. In addition, each of the parties hereto shall consult with the other with respect to, provide any necessary information with respect to and provide the other (or its counsel) copies of, all filings made by
such party with any third party (including any Governmental Body) or any other information supplied by such party to a third party in connection with this Agreement and the other Contemplated Transactions. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>Notwithstanding anything to the contrary contained in this Section&nbsp;5.7, neither Parent, Merger Sub or the Company shall
have any obligation under this Agreement to divest or agree to divest (or cause any of its Subsidiaries to divest or agree to divest) any of its respective material businesses, material product lines or material assets, or to take or agree to take
(or cause any of its Subsidiaries to take or agree to take) any other material action or agree (or cause any of its Subsidiaries to agree) to any material limitation or material restriction on any of its respective material businesses, material
product lines or material assets. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.8 Disclosure</B><B>.</B> Parent and the Company shall consult with each other before
issuing any press release or otherwise making any public statement, and the Company shall consult with Parent and consider the views and comments of Parent before any of the Symyx Corporations or any of their Representatives sends any emails or
other documents to the Company Associates generally or otherwise communicate with the Company Associates generally, with respect to the Merger or any of the other Contemplated Transactions. Notwithstanding the foregoing: (i)&nbsp;each party may,
without such consultation or consent, make any public statement in response to questions from the press, analysts, investors or those attending industry conferences and make internal
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announcements to employees, so long as such statements are consistent with previous press releases, public disclosures or public statements made jointly by the parties (or individually, if
approved by the other party), (ii)&nbsp;a party may, without the prior consent of the other party hereto, issue any such press release or make any such public announcement or statement as may be required by Legal Requirement or the rules and
regulations of the NASDAQ Global Market if it first notifies and consults with the other party hereto prior to issuing any such press release or making any such public announcement or statement; (iii)&nbsp;the Company need not consult with Parent in
connection with any press release, public statement or filing to be issued or made with respect to any Company Acquisition Proposal, Company Superior Offer or Company Change in Recommendation; and (iv)&nbsp;Parent need not consult with the Company
in connection with any press release, public statement or filing to be issued or made with respect to any Parent Acquisition Proposal, Parent Superior Offer or Parent Change in Recommendation. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.9 Tax Matters</B><B>.</B> Prior to the filing of the Form S-4 Registration Statement, the Company and Parent shall execute and deliver
to Cooley Godward Kronish LLP and to Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP tax representation letters in customary form. To the extent requested by Parent or the Company, each of Parent, Merger Sub and the Company shall confirm to Cooley
Godward Kronish LLP and to Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP the accuracy and completeness as of the Effective Time of the tax representation letters delivered pursuant to the immediately preceding sentence. Following the delivery of
the tax representation letters pursuant to the first sentence of this Section&nbsp;5.9: (a)&nbsp;Parent shall use commercially reasonable efforts to cause Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP to deliver to it a tax opinion satisfying the
requirements of Item&nbsp;601 of Regulation S-K under the Securities Act; and (b)&nbsp;the Company shall use commercially reasonable efforts to cause Cooley Godward Kronish LLP to deliver to it a tax opinion satisfying the requirements of
Item&nbsp;601 of Regulation S-K under the Securities Act. In rendering such opinions, each of such counsel shall be entitled to rely on the tax representation letters referred to in this Section&nbsp;5.9. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.10 Listing</B><B>.</B> Parent shall use reasonable best efforts to cause the shares of Parent Common Stock to be issued in the Merger,
including the Parent Common Stock to be issued upon the exercise of assumed and converted Company Options, to be approved for listing (subject to notice of issuance) on the NASDAQ Global Market at or prior to the Effective Time. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.11 Resignation of Officers and Directors</B><B>.</B> The Company shall use its commercially reasonable efforts to obtain and deliver to
Parent at or prior to the Effective Time the resignation of each officer and director of each of the Symyx Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>5.12 Board of Directors of the Combined Company; Management of the Combined Company.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The parties
shall take all actions necessary to ensure that effective immediately following the Effective Time, the Parent Board shall consist of the following members, each to be in the class identified below and to hold office from and after the Effective
Time until the earliest of appointment of his or her respective successor, resignation or proper removal: (a)&nbsp;Class I directors shall consist of Jeffrey Rodeck, Larry Ferguson and Steven Goldby; (b)&nbsp;Class II directors shall consist of Max
Carnecchia, Christopher Steffen and Timothy Harkness; and (c)&nbsp;Class III shall consist of Ken Coleman, Ricardo Levy, Chris van Ingen and Bruce Pasternack. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The parties shall take all actions necessary to ensure that effective immediately following the Effective Time, Max Carnecchia shall be the Chief Executive Officer of Parent and Michael Piraino
shall be the Senior Vice President and Chief Financial Officer of Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.13 Section&nbsp;16 Matters. </B>Subject to the
following sentence, prior to the Effective Time, Parent and the Company shall take all such steps as may be required (to the extent permitted under applicable Legal Requirements and no-action letters issued by the SEC) to cause any dispositions of
Company Common Stock
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(including derivative securities with respect to Company Common Stock) resulting from the Contemplated Transactions by each individual who is subject to the reporting requirements of
Section&nbsp;16(a) of the Exchange Act with respect to the Company, and the acquisition of Parent Common Stock (including derivative securities with respect to Parent Common Stock) by each individual who is or will be subject to the reporting
requirements of Section&nbsp;16(a) of the Exchange Act with respect to Parent, to be exempt under Rule 16b-3 under the Exchange Act. At least 30 days prior to the Closing Date, the Company shall furnish the following information to Parent for each
individual who, immediately after the Effective Time, will become subject to the reporting requirements of Section&nbsp;16(a) of the Exchange Act with respect to Parent: (a)&nbsp;the number of shares of Company Common Stock held by such individual
and expected to be exchanged for shares of Parent Common Stock pursuant to the Merger; (b)&nbsp;the number of Company Options and Company RSUs held by such individual and expected to be converted into options and/or restricted stock units to
purchase or rights to be issued shares of Parent Common Stock in connection with the Merger; and (c)&nbsp;the number of other derivative securities (if any) with respect to Company Common Stock held by such individual and expected to be converted
into shares of Parent Common Stock or derivative securities with respect to Parent Common Stock in connection with the Merger. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>5.14 Affiliates</B><B>.</B> The Company shall deliver to Parent a letter identifying all known &#147;affiliates&#148; of the Company pursuant to Rule 145 of the Securities Act, and thereafter the Company shall use its commercially
reasonable efforts to obtain a written agreement, in form and substance reasonably satisfactory to Parent, from each Person who may be so deemed as soon as practicable, and in any event within 30 days prior to the Closing. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.15 Obligations of Merger Sub</B><B>.</B> Parent shall take all action necessary to cause Merger Sub and, after the Effective Time, the
Surviving Corporation to perform their respective obligations under this Agreement and to consummate the Contemplated Transactions upon the terms and subject to the conditions set forth in this Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;6. C<SMALL>ONDITIONS</SMALL> P<SMALL>RECEDENT</SMALL> <SMALL>TO</SMALL> O<SMALL>BLIGATIONS</SMALL> <SMALL>OF</SMALL>
P<SMALL>ARENT</SMALL> <SMALL>AND</SMALL> M<SMALL>ERGER</SMALL> S<SMALL>UB</SMALL> </B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The obligations of Parent and Merger
Sub to cause the Merger to be effected and otherwise cause the Contemplated Transactions to be consummated are subject to the satisfaction, at or prior to the Closing, of each of the following conditions: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.1 Accuracy of Representations</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Each of the Company Designated Representations shall have been accurate in all material respects as of the date of this Agreement and shall be accurate in all material respects as of the
Closing Date as if made on and as of the Closing Date (except for any such representations and warranties made as of a specific date, which shall have been accurate in all material respects as of such date); <I>provided, however, </I>that, for
purposes of determining the accuracy of such representations and warranties as of the foregoing dates: (i)&nbsp;all materiality qualifications limiting the scope of such representations and warranties shall be disregarded; and (ii)&nbsp;any update
of or modification to the Company Disclosure Schedule made or purported to have been made on or after the date of this Agreement shall be disregarded. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Each of the representations and warranties of the Company (other than the Company Designated Representations) shall have been accurate in all respects as of the date of this Agreement and shall
be accurate in all respects as of the Closing Date as if made on and as of the Closing Date (except for any such representations and warranties made as of a specific date, which shall have been accurate in all respects as of such date); <I>provided,
however, </I>that: (i)&nbsp;for purposes of determining the accuracy of such representations and warranties as of the foregoing dates: (A)&nbsp;all materiality qualifications limiting the scope of such representations and warranties shall be
disregarded; and (B)&nbsp;any update of or modification to the Company Disclosure Schedule made or purported to have been made on or after the date of this Agreement shall be disregarded; and (ii)&nbsp;any inaccuracies in such representations and
warranties will be disregarded if the circumstances giving rise to all such inaccuracies (considered collectively) do not constitute, and would not reasonably be expected to have or result in, a Company Material Adverse Effect. </FONT></P> <P
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.2 Performance of Covenants</B><B>.</B> The covenants and obligations in this Agreement
that the Company is required to comply with or to perform at or prior to the Closing shall have been complied with and performed in all material respects. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.3 Effectiveness of Registration Statement</B><B>.</B> The Form S-4 Registration Statement shall have become effective in accordance with the provisions of the Securities Act; no stop order shall have
been issued by the SEC and shall remain in effect with respect to the Form S-4 Registration Statement; and no proceeding seeking such a stop order shall have been initiated by the SEC and remain pending or shall be threatened by the SEC. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.4 Stockholder Approval</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>This Agreement shall have been duly adopted by the Required Company Stockholder Vote; and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The Parent Proposals shall have been duly approved by the Required Parent Stockholder Vote. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.5 Documents</B>. Parent and Merger Sub shall have received the following agreements and documents, each of which shall be in full force and effect: </FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>a legal opinion of Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP, dated as of the Closing Date and addressed to Parent, to the
effect that the Merger will constitute a reorganization within the meaning of Section&nbsp;368 of the Code (it being understood that: (i)&nbsp;in rendering such opinion, Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP may rely upon the tax
representation letters referred to in Section&nbsp;5.9; and (ii)&nbsp;if Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP does not render such opinion or withdraws or modifies such opinion, this condition shall nonetheless be deemed to be satisfied if
Cooley Godward Kronish LLP renders such opinion to Parent); and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>a certificate executed by the Chief Executive
Officer and Chief Financial Officer of the Company confirming that the conditions set forth in 6.1, 6.2, 6.4(a), 6.6, 6.10 and 6.11 have been duly satisfied. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.6 No Company Material Adverse Effect</B><B>.</B> Since the date of this Agreement, there shall not have occurred any Company Material Adverse Effect which has not been cured, and no event shall have
occurred or circumstance shall exist that, in combination with any other events or circumstances, would reasonably be expected to result in a Company Material Adverse Effect. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.7 Governmental Approvals</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Any waiting period applicable to the consummation of the Merger under any applicable Antitrust Law (including the HSR Act) shall have expired or been terminated. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Any Governmental Authorization or other Consent required to be obtained with respect to the Merger under any applicable
Antitrust Law or other Legal Requirement shall have been obtained and shall remain in full force and effect (other than any such Governmental Authorization or Consent under other Legal Requirements, the failure to obtain which would not reasonably
be expected to result in a Company Material Adverse Effect or a Parent Material Adverse Effect). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.8 Listing</B><B>.</B>
The shares of Parent Common Stock to be issued in the Merger, including the Parent Common Stock to be issued upon the exercise of assumed and converted Company Options, shall have been approved for listing (subject to notice of issuance) on the
NASDAQ Global Market. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.9 No Restraints</B><B>.</B> No temporary restraining order, preliminary or permanent injunction or
other Order preventing the consummation of the Merger shall have been issued by any court of competent jurisdiction or other Governmental Body and remain in effect, and there shall not be any Legal Requirement enacted or deemed applicable to the
Merger that makes consummation of the Merger illegal. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.10 No Governmental Litigation</B><B>.</B> There shall not be pending or overtly
threatened any Legal Proceeding in which a Governmental Body is or is threatened to become a party: (a)&nbsp;challenging or seeking to restrain, prohibit, rescind or unwind the consummation of the Merger or any of the other Contemplated
Transactions; (b)&nbsp;seeking to prohibit or limit in any material respect Parent&#146;s ability to vote, transfer, receive dividends with respect to or otherwise exercise ownership rights with respect to the stock of the Surviving Corporation;
(c)&nbsp;relating to the Merger or the other Contemplated Transaction and that would reasonably be expected to materially and adversely affect the right or ability of Parent to own any of the material assets or materially limit the operation of the
business of any of the Symyx Corporations; (d)&nbsp;seeking to compel any of the Symyx Corporations, Parent or any Subsidiary of Parent to dispose of or hold separate any material assets or material business as a result of the Merger or any of the
other Contemplated Transactions; or (e)&nbsp;relating to the Merger or the other Contemplated Transactions and seeking to impose (or that would reasonably be expected to result in the imposition of) any criminal sanctions or criminal liability on
Parent or any of the Symyx Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.11 Current SEC Reports.</B> The Company shall have filed all statements,
reports, schedules, forms, exhibits, and other documents required to be filed pursuant to Section&nbsp;13(a) of the Exchange Act with the SEC since the date of this Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.12 FIRPTA Matters.</B> The Company shall have delivered to Parent a statement described in Section&nbsp;1.1445-2(c)(3)(i) of the United
States Treasure Regulations certifying the interests in the Company are not U.S. real property interests. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;7.
C<SMALL>ONDITIONS</SMALL> P<SMALL>RECEDENT</SMALL> <SMALL>TO</SMALL> O<SMALL>BLIGATION</SMALL> <SMALL>OF</SMALL> <SMALL>THE</SMALL> C<SMALL>OMPANY</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">The obligation of the Company to effect the Merger and otherwise consummate the Contemplated Transactions is subject to the satisfaction, at or prior to the Closing, of the following conditions:
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.1 Accuracy of Representations</B><B>.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Each of the Parent Designated Representations shall have been accurate in all material respects as of the date of this Agreement
and shall be accurate in all material respects as of the Closing Date as if made on and as of the Closing Date (except for any such representations and warranties made as of a specific date, which shall have been accurate in all material respects as
of such date); <I>provided, however, </I>that, for purposes of determining the accuracy of such representations and warranties as of the foregoing dates: (i)&nbsp;all materiality qualifications limiting the scope of such representations and
warranties shall be disregarded; and (ii)&nbsp;any update of or modification to the Parent Disclosure Schedule made or purported to have been made on or after the date of this Agreement shall be disregarded. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Each of the representations and warranties of Parent and Merger Sub (other than the Parent Designated Representations) shall
have been accurate in all respects as of the date of this Agreement and shall be accurate in all respects as of the Closing Date as if made on and as of the Closing Date (except for any such representations and warranties made as of a specific date,
which shall have been accurate in all respects as of such date); <I>provided, however, </I>that: (i)&nbsp;for purposes of determining the accuracy of such representations and warranties as of the foregoing dates: (A)&nbsp;all materiality
qualifications limiting the scope of such representations and warranties shall be disregarded; and (B)&nbsp;any update of or modification to the Parent Disclosure Schedule made or purported to have been made on or after the date of this Agreement
shall be disregarded; and (ii)&nbsp;any inaccuracies in such representations and warranties will be disregarded if the circumstances giving rise to all such inaccuracies (considered collectively) do not constitute, and would not reasonably be
expected to have or result in, a Parent Material Adverse Effect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.2 Performance of Covenants</B><B>.</B> The covenants
and obligations in this Agreement that Parent and Merger Sub are required to comply with or to perform at or prior to the Closing shall have been complied with and performed in all material respects. </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.3 Effectiveness of Registration Statement</B><B>.</B> The Form S-4 Registration
Statement shall have become effective in accordance with the provisions of the Securities Act; no stop order shall have been issued by the SEC and shall remain in effect with respect to the Form S-4 Registration Statement; and no proceeding seeking
such a stop order shall have been initiated by the SEC and remain pending or shall be threatened by the SEC. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.4
Stockholder Approval</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>This Agreement shall have been duly adopted by the Required Company Stockholder
Vote; and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The Parent Proposals shall have been duly approved by the Required Parent Stockholder Vote. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.5 Documents</B><B>.</B> The Company shall have received the following documents: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>a legal opinion of Cooley Godward Kronish LLP, dated as of the Closing Date and addressed to the Company, to the effect that the
Merger will constitute a reorganization within the meaning of Section&nbsp;368 of the Code (it being understood that: (i)&nbsp;in rendering such opinion, Cooley Godward Kronish LLP may rely upon the tax representation letters referred to in
Section&nbsp;5.9; and (ii)&nbsp;if Cooley Godward Kronish LLP does not render such opinion or withdraws or modifies such opinion, this condition shall nonetheless be deemed to be satisfied if Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP renders
such opinion to the Company); and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>a certificate executed by an executive officer of Parent confirming that the
conditions set forth in Sections 7.1, 7.2, 7.4(b), 7.6, 7.10 and 7.11 have been duly satisfied. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.6 No Parent Material
Adverse Effect</B><B>.</B> Since the date of this Agreement, there shall not have occurred any Parent Material Adverse Effect which has not been cured, and no event shall have occurred or circumstance shall exist that, in combination with any other
events or circumstances, would reasonably be expected to result in a Parent Material Adverse Effect. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.7 Governmental
Approvals</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Any waiting period applicable to the consummation of the Merger under any applicable
Antitrust Law (including the HSR Act) shall have expired or been terminated. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Any Governmental Authorization or
other Consent required to be obtained with respect to the Merger under any applicable Antitrust Law or other Legal Requirement shall have been obtained and shall remain in full force and effect (other than any such Governmental Authorization or
Consent under other Legal Requirements, the failure to obtain which would not reasonably be expected to result in a Company Material Adverse Effect or a Parent Material Adverse Effect). </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.8 Listing</B><B>.</B> The shares of Parent Common Stock to be issued in the Merger, including the Parent Common Stock to be issued upon
the exercise of assumed and converted Company Options, shall have been approved for listing (subject to notice of issuance) on the NASDAQ Global Market. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>7.9 No Restraints</B><B>.</B> No temporary restraining order, preliminary or permanent injunction or other Order preventing the consummation of the Merger shall have been issued by any court of
competent jurisdiction or other Governmental Body and remain in effect, and there shall not be any Legal Requirement enacted or deemed applicable to the Merger that makes consummation of the Merger illegal. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.10 No Governmental Litigation</B><B>.</B> There shall not be pending or overtly threatened any Legal Proceeding in which a Governmental
Body is or is threatened to become a party: (a)&nbsp;challenging or seeking to restrain, prohibit, rescind or unwind the consummation of the Merger or any of the other Contemplated
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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Transactions; (b)&nbsp;seeking to prohibit or limit in any material respect Parent&#146;s ability to vote, transfer, receive dividends with respect to or otherwise exercise ownership rights with
respect to the stock of the Surviving Corporation; (c)&nbsp;that would reasonably be expected to materially and adversely affect the right or ability of Parent or any of the Symyx Corporations to own any of the material assets or materially limit
the operation of the business of any of the Symyx Corporations; (d)&nbsp;seeking to compel any of the Symyx Corporations, Parent or any Subsidiary of Parent to dispose of or hold separate any material assets or material business as a result of the
Merger or any of the other Contemplated Transactions; or (e)&nbsp;relating to the Merger or the other Contemplated Transactions and seeking to impose (or that would reasonably be expected to result in the imposition of) any criminal sanctions or
criminal liability on Parent or any of the Symyx Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.11 Current SEC Reports.</B> Parent shall have filed all
statements, reports, schedules, forms and other documents required to be filed pursuant to Section&nbsp;13(a) of the Exchange Act with the SEC since the date of this Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;8. T<SMALL>ERMINATION</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>8.1 Termination</B><B>.</B> This Agreement may be terminated prior to the Effective Time (whether before or after adoption of this Agreement by the Company&#146;s stockholders and whether before or
after approval of the issuance of shares of Parent Common Stock in the Merger by Parent&#146;s stockholders): </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>by
mutual written consent of Parent and the Company; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>by either Parent or the Company if the Merger shall not have
been consummated by December&nbsp;31, 2010 (the &#147;<B>End Date</B>&#148;); <I>provided, however,</I> that a party shall not be permitted to terminate this Agreement pursuant to this Section&nbsp;8.1(b) if the failure to consummate the Merger by
the End Date is attributable to a failure on the part of such party to perform any covenant or obligation in this Agreement required to be performed by such party at or prior to the Effective Time; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>by either Parent or the Company if a court of competent jurisdiction or other Governmental Body shall have issued a final and
nonappealable Order, or shall have taken any other action, having the effect of permanently restraining, enjoining or otherwise prohibiting the Merger; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>by either Parent or the Company if: (i)&nbsp;the Company Stockholders&#146; Meeting (including any adjournments and postponements thereof) shall have been held and completed and the
Company&#146;s stockholders shall have taken a final vote on a proposal to adopt this Agreement; and (ii)&nbsp;this Agreement shall not have been adopted at the Company Stockholders&#146; Meeting (and shall not have been adopted at any adjournment
or postponement thereof) by the Required Company Stockholder Vote; <I>provided, however,</I> that a party shall not be permitted to terminate this Agreement pursuant to this Section&nbsp;8.1(d) if the failure to have this Agreement adopted by the
Required Company Stockholder Vote is attributable to a failure on the part of such party to perform any covenant or obligation in this Agreement required to be performed by such party at or prior to the Effective Time; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>by either Parent or the Company if: (i)&nbsp;the Parent Stockholders&#146; Meeting (including any adjournments and postponements
thereof) shall have been held and completed and Parent&#146;s stockholders shall have taken a final vote on the Parent Proposals; and (ii)&nbsp;any of the Parent Proposals shall not have been approved at the Parent Stockholders&#146; Meeting (and
shall not have been approved at any adjournment or postponement thereof) by the Required Parent Stockholder Vote; <I>provided, however</I>, that a party shall not be permitted to terminate this Agreement pursuant to this Section&nbsp;8.1(e) if the
failure to have the Parent Proposals approved by the Required Parent Stockholder Vote is attributable to a failure on the part of such party to perform any covenant or obligation in this Agreement required to be performed by such party at or prior
to the Effective Time; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) </B>by Parent (at any time prior to the adoption of this Agreement by the Required Company
Stockholder Vote) if a Company Triggering Event shall have occurred; </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) </B>by the Company (at any time prior to the approval of the Parent Proposals by the
Required Parent Stockholder Vote) if a Parent Triggering Event shall have occurred; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) </B>by Parent if: (i)&nbsp;any of
the Company&#146;s representations and warranties contained in this Agreement shall be inaccurate as of the date of this Agreement or shall have become inaccurate as of a date subsequent to the date of this Agreement (as if made on such subsequent
date), in either case, such that the condition set forth in Section&nbsp;6.1(a) or the condition set forth in Section&nbsp;6.1(b) would not be satisfied (it being understood that, for purposes of determining the accuracy of such representations and
warranties as of the date of this Agreement or as of any subsequent date: (A)&nbsp;all materiality qualifications limiting the scope of such representations and warranties shall be disregarded; and (B)&nbsp;any update of or modification to the
Company Disclosure Schedule made or purported to have been made on or after the date of this Agreement shall be disregarded); or (ii)&nbsp;any of the Company&#146;s covenants or obligations contained in this Agreement shall have been breached such
that the condition set forth in Section&nbsp;6.2 would not be satisfied; <I>provided, however</I>, that, for purposes of clauses &#147;(i)&#148; and &#147;(ii)&#148; above, if an inaccuracy in any of the Company&#146;s representations and warranties
(as of the date of this Agreement or as of a date subsequent to the date of this Agreement) or a breach of a covenant or obligation by the Company is curable by the Company within 45 days of the date Parent gives the Company notice of such
inaccuracy or breach and the Company is continuing to exercise its reasonable best efforts to cure such inaccuracy or breach, then Parent may not terminate this Agreement under this Section&nbsp;8.1(h) on account of such inaccuracy or breach unless
such inaccuracy or breach shall remain uncured for a period of 30 days commencing on the date that Parent gives the Company notice of such inaccuracy or breach; or </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:17%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(i) </B>by the Company if: (i)&nbsp;any of Parent&#146;s representations and warranties contained in this Agreement shall be inaccurate as of the date of this Agreement or shall have become inaccurate
as of a date subsequent to the date of this Agreement (as if made on such subsequent date), in either case, such that the condition set forth in Section&nbsp;7.1(a) or the condition set forth in Section&nbsp;7.1(b) would not be satisfied (it being
understood that, for purposes of determining the accuracy of such representations and warranties as of the date of this Agreement or as of any subsequent date: (A)&nbsp;all materiality qualifications limiting the scope of such representations and
warranties shall be disregarded; and (B)&nbsp;any update of or modification to the Parent Disclosure Schedule made or purported to have been made on or after the date of this Agreement shall be disregarded); or (ii)&nbsp;any of Parent&#146;s
covenants or obligations contained in this Agreement shall have been breached such that the condition set forth in Section&nbsp;7.2 would not be satisfied; <I>provided, however</I>, that, for purposes of clauses &#147;(i)&#148; and &#147;(ii)&#148;
above, if an inaccuracy in any of Parent&#146;s representations and warranties (as of the date of this Agreement or as of a date subsequent to the date of this Agreement) or a breach of a covenant or obligation by Parent is curable by Parent by
within 45 days of the date the Company gives Parent notice of such inaccuracy or breach and Parent is continuing to exercise its reasonable best efforts to cure such inaccuracy or breach, then the Company may not terminate this Agreement under this
Section&nbsp;8.1(i) on account of such inaccuracy or breach unless such inaccuracy or breach shall remain uncured for a period of 30 days commencing on the date that the Company gives Parent notice of such inaccuracy or breach. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8.2 Effect of Termination</B><B>.</B> In the event of the termination of this Agreement as provided in Section&nbsp;8.1, this Agreement
shall be of no further force or effect; <I>provided, however,</I> that: (i)&nbsp;this Section&nbsp;8.2, Section&nbsp;8.3 and Section&nbsp;9 shall survive the termination of this Agreement and shall remain in full force and effect; (ii)&nbsp;the
Confidentiality Agreement shall survive the termination of this Agreement and shall remain in full force and effect in accordance with its terms; and (iii)&nbsp;the termination of this Agreement shall not relieve any party from any liability for any
material inaccuracy in or breach of any representation, warranty, covenant, obligation or other provision contained in this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>8.3 Expenses; Termination Fees</B><B>.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Except as set forth in this Section&nbsp;8.3, all fees and
expenses incurred in connection with this Agreement and the Contemplated Transactions shall be paid by the party incurring such expenses, whether or not the Merger is consummated; <I>provided, however,</I> that Parent and the Company shall share
equally all fees and
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
expenses, other than attorneys&#146; fees, incurred in connection with: (i)&nbsp;the filing, printing and mailing of the Form&nbsp;S-4 Registration Statement and the Joint Proxy
Statement/Prospectus and any amendments or supplements thereto; and (ii)&nbsp;the filing by the parties hereto of any notice or other document under any applicable antitrust or competition Legal Requirement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>If this Agreement is terminated: (i)&nbsp;by Parent pursuant to Section&nbsp;8.1(f); or (ii)&nbsp;by Parent or the Company
pursuant to Section&nbsp;8.1(d), and in the case of clause &#147;(ii)&#148; of this sentence either: (A)&nbsp;(1)&nbsp;at or prior to the time of the termination of this Agreement a Company Acquisition Proposal shall have been disclosed, announced,
commenced, submitted or made and shall not have been withdrawn; and (2)&nbsp;on or prior to the first anniversary of such termination of this Agreement, either: (x)&nbsp;a Company Acquisition Transaction is consummated; or (y)&nbsp;a definitive
agreement relating to a Company Acquisition Transaction is entered into by a Symyx Corporation, or (B)&nbsp;a Company Triggering Event shall have occurred prior to the date of termination, then the Company shall pay to Parent, in cash at the time
specified in the following sentence, a nonrefundable fee in the amount of $7,500,000 (the &#147;<B>Company Termination Fee</B>&#148;).<B> </B>The Company Termination Fee shall be paid as follows: (x)&nbsp;in the case of clause &#147;(i)&#148; or
&#147;(ii)(B)&#148; of the preceding sentence, within two business days after termination of this Agreement; and (y)&nbsp;in the case of clause &#147;(ii)(A)&#148; of the preceding sentence, within two business days after the first to occur of the
consummation of the Company Acquisition Transaction or the entering into by a Symyx Corporation of the definitive agreement related thereto. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">If this Agreement is terminated by Parent or the Company pursuant to Section&nbsp;8.1(d), then the Company shall pay to Parent in cash within two business days after the termination of this Agreement the
amount of $1,000,000 in respect of Parent&#146;s expenses in connection with this Agreement, which shall be credited against the fees payable pursuant to this Section&nbsp;8.3(b), if any. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>If this Agreement is terminated: (i)&nbsp;by the Company pursuant to Section&nbsp;8.1(g); or (ii)&nbsp;by Parent or the Company
pursuant to Section&nbsp;8.1(e), and in the case of clause &#147;(ii)&#148; of this sentence either: (A)&nbsp;(1)&nbsp;at or prior to the time of the termination of this Agreement a Parent Acquisition Proposal shall have been disclosed, announced,
commenced, submitted or made and shall not have been withdrawn; and (2)&nbsp;on or prior to the first anniversary of such termination of this Agreement, either: (x)&nbsp;a Parent Acquisition Transaction is consummated; or (y)&nbsp;a definitive
agreement relating to a Parent Acquisition Transaction is entered into by an Accelrys Corporation, or (B)&nbsp;a Parent Triggering Event shall have occurred prior to the date of termination, then Parent shall pay to the Company, in cash at the time
specified in the following sentence, a nonrefundable fee in the amount of $7,500,000 (the &#147;<B>Parent Termination Fee</B>&#148;).<B> </B>The Parent Termination Fee shall be paid as follows: (x)&nbsp;in the case of clause &#147;(i)&#148; or
&#147;(ii)(B)&#148; of the preceding sentence, within two business days after termination of this Agreement; and (y)&nbsp;in the case of clause &#147;(ii)(A)&#148; of the preceding sentence, within two business days after the first to occur of the
consummation of the Parent Acquisition Transaction or the entering into by an Accelrys Corporation of the definitive agreement related thereto. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">If this Agreement is terminated by Parent or the Company pursuant to Section&nbsp;8.1(e), then Parent shall pay to the Company in cash within two business days after the termination of this Agreement the
amount of $1,000,000 in respect of the Company&#146;s expenses in connection with this Agreement, which shall be credited against the fees payable pursuant to this Section&nbsp;8.3(c), if any. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Any fee due under this Section&nbsp;8.3 shall be paid by wire transfer of immediately available funds to an account designated
in writing by the receiving party to the paying party. If a party fails to pay when due any amount payable by such party under this Section&nbsp;8.3, then: (i)&nbsp;such party shall reimburse the other party for all costs and expenses (including
fees and disbursements of counsel) incurred in connection with the collection of such overdue amount and the enforcement by the other party of its rights under this Section&nbsp;8.3; and (ii)&nbsp;such party shall pay to the other party interest on
such overdue amount (for the period commencing as of the date such overdue amount was originally required to be paid through the date such overdue amount is actually paid to the other party in full) at a rate per annum equal to the lower of:
(i)&nbsp;350 basis points over the &#147;prime rate&#148; (as announced by Citibank, N.A. or any successor thereto) in effect on the date such overdue amount was originally required to be paid; or (ii)&nbsp;the maximum rate permitted by applicable
Legal Requirements. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Section&nbsp;9. M<SMALL>ISCELLANEOUS</SMALL> P<SMALL>ROVISIONS</SMALL> </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.1 Amendment.</B> This Agreement may be amended with the approval of the respective boards of directors of the Company and Parent at any
time (whether before or after the adoption of this Agreement by the Company&#146;s stockholders and whether before or after approval of the Parent Proposals by Parent&#146;s stockholders); <I>provided, however,</I> that: (a)&nbsp;after any such
adoption of this Agreement by the Company&#146;s stockholders, no amendment shall be made which by applicable Legal Requirements requires further approval of the stockholders of the Company without the further approval of such stockholders; and
(b)&nbsp;after any such approval of the Parent Proposals by Parent&#146;s stockholders, no amendment shall be made which by law or regulation of the NASDAQ Global Market requires further approval of Parent&#146;s stockholders without the further
approval of such stockholders. This Agreement may not be amended except by an instrument in writing signed on behalf of each of the parties hereto. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>9.2 Waiver.</B> </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>No failure on the part of any party to exercise
any power, right, privilege or remedy under this Agreement, and no delay on the part of any party in exercising any power, right, privilege or remedy under this Agreement, shall operate as a waiver of such power, right, privilege or remedy; and no
single or partial exercise of any such power, right, privilege or remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>No party shall be deemed to have waived any claim arising out of this Agreement, or any power, right, privilege or remedy under
this Agreement, unless the waiver of such claim, power, right, privilege or remedy is expressly set forth in a written instrument duly executed and delivered on behalf of such party; and any such waiver shall not be applicable or have any effect
except in the specific instance in which it is given. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.3 No Survival of Representations and Warranties.</B> None of the
representations and warranties contained in this Agreement or in any certificate delivered pursuant to this Agreement shall survive the Merger. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>9.4 Entire Agreement; Counterparts; Exchanges by Facsimile.</B> This Agreement and the other agreements referred to herein constitute the entire agreement and supersede all prior agreements and
understandings, both written and oral, among or between any of the parties with respect to the subject matter hereof and thereof; <I>provided, however</I>, that the Confidentiality Agreement shall not be superseded and shall remain in full force and
effect in accordance with its terms (it being understood that no provision in the Confidentiality Agreement shall limit any party&#146;s rights or remedies in the case of fraud). This Agreement may be executed in several counterparts, each of which
shall be deemed an original and all of which shall constitute one and the same instrument. The exchange of a fully executed Agreement (in counterparts or otherwise) by facsimile shall be sufficient to bind the parties to the terms and conditions of
this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.5 Applicable Law; Jurisdiction; Specific Performance; Remedies.</B> This Agreement shall be governed by,
and construed in accordance with, the laws of the State of Delaware, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws thereof. In any action between any of the parties arising out of or relating to
this Agreement or any of the Contemplated Transactions: (a)&nbsp;each of the parties irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Chancery Court of the State of Delaware; and (b)&nbsp;each of
the parties irrevocably waives the right to trial by jury. The parties agree that irreparable damage would occur and that the parties would not have any adequate remedy at law in the event that any of the provisions of this Agreement were not
performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to an injunction or injunctions to prevent breaches of this Agreement and to enforce specifically the terms and
provisions of this Agreement, this being in addition to any other remedy to which they are entitled at law or in equity. All rights and remedies existing under this Agreement are cumulative to, and not exclusive of, any rights or remedies otherwise
available. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.6 Disclosure Schedules.</B> The Company Disclosure Schedule shall be arranged in
separate parts corresponding to the numbered and lettered sections contained in Section&nbsp;2. The Parent Disclosure Schedule shall be arranged in separate parts corresponding to the numbered and lettered sections contained in Section&nbsp;3. For
purposes of this Agreement: (a)&nbsp;each statement or other item of information set forth in the Company Disclosure Schedule shall be deemed to be a representation and warranty made by the Company in Section&nbsp;2; and (b)&nbsp;each statement or
other item of information set forth in the Parent Disclosure Schedule shall be deemed to be a representation and warranty made by Parent in Section&nbsp;3. The Company Disclosure Schedule and Parent Disclosure Schedule shall each be delivered as of
the date hereof, and no amendments or modifications thereto shall be made. Any purported update or modification to the Company Disclosure Schedule or Parent Disclosure Schedule after the date hereof shall be disregarded. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.7 Attorneys&#146; Fees.</B> In any action at law or suit in equity to enforce this Agreement or the rights of any of the parties
hereunder, the prevailing party in such action or suit shall be entitled to receive a reasonable sum for its attorneys&#146; fees and all other reasonable costs and expenses incurred in such action or suit. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.8 Assignability; No Third Party Rights.</B> This Agreement shall be binding upon, and shall be enforceable by and inure solely to the
benefit of, the parties hereto and their respective successors and assigns; <I>provided, however,</I> that neither this Agreement nor any party&#146;s rights or obligations hereunder may be assigned or delegated by such party without the prior
written consent of the other parties, and any attempted assignment or delegation of this Agreement or any of such rights or obligations by any party without the prior written consent of the other parties shall be void and of no effect. Except as
specifically provided in Section&nbsp;5.6, nothing in this Agreement, express or implied, is intended to or shall confer upon any Person (other than the parties hereto) any right, benefit or remedy of any nature whatsoever under or by reason of this
Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.9 Notices.</B> All notices, requests, demands and other communications under this Agreement shall be in
writing and shall be deemed to have been duly given or made as follows: (a)&nbsp;if sent by registered or certified mail in the United States return receipt requested, upon receipt; (b)&nbsp;if sent by nationally recognized overnight air courier
(such as Federal Express), two business days after mailing; (c)&nbsp;if sent by facsimile transmission before 5:00 p.m. Pacific Time, when transmitted and receipt is confirmed; (d)&nbsp;if sent by facsimile transmission after 5:00 p.m. Pacific Time
and receipt is confirmed, on the following business day; and (e)&nbsp;if otherwise actually personally delivered, when delivered, provided that such notices, requests, demands and other communications are delivered to the address set forth below, or
to such other address as any party shall provide by like notice to the other parties to this Agreement: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">if to Parent or
Merger Sub: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accelrys, Inc. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">10188 Telesis Court, Suite 100 </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">San Diego, CA 92121 </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attention: David R. Mersten, Esq. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Facsimile: (858)&nbsp;799-5107 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">with a copy (which shall not constitute notice)
to: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">4747 Executive Drive </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">12th Floor </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">San Diego, CA 92121 </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Attention: Carl R. Sanchez </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Facsimile: (858)&nbsp;458-3130 </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">if to the Company: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Symyx Technologies, Inc. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">3100 Central Expressway </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Santa Clara, CA 95051 fax </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attention: Rex Jackson </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">Facsimile: (408)&nbsp;773-4075 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">with a copy (which shall not constitute notice) to: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Cooley Godward Kronish LLP </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">5 Palo Alto Square </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">3000 El Camino Real </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Palo Alto, CA 94306 </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">Attention: Timothy J. Moore and Barbara Borden </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Facsimile: (650)&nbsp;849-7400 </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.10 Cooperation.</B> The Company agrees to cooperate fully with Parent and to execute and deliver such further documents, certificates,
agreements and instruments and to take such other actions as may be reasonably requested by Parent to evidence or reflect the Contemplated Transactions and to carry out the intent and purposes of this Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9.11 Severability. </B>Any term or provision of this Agreement that is invalid or unenforceable in any situation in any jurisdiction
shall not affect the validity or enforceability of the remaining terms and provisions of this Agreement or the validity or enforceability of the offending term or provision in any other situation or in any other jurisdiction. If a final judgment of
a court of competent jurisdiction declares that any term or provision of this Agreement is invalid or unenforceable, the parties hereto agree that the court making such determination shall have the power to limit such term or provision, to delete
specific words or phrases or to replace such term or provision with a term or provision that is valid and enforceable and that comes closest to expressing the intention of the invalid or unenforceable term or provision, and this Agreement shall be
valid and enforceable as so modified. In the event such court does not exercise the power granted to it in the prior sentence, the parties hereto agree to replace such invalid or unenforceable term or provision with a valid and enforceable term or
provision that will achieve, to the extent possible, the economic, business and other purposes of such invalid or unenforceable term or provision. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>9.12 Construction</B>. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>For purposes of this Agreement, whenever
the context requires: the singular number shall include the plural, and vice versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall
include masculine and feminine genders. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The parties hereto agree that any rule of construction to the effect that
ambiguities are to be resolved against the drafting party shall not be applied in the construction or interpretation of this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>As used in this Agreement, the words &#147;include&#148; and &#147;including,&#148; and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be
followed by the words &#147;without limitation.&#148; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Except as otherwise indicated, all references in this
Agreement to &#147;Sections,&#148; &#147;Exhibits&#148; and &#147;Schedules&#148; are intended to refer to Sections of this Agreement and Exhibits or Schedules to this Agreement. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT
SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>The bold-faced headings contained in this Agreement are for convenience of
reference only, shall not be deemed to be a part of this Agreement and shall not be referred to in connection with the construction or interpretation of this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><I>[Remainder of page intentionally left blank] </I></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>I<SMALL>N</SMALL> W<SMALL>ITNESS</SMALL> W<SMALL>HEREOF</SMALL>,</B> the parties have
caused this Agreement to be executed as of the date first above written. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0">

<TR>
<TD WIDTH="12%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="87%"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A<SMALL>CCELRYS</SMALL>, I<SMALL>NC</SMALL>.</B></FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></P> <P STYLE="font-size:3px;margin-top:0px;margin-bottom:1px">&nbsp;</P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/&nbsp;&nbsp;&nbsp;&nbsp;Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">President &amp; Chief Executive Officer</FONT></P></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A<SMALL>LTO</SMALL> M<SMALL>ERGER</SMALL> S<SMALL>UB</SMALL>, I<SMALL>NC</SMALL>.</B></FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/&nbsp;&nbsp;&nbsp;&nbsp;Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">President &amp; Chief Executive Officer</FONT></P></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>S<SMALL>YMYX</SMALL> T<SMALL>ECHNOLOGIES</SMALL>, I<SMALL>NC</SMALL>.</B></FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/&nbsp;&nbsp;&nbsp;&nbsp;Isy Goldwasser</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">Isy Goldwasser</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">Chief Executive Officer</FONT></P></TD></TR></TABLE></DIV> <P
STYLE="margin-top:345px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Merger Agreement Signature Page </I></B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>E<SMALL>XHIBIT</SMALL> A </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>C<SMALL>ERTAIN</SMALL> D<SMALL>EFINITIONS</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">For purposes of the Agreement (including this Exhibit A): </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Accelrys Corporations. </B>&#147;Accelrys
Corporations&#148; shall mean: (a)&nbsp;Parent; and (b)&nbsp;each of Parent&#146;s Subsidiaries. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Active Company
Product.</B> &#147;Active Company Product&#148; shall mean any Company Product except for each of the following: (a)&nbsp;each Company Product relating solely to the HPR Business; and (b)&nbsp;each Company Product and each Company Product Software
that was sold to Freeslate pursuant to the HPR Transaction Agreements to the extent such Company Product or Company Product Software is not material to the Company&#146;s business as conducted immediately prior to the Effective Time. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Active Company Product Software.</B> &#147;Active Company Product Software&#148; shall mean any Company Product Software except for each
of the following: (a)&nbsp;each Company Product Software relating solely to the HPR Business; and (b)&nbsp;each Company Product Software that was sold to Freeslate pursuant to the HPR Transaction Agreements to the extent such Company Product
Software is not material to the Company&#146;s business as conducted immediately prior to the Effective Time. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>COBRA.</B>
<B>&#147;</B>COBRA<B>&#148;</B> shall mean the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Code.
</B>&#147;Code&#148; shall mean the United States Internal Revenue Code of 1986, as amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Acquisition
Proposal.</B> &#147;Company Acquisition Proposal&#148; shall mean any inquiry, indication of interest, request for nonpublic, information offer or proposal (other than any of the foregoing made or submitted by Parent or Merger Sub) contemplating or
otherwise relating to or that would reasonably be expected to lead to any Company Acquisition Transaction. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company
Acquisition Transaction.</B> &#147;Company Acquisition Transaction&#148; shall mean any transaction or series of transactions (other than the Contemplated Transactions) involving: </FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; margin-left:4%; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>any merger, exchange, consolidation, business combination, issuance of securities, acquisition of securities,
reorganization, recapitalization, takeover offer, tender offer, exchange offer or other similar transaction: (i)&nbsp;in which the Company or any of its Subsidiaries is a constituent corporation and which would result in a third party beneficially
owning 15% or more of any class of equity or voting securities of the Company or any of its Subsidiaries; (ii)&nbsp;in which a Person or &#147;group&#148; (as defined in the Exchange Act and the rules promulgated thereunder) of Persons directly or
indirectly acquires beneficial or record ownership of securities representing more than 15% of the outstanding securities of any class of voting securities of the Company or any of its Subsidiaries; or (iii)&nbsp;in which the Company or any of its
Subsidiaries issues securities representing more than 15% of the outstanding securities of any class of voting securities of the Company or any of its Subsidiaries; </FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; margin-left:4%; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>any sale, lease, exchange, transfer, license, acquisition or disposition of any business or businesses or assets
that constitute or account for 15% or more of the consolidated net revenues, consolidated net income or consolidated assets of the Company or any of its Subsidiaries; or </FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; margin-left:4%; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>any liquidation or dissolution of the Company or any of its Subsidiaries. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Affiliate.</B> &#147;Company Affiliate&#148; shall mean any Person under common control with any of the Symyx Corporations within
the meaning of Section&nbsp;414(b), Section&nbsp;414(c), Section&nbsp;414(m) or Section&nbsp;414(o) of the Code, and the regulations issued thereunder; for the avoidance of doubt Freeslate, Inc. (formerly known as HPR Global, Inc.) shall not be
considered a Company Affiliate. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Associate.</B> &#147;Company Associate&#148; shall mean any current or former
officer or other employee, or current or former independent contractor, consultant or director, of or to any of the Symyx Corporations or any Company Affiliate. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Company Audited Balance Sheet.</B> &#147;Company Audited Balance Sheet&#148; shall mean the audited consolidated balance sheet of the Company and its consolidated Subsidiaries as of December&nbsp;31,
2009 included in the Company&#146;s Annual Report on Form 10-K for the year ended December&nbsp;31, 2009. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company
Board.</B> &#147;Company Board&#148; shall mean the Company&#146;s board of directors. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Common Stock.</B>
&#147;Company Common Stock&#148; shall mean the Common Stock, $0.001 par value per share, of the Company. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company
Contract.</B> &#147;Company Contract&#148; shall mean any Contract: (a)&nbsp;to which any of the Symyx&nbsp;Corporations is a party; (b)&nbsp;by which any of the Symyx Corporations or any Company IP or any other asset of any of the Symyx
Corporations is or may become bound or under which any of the Symyx Corporations has, or may become subject to, any obligation; or (c)&nbsp;under which any of the Symyx Corporations has or may acquire any right or interest. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Designated Representations.</B> &#147;Company Designated Representations&#148; shall mean the representations and warranties set
forth in Sections 2.3(a), 2.3(c), 2.3(e), 2.21, 2.22, 2.23 and 2.26. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Disclosure Schedule.</B> &#147;Company
Disclosure Schedule&#148; shall mean the Company Disclosure Schedule that has been prepared by the Company in accordance with the requirements of Section 9.6 of the Agreement and that has been delivered by the Company to Parent on the date of the
Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Employee.</B> &#147;Company Employee&#148; shall mean any director or any officer or other employee of
any of the Symyx Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Employee Agreement. </B>&#147;Company Employee Agreement&#148; shall mean each
management, employment, severance, retention, transaction bonus, change in control, consulting, relocation, repatriation or expatriation agreement or other Contract between: (a)&nbsp;any of the Symyx Corporations or any Company Affiliate; and
(b)&nbsp;any Company Associate, other than any such Contract that is terminable &#147;at will&#148; (or following a notice period imposed by applicable law) without any obligation on the part of any Symyx Corporation or any Company Affiliate to make
any severance, termination, change in control or similar payment or to provide any benefit. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Employee Plan.
</B>&#147;Company Employee Plan&#148; shall mean each plan, program, policy, practice or Contract (including any Company Foreign Plan) providing for compensation, severance, termination pay, deferred compensation, performance awards, stock or
stock-related awards, fringe benefits, change in control payments, sick pay, paid time off, vacation pay, retirement benefits or other benefits or remuneration of any kind, whether or not in writing and whether or not funded, including each
&#147;employee benefit plan,&#148; within the meaning of Section&nbsp;3(3) of ERISA (whether or not ERISA is applicable to such plan): (a)&nbsp;that is or has been maintained or contributed to, participated in, established by, sponsored, or required
to be maintained or contributed to, participated in, established by, sponsored, by any of the Symyx Corporations or any Company Affiliate for the benefit of any Company Associate; or (b)&nbsp;with respect to which any of the Symyx Corporations or
any Company Affiliate has or may incur or become subject to any liability or obligation; <I>provided, however, </I>that a Company Employee Agreement shall not be considered a Company Employee Plan. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Equity Award.</B> &#147;Company Equity Award&#148; shall mean any form of compensation (including deferred compensation) that is
or may be paid or settled in Company Common Stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Foreign Plan. </B>&#147;Company Foreign Plan&#148; shall mean
any: (a)&nbsp;plan, program, policy, practice, Contract or other arrangement of any Symyx Corporation mandated by a Governmental Body outside the
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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United&nbsp;States; (b)&nbsp;Company Employee Plan that is subject to any of the Legal Requirements of any jurisdiction outside the United States; or (c)&nbsp;Company Employee Plan that covers or
has covered any Company Associate whose services are or have been performed primarily outside the United States. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company
IP. </B>&#147;Company IP&#148; shall mean: (a)&nbsp;all Intellectual Property Rights in or to the Active Company Products and all Intellectual Property Rights in or to Active Company Product Software; and (b)&nbsp;all other Intellectual Property
Rights and Intellectual Property with respect to which any of the Symyx Corporations has (or purports to have) an ownership interest or an exclusive license or similar exclusive right, except for each Intellectual Property Rights and Intellectual
Property: (i)&nbsp;relating solely to the HPR Business; and (ii)&nbsp;that was sold to Freeslate pursuant to the HPR Transaction Agreements to the extent such Intellectual Property Rights and Intellectual Property are not material to the
Company&#146;s business as conducted immediately prior to the Effective Time. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Material Adverse Effect.</B>
&#147;Company Material Adverse Effect&#148; shall mean any effect, change, claim, event or circumstance (collectively, &#147;<B>Effect</B>&#148;) that, considered together with all other Effects, is or would reasonably be expected to be or to become
materially adverse to, or has or would reasonably be expected to have or result in a material adverse effect on: (a)&nbsp;the business, financial condition or results of operations of the Symyx Corporations taken as a whole; <I>provided,
however</I>, that, in no event shall any Effects resulting from any of the following, alone or in combination, be deemed to constitute, or be taken into account in determining whether there has occurred, a Company Material Adverse Effect:
(i)&nbsp;conditions generally affecting the industries in which the Company participates or the U.S. or global economy as a whole, to the extent that such conditions do not have a disproportionate impact on the Symyx Corporations taken as a whole;
(ii)&nbsp;general conditions in the financial markets, and any changes therein (including any changes arising out of acts of terrorism, war, weather conditions or other force majeure events), to the extent that such conditions do not have a
disproportionate impact on the Symyx Corporations, taken as a whole; (iii)&nbsp;changes in the trading price or trading volume of Company Common Stock (it being understood, however, that except as otherwise provided in clauses &#147;(i),&#148;
&#147;(ii),&#148; &#147;(iv),&#148; &#147;(v)&#148; or &#147;(vii)&#148; of this sentence, any Effect giving rise to or contributing to such changes in the trading price or trading volume of Company Common Stock may give rise to a Company Material
Adverse Effect and may be taken into account in determining whether a Company Material Adverse Effect has occurred); (iv)&nbsp;changes in GAAP (or any interpretations of GAAP) applicable to Company or any of its Subsidiaries; (v)&nbsp;the failure to
meet public estimates or forecasts of revenues, earnings of other financial metrics, in and of itself, or the failure to meet internal projections, forecasts or budgets of revenues, earnings or other financial metrics, in and of itself (it being
understood, however, that, except as otherwise provided in clauses &#147;(i),&#148; &#147;(ii),&#148; &#147;(iii),&#148; &#147;(iv)&#148; or &#147;(vi)&#148; of this sentence, any Effect giving rise to or contributing to any such failure may give
rise to a Company Material Adverse Effect and may be taken into account in determining whether a Company Material Adverse Effect has occurred); or (vi)&nbsp;loss of employees, suppliers or customers (including customer orders or Contracts) resulting
directly from the announcement or pendency of this Agreement or the Contemplated Transactions; or (b)&nbsp;the ability of the Company to consummate the Merger or any of the other Contemplated Transactions or to perform any of its covenants or
obligations under the Agreement; or (c)&nbsp;Parent&#146;s ability to vote, transfer, receive dividends with respect to or otherwise exercise ownership rights with respect to the stock of the Surviving Corporation or to exercise its rights under the
Agreement or any of the Company Stockholder Voting Agreements. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Option Plans. </B>&#147;Company Option Plans&#148;
shall mean: (a)&nbsp;the Company&#146;s 2007 Stock Incentive Plan; (b)&nbsp;2003 IntelliChem Option Plan, as amended; (c)&nbsp;the Company&#146;s 2001 Nonstatutory Stock Option Plan; (d)&nbsp;2000 Synthematix Equity Plan; and (e)&nbsp;the
Company&#146;s 1997 Stock Plan, as amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Options. </B>&#147;Company Options&#148; shall mean options to
purchase shares of Company Common Stock from the Company (whether granted by the Company pursuant to the Company Option Plans, assumed by the Company or otherwise). </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT
SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Pension Plan.</B> &#147;Company Pension Plan&#148; shall mean each:
(a)&nbsp;Company Employee Plan that is an &#147;employee pension benefit plan,&#148; within the meaning of Section&nbsp;3(2) of ERISA (whether or not ERISA is applicable to such plan); or (b)&nbsp;other occupational pension plan, including any final
salary or money purchase plan. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Preferred Stock.</B> &#147;Company Preferred Stock&#148; shall mean the Preferred
Stock, $0.001 par value per share, of the Company. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Product.</B> &#147;Company Product&#148; shall mean any product
or service: (a)&nbsp;developed, manufactured, marketed, distributed, offered, provided, leased, licensed or sold, directly or indirectly, by or on behalf of any Symyx Corporation since January&nbsp;1, 2008 period preceding the date of this Agreement
or for which any Symyx Corporation has any support or maintenance obligations; or (b)&nbsp;currently under development by or for any Symyx Corporation (whether or not in collaboration with another Person). </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Product Software. </B>&#147;Company Product Software&#148; shall mean any software (regardless of whether such software is owned
by a Symyx Corporation or licensed to a Symyx Corporation by a third party) contained or included in or provided with any Company Product or used in the development, manufacturing, maintenance, repair, support, testing or performance of any Company
Product. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company RSU.</B><B> </B>&#147;Company RSU&#148; shall mean each restricted stock unit representing the right to
vest in and be issued shares of Company Common Stock by the Company, whether granted by the Company pursuant to a Company Option Plan, assumed by the Company in connection with any merger, acquisition or similar transaction or otherwise issued or
granted and whether vested or unvested. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Source Code.</B> &#147;Company Source Code&#148; shall mean any source
code, or any portion, aspect or segment of any source code, relating to any Intellectual Property owned by or licensed to any of the Symyx Corporations or otherwise used by any of the Symyx Corporations, including the Company Product Software, but
excluding any Intellectual Property relating to or used in the HPR Business. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Superior Offer.</B> &#147;Company
Superior Offer&#148; shall mean a bona fide written Company Acquisition Proposal made by a third party, that is determined by the Company Board, in its good faith judgment, after consulting with a financial advisor of nationally recognized
reputation and outside legal counsel, and after taking into account all legal, regulatory, financial and other aspects of the proposal, including the likelihood and anticipated timing of consummation, to be more favorable from a financial point of
view to the Company&#146;s stockholders than the Merger determined on a basis of long-term value; <I>provided, however</I>, that for purposes of this definition of &#147;Company Superior Offer,&#148; the defined term &#147;Company Acquisition
Proposal&#148; shall have the meaning assigned to such term herein, except that all references to &#147;15%&#148; contained in the definition of &#147;Company Acquisition Transaction&#148; when it is used in the definition of Company Acquisition
Proposal shall be deemed to be a reference to &#147;50%.&#148; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Triggering Event.</B> A &#147;Company Triggering
Event&#148; shall be deemed to have occurred if: (a)&nbsp;the Company Board shall have failed to recommend that the Company&#146;s stockholders vote to adopt the Agreement, or shall have withdrawn or shall have modified in a manner adverse to Parent
the Company Board Recommendation; (b)&nbsp;the Company shall have failed to include in the Joint Proxy Statement/Prospectus the Company Board Recommendation or a statement to the effect that the Company Board has determined and believes that the
Merger is advisable to, and in the best interests of, the Company&#146;s stockholders; (c)&nbsp;the Company Board fails to reaffirm the Company Board Recommendation, or fails to reaffirm its determination that the Merger is in the best interests of
the Company&#146;s stockholders, within 10 business days after Parent requests in writing that such recommendation or determination be reaffirmed; (d)&nbsp;the Company Board shall have approved, endorsed or recommended any Company Acquisition
Proposal; (e)&nbsp;the Company shall have entered into any letter of intent or similar document or any Contract relating to any Company Acquisition Proposal; (f)&nbsp;a tender or exchange offer relating to securities of the Company shall have been
commenced and the Company shall not
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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have sent to its securityholders, within 10 business days after the commencement of such tender or exchange offer, a statement disclosing that the Company recommends rejection of such tender or
exchange offer; (g)&nbsp;a Company Acquisition Proposal is publicly announced, and the Company fails to issue a press release announcing its opposition to such Company Acquisition Proposal within 10 business days after such Company Acquisition
Proposal is announced; or (h)&nbsp;the Company shall have breached in any material respect any material provision of Section&nbsp;4.4(a) or Section&nbsp;5.2 of the Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Company Warrant. </B>&#147;Company Warrant&#148; shall mean each warrant to purchase shares of Company Common Stock (or exercisable for
cash). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Confidentiality Agreement. </B>&#147;Confidentiality Agreement&#148; shall mean that certain letter agreement,
dated as of April&nbsp;16, 2009, between the Company and Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Consent.</B> &#147;Consent&#148; shall mean any approval,
consent, ratification, permission, waiver or authorization (including any Governmental Authorization). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Contemplated
Transactions.</B> &#147;Contemplated Transactions&#148; shall mean the Merger and the other transactions contemplated by the Agreement, the Company Stockholder Voting Agreements, the Rights Agreement Amendment and the Parent Stockholder Voting
Agreements. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Contract.</B> &#147;Contract&#148; shall mean any written, oral or other agreement, contract, subcontract,
lease, understanding, arrangement, instrument, note, option, warranty, purchase order, license, sublicense, insurance policy, benefit plan or legally binding commitment or undertaking of any nature. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>DGCL. </B>&#147;DGCL&#148; shall mean the Delaware General Corporation Law. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>DOL. </B>&#147;DOL&#148; shall mean the United States Department of Labor. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Employment Site.</B> &#147;Employment Site&#148; with respect to an Entity, shall mean each of the following: (a)&nbsp;each site of
employment; or (b)&nbsp;one or more facilities or operating units within any site of employment or facility of such Entity. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>Encumbrance.</B> &#147;Encumbrance&#148; shall mean any lien, pledge, hypothecation, charge, mortgage, easement, encroachment, imperfection of title, title exception, title defect, right of possession, lease, tenancy license, security
interest, encumbrance, claim, infringement, interference, option, right of first refusal, preemptive right, community property interest or restriction of any nature (including any restriction on the voting of any security, any restriction on the
transfer of any security or other asset, any restriction on the receipt of any income derived from any asset, any restriction on the use of any asset and any restriction on the possession, exercise or transfer of any other attribute of ownership of
any asset). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Entity.</B> &#147;Entity&#148; shall mean any corporation (including any non-profit corporation), general
partnership, limited partnership, limited liability partnership, joint venture, estate, trust, company (including any company limited by shares, limited liability company or joint stock company), firm, society or other enterprise, association,
organization or entity. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Environmental Law. </B>&#147;Environmental Law&#148; shall mean any federal, state, local or
foreign Legal Requirement relating to pollution worker safety, exposure of any individual to Materials of Environmental Concern or protection of human health or the environment (including ambient air, surface water, ground water, land surface or
subsurface strata), including any Legal Requirement relating to emissions, discharges, releases or threatened releases of Materials of Environmental Concern, or otherwise relating to the manufacture, processing, distribution, use, treatment,
storage, disposal, transport or handling of Materials of Environmental Concern. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ERISA.</B> &#147;ERISA&#148; shall mean
the Employee Retirement Income Security Act of 1974, as amended. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exchange Act.</B> &#147;Exchange Act&#148; shall mean the Securities Exchange Act of
1934, as amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Form S-4 Registration Statement.</B> &#147;Form S-4 Registration Statement&#148; shall mean the
registration statement on Form S-4 to be filed with the SEC by Parent in connection with the issuance of Parent Common Stock in the Merger, as said registration statement may be amended prior to the time it is declared effective by the SEC.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>GAAP. </B>&#147;GAAP&#148; shall mean generally accepted accounting principles in the United States. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Governmental Authorization.</B> &#147;Governmental Authorization&#148; shall mean any: (a)&nbsp;permit, license, certificate, franchise,
permission, variance, clearance, registration, qualification or authorization issued, granted, given or otherwise made available by or under the authority of any Governmental Body or pursuant to any Legal Requirement; or (b)&nbsp;right under any
Contract with any Governmental Body. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Freeslate.</B> &#147;Freeslate&#148; shall mean Freeslate, Inc. (formerly HPR Global,
Inc.). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Governmental Body.</B> &#147;Governmental Body&#148; shall mean any: (a)&nbsp;nation, state, commonwealth,
province, territory, county, municipality, district or other jurisdiction of any nature; (b)&nbsp;federal, state, local, municipal, foreign or other government; (c)&nbsp;governmental or quasi-governmental authority of any nature (including any
governmental division, department, agency, commission, instrumentality, official, ministry, fund, foundation, center, organization, unit, body or Entity and any court or other tribunal); or (d)&nbsp;self-regulatory organization (including the NASDAQ
Global Market). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>HPR Agreement.</B> &#147;HPR Agreement&#148; shall mean that certain Asset Purchase Agreement, dated as of
February&nbsp;11, 2010, by and among Freeslate, the Company and Symyx Solutions, Inc. (&#147;<B>Symyx Solutions</B>&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>HPR Business. &#147;</B>HPR Business&#148; shall mean the business referred to as Symyx HPR in the Company&#146;s Annual Report on Form 10-K for the year ended December&nbsp;31, 2009, including the HPR tools business and contract
research services operations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>HPR Transaction Agreements. </B>&#147;HPR Transaction Agreements&#148; shall mean the
following (referred to collectively): (a)&nbsp;that certain Software License, Services and Co-Marketing Agreement, dated March&nbsp;1, 2010, by and between Symyx Solutions and Freeslate; (b)&nbsp;that certain Technology License Agreement, dated
February&nbsp;11, 2010 by and between Symyx Solutions and Freeslate; and (c)&nbsp;the HPR Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>HSR Act.</B>
&#147;HSR Act&#148; shall mean the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Intellectual
Property. </B>&#147;Intellectual Property&#148; shall mean algorithms, apparatus, databases, data collections, diagrams, formulae, inventions (whether or not patentable), know-how, logos, marks (including brand names, product names, logos, and
slogans), methods, processes, proprietary information, protocols, schematics, specifications, software, software code (in any form, including source code and executable or object code), techniques, user interfaces, URLs, web sites, works of
authorship and other forms of technology (whether or not embodied in any tangible form and including all tangible embodiments of the foregoing, such as instruction manuals, laboratory notebooks, prototypes, samples, studies and summaries).
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Intellectual Property Rights.</B> &#147;Intellectual Property Rights&#148; shall mean all rights of the following types,
which may exist or be created under the laws of any jurisdiction in the world: (a)&nbsp;rights associated with works of authorship, including exclusive exploitation rights, copyrights, moral rights and mask works; (b)&nbsp;trademark, trade name and
domain name rights and similar rights; (c)&nbsp;trade secret rights; (d)&nbsp;patent and industrial property rights; (e)&nbsp;other proprietary rights in Intellectual Property; and (f)&nbsp;rights in or relating to registrations, renewals,
extensions, combinations, divisions and reissues of, and applications for, any of the rights referred to in clauses &#147;(a)&#148; through &#147;(e)&#148; above. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT
SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>IRS. </B>&#147;IRS&#148; shall mean the United States Internal Revenue Service.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Joint Proxy Statement/Prospectus.</B> &#147;Joint Proxy Statement/Prospectus&#148; shall mean the joint proxy
statement/prospectus to be sent to the Company&#146;s stockholders in connection with the Company Stockholders&#146; Meeting and to Parent&#146;s stockholders in connection with the Parent Stockholders&#146; Meeting. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Legal Proceeding.</B> &#147;Legal Proceeding&#148; shall mean any action, suit, litigation, arbitration, proceeding (including any civil,
criminal, administrative, investigative or appellate proceeding), hearing, inquiry, audit, examination or investigation commenced, brought, conducted or heard by or before, or otherwise involving, any court or other Governmental Body or any
arbitrator or arbitration panel. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Legal Requirement.</B> &#147;Legal Requirement&#148; shall mean any federal, state,
local, municipal, foreign or other law, statute, constitution, principle of common law, resolution, ordinance, code, edict, decree, rule, regulation, order, award, ruling or requirement issued, enacted, adopted, promulgated, implemented or otherwise
put into effect by or under the authority of any Governmental Body (or under the authority of the NASDAQ Global Market). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>Made Available.</B> Any statement in the Agreement to the effect that any information, document or other material has been &#147;Made Available&#148; shall mean that: (a)&nbsp;with respect to information, document or other material Made
Available by the Company: (i)&nbsp;such information, document or material was made available by the Company for review by Parent or Parent&#146;s Representatives for a reasonable period of time prior to the execution of the Agreement in the virtual
data room maintained by the Company with Merrill Data Site in connection with the transactions contemplated by the Agreement (it being understood that a document that was only made available for review in the virtual data room in the two days prior
to the execution of the Agreement shall only be deemed to have been made available for a reasonable period of time if the Company shall have promptly notified Parent or its outside legal counsel in writing that such document was uploaded into the
virtual data room); and (ii)&nbsp;Parent and Parent&#146;s Representatives had access to such information, document or material throughout such period of time; and (b)&nbsp;with respect to information, document or other material Made Available by
Parent: (i)&nbsp;such information, document or material was made available by Parent for review by the Company or the Company&#146;s Representatives for a reasonable period of time prior to the execution of the Agreement in the virtual data room
maintained by Parent with RR Donnelley in connection with the transactions contemplated by the Agreement (it being understood that a document that was only made available for review in the virtual data room in the two days prior to the execution of
the Agreement shall only be deemed to have been made available for a reasonable period of time if Parent shall have promptly notified the Company or its outside legal counsel in writing that such document was uploaded into the virtual data room);
and (ii)&nbsp;the Company and the Company&#146;s Representatives had access to such information, document or material throughout such period of time. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Materials of Environmental Concern.</B> &#147;Materials of Environmental Concern&#148; shall mean any chemicals, pollutants, contaminants, wastes, toxic substances, petroleum and petroleum products and
any other substance that is now or hereafter regulated by any Environmental Law or that is otherwise a danger to health, reproduction or the environment. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Order. </B>&#147;Order&#148; shall mean any order, writ, injunction, judgment or decree. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Other Parent Proposals. </B>&#147;Other Parent Proposals&#148; shall mean: (a)&nbsp;a proposal for the election of directors whose terms are expiring; and (b)&nbsp;ratification of the selection of
Parent&#146;s independent registered public accounting firm. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Acquisition Proposal.</B> &#147;Parent Acquisition
Proposal&#148; shall mean any inquiry, indication of interest, request for nonpublic information, offer or proposal (other than any of the foregoing made or submitted by the Company) contemplating or otherwise relating to or that would reasonably be
expected to lead to any Parent Acquisition Transaction. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Acquisition Transaction.</B> &#147;Parent Acquisition Transaction&#148; shall mean
any transaction or series of transactions (other than the Contemplated Transactions) involving: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:4%; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>any
merger, exchange, consolidation, business combination, issuance of securities, acquisition of securities, reorganization, recapitalization, takeover offer, tender offer, exchange offer or other similar transaction: (i)&nbsp;in which Parent or any of
its Subsidiaries is a constituent corporation and which would result in a third party beneficially owning 15% or more of any class of equity or voting securities of Parent or any of its Subsidiaries; (ii)&nbsp;in which a Person or &#147;group&#148;
(as defined in the Exchange Act and the rules promulgated thereunder) of Persons directly or indirectly acquires beneficial or record ownership of securities representing more than 15% of the outstanding securities of any class of voting securities
of Parent or any of its Subsidiaries; or (iii)&nbsp;in which Parent or any of its Subsidiaries issues securities representing more than 15% of the outstanding securities of any class of voting securities of Parent or any of its Subsidiaries;
</FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:4%; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>any sale, lease, exchange, transfer, license, acquisition or disposition of any business or
businesses or assets that constitute or account for 15% or more of the consolidated net revenues, consolidated net income or consolidated assets of Parent or any of its Subsidiaries; or </FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; margin-left:4%; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>any liquidation or dissolution of Parent or any of its Subsidiaries. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Affiliate.</B> &#147;Parent Affiliate&#148; shall mean any Person under common control with any of the Accelrys Corporations
within the meaning of Section&nbsp;414(b), Section&nbsp;414(c), Section&nbsp;414(m) or Section&nbsp;414(o) of the Code, and the regulations issued thereunder. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Associate.</B> &#147;Parent Associate&#148; shall mean any current or former officer or other employee, or current or former independent contractor, consultant or director, of or to any of the
Accelrys Corporations or any Parent Affiliate. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Board.</B> &#147;Parent Board&#148; shall mean Parent&#146;s board
of directors. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Contract.</B> &#147;Parent Contract&#148; shall mean any Contract: (a)&nbsp;to which any of the
Accelrys Corporations is a party; (b)&nbsp;by which any of the Accelrys Corporations or any Company IP or any other asset of any of the Accelrys Corporations is or may become bound or under which any of the Accelrys Corporations has, or may become
subject to, any obligation; or (c)&nbsp;under which any of the Accelrys Corporations has or may acquire any right or interest. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>Parent Common Stock.</B> &#147;Parent Common Stock&#148; shall mean the Common Stock, $0.0001 par value per share, of Parent. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Designated Representations.</B> &#147;Parent Designated Representations&#148; shall mean the representations and warranties set forth in Sections 3.3(a), 3.3(c), 3.3(d), 3.3(f), 3.21, 3.22,
3.23, 3.26, 3.27 and 3.28. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Disclosure Schedule.</B> &#147;Parent Disclosure Schedule&#148; shall mean the Parent
Disclosure Schedule that has been prepared by Parent in accordance with the requirements of Section&nbsp;9.6 of the Agreement and that has been delivered by Parent to the Company on the date of the Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Employee. </B>&#147;Parent Employee&#148; shall mean any director or any officer or any other employee of any of the Accelrys
Corporations. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Employee Agreement. </B>&#147;Parent Employee Agreement&#148; shall mean any management, employment,
severance, retention, transaction bonus, change in control, consulting, relocation, repatriation or expatriation agreement or other Contract between: (a)&nbsp;any of the Accelrys Corporations; and (b)&nbsp;any Parent Employee, other than any such
Contract that is terminable &#147;at will&#148; (or following a notice period imposed by applicable law) without any obligation on the part of any Accelrys Corporation or any Parent Affiliate to make any severance, termination, change in control or
similar payment or to provide any benefit. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Employee Plan.</B> &#147;Parent Employee Plan&#148; shall mean any plan, program,
policy, practice or Contract (including any Parent Foreign Plan) providing for compensation, severance, termination pay, deferred compensation, performance awards, stock or stock-related awards, fringe benefits, change in control payments, sick pay,
paid time off, vacation pay, retirement benefits or other benefits or remuneration of any kind, whether or not in writing and whether or not funded, including each &#147;employee benefit plan,&#148; within the meaning of Section&nbsp;3(3) of ERISA
(whether or not ERISA is applicable to such plan): (a)&nbsp;that is maintained or contributed to, or required to be maintained or contributed to, by any of the Accelrys Corporations for the benefit of any Parent Employee; or (b)&nbsp;with respect to
which any of the Accelrys Corporations has or may incur or become subject to any liability or obligation; <I>provided, however, </I>that a Parent Employee Agreement shall not be considered a Parent Employee Plan. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Equity Award. </B>&#147;Parent Equity Award&#148; shall mean any form of compensation (including deferred compensation) that is or
may be paid or settled in Parent Common Stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent ESPP. </B>&#147;Parent ESPP&#148; shall mean Parent&#146;s 2005
Employee Stock Purchase Plan. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Foreign Plan.</B> &#147;Parent Foreign Plan&#148; shall mean any: (a)&nbsp;plan,
program, policy, practice, Contract or other arrangement of any Accelrys Corporation mandated by a Governmental Body outside the United States; (b)&nbsp;Parent Employee Plan that is subject to any of the Legal Requirements of any jurisdiction
outside the United States; or (c)&nbsp;Parent Employee Plan that covers or has covered any Parent Associate whose services are or have been performed primarily outside the United States. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent IP.</B> &#147;Parent IP&#148; shall mean: (a)&nbsp;all Intellectual Property Rights in or to the Parent Products and all
Intellectual Property Rights in or to Parent Product Software; and (b)&nbsp;all other Intellectual Property Rights and Intellectual Property with respect to which any of the Accelrys Corporations has (or purports to have) an ownership interest or an
exclusive license or similar exclusive right. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Material Adverse Effect. </B>&#147;Parent Material Adverse
Effect&#148; shall mean any Effect that, considered together with all other Effects, is or would reasonably be expected to be or to become materially adverse to, or has or would reasonably be expected to have or result in a material adverse effect
on: (a)&nbsp;the business, financial condition or results of operations of the Accelrys Corporations taken as a whole; <I>provided, however</I>, that, in no event shall any Effects resulting from any of the following, alone or in combination, be
deemed to constitute, or be taken into account in determining whether there has occurred, a Parent Material Adverse Effect: (i)&nbsp;conditions generally affecting the industries in which Parent participates or the U.S. or global economy as a whole,
to the extent that such conditions do not have a disproportionate impact on the Accelrys Corporations taken as a whole; (ii)&nbsp;general conditions in the financial markets, and any changes therein (including any changes arising out of acts of
terrorism, war, weather conditions or other force majeure events), to the extent that such conditions do not have a disproportionate impact on the Accelrys Corporations taken as a whole; (iii)&nbsp;changes in the trading price or trading volume of
Parent Common Stock (it being understood, however, that , except as otherwise provided in clauses &#147;(i),&#148; &#147;(ii),&#148; &#147;(iv),&#148; &#147;(v)&#148; or &#147;(vi)&#148; of this sentence, any Effect giving rise to or contributing to
such changes in the trading price or trading volume of Parent Common Stock may give rise to a Parent Material Adverse Effect and may be taken into account in determining whether a Parent Material Adverse Effect has occurred); (iv)&nbsp;changes in
GAAP (or any interpretations of GAAP) applicable to Parent or any of its Subsidiaries; (v)&nbsp;the failure to meet public estimates or forecasts of revenues, earnings of other financial metrics, in and of itself, or the failure to meet internal
projections, forecasts or budgets of revenues, earnings or other financial metrics, in and of itself (it being understood, however, that, except as otherwise provided in clauses &#147;(i),&#148; &#147;(ii),&#148; &#147;(iii),&#148; &#147;(iv)&#148;
or &#147;(vi)&#148; of this sentence, any Effect giving rise to or contributing to any such failure may give rise to a Parent Material Adverse Effect and may be taken into account in determining whether a Parent Material Adverse Effect has
occurred); or (vi)&nbsp;loss of employees, suppliers or customers (including customer orders or Contracts) resulting directly from the announcement or pendency of this Agreement or the Contemplated Transactions; or (b)&nbsp;the ability of Parent to
consummate the Merger or to perform any of its obligations under the Agreement. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Material Contract.</B> &#147;Parent Material Contract&#148; shall have the meaning
assigned to such term in Section 3. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Option Plans. </B>&#147;Parent Option Plans&#148; shall mean:
(a)&nbsp;Parent&#146;s 1994 Incentive Stock Plan, as amended; (b)&nbsp;Parent&#146;s 1995 Director Option Plan, as amended; (c)&nbsp;Parent&#146;s 2000 Stock Option Plan, (d)&nbsp;Parent&#146;s 2004 New Hire Equity Incentive Plan; and
(e)&nbsp;Parent&#146;s 2004 Stock Incentive Plan, as amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Options.</B> &#147;Parent Options&#148; shall mean
options to purchase shares of Parent Common Stock from Parent (whether granted by Parent pursuant to the Parent Option Plans, assumed by Parent or otherwise). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Pension Plan. </B>&#147;Parent Pension Plan&#148; shall mean each: (a)&nbsp;Parent Employee Plan that is an &#147;employee pension benefit plan,&#148; within the meaning of Section&nbsp;3(2) of
ERISA (whether or not ERISA is applicable to such plan); or (b)&nbsp;other occupational pension plan, including any final salary or money purchase plan. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Preferred Stock.</B> &#147;Parent Preferred Stock&#148; shall mean the Preferred Stock, $0.0001 par value per share, of the Parent. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Product.</B> &#147;Parent Product&#148; shall mean any product or service: (a)&nbsp;developed, manufactured, marketed,
distributed, offered, provided, leased, licensed or sold, directly or indirectly, by or on behalf of any Accelrys Corporation since January&nbsp;1, 2008 period preceding the date of this Agreement or for which any Accelrys Corporation has any
support or maintenance obligations; or (b)&nbsp;currently under development by or for any Accelrys Corporation (whether or not in collaboration with another Person). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Product Software.</B> &#147;Parent Product Software&#148; shall mean any software (regardless of whether such software is owned by an Accelrys Corporation or licensed to an Accelrys Corporation
by a third party) contained or included in or provided with any Parent Product or used in the development, manufacturing, maintenance, repair, support, testing or performance of any Parent Product. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Rights Agreement.</B> &#147;Parent Rights Agreement&#148; shall mean the Preferred Stock Rights Agreement, dated as of
September&nbsp;6, 2002, between the Parent and American Stock Transfer&nbsp;&amp; Trust Company, as Rights Agent (including Exhibit A thereto, the Certificate of Designation, Preferences and Rights of Series A Junior Participating Preferred Stock).
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent RSU.</B> &#147;Parent RSU&#148; shall mean each restricted stock unit representing the right to vest in and be
issued shares of Parent Common Stock by Parent, whether granted by Parent pursuant to a Parent Option Plan, assumed by Parent in connection with any merger, acquisition or similar transaction or otherwise issued or granted and whether vested or
unvested. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Source Code.</B> &#147;Parent Source Code&#148; shall mean any source code, or any portion, aspect or
segment of any source code, relating to any Intellectual Property owned by or licensed to any of the Accelrys Corporations or otherwise used by any of the Accelrys Corporations, including the Company Product Software. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Superior Offer.</B> &#147;Parent Superior Offer&#148; shall mean a bona fide written Parent Acquisition Proposal made by a third
party, that is determined by the Parent Board, in its good faith judgment, after consulting with a financial advisor of nationally recognized reputation and outside legal counsel, and after taking into account all legal, regulatory, financial and
other aspects of the proposal, including the likelihood and anticipated timing of consummation, to be more favorable from a financial point of view to Parent&#146;s stockholders than the Merger determined on a basis of long-term value; <I>provided,
however</I>, that for purposes of this definition of &#147;Parent Superior Offer,&#148; the defined term &#147;Parent Acquisition Proposal&#148; shall have the meaning assigned to such term herein, except that all references to &#147;15%&#148;
contained in the definition of &#147;Parent Acquisition Transaction&#148; when it is used in the definition of Parent Acquisition Proposal shall be deemed to be a reference to &#147;50%.&#148; </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Triggering Event.</B> A &#147;Parent Triggering Event&#148; shall be deemed to
have occurred if: (a)&nbsp;the Parent Board shall have failed to recommend that Parent&#146;s stockholders vote to approve the Parent Proposals, or shall have withdrawn or shall have modified in a manner adverse to the Company the Parent Board
Recommendation; (b)&nbsp;Parent shall have failed to include in the Joint Proxy Statement/Prospectus the Parent Board Recommendation or a statement to the effect that the Parent Board has determined and believes that the Parent Proposals are
advisable to, and in the best interests of, the Parent&#146;s stockholders; (c)&nbsp;the Parent Board fails to reaffirm the Parent Board Recommendation, or fails to reaffirm its determination that the Parent Proposals are in the best interests of
Parent&#146;s stockholders, within 10 business days after the Company requests in writing that such recommendation or determination be reaffirmed; (d)&nbsp;the Parent Board shall have approved, endorsed or recommended any Parent Acquisition
Proposal; (e)&nbsp;Parent shall have entered into any letter of intent or similar document or any Contract relating to any Parent Acquisition Proposal; (f)&nbsp;a tender or exchange offer relating to securities of Parent shall have been commenced
and Parent shall not have sent to its securityholders, within 10 business days after the commencement of such tender or exchange offer, a statement disclosing that Parent recommends rejection of such tender or exchange offer; (g)&nbsp;a Parent
Acquisition Proposal is publicly announced, and Parent fails to issue a press release announcing its opposition to such Parent Acquisition Proposal within 10 business days after such Parent Acquisition Proposal is announced; or (h)&nbsp;Parent shall
have breached in any material respect any material provision of Section&nbsp;4.4(b) or Section&nbsp;5.3 of the Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>Parent Unaudited Balance Sheet.</B> &#147;Parent Unaudited Balance Sheet&#148; shall mean the unaudited consolidated balance sheet of Parent and its consolidated Subsidiaries as of December&nbsp;31, 2009 included in Parent&#146;s
Quarterly Report on Form 10-Q for the quarter ended December&nbsp;31, 2009. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Parent Warrant. </B>&#147;Parent Warrant&#148;
shall mean each warrant to purchase shares of Parent Common Stock (or exercisable for cash). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Person.</B>
&#147;Person&#148; shall mean any individual, Entity or Governmental Body. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Registered IP.</B> &#147;Registered IP&#148;
shall mean all Intellectual Property Rights that are registered, filed or issued with, by or under the authority of any Governmental Body, including all patents, registered copyrights, registered mask works and registered trademarks and all
applications for any of the foregoing. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Release.</B> &#147;Release&#148; shall mean any spilling, leaking, emitting,
discharging, depositing, escaping, leaching, dumping or other releasing into the environment, whether intentional or unintentional. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>Representatives.</B> &#147;Representatives&#148; shall mean directors, officers, other employees, agents, attorneys, accountants, investment bankers, other advisors and representatives. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Sarbanes-Oxley Act.</B> &#147;Sarbanes-Oxley Act&#148; shall mean the Sarbanes-Oxley Act of 2002, as it may be amended from time to time.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SEC. </B>&#147;SEC&#148; shall mean the United States Securities and Exchange Commission. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Securities Act.</B> &#147;Securities Act&#148; shall mean the Securities Act of 1933, as amended. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Subsidiary.</B> An Entity shall be deemed to be a &#147;Subsidiary&#148; of another Person if such Person directly or indirectly owns or
purports to own, beneficially or of record: (a)&nbsp;an amount of voting securities of or other interests in such Entity that is sufficient to enable such Person to elect at least a majority of the members of such Entity&#146;s board of directors or
other governing body; or (b)&nbsp;at least 50% of the outstanding equity, voting or financial interests in such Entity. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>Symyx Corporations.</B> &#147;Symyx Corporations&#148; shall mean: (a)&nbsp;the Company; and (b)&nbsp;each of Company&#146;s Subsidiaries. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Tax. </B>&#147;Tax&#148; shall mean any federal, state, local, foreign or other tax
(including any income tax, franchise tax, capital gains tax, gross receipts tax, value-added tax, surtax, estimated tax, unemployment tax, national health insurance tax, excise tax, ad valorem tax, transfer tax, stamp tax, sales tax, use tax,
property tax, business tax, withholding tax or payroll tax), tariff, customs duty, and any charge, fine, penalty or interest related to a tax, imposed, assessed or collected by or under the authority of any Governmental Body. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Tax Return.</B> &#147;Tax Return&#148; shall mean any return (including any information return), report, statement, declaration,
estimate, schedule, notice, notification, form, election, certificate or other document or information, and any amendment or supplement to any of the foregoing, filed with or submitted to, or required to be filed with or submitted to, any
Governmental Body in connection with the determination, assessment, collection or payment of any Tax or in connection with the administration, implementation or enforcement of or compliance with any Legal Requirement relating to any Tax. </FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>EXHIBIT B </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>AMENDED AND RESTATED </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>CERTIFICATE OF INCORPORATION
</B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>OF </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>SYMYX TECHNOLOGIES, INC. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>I. </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The name of this corporation is <B>S<SMALL>YMYX</SMALL> T<SMALL>ECHNOLOGIES</SMALL>, I<SMALL>NC</SMALL>.</B> </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>II. </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The
address of the registered office of the corporation in the State of Delaware is 2711 Centerville Road, Suite 400, Wilmington, Delaware 19808, County of New Castle, and the name of the registered agent of the corporation in the State of Delaware at
such address is Corporation Service Company. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>III. </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The purpose of this corporation is to engage in any lawful act or activity for which a corporation may be organized under the Delaware
General Corporation Law (<B>&#147;DGCL&#148;</B>). </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>IV. </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">This corporation is authorized to issue only one class of stock, which shall be designated <B>&#147;Common Stock&#148;</B>. The total number
of shares of Common Stock presently authorized is One Thousand (1,000), each having a par value of one-tenth of one cent ($0.001). </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>V. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The management of the business and the conduct of the affairs of the corporation shall be vested in its
Board of Directors. The number of directors which shall constitute the whole Board of Directors shall be fixed by the Board of Directors in the manner provided in the Bylaws. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>VI. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A.</B>&nbsp;&nbsp;&nbsp;&nbsp;The liability
of the directors for monetary damages shall be eliminated to the fullest extent under applicable law. If the DGCL is amended to authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of a
director of the corporation shall be eliminated or limited to the fullest extent permitted by the DGCL, as so amended. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>B.</B>&nbsp;&nbsp;&nbsp;&nbsp;This corporation is authorized to provide indemnification of agents (as defined in Section&nbsp;317 of the California General Corporation Law (<B>&#147;CGCL&#148;</B>)) for breach of duty to the corporation
and its stockholders through bylaw provisions or through agreements with the agents, or through stockholder resolutions, or otherwise, in excess of the indemnification otherwise permitted by Section&nbsp;317 of the CGCL, subject, at any time or
times that the corporation is subject to Section&nbsp;2115(b) of the CGCL, to the limits on such excess indemnification set forth in Section&nbsp;204 of the CGCL. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT
SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>C.</B>&nbsp;&nbsp;&nbsp;&nbsp;Any repeal or modification of this Article&nbsp;VI shall be
prospective and shall not affect the rights under this Article&nbsp;VI in effect at the time of the alleged occurrence of any act or omission to act giving rise to liability or indemnification. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>VII. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The
corporation reserves the right to amend, alter, change or repeal any provision contained in this Certificate of Incorporation, in the manner now or hereafter prescribed by statute, and all rights conferred upon the stockholders herein are granted
subject to this reservation. The Board of Directors is expressly empowered to adopt, amend or repeal the Bylaws of the corporation. The stockholders shall also have power to adopt, amend or repeal the Bylaws of the corporation; <U>provided</U>,
<U>however</U>, that, in addition to any vote of the holders of any class or series of stock of the corporation required by law or by this Certificate of Incorporation, the affirmative vote of the holders of at least a majority of the voting power
of all of the then-outstanding shares of the capital stock of the corporation entitled to vote generally in the election of directors, voting together as a single class, shall be required to adopt, amend or repeal any provision of the Bylaws of the
corporation. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>EXHIBIT C </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>AMENDED AND RESTATED </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>BYLAWS </B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>OF </B></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SYMYX
TECHNOLOGIES, INC. </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>ARTICLE I </U></B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2">STOCKHOLDERS </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;1.&nbsp;Annual Meeting </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">An annual meeting of the stockholders, for the election of directors to succeed those whose terms expire and for the transaction of such
other business as may properly come before the meeting, shall be held at such place, on such date and at such time as the Board of Directors (the &#147;Board&#148;) shall fix each year. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;2.&nbsp;Special Meetings </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Special meetings of the stockholders
may be called at any time, either by the Board or by the Chairman of the Board.&nbsp;The Chairman of the Board shall call a special meeting of the stockholders whenever a request to do so is made in writing by stockholders representing a majority of
the shares of the Corporation. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;3.&nbsp;Notice of Meetings </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Written notice of all meetings of the stockholders shall be given, not less than ten (10)&nbsp;nor more than sixty (60)&nbsp;days before the
date on which the meeting is to be held, to each stockholder entitled to vote at such meeting.&nbsp;The notice shall state the place, date and hour of the meeting, and, in the case of a special meeting, the purpose for which the meeting is called.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Whenever any notice is required to be given to the stockholders, a waiver thereof, in writing, signed by the stockholder
entitled to such notice, whether signed before or after the time stated therein, shall be equivalent to the giving of the notice. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><U>Section&nbsp;4.&nbsp;Quorum </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">At any meeting of the stockholders, the holders of a majority of all of the stock
entitled to vote at the meeting, present in person or by proxy, shall constitute a quorum.</FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;5.&nbsp;Voting Procedure
</U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">If the object of a meeting is to elect directors or take a vote of the stockholders on any proposition, the Secretary
shall receive and canvass the votes given at such meeting and report the result of the meeting to the Chairman of the Board. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><U>Section&nbsp;6.&nbsp;Action by Consent </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Any action required by these Bylaws or by the applicable state law to
be taken at a meeting of the stockholders, or any action which may be taken at any annual or special meeting of the stockholders may be taken without a meeting without prior notice and without vote, if consents in writing setting forth the action so
taken, shall be signed by the holders of outstanding stock having not less than the minimum number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote thereon were present and voted;
and shall be filed with the minutes of meetings of stockholders. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>ARTICLE II </U></B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">BOARD OF DIRECTORS </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;1.&nbsp;Powers of the Directors </U>
</FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The directors shall have and take entire general charge and supervision of the business and affairs of the
Corporation.&nbsp;They may appoint one of their members as Chairman of the Board.&nbsp;They may also, by a resolution adopted by a majority of the Board, designate two or more directors to constitute an executive committee.&nbsp;The Chairman of the
Board shall be a member of the executive committee. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Board or the executive committee may appoint such officers and agents
as may be necessary in the judgment of the directors or the executive committee.&nbsp;Any officers or agents so appointed shall be removable with or without cause by the Board or by the executive committee.&nbsp;Any vacancy in any office may be
filled in the same manner.&nbsp;In the absence or disqualification of any member of the executive committee, the members of the committee present at the meeting and not disqualified from voting may by unanimous vote appoint another member of the
Board to act at the meeting in place of the absent or disqualified member. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Unless otherwise directed by the Board of
Directors, the Chairman of the Board, or such other officer or agent as the Chairman of the Board or Board of Directors may designate, shall have authority to vote and otherwise act on behalf of the Corporation, in person or by proxy, at any meeting
of stockholders, or with respect to any action of stockholders, of any other corporation in which this Corporation may hold securities, and otherwise to exercise any and all rights and powers that this Corporation may possess by reason of its
ownership of securities in any other corporation. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;2.&nbsp;Number, Election and Terms of Office </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The number of directors shall not be less than one (1)&nbsp;nor more than ten (10), as determined by a majority vote of the total number of
directors then serving in office.&nbsp;Each director shall continue in office for a term of one (1)&nbsp;year and until such person&#146;s successor has been elected and qualified. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">In the case of the death or the resignation of any director(s) of the Corporation, a majority of the surviving or remaining directors may
fill the vacancy (or vacancies) until a successor (or successors) is (are) elected at a stockholders&#146; meeting. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><U>Section&nbsp;3.&nbsp;Meetings of the Directors </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Regular meetings of the Board shall be held at such place or
places, on such date or dates and at such time or times as shall have been established by the Board.&nbsp;A notice of each such regular meeting shall not be required. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Special meetings of the Board may be called by the Chairman of the Board whenever such person may think proper.&nbsp;A special meeting shall be called when a written request is made by at least one-third
of the entire Board.&nbsp;Notice of the place, date and time of each such special meeting shall be given by mailing or telephoning such notice to each director at least twenty-four (24)&nbsp;hours before the time named for the meeting. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">A majority of the total number of directors shall constitute a quorum for any meeting of the Board.&nbsp;Any action required or
permitted, by these Bylaws or applicable state law, at any meeting of the Board of Directors or any committee thereof, may be taken without a meeting if all members of the Board or committee, as the case may be, consent thereto in writing, and
consents are filed with the minutes of proceedings of the Board or committee. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;4.&nbsp;Waiver of Notice </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Whenever any notice is required to be given to any director, a waiver thereof in writing, signed by the person entitled to such notice,
whether signed before or after the time stated in the notice, shall be equivalent to the giving of such notice. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attendance of
a director at a meeting, or execution by a director of a written consent in lieu thereof, shall constitute a waiver of notice of such meeting, except where the director attends the meeting for the express purpose of objecting to the transaction of
any business on the ground that the meeting is not lawfully called or convened. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;5.&nbsp;Committees of the Board
</U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Board, by a vote of a majority of the total number of directors, may, from time to time, designate committees of the
Board, with such lawfully delegable powers and duties as it thereby confers, to serve at the pleasure of the Board.&nbsp;Each committee may determine procedural rules for the conduct of its meetings and business, and shall act in accordance
therewith, unless otherwise provided by the Board of Directors in the resolution establishing the committee. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>ARTICLE III
</U></B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">OFFICERS </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><U>Section&nbsp;1.&nbsp;Generally </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The officers of the Corporation shall consist of a President, one or more Vice
Presidents, a Secretary, a Treasurer and such other officers as may, from time to time, be appointed by the Board.&nbsp;Officers shall be elected by the Board which shall consider that subject at its first meeting after every annual meeting of
stockholders.&nbsp;Each officer shall hold office until a successor is elected and qualified or until such officer&#146;s earlier resignation or removal.&nbsp;Any number of offices may be held by the same person. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;2.&nbsp;President </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">The President shall perform such duties as usually pertain to the office and as may be assigned by the Board of Directors of the Corporation. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><U>Section&nbsp;3.&nbsp;Vice President </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Each Vice President shall perform such duties as usually pertain to the
office to which appointed and such other duties as may from time to time be assigned.</FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;4.&nbsp;Secretary and Assistant
Secretaries </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Secretary shall issue all authorized notices for, and shall keep minutes of, all meetings of the
stockholders and the Board.&nbsp;The Secretary shall have general charge over the corporate books. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Each Assistant Secretary
shall perform such duties of the Secretary as may from time to time be assigned. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;5. Treasurer </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Treasurer shall have the custody of all monies and securities of the Corporation and shall keep regular books of account. The Treasurer
shall make such disbursements of the funds of the Corporation as are proper and shall render, from time to time, an account of all such transactions and of the financial condition of the Corporation. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Assistant Treasurer shall perform such duties of the Treasurer as may from time to time be assigned. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;6.&nbsp;Delegation of Authority </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">The Board may, from time to time, assign or delegate the powers or duties of any officer to any other officers or agents of the Corporation, notwithstanding any provision hereof. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>ARTICLE IV </U></B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman"
SIZE="2">MISCELLANEOUS </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;1.&nbsp;Indemnification of Directors, Officers and Employees </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Corporation shall indemnify any person who was or is a party or is threatened to be made a party to any action, suit or proceeding,
whether civil, criminal, administrative or investigative (including any action or suit by or in the right of the corporation) by reason of the fact that such person is or was a director, officer, employee or agent of the corporation, or, while such
person is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, against expenses (including attorneys&#146; fees), judgments, fines
and amounts paid in settlement actually and reasonably incurred by such person in connection with such action, suit or proceeding, but in each case only if and to the extent permitted under applicable state or federal law. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The indemnification provided herein shall not be deemed exclusive of any other rights to which those indemnified may be entitled, and shall
continue as to a person who has ceased to be a director, officer, employee or agent and shall inure to the benefit of the heirs and personal representatives of such a person. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;2.&nbsp;Certificates of Stock </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Certificates of stock in the
Corporation shall be issued by the Treasurer in the name of the stockholder and shall be signed on behalf of the Corporation by the Chairman of the Board of Directors, or the President or Vice President and by the Treasurer or an Assistant Treasurer
or the Secretary or an Assistant Secretary.&nbsp;Any or all of the signatures on the certificates may be facsimile. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><U>Section&nbsp;3.&nbsp;Facsimile Signatures </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">In addition to the provision for the use of facsimile signatures on
stock certificates as provided in Section&nbsp;2 of Article IV, facsimile signatures of any officer or officers of the Corporation may be used whenever and as authorized by the Board of Directors. </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;4.&nbsp;Fiscal Year </U></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">The fiscal year of the Corporation shall be identical with the calendar year. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>Section&nbsp;5.&nbsp;Seal </U></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Board may provide a suitable seal containing the name of the Corporation, which seal shall be in the charge of the Secretary. </FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>ARTICLE V </U></B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">AMENDMENTS </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">These Bylaws may be amended or repealed by the
Board or by the stockholders. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">C-5 </FONT></P>

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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.1
<SEQUENCE>3
<FILENAME>dex41.htm
<DESCRIPTION>FIRST AMENDMENT TO RIGHTS AGREEMENT
<TEXT>
<HTML><HEAD>
<TITLE>First Amendment to Rights Agreement</TITLE>
</HEAD>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 4.1 </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>FIRST AMENDMENT TO RIGHTS AGREEMENT </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">This
<B>F<SMALL>IRST</SMALL> A<SMALL>MENDMENT</SMALL> <SMALL>TO</SMALL> R<SMALL>IGHTS</SMALL> A<SMALL>GREEMENT</SMALL></B><SMALL></SMALL> (this &#147;<U>Amendment</U>&#148;), dated as of April&nbsp;5, 2010, is made and entered into by and between
<B>A<SMALL>CCELRYS</SMALL>, I<SMALL>NC</SMALL>. </B>(formerly Pharmacopeia, Inc.), a Delaware corporation (the &#147;<U>Company</U>&#148;), and <B>A<SMALL>MERICAN</SMALL> S<SMALL>TOCK</SMALL> T<SMALL>RANSFER</SMALL>&nbsp;&amp; T<SMALL>RUST</SMALL>
C<SMALL>O</SMALL>.</B>, as rights agent (the &#147;<U>Rights Agent</U>&#148;).&nbsp;Capitalized terms not otherwise defined in this Amendment shall have the meaning ascribed to such terms in the Rights Agreement (as defined below).</FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>W<SMALL>HEREAS</SMALL></B><SMALL></SMALL>, the Company and the Rights Agent previously entered into that certain Rights Agreement, dated
as of September&nbsp;6, 2002 (the &#147;<U>Rights Agreement</U>&#148;); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>W<SMALL>HEREAS</SMALL></B><SMALL></SMALL>, the
Company proposes to enter into an Agreement and Plan of Merger and Reorganization (as it may be amended from time to time, the &#147;<U>Merger Agreement</U>&#148;) with Alto Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of
the Company (&#147;<U>Merger Sub</U>&#148;), and Symyx Technologies, Inc., a Delaware corporation (&#147;<U>Symyx</U>&#148;), pursuant to which Merger Sub will merge with and into Symyx, the separate corporate existence of Merger Sub will cease and
Symyx will survive as a wholly-owned subsidiary of the Company (the &#147;<U>Merger</U>&#148;); </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>W<SMALL>HEREAS</SMALL></B><SMALL></SMALL>, the Board of Directors of the Company has determined that, in connection with the execution of the Merger Agreement, it is necessary and desirable to amend the Rights Agreement to exempt, among
other things, the Merger Agreement, the execution thereof and the transactions contemplated thereby, including, without limitation, the Merger, from the application of the Rights Agreement, in each case as set forth in this Amendment; and
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>W<SMALL>HEREAS</SMALL></B><SMALL></SMALL>, (i)&nbsp;Section&nbsp;27 of the Rights Agreement provides that, prior to the
occurrence of a Distribution Date or Triggering Event, the Company may, without the approval of any holders of certificates representing shares of Common Stock and associated Rights, supplement or amend any provision of the Rights Agreement;
(ii)&nbsp;pursuant to the terms of the Rights Agreement and in accordance with Section&nbsp;27 thereof, the Company has directed that the Rights Agreement should be amended and supplemented as set forth in this Amendment prior to the execution of
the Merger Agreement; and (iii)&nbsp;pursuant to Section&nbsp;27 of the Rights Agreement, an appropriate officer of the Company is hereby delivering a certificate to the Rights Agent stating that this Amendment complies with the terms of
Section&nbsp;27 of the Rights Agreement and does not change or increase the Rights Agent&#146;s duties, liabilities, rights or obligations under Rights Agreement. </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>N<SMALL>OW</SMALL>, T<SMALL>HEREFORE</SMALL></B><SMALL></SMALL>, in consideration of the
premises and the mutual agreements herein set forth, the parties hereby agree as follows: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">1. <U>Amendments to Rights
Agreement</U>. </FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">(a)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">The definition of &#147;Acquiring Person&#148; in Section&nbsp;1(a) of the Rights Agreement is amended by inserting the following as a new paragraph at the end of such
definition: </FONT></TD></TR></TABLE> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">&#147;Notwithstanding anything in this Section&nbsp;1(a) to the contrary, neither Symyx
Technologies, Inc., a Delaware corporation (&#147;Symyx&#148;), nor any of its stockholders, nor any of their respective Affiliates or Associates, either individually or in any combination, shall be deemed to be or become an &#147;Acquiring
Person&#148; by virtue of, or as a result of (i)&nbsp;the approval, execution, delivery or performance of the Agreement and Plan of Merger and Reorganization, dated April&nbsp;5, 2010, by and among the Company, Alto Merger Sub, Inc., a Delaware
corporation and a wholly-owned subsidiary of the Company (&#147;Merger Sub&#148;), and Symyx (the &#147;Merger Agreement&#148;), (ii)&nbsp;the execution and delivery of the Company Stockholder Voting Agreements (as defined in the Merger Agreement)
by and between the Company and certain stockholders of Symyx, or (iii)&nbsp;the performance or consummation of any of the other Contemplated Transactions (as defined in the Merger Agreement), including without limitation, the Merger (the foregoing
actions being referred to as the &#147;Permitted Events&#148;).&#148; </FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">(b)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">The definition of &#147;Stock Acquisition Date&#148; in Section&nbsp;1(hh) of the Rights Agreement is amended to add the following sentence at the end thereof:
</FONT></TD></TR></TABLE> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">&#147;Notwithstanding anything in this Agreement to the contrary, a Stock Acquisition Date shall not be deemed
to have occurred by virtue of, or as a result of, any Permitted Event or the public announcement thereof.&#148; </FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">(c)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Section&nbsp;3(a) of the Rights Agreement is amended to add the following sentence at the end thereof: </FONT></TD></TR></TABLE> <P
STYLE="margin-top:6px;margin-bottom:0px; margin-left:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">&#147;Notwithstanding anything in this Agreement to the contrary, a Distribution Date shall not be deemed to have occurred, and no separate
Rights Certificate will be issued or issuable, by virtue of, or as the result of, any Permitted Event.&#148; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">2.
<U>Officer&#146;s Certificate</U>. By executing this Amendment below, the undersigned duly appointed officer of the Company certifies that this Amendment has been executed and delivered in compliance with the terms of Section&nbsp;27 of the Rights
Agreement and does not change or increase the Rights Agent&#146;s duties, liabilities, rights or obligations under the Rights Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">3. <U>Interpretation</U>.&nbsp;The term &#147;Agreement&#148; as used in the Rights Agreement shall be deemed to refer to the Rights Agreement as amended hereby. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">4. <U>Severability</U>. If any term, provision, covenant or restriction of this Amendment is held by a court of competent jurisdiction or
other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment, and of the Rights Agreement, shall remain in full force and effect and shall in no way be affected, impaired
or invalidated. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">5. <U>Waiver of Notice</U>.<I>&nbsp;</I>The Rights Agent and the Company hereby waive any notice requirement
under the Rights Agreement pertaining to the matters covered by this Amendment. </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">6. <U>Effectiveness</U>.&nbsp;This Amendment shall be deemed effective as of the date first
written above.&nbsp;Except as expressly amended herein, all other terms and conditions of the Rights Agreement shall remain in full force and effect.&nbsp;Without limiting the foregoing, the Rights Agent shall not be subject to, nor required to
interpret or comply with, or determine if any Person has complied with, the Merger Agreement even though reference thereto may be made in this Amendment and the Rights Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">7. <U>Termination</U>. Notwithstanding anything to the contrary set forth herein, this Amendment shall terminate and be of no further force
or effect in the event of the termination of the Merger Agreement for any reason. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">8. <U>Governing Law</U>. This Amendment
shall be deemed a contract made under the laws of the State of Delaware, and for all purposes of this Amendment shall be governed by and construed in accordance with the laws of such State applicable to contracts made and to be performed entirely
within such State. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">9. <U>Counterparts</U>.&nbsp;This Amendment may be executed in any number of counterparts (including by
facsimile), each of which shall be an original and all of which shall constitute one and the same document. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">[REMAINDER OF PAGE
INTENTIONALLY LEFT BLANK] </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>I<SMALL>N</SMALL> W<SMALL>ITNESS</SMALL> W<SMALL>HEREOF</SMALL></B><SMALL></SMALL>, the
parties have caused this Amendment to be duly executed as of the day and year first written above. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
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<TD VALIGN="bottom" WIDTH="1%"></TD>
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<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2">ACCELRYS, INC.</FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ David R. Mersten</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">David R. Mersten</FONT></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Senior Vice President,</FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px"><FONT STYLE="font-family:Times New Roman"
SIZE="2">General Counsel and Secretary</FONT></P></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">AMERICAN STOCK TRANSFER &amp; TRUST CO.,</FONT></P> <P STYLE="margin-top:0px;margin-bottom:1px"><FONT
STYLE="font-family:Times New Roman" SIZE="2">as Rights Agent</FONT></P></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Paula Caroppoli</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Paula Caroppoli</FONT></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Vice President</FONT></TD></TR></TABLE></DIV>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>4
<FILENAME>dex101.htm
<DESCRIPTION>FORM OF VOTING AGREEMENT
<TEXT>
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<TITLE>Form of Voting Agreement</TITLE>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 10.1 </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>VOTING AGREEMENT </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>T<SMALL>HIS</SMALL>
V<SMALL>OTING</SMALL> A<SMALL>GREEMENT</SMALL> (</B>&#147;<U>Voting Agreement</U>&#148;) is entered into as of April&nbsp;5, 2010, by and between <B>A<SMALL>CCELRYS</SMALL>, I<SMALL>NC</SMALL>.</B>, a Delaware corporation
(&#147;<U>Parent</U>&#148;), and <U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U> (&#147;<U>Stockholder</U>&#148;). </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>R<SMALL>ECITALS</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A. </B>Stockholder is a holder of record and
the &#147;beneficial owner&#148; (within the meaning of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the &#147;<U>Exchange Act</U>&#148;)) of certain shares of common stock of Symyx Technologies, Inc., a Delaware corporation
(the &#147;<U>Company</U>&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>B. </B>Parent, Alto Merger Sub, Inc., a Delaware corporation (&#147;<U>Merger
Sub</U>&#148;), and the Company are entering into an Agreement and Plan of Merger and Reorganization of even date herewith (the &#147;<U>Merger Agreement</U>&#148;), which provides (subject to the conditions set forth therein) for the merger of
Merger Sub into the Company (the &#147;<U>Merger</U>&#148;). Capitalized terms used but not otherwise defined in this Voting Agreement have the meanings assigned to such terms in the Merger Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>C. </B>In the Merger, each outstanding share of common stock of the Company is to be converted into the right to receive 0.7802 shares of
Parent Common Stock. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>D. </B>Stockholder is entering into this Voting Agreement in order to induce Parent to enter into the
Merger Agreement and cause the Merger to be consummated. </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A<SMALL>GREEMENT</SMALL> </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The parties to this Voting Agreement, intending to be legally bound, agree as follows: </FONT></P> <P
STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SECTION 1. C<SMALL>ERTAIN</SMALL> D<SMALL>EFINITIONS</SMALL> </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">For purposes of this Voting Agreement: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>&#147;<U>Expiration
Date</U>&#148; shall mean the earlier of: (i)&nbsp;the date on which the Merger Agreement is terminated pursuant to Section&nbsp;8 thereof; (ii)&nbsp;the date upon which the Merger becomes effective; or (iii)&nbsp;such date and time as any amendment
or change to the Merger Agreement is effected without the Stockholder&#146;s consent that (A)&nbsp;decreases the Exchange Ratio or (B)&nbsp;materially and adversely affects the Stockholder. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Stockholder shall be deemed to &#147;<U>Own</U>&#148; or to have acquired &#147;<U>Ownership</U>&#148; of a security if
Stockholder: (i)&nbsp;is the record owner of such security; or (ii)&nbsp;is the &#147;beneficial owner&#148; (within the meaning of Rule 13d-3 under the Exchange Act) of such security. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>&#147;<U>Subject Securities</U>&#148; shall mean: (i)&nbsp;all securities of the Company (including all shares of Company Common
Stock and all options, restricted stock units, warrants and other rights to acquire shares of Company Common Stock) Owned by Stockholder as of the date of this Voting Agreement; and (ii)&nbsp;all additional securities of the Company (including all
additional shares of Company Common Stock and all additional options, restricted stock units, warrants and other rights to acquire shares of Company Common Stock) of which Stockholder acquires Ownership during the Voting Period (whether such
acquisition is a result of purchases or other transfers of Company Common Stock to Stockholder or by virtue of a stock dividend, stock split, recapitalization, reclassification, subdivision, combination or exchange of shares). </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>A Person shall be deemed to have effected a &#147;<U>Transfer</U>&#148; of a
security if such Person directly or indirectly: (i)&nbsp;sells, pledges, encumbers, grants an option with respect to, transfers or disposes of such security or any interest in such security to any Person other than Parent; (ii)&nbsp;enters into an
agreement or commitment contemplating the possible sale of, pledge of, encumbrance of, grant of an option with respect to, transfer of or disposition of such security or any interest therein to any Person other than Parent; or (iii)&nbsp;reduces
such Person&#146;s beneficial ownership of, interest in or risk relating to such security. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) </B>&#147;<U>Voting
Period</U>&#148; shall mean the period commencing on the date of this Voting Agreement and ending on the Expiration Date. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SECTION 2.
T<SMALL>RANSFER</SMALL> <SMALL>OF</SMALL> S<SMALL>UBJECT</SMALL> S<SMALL>ECURITIES</SMALL> <SMALL>AND</SMALL> V<SMALL>OTING</SMALL> R<SMALL>IGHTS</SMALL> </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>2.1 Restriction on Transfer of Subject Securities</B>.<B> </B>Subject to Section&nbsp;2.3, during the Voting Period, Stockholder shall not, directly or indirectly, cause or permit any Transfer of any
of the Subject Securities to be effected; <I>provided</I>, <I>however</I>, that nothing contained in this Voting Agreement will be deemed to restrict the ability of Stockholder to exercise any Company Equity Awards held by Stockholder prior to the
Expiration Date. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.2 Restriction on Transfer of Voting Rights</B>. During the Voting Period, Stockholder shall ensure
that: (a)&nbsp;none of the Subject Securities is deposited into a voting trust; and (b)&nbsp;no proxy is granted inconsistent with this Voting Agreement, and no voting agreement or similar agreement is entered into, with respect to any of the
Subject Securities. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2.3 Permitted Transfers</B>. Section&nbsp;2.1 shall not prohibit a Transfer of Subject Securities by
Stockholder: (a)&nbsp;if Stockholder is an individual: (i)&nbsp;to any member of Stockholder&#146;s immediate family; or to a trust for the benefit of Stockholder or any member of Stockholder&#146;s immediate family; or (ii)&nbsp;upon the death of
Stockholder; or (b)&nbsp;if Stockholder is a partnership or limited liability company, to one or more partners or members of Stockholder or to an affiliated corporation under common control with Stockholder; <I>provided, however,</I> that a Transfer
referred to in this Section&nbsp;2.3 shall be permitted only if, as a precondition to such Transfer, the transferee agrees in a writing, reasonably satisfactory in form and substance to Parent, to be bound by all of the terms of this Voting
Agreement. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SECTION 3. V<SMALL>OTING</SMALL> <SMALL>OF</SMALL> S<SMALL>HARES</SMALL> </B></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.1 Voting Covenant</B>.<B> </B>Stockholder hereby agrees that, prior to the Expiration Date, at any meeting of the stockholders of the
Company, however called, or at any adjournment or postponement thereof and on every action or approval by written consent of the stockholders of the Company, unless otherwise directed in writing by Parent, Stockholder shall cause any issued and
outstanding shares of Company Common Stock Owned by Stockholder as of the record date with respect to such meeting to be voted: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman"
SIZE="2"><B>(a) </B>in favor of the adoption of the Merger Agreement; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>against any Company Acquisition Proposal;
and </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>against any other action, agreement, proposal or transaction involving any of the Symyx Corporations which
other action, agreement, proposal or transaction would compete with, interfere with, impede, frustrate, prevent, burden or nullify the Merger or the Merger Agreement. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT
SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Prior to the Expiration Date, Stockholder shall not enter into any agreement or understanding with any
Person to vote or give instructions in any manner inconsistent with clause &#147;(a),&#148; clause &#147;(b)&#148; or clause &#147;(c)&#148; of the preceding sentence. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>3.2 P<SMALL>ROXY</SMALL></B><SMALL></SMALL> </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>Contemporaneously with
the execution of this Voting Agreement: (i)&nbsp;Stockholder shall deliver to Parent a proxy in the form attached to this Voting Agreement as <B>Exhibit A</B>, which shall be irrevocable to the fullest extent permitted by law (at all times during
the Voting Period) with respect to the shares referred to therein (the &#147;<U>Proxy</U>&#148;); and (ii)&nbsp;if applicable, Stockholder shall cause to be delivered to Parent an additional proxy (in the form attached hereto as <B>Exhibit A</B>)
executed on behalf of the record owner of any outstanding shares of Company Common Stock that are owned beneficially (within the meaning of Rule 13d-3 under the Exchange Act), but not of record by Stockholder. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>Stockholder shall not enter into any tender, voting or other agreement, or grant a proxy or power of attorney, with respect to
the Subject Securities that is inconsistent with this Voting Agreement or otherwise take any other action with respect to the Subject Securities that would in any way restrict, limit or interfere with the performance of Stockholder&#146;s
obligations hereunder or the transactions contemplated hereby. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SECTION 4. A<SMALL>DDITIONAL</SMALL> C<SMALL>OVENANTS</SMALL>
<SMALL>OF</SMALL> S<SMALL>TOCKHOLDER</SMALL> </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.1 No Solicitation.</B> Stockholder agrees that, during the Voting
Period, Stockholder shall not (without limiting any of the other restrictions in this Voting Agreement), directly or indirectly, take or authorize to be taken any action that the Company is prohibited from taking or authorizing to be taken pursuant
to Section&nbsp;4.4 of the Merger Agreement </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4.2 Notice of Certain Events.</B> Stockholder agrees to promptly notify Parent
of any development occurring after the date hereof that causes any breach of any of the representations and warranties of Stockholder set forth in Section&nbsp;5 herein. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>SECTION 5. R<SMALL>EPRESENTATIONS</SMALL> <SMALL>AND</SMALL> W<SMALL>ARRANTIES</SMALL> <SMALL>OF</SMALL> S<SMALL>TOCKHOLDER</SMALL> </B></FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Stockholder hereby represents and warrants to Parent as follows: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.1 Authorization, etc</B>.<B> </B>Stockholder has the power, authority and capacity to execute and deliver this Voting Agreement and the
Proxy and to perform Stockholder&#146;s obligations hereunder and thereunder. This Voting Agreement and the Proxy have been duly executed and delivered by Stockholder and, assuming the due authorization, execution and delivery of this Voting
Agreement by Parent, constitute legal, valid and binding obligations of Stockholder, enforceable against Stockholder in accordance with their terms, subject to: (a)&nbsp;laws of general application relating to bankruptcy, insolvency and the relief
of debtors; and (b)&nbsp;rules of law governing specific performance, injunctive relief and other equitable remedies. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.2
No Conflicts or Consents. </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>The execution and delivery of this Voting Agreement and the Proxy by Stockholder do
not, and the performance of this Voting Agreement and the Proxy by Stockholder will not: (i)&nbsp;conflict with or violate any Legal Requirement or Order applicable to Stockholder or by which Stockholder or any of Stockholder&#146;s properties is or
may be bound or affected; or (ii)&nbsp;result in or
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3 </FONT></P>


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constitute (with or without notice or lapse of time) any breach of or default under, or give to any other Person (with or without notice or lapse of time) any right of termination, amendment,
acceleration or cancellation of, or result (with or without notice or lapse of time) in the creation of any Encumbrance on any of the Subject Securities. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The execution and delivery of this Voting Agreement and the Proxy by Stockholder do not, and the performance of this Voting Agreement and the Proxy by Stockholder will not, require any Consent
of any Person. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.3 Title to Securities</B>. As of the date of this Voting Agreement: (a)&nbsp;Stockholder holds of record
(free and clear of any Encumbrances) the number of outstanding shares of Company Common Stock set forth under the heading &#147;Shares Held of Record&#148; on the signature page hereof; (b)&nbsp;Stockholder holds (free and clear of any Encumbrances)
the options, restricted stock units, warrants and other rights to acquire shares of Company Common Stock set forth under the heading &#147;Options and Other Rights&#148; on the signature page hereof; (c)&nbsp;Stockholder Owns the additional
securities of the Company set forth under the heading &#147;Additional Securities Beneficially Owned&#148; on the signature page hereof; and (d)&nbsp;Stockholder does not directly or indirectly Own any shares of capital stock or other securities of
the Company, or any option, restricted stock unit, warrant or other right to acquire (by purchase, conversion or otherwise) any shares of capital stock or other securities of the Company, other than the shares and options, restricted stock units,
warrants and other rights set forth on the signature page hereof. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5.4 Accuracy of Representations</B>. The representations
and warranties contained in this Voting Agreement are accurate in all respects as of the date of this Voting Agreement, and will be accurate in all respects at all times prior to the Expiration Date as if made as of any such time or date.
</FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SECTION 6. M<SMALL>ISCELLANEOUS</SMALL> </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.1 Stockholder Information</B>. Stockholder hereby agrees to permit Parent, the Company and Merger Sub to publish and disclose in the Form S-4 Registration Statement, the Joint Proxy
Statement/Prospectus and any other public disclosure that Parent and the Company mutually determine to be necessary or desirable in connection with the Merger and any other transactions contemplated by the Merger Agreement Stockholder&#146;s
identity and ownership of shares of Company Common Stock and the nature of Stockholder&#146;s commitments, arrangements and understandings under this Voting Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.2 Further Assurances</B>. From time to time and without additional consideration, Stockholder shall execute and deliver, or cause to be executed and delivered, such additional transfers, assignments,
endorsements, proxies, consents and other instruments, and shall take such further actions, as Parent may reasonably request for the purpose of carrying out and furthering the intent of this Voting Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.3 Expenses</B>. All costs and expenses incurred in connection with the transactions contemplated by this Voting Agreement shall be paid
by the party incurring such costs and expenses. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.4 Notices</B>. Any notice or other communication under this Voting
Agreement shall be in writing and shall be deemed to have been duly given or made as follows: (a)&nbsp;if sent by registered or certified mail in the United States return receipt requested, upon receipt; (b)&nbsp;if sent by nationally recognized
overnight air courier (such as Federal Express), one business day after mailing; (c)&nbsp;if sent by facsimile transmission before 5:00 p.m., when transmitted and receipt is confirmed; (d)&nbsp;if sent by facsimile transmission after 5:00 p.m. and
receipt is confirmed, on the following business day; and (e)&nbsp;if otherwise actually personally delivered, when delivered, provided that such notices, requests, demands and other communications are delivered to the address set forth below, or to
such other address as any party shall provide by like notice to the other parties to this Voting Agreement: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">if to
Stockholder: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">at the address set forth on the signature page hereof; and </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">4 </FONT></P>


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<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">if to Parent: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accelrys, Inc. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman"
SIZE="2">10188 Telesis Court, Suite 100 </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">San Diego, CA 92121 </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attention: David R. Mersten, Esq. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Facsimile: (858)&nbsp;799-5107 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">with a copy to: </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Paul, Hastings, Janofsky&nbsp;&amp; Walker LLP </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">4747 Executive Drive, Ste 1200 </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">San Diego, CA 92121 </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Attention: Carl R. Sanchez </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:13%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">Facsimile: (858)&nbsp;458-3130 </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.5 Severability</B>. Any term or provision of
this Voting Agreement that is invalid or unenforceable in any situation in any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this Voting Agreement or the validity or enforceability of the
offending term or provision in any other situation or in any other jurisdiction. Upon such determination that any term or provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this
Voting Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the fullest extent possible. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.6 Entire Agreement</B>. This Voting Agreement, the Proxy, the Merger Agreement and any other documents delivered by the parties in
connection herewith constitute the entire agreement between the parties with respect to the subject matter hereof and thereof and supersede all prior agreements and understandings between the parties with respect thereto. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.7 Amendments</B>. This Voting Agreement may not be amended, modified, altered or supplemented other than by means of a written
instrument duly executed and delivered on behalf of Parent and Stockholder. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.8 Assignment; Binding Effect; No Third Party
Rights</B>. Except as provided herein, neither this Voting Agreement nor any of the interests or obligations hereunder may be assigned or delegated by Stockholder, and any attempted or purported assignment or delegation of any of such interests or
obligations shall be void. Subject to the preceding sentence, this Voting Agreement shall be binding upon Stockholder and Stockholder&#146;s heirs, estate, executors and personal representatives and Stockholder&#146;s successors and assigns, and
shall inure to the benefit of Parent and its successors and assigns. Without limiting any of the restrictions set forth in Section&nbsp;2, Section&nbsp;3 or elsewhere in this Voting Agreement, this Voting Agreement shall be binding upon any Person
to whom any Subject Securities are transferred. Nothing in this Voting Agreement is intended to confer on any Person (other than Parent and its successors and assigns) any rights or remedies of any nature. </FONT></P> <P
STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5 </FONT></P>


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<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.9 Specific Performance</B>.<B> </B>The parties agree that irreparable damage would
occur in the event that any of the provisions of this Voting Agreement or the Proxy were not performed in accordance with its specific terms or were otherwise breached. Stockholder agrees that, in the event of any breach or threatened breach by
Stockholder of any covenant or obligation contained in this Voting Agreement or in the Proxy, Parent shall be entitled (in addition to any other remedy that may be available to it, including monetary damages) to obtain: (a)&nbsp;a decree or order of
specific performance to enforce the observance and performance of such covenant or obligation; and (b)&nbsp;an injunction restraining such breach or threatened breach. Stockholder further agrees that neither Parent nor any other Person shall be
required to obtain, furnish or post any bond or similar instrument in connection with or as a condition to obtaining any remedy referred to in this Section&nbsp;6.9, and Stockholder irrevocably waives any right he or it may have to require the
obtaining, furnishing or posting of any such bond or similar instrument. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.10 Attorneys&#146; Fees</B>. If any Legal
Proceeding relating to this Voting Agreement or the enforcement of any provision of this Voting Agreement is brought against Stockholder, the prevailing party shall be entitled to recover reasonable attorneys&#146; fees, costs and disbursements (in
addition to any other relief to which the prevailing party may be entitled). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.11 Non-Exclusivity</B>. The rights and
remedies of Parent under this Voting Agreement are not exclusive of or limited by any other rights or remedies which it may have, whether at law, in equity, by contract or otherwise, all of which shall be cumulative (and not alternative).
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.12 Governing Law; Jurisdiction; Waiver of Jury Trial</B>. This Voting Agreement and the Proxy shall be governed by, and
construed in accordance with, the laws of the State of Delaware, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws thereof. In any action between any of the parties arising out of or relating to this
Voting Agreement, the Proxy or any of the transactions contemplated by this Voting Agreement or the Proxy, each of the parties: (a)&nbsp;irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Chancery
Court of the State of Delaware; (b)&nbsp;irrevocably waives the right to trial by jury; and (c)&nbsp;irrevocably consents to service of process by first class certified mail, return receipt requested, postage prepaid, to the address at which
Stockholder or Parent, as the case may be, is to receive notice in accordance with Section&nbsp;6.4. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.13 Counterparts;
Exchanges by Facsimile or Electronic Delivery</B>.<B> </B>This Voting Agreement may be executed in separate counterparts, each of which when so executed and delivered shall be an original, but all such counterparts shall together constitute one and
the same instrument. The exchange of a fully executed Voting Agreement (in counterparts or otherwise) by facsimile or electronic delivery shall be sufficient to bind the parties to the terms and conditions of this Voting Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.14 Captions</B>. The captions contained in this Voting Agreement are for convenience of reference only, shall not be deemed to be a
part of this Voting Agreement and shall not be referred to in connection with the construction or interpretation of this Voting Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B>6.15 Waiver</B>. Subject to the remainder of this Section&nbsp;6.15, at any time prior to the Expiration Date, any party hereto may: (a)&nbsp;extend the time for the performance of any of the
obligations or other acts of the other parties to this Voting Agreement; (b)&nbsp;waive any inaccuracy in or breach of any representation, warranty, covenant or obligation of the other party in this Voting Agreement or in any document delivered
pursuant to this Voting Agreement; and (c)&nbsp;waive compliance with any covenant, obligation or condition for the benefit of such party contained in this Voting Agreement. No failure on the part of Parent to exercise any power, right, privilege or
remedy under this Voting Agreement, and no delay on the part of Parent in exercising any power, right, privilege or remedy under this Voting Agreement, shall
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6 </FONT></P>


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<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise of any such power, right, privilege or remedy shall preclude any other or further exercise thereof
or of any other power, right, privilege or remedy. Parent shall not be deemed to have waived any claim available to Parent arising out of this Voting Agreement, or any power, right, privilege or remedy of Parent under this Voting Agreement, unless
the waiver of such claim, power, right, privilege or remedy is expressly set forth in a written instrument duly executed and delivered on behalf of Parent; and any such waiver shall not be applicable or have any effect except in the specific
instance in which it is given. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.16 Independence of Obligations</B>.<B> </B>The covenants and obligations of Stockholder
set forth in this Voting Agreement shall be construed as independent of any other Contract between Stockholder, on the one hand, and the Company or Parent, on the other. The existence of any claim or cause of action by Stockholder against the
Company or Parent shall not constitute a defense to the enforcement of any of such covenants or obligations against Stockholder. Nothing in this Voting Agreement shall limit any of the rights or remedies of Parent under the Merger Agreement, or any
of the rights or remedies of Parent or any of the obligations of Stockholder under any agreement between Stockholder and Parent or any certificate or instrument executed by Stockholder in favor of Parent; and nothing in the Merger Agreement or in
any other such agreement, certificate or instrument, shall limit any of the rights or remedies of Parent or any of the obligations of Stockholder under this Voting Agreement. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.17 Other Capacities</B>.<B></B> Notwithstanding any provision of this Voting Agreement to the contrary, nothing in this Voting
Agreement shall limit or restrict Stockholder from acting in good faith in Stockholder&#146;s capacity as a director or officer of the Company (it being understood that this Voting Agreement shall apply to Stockholder solely in Stockholder&#146;s
capacity as a stockholder of the Company). </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.18 Construction</B>.<B></B> </FONT></P> <P
STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) </B>For purposes of this Voting Agreement, whenever the context requires: the singular number shall include the plural, and vice
versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include masculine and feminine genders. </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) </B>The parties agree that any rule of construction to the effect that ambiguities are to be resolved against the drafting party
shall not be applied in the construction or interpretation of this Voting Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) </B>As used in this Voting
Agreement, the words &#147;include&#148; and &#147;including,&#148; and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words &#147;without limitation.&#148; </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) </B>Except as otherwise indicated, all references in this Voting Agreement to &#147;Sections&#148; and &#147;Exhibits&#148; are
intended to refer to Sections of this Voting Agreement and Exhibits to this Voting Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><I>[Remainder of page
intentionally left blank.] </I></FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>I<SMALL>N</SMALL> W<SMALL>ITNESS</SMALL> W<SMALL>HEREOF</SMALL>, </B>Parent and
Stockholder have caused this Voting Agreement to be executed as of the date first written above. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0">

<TR>
<TD WIDTH="19%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="80%"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>A<SMALL>CCELRYS</SMALL>, I<SMALL>NC</SMALL>.</B></FONT></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&nbsp;</B></FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Title</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>S<SMALL>TOCKHOLDER</SMALL></B></FONT></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>&nbsp;</B></FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Signature</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;</FONT></P></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2">Printed Name</FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Address:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;</FONT></P></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Facsimile:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">&nbsp;</FONT></P></TD></TR></TABLE></DIV> <P
STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TR>
<TD WIDTH="34%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD></TR>
<TR>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="border-bottom:1px solid #000000"> <P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Shares Held of Record</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1px solid #000000"> <P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Options and Other Rights</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1px solid #000000"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Additional Securities</B></FONT></P> <P
STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Beneficially Owned</B></FONT></P></TD></TR></TABLE>

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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>E<SMALL>XHIBIT</SMALL> A </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"
ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>F<SMALL>ORM</SMALL> <SMALL>OF</SMALL> I<SMALL>RREVOCABLE</SMALL> P<SMALL>ROXY</SMALL> </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2"><B><I>Proxy </I></B></FONT></P>

<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>I<SMALL>RREVOCABLE</SMALL> P<SMALL>ROXY</SMALL> </B></FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The undersigned stockholder (the &#147;<U>Stockholder</U>&#148;) of Symyx Technologies, Inc. a Delaware corporation (the
&#147;<U>Company</U>&#148;), hereby irrevocably (to the fullest extent permitted by law) appoints and constitutes Accelrys, Inc., a Delaware corporation (&#147;<U>Parent</U>&#148;), and Max Carnecchia and Michael A. Piraino, solely in their
capacities as executive officers of Parent, and each of them, the attorneys and proxies of the Stockholder, with full power of substitution and resubstitution, to the full extent of the Stockholder&#146;s rights with respect to the outstanding
shares of capital stock of the Company owned of record by the Stockholder as of the date of this proxy, which shares are specified on the final page of this proxy. (The shares of the capital stock of the Company referred to in the immediately
preceding sentence are referred to as the &#147;<U>Shares</U>.&#148;) Upon the execution of this proxy, all prior proxies given by the Stockholder with respect to any of the Shares are hereby revoked, and the Stockholder agrees that no subsequent
proxies inconsistent with this Proxy will be given with respect to any of the Shares. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">This proxy is irrevocable, is coupled
with an interest and is granted in connection with, and as security for, the Voting Agreement, dated as of the date hereof, between Parent and the Stockholder (the &#147;<U>Voting Agreement</U>&#148;), and is granted in consideration of Parent
entering into the Agreement and Plan of Merger and Reorganization, dated as of the date hereof, among Parent, Alto Merger Sub, Inc., a wholly-owned subsidiary of Parent, and the Company (the &#147;<U>Merger Agreement</U>&#148;). This proxy will
terminate on the Expiration Date (as defined in the Voting Agreement). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Prior to the Expiration Date, the attorneys and
proxies named above will be empowered, and may exercise this proxy, to vote any Shares owned by the undersigned, at any meeting of the stockholders of the Company, however called, or at any adjournment or postponement thereof and on every action or
approval by written consent of the stockholders of the Company: </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(a) in favor of the adoption of the Merger Agreement;
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(b) against any Company Acquisition Proposal (as such terms are defined in the Merger Agreement); and </FONT></P> <P
STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(c) against any other action, agreement, proposal or transaction involving any of the Symyx Corporations which other action, agreement,
proposal or transaction would compete with, interfere with, impede, frustrate, prevent, burden or nullify the Merger or the Merger Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT
STYLE="font-family:Times New Roman" SIZE="2">The Stockholder may vote the Shares on all other matters not referred to in this proxy, and the attorneys and proxies named above may not exercise this proxy with respect to such other matters.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">This proxy shall be binding upon the heirs, estate, executors, personal representatives, successors and assigns of the
Stockholder (including any transferee of any of the Shares). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Any term or provision of this proxy that is invalid or
unenforceable in any situation in any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this proxy or the validity or enforceability of the offending term or provision in any other situation or in
any other jurisdiction. Upon such determination that any term or provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this proxy so as to effect the original intent of the parties
as closely as possible in an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the fullest extent possible. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT
STYLE="font-family:Times New Roman" SIZE="2">[<I>Signature page follows</I>] </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Proxy </I></B></FONT></P>

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<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dated: April&nbsp;5, 2010</FONT></TD>
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<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>S<SMALL>TOCKHOLDER</SMALL></B></FONT></TD></TR>
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<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Number of shares of common stock of the Company owned of record as of the date of this proxy:</FONT></TD></TR>
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STYLE="font-family:Times New Roman" SIZE="2"><B><I>Proxy </I></B></FONT></P>
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