<SUBMISSION>
<ACCESSION-NUMBER>0001193125-10-089449
<TYPE>8-K
<PUBLIC-DOCUMENT-COUNT>6
<PERIOD>20100421
<ITEMS>5.02
<ITEMS>8.01
<ITEMS>9.01
<FILING-DATE>20100422
<DATE-OF-FILING-DATE-CHANGE>20100422
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>ACCELRYS, INC.
<CIK>0001002388
<ASSIGNED-SIC>7372
<IRS-NUMBER>330557266
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>0331
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>8-K
<ACT>34
<FILE-NUMBER>000-27188
<FILM-NUMBER>10763135
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
<PHONE>(858) 799-5000
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>10188 TELESIS COURT, SUITE 100
<CITY>SAN DIEGO
<STATE>CA
<ZIP>92121-3752
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>PHARMACOPEIA INC
<DATE-CHANGED>19951018
</FORMER-COMPANY>
</FILER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>d8k.htm
<DESCRIPTION>FORM 8-K
<TEXT>
<HTML><HEAD>
<TITLE>Form 8-K</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">

 <P STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P>
<P STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P> <P STYLE="margin-top:4px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>UNITED STATES </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>SECURITIES AND EXCHANGE COMMISSION </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>Washington, D.C. 20549 </B></FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center>
<P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="5"><B>FORM 8-K </B>
</FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>CURRENT REPORT </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>PURSUANT TO SECTION 13 OR 15(d) OF THE </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>SECURITIES EXCHANGE ACT OF 1934 </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="3"><B>Date of Report (Date of earliest event reported): April&nbsp;21, 2010 </B></FONT></P>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:6px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="6"><B>ACCELRYS, INC. </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(Exact Name of Registrant as Specified in Charter) </B></FONT></P>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TR>
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<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Delaware</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>0-27188</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>33-0557266</B></FONT></TD></TR>
<TR>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(State or Other Jurisdiction</B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>of Incorporation)</B></FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Commission&nbsp;File Number</B></FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(I.R.S. Employer</B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:1px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Identification Number)</B></FONT></P></TD></TR></TABLE>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10188 Telesis Court, San Diego, California 92121-4779 </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Address of Principal Executive Offices) (Zip Code) </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Registrant&#146;s telephone number, including area code: (858)&nbsp;799-5000 </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>N/A </B></FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>(Former Name, or Former Address, if Changed Since Last Report) </B></FONT></P>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P><center> <P STYLE="line-height:6px;margin-top:0px;margin-bottom:2px;border-bottom:1pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the
following provisions: </FONT></P> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#120;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) </FONT></TD></TR></TABLE>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) </FONT></TD></TR></TABLE>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) </FONT></TD></TR></TABLE>
<P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><FONT STYLE="FONT-FAMILY:WINGDINGS">&#168;</FONT></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) </FONT></TD></TR></TABLE>
<P STYLE="font-size:8px;margin-top:0px;margin-bottom:0px">&nbsp;</P> <P STYLE="line-height:0px;margin-top:0px;margin-bottom:0px;border-bottom:0.5pt solid #000000">&nbsp;</P>
<P STYLE="line-height:3px;margin-top:0px;margin-bottom:2px;border-bottom:0.5pt solid #000000">&nbsp;</P>

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<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="10%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;5.02.</B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.
</B></FONT></TD></TR></TABLE> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Offer Letter and Employment Agreement with New Executive Vice President of Sales, Marketing and Services
</I></B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">On April&nbsp;21, 2010, Accelrys, Inc. (the &#147;<B>Company</B>&#148;) provided an offer letter (the &#147;<B>Offer Letter</B>&#148;)
to Mr.&nbsp;Todd Johnson memorializing the terms of his appointment as the Company&#146;s Executive Vice President of Sales, Marketing and Services. Mr.&nbsp;Johnson previously served as a Senior Vice President of the Company and assisted with
various marketing and operations-related tasks. Pursuant to the Offer Letter, Mr.&nbsp;Johnson will earn a base salary of $300,000 and will participate in the Company&#146;s Management Incentive Plan, with an annual target bonus of 100% of his base
salary. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Company and Mr.&nbsp;Johnson also entered into an employment agreement dated April&nbsp;21, 2010 (the &#147;<B>Employment
Agreement</B>&#148;). Pursuant to the Employment Agreement, if Mr.&nbsp;Johnson is terminated without Cause or resigns for Good Reason (as both are defined in the Employment Agreement), he will be eligible to receive as severance one year&#146;s
base salary. If Mr.&nbsp;Johnson is terminated without Cause or resigns for Good Reason in connection with a Change of Control (as defined in the Employment Agreement), he will be eligible to receive as severance one year&#146;s base salary and
payment of his annual target bonus. The Company&#146;s severance obligations are conditioned upon Mr.&nbsp;Johnson&#146;s execution of a release in favor of the Company and compliance with certain non-competition and non-solicitation obligations as
set forth in the Employment Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The foregoing descriptions of the Offer Letter and Employment Agreement are intended only as summaries
of the material terms of the Offer Letter and Employment Agreement and are qualified in their entireties by reference to the full Offer Letter and Employment Agreement, copies of which are attached hereto as Exhibit 10.1 and Exhibit 10.2,
respectively, to this Form 8-K and are hereby incorporated by reference herein. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Equity Awards for New Executive Vice President of
Sales, Marketing and Services </I></B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Mr.&nbsp;Johnson has been awarded stock options to purchase an aggregate of 150,000 shares of the
Company&#146;s common stock, priced at the closing price of the Company&#146;s common stock on the date of grant and subject to vesting over four years. Mr.&nbsp;Johnson was also awarded restricted stock units representing the right to receive an
aggregate of 100,000 shares of the Company&#146;s common stock. The shares underlying these units will vest over a period of three years from the date of grant. All of the foregoing equity awards were made pursuant to the terms of the Company&#146;s
Amended and Restated 2004 Stock Incentive Plan and the Company&#146;s applicable stock option and restricted stock unit agreements. </FONT></P>
<P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>Resignation of Senior Vice President, Worldwide Sales and Services </I></B></FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">In connection with the appointment of Mr.&nbsp;Johnson as described above, on April&nbsp;21, 2010, Ms.&nbsp;Ilene Vogt resigned as the Company&#146;s
Senior Vice President, Worldwide Sales and Services. Concurrently with her resignation, Ms.&nbsp;Vogt and the Company entered into a Separation Agreement and Release (the &#147;<B>Separation Agreement</B>&#148;). Pursuant to the Separation
Agreement, Ms.&nbsp;Vogt will receive a total severance amount of $250,000, paid over a period of twelve months, and will be eligible to receive a lump-sum payment equal to the amount of any bonus earned by her pursuant to the Company&#146;s 2010
Management Incentive Plan. The amount of any such bonus will be determined in good faith by the Company&#146;s board of directors in accordance with the terms of the 2010 Management Incentive Plan, provided that the Company has agreed that the
individual discretionary portion of Ms.&nbsp;Vogt&#146;s bonus will be equal to $45,000. The Company&#146;s severance obligations are conditioned upon Ms.&nbsp;Vogt&#146;s compliance with certain non-competition and non-solicitation obligations set
forth in the Separation Agreement. The Separation Agreement also provides that Ms.&nbsp;Vogt will remain employed by the Company to assist with transitioning her duties until May&nbsp;5, 2010. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The foregoing description is intended only as a summary of the material terms of the Separation Agreement and is qualified in its entirety by reference
to the full Separation Agreement, a copy of which is attached as Exhibit 10.3 to this Form 8-K and is hereby incorporated by reference herein. </FONT></P>

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<TR>
<TD WIDTH="10%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;8.01</B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Other Events. </B></FONT></TD></TR></TABLE> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">On April&nbsp;21, 2010,
the Company issued a press release announcing the appointment of Mr.&nbsp;Johnson as the Company&#146;s Executive Vice President of Sales, Marketing and Services and the departure of Ms.&nbsp;Vogt as the Company&#146;s Senior Vice President,
Worldwide Sales and Services. A copy of the press release is attached hereto as Exhibit&nbsp;99.1 and is hereby incorporated by reference herein. </FONT></P> <P STYLE="font-size:18px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="10%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Item&nbsp;9.01.</B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Financial Statements and Exhibits. </B></FONT></TD></TR></TABLE>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:2%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><I>(d) Exhibits. </I></B></FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
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<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">10.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">Offer Letter from the Company to Todd Johnson</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">10.2</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">Employment Agreement, dated as of April 21, 2010, by and between the Company and Todd Johnson</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">10.3</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">Separation Agreement and Release, dated as of April 21, 2010, by and between the Company and Ilene Vogt</FONT></TD></TR>
<TR>
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">99.1</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD VALIGN="bottom" NOWRAP><FONT STYLE="font-family:Times New Roman" SIZE="2">Press release dated April 21, 2010</FONT></TD></TR></TABLE>

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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>SIGNATURES </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0">

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<TD WIDTH="6%"></TD>
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<TD WIDTH="92%"></TD></TR>
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<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>ACCELRYS, INC.</B></FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/&nbsp;&nbsp;&nbsp;&nbsp;M<SMALL>ICHAEL</SMALL> A.
P<SMALL>IRAINO&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</SMALL></FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Michael A. Piraino</B></FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="1"><B>Senior Vice President and Chief Financial Officer</B></FONT></TD></TR></TABLE></DIV>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Date: April&nbsp;21, 2010 </FONT></P>
</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>dex101.htm
<DESCRIPTION>OFFER LETTER
<TEXT>
<HTML><HEAD>
<TITLE>Offer Letter</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 10.1 </B></FONT></P>
 <P STYLE="margin-top:12px;margin-bottom:0px">

<IMG SRC="g36430g37s91.jpg" ALT="LOGO"> </P>
 <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Todd Johnson </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>VIA ELECTRONIC MAIL </B></FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dear Todd:
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">The following will confirm the terms of your continuing employment with Accelrys: </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>Position/Location</U>:</B> You will assume the position of Accelrys&#146; Executive Vice President of Sales, Marketing and Services. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>Compensation</U>:</B> Your compensation in the above position will include an annual base salary of $300,000.00, less applicable withholdings, paid
during the Company&#146;s regular payroll periods. In addition, you will be eligible to participate in our Management Incentive Plan (the &#147;Plan&#148;) designed to allow you to earn initially up to an additional 100% at plan of your annual base
salary in incentive compensation upon achievement of a combination of corporate performance objectives and individual achievement targets as determined by the Board. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>Employment</U>:</B> You will continue to be eligible to participate in our comprehensive employee benefits package, including health, disability
and life insurance; participation in our 401(k) retirement savings plan; and vacation benefits. You also remain eligible for any other benefits provided to our senior executives including long term care and enhanced life and long term disability
insurance benefits. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px;padding-bottom:0px;"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>Equity Award</U>:</B> The Human Resources Committee of the Board of Directors
(&#147;Committee&#148;) awarded you a non-qualified option to purchase 125,000 shares of common stock on April&nbsp;9, 2010. In addition, on April&nbsp;19, 2010, the Committee&#146;s awarded you an additional option to purchase 25,000 shares of
common stock. Each stock option was priced at the closing price of the Company&#146;s stock on the date of the grant and each option commenced vesting on the grant date. Each option shall vest as follows:
<FONT SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">&nbsp;1</SUP></FONT><FONT SIZE="2">/</FONT><FONT SIZE="1">4</FONT><FONT STYLE="font-family:Times New Roman" SIZE="2"> of the stock underlying the option shall vest
on the one year anniversary of each grant date and 1/48</FONT><FONT STYLE="font-family:Times New Roman" SIZE="1"><SUP STYLE="vertical-align:baseline; position:relative; bottom:.8ex">th</SUP></FONT><FONT STYLE="font-family:Times New Roman" SIZE="2">
of the stock underlying the option shall vest monthly thereafter so that each option shall be fully vested four years from the date of the grant of that option. The Committee also awarded you 60,000 restricted stock units on April&nbsp;9, 2010. In
addition, on April&nbsp;19, 2010, the Committee awarded you an additional 40,000 restricted stock units. 1/3 of the stock underlying the units will vest upon the first anniversary of each grant date; another 1/3 will vest on the second anniversary
of each grant date and the final 1/3 will vest on the third anniversary of each grant date. All equity awards contemplated by this paragraph are issued pursuant to the Company&#146;s 2004 Stock Incentive Plan. </FONT></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>Employment Agreement</U></B><B>:</B> Concurrently herewith the Company is providing you with an employment agreement setting forth the terms of
your employment. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">I look forward to your continuing involvement in what we are confident represents an exciting and professionally rewarding
venture. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0">

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<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accelrys, Inc.</FONT></TD></TR>
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<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
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<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Max Carnecchia</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">President and Chief Executive Officer</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accelrys, Inc.</FONT></TD></TR></TABLE></DIV>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.2
<SEQUENCE>3
<FILENAME>dex102.htm
<DESCRIPTION>EMPLOYMENT AGREEMENT
<TEXT>
<HTML><HEAD>
<TITLE>Employment Agreement</TITLE>
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 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 10.2 </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>EMPLOYMENT AGREEMENT </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">This <B>EMPLOYMENT AGREEMENT</B> (the &#147;Agreement&#148;) is made and entered into as of the Effective Date, as defined below, by and between
Accelrys, Inc.<B>,</B> a Delaware corporation (hereinafter, the &#147;Company&#148;), and Todd Johnson, an individual (hereinafter, &#147;Executive&#148;). </FONT></P>
<P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>RECITALS </U></B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>WHEREAS,</B> Executive is continuing employment with the Company on the terms set forth herein and in the offer letter dated
April&nbsp;9, 2010 from Max Carnecchia (&#147;Offer Letter&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>NOW, THEREFORE,</B> in consideration of their mutual
promises and intending to be legally bound, the parties agree as follows: </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>1. <U>EMPLOYMENT</U></B>. </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) <U>Title and Location</U>.</B> The Company shall employ Executive as its Executive Vice President of Sales, Marketing and Services
upon the terms and conditions set forth in this Agreement, and Executive hereby accepts such employment. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) <U>Duties and
Responsibilities</U>.</B> Executive&#146;s duties, powers and responsibilities in such capacity shall be those which are customary for such position, as may be determined from time to time by the Company. Executive agrees to perform and discharge
such duties well and faithfully. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) <U>No Conflicts</U>.</B> Executive&#146;s position under this Agreement is a
full-time position. Executive agrees to devote Executive&#146;s full business time, effort, attention and energies to this position. Executive will not render any professional services or engage in any activity that might be competitive with,
adverse to the best interest of, or create the appearance of a conflict of interest with, the Company. Executive agrees to abide by the policies, rules and regulations of the Company as they may be amended from time to time. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) <U>No Other Agreement</U>.</B> Executive represents and warrants the Executive is not bound by any employment, consulting,
noncompetition, confidentiality, finders, marketing or other agreement or arrangement that would, or might reasonably be expected to, prohibit or restrict Executive in any manner from performing Executive&#146;s duties and obligations hereunder.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>2. <U>TERM</U>.</B> The term of this Agreement shall commence upon execution (the &#147;Effective Date&#148;) and shall
continue thereafter until the effective date of termination set forth in Section&nbsp;13, below (&#147;Term&#148;). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>3.
<U>COMPENSATION</U>.</B> As compensation for Executive&#146;s services under this Agreement: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) <U>Base Salary</U>.</B>
The Company will pay Executive an initial annual base salary as set forth in the Offer Letter (&#147;Base Salary&#148;), to be paid semi-monthly in equal installments, less normally applicable payroll deductions. Executive&#146;s Base Salary will be
subject to annual review and adjustment by the Company&#146;s Board of Directors (&#147;Board&#148;) or a duly appointed committee thereof, in either case in its sole discretion. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) <U>Incentive Bonus</U>.</B> Executive shall be eligible to participate in the Company&#146;s management incentive plan, as may be
implemented and modified by the Company at its sole discretion. The Company and Executive agree that Executive&#146;s initial bonus target percentage will be as set forth in the Offer Letter. Such amounts, payable to Executive under this plan or any
other bonus program, shall be referred to herein as the &#147;Incentive Bonus.&#148; The Incentive Bonus for any year will be paid after the conclusion of the applicable fiscal year, based upon the Board of Directors&#146; determination as to the
amount of such bonus earned pursuant to the terms of the management incentive plan, provided Executive is employed by the Company or its successor on that date. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">1 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) <U>Vacation and Other Benefits</U>. </B>Executive shall be entitled to the benefit of
paid vacation, holidays, group medical, accident and long-term disability insurance and other fringe benefits and tax qualified retirement plans as the Company shall make available from time to time to its other similarly situated senior executives.
The Company may change or amend its benefits as it deems appropriate from time to time. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>4. <U>TERMINATION AND EFFECT OF
TERMINATION</U>.</B> Executive&#146;s employment hereunder is <B>AT WILL</B> and may be terminated at any time by the Company for any reason. In the event of termination of Executive&#146;s employment, the Company shall have no liability to
Executive for compensation or benefits, except as specified in this Section&nbsp;4 or as required by the Company&#146;s benefits policy. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) <U>Termination by the Company for Cause</U>.</B> Executive&#146;s employment may be terminated by the Company for Cause at any
time upon delivery of written notice to Executive. Upon such a termination, the Company shall have no obligation to Executive other than the payment of all accrued, but unpaid, Base Salary and any unpaid expenses or expense reimbursements prior to
the effective date of such termination. For purposes of this Agreement, &#147;Cause&#148; means the occurrence of any one or more of the following events or conditions: </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(i) any material failure on the part of Executive (other than by reason of disability as provided in Section&nbsp;4(e) below) to
faithfully and professionally carry out Executive&#146;s duties or to comply with any other material provision of this Agreement, which failure continues for ten (10)&nbsp;days after written notice detailing such failure is delivered by the Company;
provided, that the Company shall not be required to provide such notice in the event that such failure (A)&nbsp;is not susceptible to remedy or (B)&nbsp;relates to the same type of acts or omissions as to which notice has been given on a prior
occasion; </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(ii) Executive&#146;s dishonesty (which shall include without limitation any misuse or misappropriation of the
Company&#146;s assets), or other willful misconduct, if such dishonesty or other willful misconduct is intended to or likely to injure the business of the Company; </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(iii) Executive&#146;s conviction of any felony or of any other crime involving moral turpitude, whether or not relating to
Executive&#146;s employment; </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(iv) Executive&#146;s insobriety or use of drugs, chemicals or controlled substances either
(A)&nbsp;in the course of performing Executive&#146;s duties and responsibilities under this Agreement, or (B)&nbsp;otherwise affecting the ability of Executive to perform the same; </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(v) Executive&#146;s failure to comply with a lawful written direction of the Company or the Board of Directors; or </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(vi) Any wanton or willful dereliction of duties by Executive. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">The existence of any of the foregoing events or conditions shall be determined by the Company in the exercise of its reasonable judgment.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) <U>Involuntary Termination by the Company without Cause or Resignation by Executive with Good Reason</U>.</B> The
Company may involuntarily terminate Executive&#146;s employment under this Agreement at any time during the Term without Cause upon delivery of written notice to Executive, and Executive may resign at any time during the Term with Good Reason (as
defined in </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">2 </FONT></P>


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Section&nbsp;4(c), below). Except as provided by Section&nbsp;4(g) hereof concerning termination in connection with a Change of Control (as defined in such Section&nbsp;4(g)), if, during the
Term, Executive&#146;s employment is terminated involuntarily by the Company without Cause pursuant to this Section&nbsp;4(b) or Executive resigns for Good Reason pursuant to Section&nbsp;4(c) during the Term, the Company shall: </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(i) pay Executive all compensation and benefits accrued, but unpaid, up to the effective date of termination; and </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(ii) provided that, and for so long as, Executive complies with Executive&#146;s obligations set forth in Sections 6 and 7, below,
continue to pay Executive each month (in accordance with the Company&#146;s regular payroll practices) an amount equal to one twelfth (1/12)&nbsp;Executive&#146;s annual Base Salary in effect as of the effective date of termination, for a period of
twelve (12)&nbsp;months after the effective date of termination; </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) <U>Termination by Executive for Good Reason</U>.</B>
Executive may terminate his/her employment under this Agreement during the Term for Good Reason upon the provision of advance written notice to the Company no later than thirty (30)&nbsp;days after the initial occurrence of the events or conditions
upon which Executive is basing such termination and specifying in reasonable detail the events or conditions upon which Executive is basing such termination. The Company will be given the opportunity, but shall have no obligation, to
&#147;cure&#148; such events or conditions within thirty (30)&nbsp;days after the provision by Executive of such notice. Subject to the provisions of Section&nbsp;4(g) hereof (concerning termination in connection with a Change of Control), if the
Company elects in a written notice to Executive not to cure such events or conditions or otherwise fails to so cure such events or conditions within such thirty (30)&nbsp;day period, Executive may terminate Executive&#146;s employment with the
Company for Good Reason effective at the end of such 30 day notice period. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">For purposes of this Agreement, &#147;Good
Reason&#148; means any one or more of the following events or conditions: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(i) the Company&#146;s breach of any of the
material terms of this Agreement; or </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(ii) a reduction of more than 10% in Executive&#146;s annual Base Salary then-in-effect
without Executive&#146;s consent (other than such a reduction applicable generally to other senior executives of the Company) </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Solely for
purposes of Section&nbsp;4(g) below, &#147;Good Reason&#148; also means a reduction in the Executive&#146;s target bonus. For the avoidance of doubt, other than in the event of Change of Control Termination Without Cause or Resignation for Good
Reason, as set forth in Section&nbsp;4(g), below, Executive&#146;s bonus target percentage may be modified by the Board or a duly appointed committee thereof at any time at the Board&#146;s or such committee&#146;s sole discretion. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) <U>Termination by Executive without Good Reason (Voluntary Resignation)</U>.</B> Executive may voluntarily resign his position and
terminate his/her employment under this Agreement without Good Reason at any time. Upon such a termination, the Company shall have no obligation to pay compensation and provide benefits to Executive other than the payment of all accrued, but unpaid,
Base Salary and any other unpaid expenses or expense reimbursements prior to the effective date of such termination. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e)
<U>Disability</U>.</B> If Executive becomes disabled for more than one hundred eighty (180)&nbsp;days in any twelve (12)&nbsp;month period, the Company shall have the right to terminate Executive&#146;s employment upon written notice to Executive.
Executive shall be deemed disabled for purposes of this Agreement </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">3 </FONT></P>


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either (i)&nbsp;if Executive is deemed disabled for purposes of any long-term disability insurance policy paid for by the Company and at the time in effect, or (ii)&nbsp;if in the exercise of the
Company&#146;s reasonable judgment, due to accident, mental or physical illness, Executive cannot perform Executive&#146;s duties. In the event that during the Term, the Company shall terminate Executive due to disability, as described above,
Executive shall be entitled to receive the benefits set forth in Section&nbsp;4(b) (i.e., as if Executive were terminated by the Company without Cause). </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) <U>Death</U>.</B> In the event of the death of Executive, this Agreement shall automatically terminate and any obligation to
continue to pay compensation and benefits shall cease as of the date of death, except for the payment of all accrued, but unpaid, Base Salary and any other unpaid expenses or expense reimbursement prior to the date of death. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(g) <U>Change of Control Termination Without Cause or Resignation for Good Reason</U>.</B> </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) <U>Benefits</U>. S</B>ubject to Section&nbsp;4(i) below<B>, </B>in the event, Executive&#146;s employment under this Agreement is
terminated by the Company involuntarily without Cause at any time during the period commencing two (2)&nbsp;months before and ending within eighteen (18)&nbsp;months after the occurrence of a Change of Control during the Term, or Executive
terminates employment with the Company for Good Reason at any time during the period commencing two (2)&nbsp;months before and ending within eighteen (18)&nbsp;months after the occurrence of a Change of Control during the Term, the Company shall, in
lieu of providing Executive with any amounts or benefits otherwise payable under this Agreement: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(A) pay Executive all
compensation and benefits accrued, but unpaid, up to the effective date of termination; and </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(B) provided that, and for so
long as, Executive complies with his/her obligations set forth in Sections 6 and 7, below, continue to pay Executive each month in accordance with the Company&#146;s regular payroll practices an amount equal to one twelfth
(1/12)&nbsp;Executive&#146;s annual Base Salary in effect as of the effective date of termination; for a period of twelve months after the effective date of termination; and </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(C) provided that, and for so long as, Executive complies with his/her obligations set forth in Sections 6 and 7, below, pay Executive,
each month for a period of twelve (12)&nbsp;months, in accordance with the Company&#146;s payroll practices, one twelfth (1/12)&nbsp;of an amount obtained by multiplying Executive&#146;s target bonus percentage in effect as of the effective date of
termination (expressed as a decimal) times Executive&#146;s annual Base Salary in effect as of such date of termination . </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Anything contained in this Section&nbsp;4(g)(i) to the contrary notwithstanding, Executive shall not be entitled to any of the benefits
set forth in this Section&nbsp;4(g)(i) if Executive resigns and terminates such employment voluntarily (other than for Good Reason) or is terminated by the Company (including without limitation any Acquiring Company) for Cause. </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">For purposes of Sections 4(g)(i) and (ii)&nbsp;hereof, the term the &#147;Company&#148; shall include any Acquiring Company (as defined
below) and all obligations of the Company under such Section shall be assumed by any Acquiring Company. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">4 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(ii) <U>Definition of &#147;Change of Control</U>.&#148;</B> For purposes of this
Agreement, a &#147;Change of Control&#148; of the Company shall mean the occurrence of any of the following events or circumstances: </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(A) any &#147;person&#148; (within the meaning of Section&nbsp;13(d) or 14(d) of the Securities Exchange Act of 1934, as amended (the
&#147;Exchange Act&#148;)), including a &#147;group&#148; within the meaning of such Section&nbsp;13(d) but excluding the Company and any of its subsidiaries and any employee benefit plan sponsored or maintained by the Company or any subsidiary
thereof (a &#147;Person&#148;), shall become the &#147;beneficial owner&#148; (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing fifty percent (50%)&nbsp;or more of the combined
voting power of the Company&#146;s then outstanding securities entitled to vote generally in the election of directors (&#147;Company Voting Securities&#148;); or </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(B) the consummation of a merger or consolidation of the Company, or the acceptance by the stockholders of the Company of shares in a
share exchange, where the Persons who were the beneficial owners of Company Voting Securities, outstanding immediately prior to such merger, consolidation or share exchange, do not beneficially own, directly or indirectly, immediately after such
merger, consolidation or share exchange, securities representing more than fifty percent (50%)&nbsp;of the combined voting power of the then outstanding Company Voting Securities or voting securities of the Acquiring Company in such merger,
consolidation or share exchange, in substantially the same proportions as their ownership of the Company Voting Securities immediately prior to such merger, consolidation or share exchange; or </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(C) a sale, exchange or other disposition or transfer (in one transaction or a series of related transactions) of all or substantially
all of the assets of the Company; provided, that a Change of Control shall not be deemed to have occurred where (x)&nbsp;the Company sells, exchanges or otherwise disposes or transfers all or substantially all of its assets to another corporation
which is beneficially owned, directly or indirectly, immediately following such transaction by the holders of Company Voting Securities in substantially the same proportions as their ownership of the Company Voting Securities immediately prior to
such transaction and (y)&nbsp;such corporation expressly assumes this Agreement; or </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(D) such time as the Continuing Directors
(as defined below) do not constitute at least a majority of the Board of Directors of the Company (or, if applicable, of a successor to the Company), where the term &#147;Continuing Director&#148; means at any date a member of the Board who was
(x)&nbsp;a member of the Board on the date of this Agreement or (y)&nbsp;nominated or elected subsequent to such date by at least a majority of the directors who were Continuing Directors at the time of such nomination or election or whose election
to the Board was recommended or endorsed by at least a majority of the directors who were Continuing Directors at the time of such nomination or election (it being understood that no individual whose initial assumption of office occurred as a result
of an actual or threatened election contest with respect to the election or removal of directors or other actual or threatened solicitation of proxies or consents by or on behalf of a Person other than the Board shall be a Continuing Director).
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">5 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; margin-left:17%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Provided, however, that, notwithstanding anything to the contrary in this Agreement,
Executive acknowledges and agrees that in no event will the consummation of the transactions contemplated by that certain Agreement and Plan or Merger and Reorganization, dated as of April&nbsp;5, 2010, by and among the Company, Alto Merger Sub,
Inc. and Symyx Technologies, Inc. constitute or give rise to a &#147;Change of Control&#148; for purposes of any provision of this Agreement. </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(iii) <U>Definition of &#147;Acquiring Company</U>.&#148; </B>For purposes of Section&nbsp;4 of this Agreement, an &#147;Acquiring
Company&#148; shall mean the resulting or surviving corporation, or the company issuing cash or securities (or its ultimate parent company), in a merger, consolidation or share exchange involving the Company, or the successor corporation to the
Company (whether in any such transaction or otherwise). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(h) Section&nbsp;409A</B>. If any benefit or amount payable to
Executive under this Section&nbsp;4 hereof on account of the Executive&#146;s termination of employment constitutes &#147;nonqualified deferred compensation&#148; within the meaning of Section&nbsp;409A of the Internal Revenue Code
(&#147;409A&#148;), payment of such benefit or amount shall commence within sixty (60)&nbsp;days following the Executive&#146;s &#147;separation from service&#148; within the meaning of Treasury Regulation Section&nbsp;1.409A-1(h), which in part
provides that a separation from service will be deemed to occur if the Company and Executive reasonably anticipate that Executive shall perform no further services for the Company (whether an employee or an independent contractor) or that the level
of bona fide services Executive will perform in the future (whether as an employee or an independent contractor) will permanently decrease to no more than 49 percent of the average level of bona fide services performed (whether as an employee or
independent contractor) over the immediately preceding 36-month period. If Executive has failed to execute the release described in Section&nbsp;4(j) below within sixty (60)&nbsp;days of Executive&#146;s separation of service, the payments described
in Section&nbsp;4(b), (c)&nbsp;and (g)&nbsp;shall be forfeited. If, at the time Executive incurs a separation from service, Executive is a &#147;specified employee&#148; within the meaning of 409A, any benefit or amount payable to the Executive
under this Section&nbsp;4 on account of Executive&#146;s termination of employment that constitutes nonqualified deferred compensation subject to 409A shall be delayed until the first day of the seventh month following the Executive&#146;s
separation from service (the &#147;409A Suspension Period&#148;). Within 14 calendar days after the end of the 409A Suspension Period, the Company shall pay to the Executive a lump sum payment in cash equal to any payments that the Company would
otherwise have been required to provide under this Section&nbsp;4 but for the imposition of the 409A Suspension Period. Thereafter, the Executive shall receive any remaining payments due under this Section&nbsp;4 in accordance with the terms of this
Section (as if there had not been any suspension period beforehand). </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(i) <U>Liquidated Damages/Release</U>. </B>Executive
acknowledges that, upon executing a release as set forth below, any payments and benefits resulting from a termination of Executive&#146;s employment under Section&nbsp;4(b), (c)&nbsp;or (g)&nbsp;of this Agreement which are not required by law are
in satisfaction of any and all claims that Executive may have against the Company or any Acquiring Company (other than benefits under the Company&#146;s benefit plans that by their terms survive termination of employment, benefits under the
Consolidated Omnibus Budget Reconciliation Act of 1985, as amended, and rights to indemnification under certain indemnification arrangements for officers of the Company), and represent liquidated damages (and not a penalty). The Company will require
that Executive execute and not revoke a separation agreement and a release of all claims in favor of the Company in a form reasonably satisfactory to the Company prior to, and as a condition to, receipt of such payments and benefits. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>5. <U>TAXES</U>.</B> Executive will be responsible for the payment of any tax liability incurred as a result of this Agreement. The
Company may withhold tax on any payments or benefits provided to Executive as required by law or regulation. The Executive is solely responsible and liable for the satisfaction of all taxes and penalties that may arise under Section&nbsp;409A of the
Code, and the Company shall not have any obligation to indemnify or otherwise hold Executive harmless from any or all of such taxes. The Company shall have the sole discretion to interpret the requirements of the Code, including Section&nbsp;409A,
for purposes of this provision, but shall only act in accordance with written advice from its Advisors </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">6 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Nevertheless, if the Company or Executive determine that delaying severance payments will
avoid subjecting Executive to Section&nbsp;409(A) taxes and penalties, the Company shall modify the payment terms of this Agreement to the limited extent, and for the minimum deferral period, that the Company reasonably determines is necessary to
avoid subjecting Executive to Section&nbsp;409A penalties. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>6.</B> <B><U>CONFIDENTIAL INFORMATION</U>.</B> Except as
reasonably necessary to perform Executive&#146;s duties hereunder, Executive agrees not to reveal to any other person or entity or use for Executive&#146;s own benefit any confidential information of or about the Company or its operations, both
during and after Executive&#146;s employment under this Agreement, including without limitation marketing plans, financial information, key personnel, Executives&#146; capabilities, salaries and benefits, customer lists, pricing and cost structures,
operation methods and any other information not available to the public, without the Company&#146;s prior written consent. These obligations are in addition to any similar obligations set forth in the Company&#146;s Invention and Non-Disclosure
Agreement. <B> </B></FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>7.</B> <B><U>NON-COMPETITION; NON-SOLICITATION; NON-DISPARAGEMENT</U>.</B> </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) <U>Restrictions</U>.</B> For so long as Executive is receiving benefits pursuant to section 4, above, Executive shall not, directly
or indirectly: </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(i) be employed by, engaged in or participate in the ownership, management, operation or control of, or act in
any advisory or other capacity (including as an individual, principal, agent Executive, consultant or otherwise) for, any Competing Entity which conducts its business within the Territory (as the terms Competing Entity and Territory are hereinafter
defined); provided, however, that notwithstanding any of the foregoing, Executive may make solely passive investments in any Competing Entity the common stock of which is &#147;publicly held&#148; and of which Executive shall not own or control,
directly or indirectly, in the aggregate securities which constitute 5% or more of the voting power of such Competing Entity; </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(ii) solicit or divert any business or any customer or known prospective customer from the Company or its affiliates or assist any person
or entity in doing so or attempting to do so; </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(iii) cause or seek to cause any person or entity to refrain from dealing or
doing business with the Company or its affiliates or assist any person or entity in doing so; or </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(iv) solicit for employment,
or advise or recommend to any other person or entity that he, she or it employ or solicit for employment or retention as an employee or consultant, any person who is an employee of, or exclusive consultant to, the Company (provided that this
prohibition shall not apply in the event of a Change of Control Termination or Resignation, as set forth in Section&nbsp;4(g), above). </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(v) make any derogatory or disparaging statement regarding the Company, its affiliates, directors, or its employees. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">In the event Executive violates any of the foregoing restrictions, all payments or benefits being provided pursuant to Sections 4(b) and
(c)&nbsp;shall immediately cease. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">7 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) <U>Definitions</U>.</B> For purposes of this Section&nbsp;7: </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(i) &#147;Competing Entity&#148; means any entity which is presently or hereafter engaged in any business of the type or character
engaged in by the Company or any of its affiliates including, without limitation, (A)&nbsp;the business of developing, marketing or selling software programs which use molecular simulation or analysis to predict chemical or biological activities;
(B)&nbsp;the business of developing, marketing or selling software programs that store, manage or analyze chemical or biological information or (C)&nbsp;any business which is otherwise competitive with a business conducted by the Company or any of
its affiliates; and </FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px; margin-left:13%"><FONT STYLE="font-family:Times New Roman" SIZE="2">(ii) &#147;Territory&#148; means North America, Europe and Asia. </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; margin-left:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Notwithstanding anything in the above to the contrary, Executive may engage in the activities set forth in Section&nbsp;7(a) hereof with
the prior written consent of the Company, which consent shall not be unreasonably withheld. Further, in determining whether a specific activity by Executive for a Competing Entity shall be permitted, the Company will consider, among other things,
the nature and scope of (A)&nbsp;the duties to be performed by Executive and (B)&nbsp;the business activities of the Competing Entity at the time of Executive&#146;s proposed engagement by such entity. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) <U>Acknowledgement</U>.</B> Executive acknowledges and agrees that the covenants set forth in this Section are reasonable and
necessary in all respects for the protection of the Company&#146;s legitimate business interests (including without limitation the Company&#146;s confidential, proprietary information and trade secrets and client good-will, which represents a
significant portion of the Company&#146;s net worth and in which the Company has a property interest). Executive acknowledges and agrees that, in the event that Executive breaches any of the covenants set forth in this Section (other than that
provided for in Section&nbsp;7(a)(i)), the Company shall be irreparably harmed and shall not have an adequate remedy at law; and, therefore, in the event of such a breach, the Company shall be entitled to injunctive relief, in addition to (and not
exclusive of) any other remedies (including monetary damages) to which the Company may be entitled under law. If any covenant set forth in this Section&nbsp;7 is deemed invalid or unenforceable for any reason, it is the parties&#146; intention that
such covenants be equitably reformed or modified to the extent necessary (and only to such extent to) render it valid and enforceable in all respects. In the event that the time period and geographic scope referenced above is deemed unreasonable,
overbroad, or otherwise invalid, it is the parties&#146; intention that the enforcing court shall reduce or modify the time period and/or geographic scope to the extent necessary (and only to such extent necessary) to render such covenants
reasonable, valid and enforceable in all respects. </FONT></P> <P STYLE="margin-top:18px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>8. <U>ARBITRATION</U>.</B> </FONT></P>
<P STYLE="margin-top:6px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(a) <U>General</U>.</B> In consideration of Executive&#146;s service to the Company, its promise to arbitrate all employment related
disputes and Executive&#146;s receipt of the compensation, pay raises and other benefits paid to Executive by the Company, at present and in the future, Executive agrees that any and all controversies, claims, or disputes with anyone (including the
Company and any employee, officer, director, shareholder or benefit plan of the Company in their capacity as such or otherwise) arising out of, relating to, or resulting from Executive&#146;s service to the Company under this Agreement or otherwise
or the termination of Executive&#146;s service with the Company, including any breach of this Agreement, will be subject to binding arbitration under the Arbitration Rules set forth in California Code of Civil Procedure Section&nbsp;1280 through
1294.2, including Section&nbsp;1283.05 (the &#147;Rules&#148;) and pursuant to California law. Disputes which Executive agrees to arbitrate, and thereby agrees to waive any right to a trial by jury, include any statutory claims under state or
federal law, including, but not limited to, claims under Title </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">8 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
VII of the Civil Rights Act of 1964, the Americans with Disabilities Act of 1990, the Age Discrimination in Employment Act of 1967, the Older Workers Benefit Protection Act, the California Fair
Employment and Housing Act, the California Labor Code, claims of harassment, discrimination or wrongful termination and any statutory claims. Executive further understands that this Agreement to arbitrate also applies to any disputes that the
Company may have with Executive. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(b) <U>Procedure</U></B>. Executive agrees that any arbitration will be administered by
the American Arbitration Association (&#147;AAA&#148;) and that a neutral arbitrator will be selected in a manner consistent with its National Rules for the Resolution of Employment Disputes. The arbitration proceedings will allow for discovery
according to the rules set forth in the <I>National Rules for the Resolution of Employment Disputes or California Code of Civil Procedure</I>. Executive agrees that the arbitrator will have the power to decide any motions brought by any party to the
arbitration, including motions for summary judgment and/or adjudication and motions to dismiss and demurrers, prior to any arbitration hearing. Executive agrees that the arbitrator will issue a written decision on the merits. Executive also agrees
that the arbitrator will have the power to award any remedies, including attorneys&#146; fees and costs, available under applicable law. Executive understands the Company will pay for any administrative or hearing fees charged by the arbitrator or
AAA except that Executive will pay the first $125.00 of any filing fees associated with any arbitration Executive initiates. Executive agrees that the arbitrator will administer and conduct any arbitration in a manner consistent with the Rules and
that to the extent that the AAA&#146;s National Rules for the Resolution of Employment Disputes conflict with the Rules, the Rules will take precedence. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(c) <U>Remedy</U></B>. Except as provided by the Rules, arbitration will be the sole, exclusive and final remedy for any dispute
between Executive and the Company. Accordingly, except as provided for by the Rules, neither Executive nor the Company will be permitted to pursue court action regarding claims that are subject to arbitration. Notwithstanding, the arbitrator will
not have the authority to disregard or refuse to enforce any lawful Company policy, and the arbitrator will not order or require the Company to adopt a policy not otherwise required by law which the Company has not adopted. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(d) <U>Availability of Injunctive Relief</U></B>. In addition to the right under the Rules to petition the court for provisional
relief, Executive agrees that any party may also petition the court for injunctive relief where either party alleges or claims a violation of this Agreement or the Confidentiality Agreement or any other agreement regarding trade secrets,
confidential information, nonsolicitation or Labor Code &#167;2870. In the event either party seeks injunctive relief, the prevailing party will be entitled to recover reasonable costs and attorneys&#146; fees. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(e) <U>Administrative Relief</U></B>. Executive understands that this Agreement does not prohibit Executive from pursuing an
administrative claim with a local, state or federal administrative body such as the Department of Fair Employment and Housing, the Equal Employment Opportunity Commission or the workers&#146; compensation board. This Agreement does, however,
preclude Executive from pursuing court action regarding any such claim. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:8%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>(f) <U>Voluntary Nature of Agreement</U></B>.
Executive acknowledges and agrees that Executive is executing this Agreement voluntarily and without any duress or undue influence by the Company or anyone else. Executive further acknowledges and agrees that Executive has carefully read this
Agreement and that Executive has asked any questions needed for Executive to understand the terms, consequences and binding effect of this Agreement and fully understand it, including that Executive is waiving Executive&#146;s right to a jury trial.
Finally, Executive agrees that Executive has been provided an opportunity to seek the advice of an attorney of Executive&#146;s choice before signing this Agreement. </FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">9 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>9. <U>WAIVER</U>.</B> The waiver by the Company of any breach of any provision of this
Agreement shall not operate or be construed as a waiver of any subsequent breach by Executive of any provision of this Agreement. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>10.</B> <B><U>SEVERABILITY</U>.</B> The parties have carefully reviewed the provisions of this Agreement and agree that they are fair
and equitable. However, in light of the possibility of differing interpretations of law and changes of circumstances, the parties agree that in the event that any section, paragraph or term of this Agreement shall be determined to be invalid or
unenforceable by any competent authority or tribunal for any reason, the remainder of this Agreement shall be unaffected thereby and shall remain in full force and effect. Moreover, if any of the provisions of this Agreement is determined by a court
of competent jurisdiction to be excessively broad as to duration, activity, geographic application or subject, it shall be construed by limiting or reducing it to the extent legally permitted so as to be enforceable to the extent compatible with
then applicable law. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>11.</B> <B><U>SUCCESSORS AND ASSIGNS.</U></B> This Agreement shall bind and inure to the benefit of
the successors and assigns of the Company and the heirs, executors or personal representatives of Executive. This Agreement may not be assigned by Executive. This Agreement may be assigned to any successor in interest to the Company (including by
way of merger, consolidation or reorganization, or by way of any assignment of all or substantially all of the Company&#146;s assets, business or properties), and Executive hereby consents to such assignment. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>12.</B> <B><U>ENTIRE AGREEMENT; AMENDMENTS</U>.</B> This Agreement, including the recitals (which are a part hereof), together with
the applicable bylaws and policies of the Company, constitutes the entire Agreement between the parties hereto and there are no other understandings, agreements or representations, expressed or implied This Agreement supersedes any and all prior or
contemporaneous agreements, oral or written, concerning Executive&#146;s employment and compensation, except for any invention assignment and confidentiality terms of any agreement signed by Executive. This Agreement may be amended only in writing
signed by Executive and an authorized member of the Board. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>13. TERMINATION; SURVIVAL. </B>The Company may terminate this
Agreement upon written notice delivered to Executive. Such notice may be delivered to Executive at any time after the Effective Date, which termination shall be effective twelve months after delivery of such notice to Executive. Sections 5 (five)
through 14 (fourteen), inclusive shall survive the termination of this Agreement. The obligations of Section&nbsp;4 (four) shall survive only with regards to termination of employment occurring prior to the effective date of termination of this
Agreement or with regards to a Change of Control occurring prior to the effective date of termination of this Agreement. In all other respects the parties&#146; obligations set forth in Section&nbsp;4 (four), above, shall terminate upon termination
of this Agreement. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">10 </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>14. <U>GOVERNING LAW</U>.</B> This Agreement shall be governed by and construed in
accordance with the laws (other than conflicts of laws principles) of the State of California applicable to contracts executed in and to be performed entirely within such State by residents of such state. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dated as of April 21, 2010. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P><DIV ALIGN="right">
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<TR>
<TD WIDTH="12%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="87%"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2">ACCELRYS, INC.</FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Max Carnecchia</FONT></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Chief Executive Officer</FONT></TD></TR>
<TR>
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR>
<TD VALIGN="top" COLSPAN="3"><FONT STYLE="font-family:Times New Roman" SIZE="2">EXECUTIVE</FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">By:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Todd Johnson</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Name:</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Todd Johnson</FONT></TD></TR></TABLE></DIV> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">11 </FONT></P>

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<DOCUMENT>
<TYPE>EX-10.3
<SEQUENCE>4
<FILENAME>dex103.htm
<DESCRIPTION>SEPARATION AGREEMENT AND RELEASE
<TEXT>
<HTML><HEAD>
<TITLE>Separation Agreement and Release</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 10.3 </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>SEPARATION AGREEMENT AND RELEASE </U></B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">This Separation Agreement and Release (&#147;Agreement&#148;) is made by and between Ilene Vogt (&#147;Employee&#148;) and Accelrys, Inc.
(&#147;Company&#148;) (jointly referred to as the &#147;Parties&#148;). </FONT></P> <P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>RECITALS </U></B></FONT></P>
<P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee has been employed by the Company as its Senior Vice President of Worldwide Sales in accordance with the terms of an employment agreement dated on or about
August&nbsp;5, 2008 (the &#147;Employment Agreement&#148;). </FONT></TD></TR></TABLE> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee is hereby resigning as the Company&#146;s Senior Vice President of Worldwide Sales but will remain employed to assist in transition until May&nbsp;5, 2010
(&#147;Termination Date&#148;); </FONT></TD></TR></TABLE> <P STYLE="font-size:6px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR>
<TD WIDTH="4%"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT STYLE="font-family:Times New Roman" SIZE="2">3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">The Parties wish to set forth the terms of such termination as set forth herein. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">NOW THEREFORE, in consideration of the promises made herein, the Parties hereby agree as follows: </FONT></P>
<P STYLE="margin-top:24px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B><U>AGREEMENT </U></B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">1. <U>Resignation and Termination of Employment</U>. Employee is hereby resigning as the Company&#146;s Senior Vice President of
Worldwide Sales and from all offices which she holds, but will remain employed until May&nbsp;5, 2010 to assist with transitioning her responsibilities. This Agreement shall become effective and enforceable on the first day following the expiration
of the revocation period set forth in Section&nbsp;9, below (the &#147;Effective Date&#148;). Between the execution date and Termination Date Employee shall remain employed by the Company at her current salary and with benefits at the level at which
such benefits were provided prior to the Effective Date and shall be available to perform tasks as reasonably requested by the Company. As of the Termination Date, Employee shall be paid her earned wages through that date and any accrued and unused
vacation time, which vacation time equals $23,266.83. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">2. <U>Company&#146;s Obligations</U>. Provided that, and so long as,
Employee abides by the obligations set forth in Section&nbsp;7 of the Employment Agreement, the Company shall pay Employee the aggregate total sum of $250,000 (two hundred and fifty thousand dollars), less applicable withholdings. This aggregate
amount will be paid in 24 equal installments of $10,416.67 (ten thousand four hundred sixteen dollars and sixty seven cents), less applicable withholdings, on each of the Company&#146;s regular payroll days, commencing on the Company&#146;s first
payroll period after the Effective Date and ending twelve months thereafter. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">3. <U>Bonus Payment</U>. When bonus payments are
made to the Company&#146;s executives pursuant to the Company&#146;s fiscal year 2010 Management Incentive Plan (the &#147;Plan&#148;), in the payroll cycle following its approval, Company shall tender to Employee a lump sum amount based upon the
percentage achievement against objectives as determined by the Company&#146;s board of directors at the conclusion of the fiscal year to have been earned pursuant to the terms of the Plan, provided that the parties agree that such bonus will include
the payment of $45,000 for the individual discretionary portion of her bonus. For the avoidance of doubt, Employee shall not be eligible for a bonus pursuant to the Company&#146;s 2011 management incentive plan or other plans. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">4. <U>Full Satisfaction of Salary, Benefits and Vesting Obligations</U>. Employee acknowledges and agrees that, subject to complying with
the terms set forth in Sections 2 and 3 hereof, the Company has paid all salary, wages, accrued vacation and any and all other benefits due to Employee. Employee further acknowledges and agrees that any options to purchase the Company&#146;s stock,
restricted stock units or other equity rights cease vesting as of the Termination Date, that any unvested equity rights shall be cancelled and that Employee may exercise any vested stock options within 90 days of the Termination Date, solely in
accordance with the terms of the applicable stock option plans and grants. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">5. <U>Release of Claims</U>. Employee agrees that
the foregoing consideration represents settlement in full of all outstanding obligations owed to Employee by the Company and its affiliates, officers, managers, supervisors, agents and employees. Employee, on her own behalf, and on behalf of her
respective heirs, family members, executors, agents, and assigns, hereby fully and forever releases the Company and its officers, directors, employees, agents, investors, shareholders, administrators, affiliates, divisions, subsidiaries, predecessor
and successor corporations, and assigns (collectively &#147;the Released parties&#148;) from any duty, obligation or cause of action relating to any matters of any kind, </FONT></P>

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 <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">
whether presently known or unknown, suspected or unsuspected arising from or relating to any omissions, acts or facts that have occurred up until and including the Effective Date. Claims released
hereunder include, without limitation, claims relating to Employee&#146;s employment and the termination of employment; claims relating to the Employment Agreement, claims relating to, or arising from, wrongful or constructive termination; claims
relating to the right to purchase, or actual purchase or exercise of Company stock; claims relating to fraud, misrepresentation, breach of duty, securities claims; breach of contract, infliction of emotional distress, misrepresentation, unfair
business practices, defamation, libel, slander, negligence, personal injury, and any other tortuous conduct claims; claims for violation of any federal, state or municipal statute, including, but not limited to, Title VII of the Civil Rights Act of
1964, the Civil Rights Act of 1991, the Age Discrimination in Employment Act of 1967, the Americans with Disabilities Act of 1990, the Fair Labor Standards Act, the Employee Retirement Income Security Act of 1974, The Worker Adjustment and
Retraining Notification Act, the Older Workers Benefit Protection Act, the Family and Medical Leave Act, the California Family Rights Act, the California Fair Employment and Housing Act, and the California Labor Code. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">6. <U>Civil Code Section&nbsp;1542</U>. Employee represents that she is not aware of any claim other than the claims that are released by
this Agreement. Employee acknowledges that she has had the opportunity to be advised by legal counsel and is familiar with the provisions of California Civil Code Section&nbsp;1542, which provides as follows: </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HER FAVOR AT THE TIME OF EXECUTING
THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY AFFECTED HER SETTLEMENT WITH THE DEBTOR. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee, being aware of
said code section, agrees to expressly waive any rights she may have hereunder, as well as under any other statute or common law principles of similar effect. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">7. <U>No Pending or Future Lawsuits/Covenant not to Sue</U>. Employee represents that she has no lawsuits, claims, or actions pending in
ER name, or on behalf of any other person or entity, against the Released Parties. Employee represents and agrees that she does not intend to bring, and will not bring, any claims on her own behalf or on behalf of any other person or entity against
the Released Parties, whether in court, in an administrative hearing or otherwise. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">8. <U>Complete Release</U>. Employee
agrees that the release set forth herein shall be and remain in effect in all respects a complete general release. This release does not extend to any obligations incurred under this Agreement. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">9. <U>Consideration Period and Revocation</U>. The Parties agree that Employee has 21 days from the date of receipt of this Agreement to
consider executing such Agreement, and may use as much or as little of such period as he&#146;d like. Employee may revoke this Agreement after its execution by delivering written notice of revocation to the Company&#146;s Vice President of Human
Resources on or before the seventh day following execution, or, if such day falls on a weekend or holiday, the first non-weekend or holiday day thereafter. If Employee revokes this Agreement, the Company shall have no obligation hereunder or under
the Employment Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">10. <U>Voluntary Execution and Opportunity to Seek Legal Counsel</U>. This Agreement is executed
voluntarily and without any duress or undue influence on the part or behalf of the Parties hereto, with the full intent of releasing all claims. Employee acknowledges that she has read this Agreement; has been provided with the opportunity to be
represented in the preparation, negotiation, and execution of this Agreement by legal counsel of her choice or has voluntarily declined to seek such counsel. Employee further represents that she understands the terms and consequences of this
Agreement and the releases herein; and she is fully aware of the legal and binding effect of the releases therein. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">11.
<U>Breach</U>. Employee acknowledges and agrees that any breach of any provision of this Agreement shall constitute a material breach of this Agreement and shall entitle the Company immediately to recover the severance benefits provided to Employee
under this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">12. <U>No Admission of Liability</U>. The Parties understand and acknowledge that this Agreement
constitutes a compromise and settlement of actual or potential disputed claims. No action taken by the Parties hereto shall be deemed or construed to be an admission of any fault or liability whatsoever to the other party or to any third party.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">13. <U>Costs</U>. The Parties shall each bear their own costs, expert fees, attorneys&#146; fees and other fees incurred in
connection with this Agreement, except as provided herein. </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">-2- </FONT></P>


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 <P STYLE="margin-top:0px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">14. <U>Arbitration</U>. The Parties agree that any and all disputes arising out of the terms
of this Agreement, their interpretation, and any of the matters herein released, shall be subject to binding arbitration in San Diego County before the American Arbitration Association under its National Rules for the Resolution of Employment
Disputes, supplemented by the California Code of Civil Procedure. The Parties agree that the prevailing party in any arbitration shall be entitled to injunctive relief in any court of competent jurisdiction to enforce the arbitration award. The
Parties agree that the prevailing party in any arbitration shall be awarded its reasonable attorneys&#146; fees and costs. <B>The Parties hereby agree to waive their right to have any dispute between them resolved in a court of law by a judge or
jury. </B>This paragraph will not prevent either party from seeking injunctive relief (or any other provisional remedy) from any court having jurisdiction over the Parties and the subject matter of their dispute relating to Employee&#146;s
obligations under this Agreement and the Confidentiality Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">15. <U>Authority</U>. Each party represents and warrants
that it has the authority to act to enter into and effectuate the terms of this Agreement. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">16. <U>No Representations</U>. In
entering into this Agreement, neither party has relied upon any representations or statements made by the other party hereto, except as expressly set forth in this Agreement. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">17. <U>Severability</U>. In the event that any provision, or any portion thereof, becomes or is declared by a court of competent
jurisdiction to be illegal, unenforceable or void, this Agreement shall continue in full force and effect without said provision or portion of said provision. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">18. <U>Entire Agreement</U>. This Agreement represents the entire agreement and understanding between the Company and Employee concerning
the subject matter of this Agreement and Employee&#146;s relationship with the Company, and supersedes and replaces any and all prior agreements and understandings between the Parties concerning the subject matter hereof. Nothing herein supersedes
Employee&#146;s confidentiality obligations set forth in Section&nbsp;6 of the Employment Agreement, or confidentiality or invention assignment obligations set forth in other agreements executed by Employee, which remain in full force and effect.
</FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">19. <U>No Waiver</U>. The failure of either party to insist upon the performance of any of the terms and conditions in this
Agreement, or the failure to prosecute any breach of any of the terms and conditions of this Agreement, shall not be construed as a subsequent waiver of any such terms or conditions. This entire Agreement shall remain in full force and effect as if
no such forbearance or failure of performance had occurred. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">20. <U>No Oral Modification</U>. This Agreement may only be
amended in a writing signed by Employee and the Chief Executive Officer of the Company. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">21. <U>Governing Law</U>. This
Agreement shall be construed, interpreted, governed, and enforced in accordance with the laws of the State of California, without regard to choice-of-law provisions. Employee hereby consents to personal and exclusive jurisdiction and venue in the
State of California. </FONT></P> <P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">22. <U>Counterparts</U>. This Agreement may be executed in counterparts, and each counterpart shall have
the same force and effect as an original and shall constitute an effective, binding agreement on the part of each of the undersigned. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px; text-indent:4%"><FONT STYLE="font-family:Times New Roman" SIZE="2">23. <U>Taxes </U>Employee will be responsible for the payment of any tax liability incurred as a result of this Agreement, including,
without limitation, any taxes and penalties that may arise under Section&nbsp;409A of the Internal Revenue Code. </FONT></P> <P STYLE="font-size:12px;margin-top:0px;margin-bottom:0px">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" ALIGN="center">

<TR>
<TD WIDTH="33%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="33%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Employee</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Accelrys, Inc.</FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Ilene Vogt</FONT></P></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0px;margin-bottom:1px;border-bottom:1px solid #000000"><FONT STYLE="font-family:Times New Roman" SIZE="2">/s/ Max Carnecchia</FONT></P></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Ilene Vogt</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Max Carnecchia</FONT></TD></TR>
<TR>
<TD VALIGN="top"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dated: April 21, 2010</FONT></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Chief Executive Officer</FONT></TD></TR>
<TR>
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom"><FONT STYLE="font-family:Times New Roman" SIZE="2">Dated: April 21, 2010</FONT></TD></TR></TABLE> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT SIZE="1">&nbsp;</FONT></P>
 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2">-3- </FONT></P>

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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>5
<FILENAME>dex991.htm
<DESCRIPTION>PRESS RELEASE
<TEXT>
<HTML><HEAD>
<TITLE>Press Release</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">

 <P STYLE="margin-top:0px;margin-bottom:0px" ALIGN="right"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Exhibit 99.1 </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px" ALIGN="center"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Accelrys Appoints Todd Johnson as Executive Vice President of Sales, Marketing and Services </B></FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">SAN DIEGO, California, April&nbsp;21, 2010 &#151; Accelrys, Inc. (NASDAQ: ACCL) today announced the appointment of Todd Johnson as its Executive Vice
President of Sales, Marketing and Services. Mr.&nbsp;Johnson initially joined the Company in January 2009 as its Interim Chief Executive Officer. After the Company appointed Max Carnecchia as its Chief Executive Officer in July 2009,
Mr.&nbsp;Johnson remained a Senior Vice President of the Company and was proactively engaged in a number of marketing and sales-related endeavors. </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">In connection with his appointment, the Company also announced the departure of Ilene Vogt, who had been the Company&#146;s Senior Vice President of
Worldwide Sales and Services. In commenting on Mr.&nbsp;Johnson&#146;s appointment Mr.&nbsp;Carnecchia stated, &#147;One of Todd&#146;s key strengths is aligning and optimizing market strategy with supporting go to market activities. As we look
forward to our 2011 fiscal year, we are excited to add Todd&#146;s leadership and experience to our sales and marketing organizations.&#148; </FONT></P>
<P STYLE="margin-top:12px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Prior to joining Accelrys, Todd Johnson was the Chief Executive Officer for Kontiki, Inc., before negotiating its successful sale to VeriSign, Inc.,
where he was the Senior Vice President of their Broadband Content business. He has extensive management and leadership experience through tenure of senior executive positions at a number of companies, including Silicon Graphics, Inc, having earlier
honed his business skills at Hewlett-Packard Company, and the University of Santa Clara, where he graduated with a B.Sc. degree in Marketing. </FONT></P>
<P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>About Accelrys </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Headquartered in San
Diego, California, Accelrys develops scientific business intelligence software and solutions for the life sciences, energy, chemicals, aerospace, and consumer products industries. Our customers include many Fortune 500 companies and other commercial
entities, as well as academic and government entities. We have a vast portfolio of computer-aided design modeling and simulation offerings which assist our customers in conducting scientific experiments &#145;in silico&#146; in order to reduce the
duration and cost of discovering and developing new drugs and materials. Our scientific business intelligence platform underlies most of our computer-aided design modeling and simulation offerings. Our platform can be used with our products, our
competitors&#146; products and our customers&#146; proprietary predictive science products. Its flexibility, ease-of-use and advanced chemical, text and image analysis and reporting capabilities enable our customers to mine, aggregate, analyze and
report scientific data from disparate sources, thereby better utilizing scientific data within their organizations. For more information about Accelrys, please visit our website at http://<U>www.accelrys.com</U>. </FONT></P>
<P STYLE="margin-top:18px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><B>Contacts </B></FONT></P> <P STYLE="margin-top:6px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Maria Krinsky </FONT></P>
<P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">Kickstart for Accelrys </FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2">(415) 509-0498
</FONT></P> <P STYLE="margin-top:0px;margin-bottom:0px"><FONT STYLE="font-family:Times New Roman" SIZE="2"><U>mkrinsky@kickstartconsulting.com</U> </FONT></P>
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<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g36430g37s91.jpg
<DESCRIPTION>GRAPHIC
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end
</TEXT>
</DOCUMENT>
</SUBMISSION>
