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EXHIBIT 31.1​

CERTIFICATION OF CHIEF EXECUTIVE OFFICER
PURSUANT TO RULES 13a-14(A) AND 15d-14(A)
OF THE SECURITIES EXCHANGE ACT OF 1934

I, David Johnson, certify that:

1.

I have reviewed this amendment to the Annual Report on Form 10-K of Alliqua BioMedical, Inc. (the “registrant”);

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2.

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

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​	Date: April 30, 2018	​	​	By:	​	​	/s/ David Johnson	​
​	​	​	​	​	​	​	David Johnson Chief Executive Officer (Principal Executive Officer)	​