<SUBMISSION>
<ACCESSION-NUMBER>0001144204-18-019825
<TYPE>3
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<PERIOD>20180401
<FILING-DATE>20180409
<DATE-OF-FILING-DATE-CHANGE>20180409
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Warusz Joseph Michael
<CIK>0001468000
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>3
<ACT>34
<FILE-NUMBER>001-36278
<FILM-NUMBER>18746507
</FILING-VALUES>
<MAIL-ADDRESS>
<STREET1>12 TEAL DRIVE
<CITY>LANGHORNE
<STATE>PA
<ZIP>19047
</MAIL-ADDRESS>
</REPORTING-OWNER>
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>Alliqua BioMedical, Inc.
<CIK>0001054274
<ASSIGNED-SIC>3841
<IRS-NUMBER>582349413
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>1010 STONY HILL ROAD
<STREET2>SUITE 200
<CITY>YARDLEY
<STATE>PA
<ZIP>19067
<PHONE>215-702-8550
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>1010 STONY HILL ROAD
<STREET2>SUITE 200
<CITY>YARDLEY
<STATE>PA
<ZIP>19067
</MAIL-ADDRESS>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>Alliqua, Inc.
<DATE-CHANGED>20101222
</FORMER-COMPANY>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>HEPALIFE TECHNOLOGIES INC
<DATE-CHANGED>20030529
</FORMER-COMPANY>
<FORMER-COMPANY>
<FORMER-CONFORMED-NAME>ZETA CORP
<DATE-CHANGED>20030219
</FORMER-COMPANY>
</ISSUER>
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<DESCRIPTION>OWNERSHIP DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2018-04-01</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001054274</issuerCik>
        <issuerName>Alliqua BioMedical, Inc.</issuerName>
        <issuerTradingSymbol>ALQA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001468000</rptOwnerCik>
            <rptOwnerName>Warusz Joseph Michael</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ALLIQUA BIOMEDICAL, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1010 STONY HILL ROAD</rptOwnerStreet2>
            <rptOwnerCity>YARDLEY</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>19067</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Mr. Warusz was appointed Chief Financial Officer by the Board of Directors on March 15, 2018, effective April 1, 2018.</remarks>

    <ownerSignature>
        <signatureName>/s/ Joseph Warusz</signatureName>
        <signatureDate>2018-04-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
