v3.19.3

Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
May 31, 2019 | Oct. 31, 2018 | Sep. 30, 2019 | Sep. 30, 2019 | Dec. 31, 2018 | Jan. 01, 2019
Impairment of Long-Lived Assets Held-for-use |  |  |  | $ 0 | $ 0 |
Grant Reimbursements |  |  | $ 700,000 | 1,900,000 |  |
Gain (Loss) on Extinguishment of Debt, Total |  | $ 11,000 |  |  |  |
Operating Lease, Liability, Total |  |  | 743,000 | 743,000 |  |
Lessee, Operating Lease, Liability, Payments, Due, Total |  |  | 891,000 | 891,000 |  |
Operating Lease, Right-of-Use Asset |  |  | 687,000 | 687,000 |  |
Accounting Standards Update 2016-02 [Member] |  |  |  |  |  |
Operating Lease, Liability, Total |  |  |  |  |  | $ 227,000
Lessee, Operating Lease, Liability, Payments, Due, Total |  |  |  |  |  | $ 239,000
Lessee, Operating Lease, Discount Rate |  |  |  |  |  | 9.41%
Operating Lease, Right-of-Use Asset |  |  |  |  |  | $ 227,000
Modified March 2018 and Modified September 2018 Notes [Member] |  |  |  |  |  |
Embedded Derivative, Fair Value of Embedded Derivative Asset |  |  | 0 | 0 | 0 |
Embedded Derivative, Fair Value of Embedded Derivative Liability |  |  | 0 | 0 | 0 |
Research and Development Expense [Member] |  |  |  |  |  |
Collaboration Initiation Payment | $ 75,000 |  |  |  |  |
Money Market Funds [Member] |  |  |  |  |  |
Restricted Cash, Total |  |  | 198,000 | 198,000 |  |
Letter of Credit 1 [Member] |  |  |  |  |  |
Restricted Cash, Total |  |  | $ 55,000 | $ 55,000 | 55,000 |
Minimum [Member] |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  |  | 3 years |  |
Maximum [Member] |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  |  | 5 years |  |
Grants Receivable |  |  |  |  | $ 5,700,000 |
Accounts Payable 1 [Member] | Supplier Concentration Risk [Member] | Nitto-Denko Avecia, Inc. [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 26.00% |  |
Accounts Payable 1 [Member] | Supplier Concentration Risk [Member] | Vendor 1 [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 26.00% | 52.00% |
Accounts Payable 1 [Member] | Supplier Concentration Risk [Member] | Vendor 2 [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 26.00% | 26.00% |
Accounts Payable 1 [Member] | Supplier Concentration Risk [Member] | Vendor 3 [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  | 23.00% | 15.00% |
Accounts Payable 1 [Member] | Supplier Concentration Risk [Member] | Two of the Three Vendors Supporting Clinical Study Activities [Member] |  |  |  |  |  |
Concentration Risk, Percentage |  |  |  |  | 67.00% |

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