Note 11 - Stock Options - Summary of Stock Option Activity (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	9 Months Ended
Sep. 30, 2019	Sep. 30, 2019
Number of Options, outstanding (in shares)	690
Number of Options, Alliqua options assumed in merger (in shares)	690	731
Number of Options, exercised (in shares)
Number of Options, expired (in shares)	(17)
Number of Options, outstanding (in shares)	731
Number of Options, exercisable (in shares)		550
Weighted Average Exercise Price, outstanding (in dollars per share)	$ 2.76
Weighted Average Exercise Price, Alliqua options assumed in merger (in dollars per share)	2.76	$ 23.38
Weighted Average Exercise Price, exercised (in dollars per share)
Weighted Average Exercise Price, expired (in dollars per share)	93.48
Weighted Average Exercise Price, outstanding (in dollars per share)	$ 23.38
Weighted Average Exercise Price, exercisable (in dollars per share)		$ 30.07
Weighted Average Remaining Life in Years, outstanding (Year)	6 years 36 days
Weighted Average Remaining Life in Years, exercisable (Year)	5 years 292 days
Intrinsic Value, outstanding		$ 33
Intrinsic Value, exercisable		$ 33
Alliqua Biomedical, Inc. [Member]
Number of Options, Alliqua options assumed in merger (in shares)	58	58
Number of Options, outstanding (in shares)	58
Weighted Average Exercise Price, Alliqua options assumed in merger (in dollars per share)	$ 289.76	$ 289.76
Weighted Average Exercise Price, outstanding (in dollars per share)	$ 289.76

The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options of the plan that expired.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of share options (or share units) exercised during the current period.

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