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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.

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Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity.

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Carrying amount as of the balance sheet date of amounts due under the terms of governmental, corporate, or foundation grants.

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The aggregate amount of write-downs for impairments recognized during the period for long lived assets held for use (including those held for disposal by means other than sale).

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Discount rate used by lessee to determine present value of operating lease payments.

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Cash outflow in the form of capital distributions and dividends to common shareholders, preferred shareholders and noncontrolling interests.

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Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.

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Amount of cash restricted as to withdrawal or usage. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits.

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Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($)	1 Months Ended	3 Months Ended	6 Months Ended	12 Months Ended
	Oct. 31, 2018	Jun. 30, 2019	Jun. 30, 2019	Dec. 31, 2018	Jan. 01, 2019
Impairment of Long-Lived Assets Held-for-use			$ 0	$ 0
Payments of Dividends, Total			0
Grant Reimbursements		$ 1,104,000	1,198,000
Reclassification of Warrant into Equity		234,000	234,000
Gain (Loss) on Extinguishment of Debt, Total	$ 11,000
Operating Lease, Liability, Total		840,000	840,000
Lessee, Operating Lease, Liability, Payments, Due, Total		1,007,000	1,007,000
Operating Lease, Right-of-Use Asset		779,000	779,000
Accounting Standards Update 2016-02 [Member]
Operating Lease, Liability, Total					$ 227,000
Lessee, Operating Lease, Liability, Payments, Due, Total					$ 239,000
Lessee, Operating Lease, Discount Rate					9.41%
Operating Lease, Right-of-Use Asset					$ 227,000
Modified March 2018 and Modified September 2018 Notes [Member]
Embedded Derivative, Fair Value of Embedded Derivative Asset		0	0	0
Embedded Derivative, Fair Value of Embedded Derivative Liability		0	0	0
Research and Development Expense [Member]
Collaboration Initiation Payment		75,000	75,000
Money Market Funds [Member]
Restricted Cash, Total		200,000	200,000
Letter of Credit 1 [Member]
Restricted Cash, Total		$ 55,000	$ 55,000	55,000
Minimum [Member]
Property, Plant and Equipment, Useful Life			3 years
Maximum [Member]
Property, Plant and Equipment, Useful Life			5 years
Grants Receivable				$ 5,700,000
Accounts Payable 1 [Member] \| Supplier Concentration Risk [Member] \| Vendor 1 [Member]
Concentration Risk, Percentage			26.00%	52.00%
Accounts Payable 1 [Member] \| Supplier Concentration Risk [Member] \| Vendor 2 [Member]
Concentration Risk, Percentage			22.00%	26.00%
Accounts Payable 1 [Member] \| Supplier Concentration Risk [Member] \| Vendor 3 [Member]
Concentration Risk, Percentage			17.00%	15.00%
Accounts Payable 1 [Member] \| Supplier Concentration Risk [Member] \| Two of the Three Vendors Supporting Clinical Study Activities [Member]
Concentration Risk, Percentage			44.00%	67.00%