Note 10 - Stock Options - Summary of Stock Option Activity (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	6 Months Ended
Jun. 30, 2019	Jun. 30, 2019
Number of Options, outstanding (in shares)	690
Weighted Average Exercise Price, outstanding (in dollars per share)	$ 2.76
Number of Options, Alliqua options assumed in merger (in shares)	690	748
Weighted Average Exercise Price, Alliqua options assumed in merger (in dollars per share)	$ 2.76	$ 24.95
Number of Options, exercised (in shares)
Weighted Average Exercise Price, exercised (in dollars per share)
Number of Options, cancelled (in shares)
Weighted Average Exercise Price, cancelled (in dollars per share)
Number of Options, outstanding (in shares)	748
Weighted Average Exercise Price, outstanding (in dollars per share)	$ 24.95
Weighted Average Remaining Life in Years, outstanding (Year)	6 years 73 days
Intrinsic Value, outstanding		$ 188
Number of Options, exercisable (in shares)		530
Weighted Average Exercise Price, exercisable (in dollars per share)		$ 33.93
Weighted Average Remaining Life in Years, exercisable (Year)	5 years 255 days
Intrinsic Value, exercisable		$ 188
Alliqua Biomedical, Inc. [Member]
Number of Options, Alliqua options assumed in merger (in shares)	58	58
Weighted Average Exercise Price, Alliqua options assumed in merger (in dollars per share)	$ 289.76	$ 289.76
Number of Options, outstanding (in shares)	58
Weighted Average Exercise Price, outstanding (in dollars per share)	$ 289.76

The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of share options (or share units) exercised during the current period.

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