v3.19.3

Note 10 - Stock Options (Tables) | 6 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2019 | Dec. 31, 2018
Notes Tables |  |
Share-based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Options |  | Weighted Average Exercise Price |  | Weighted Average Remaining Life In Years |  | Intrinsic Value |
Outstanding, December 31, 2018 |  | 690 |  | $ | 2.76 |  |  |  |  |
Alliqua options assumed in Merger |  | 58 |  | 289.76 |  |  |  |  |
Exercised |  | — |  | — |  |  |  |  |
Cancelled |  | — |  | — |  |  |  |  |
Outstanding, June 30, 2019 |  | 748 |  | $ | 24.95 |  | 6.2 |  | $ | 188 |
Exercisable, June 30, 2019 |  | 530 |  | $ | 33.93 |  | 5.7 |  | $ | 188 |
|  |  |  | Outstanding Options
|  |  |  |  |  |  |  |  | Weighted- |  |  |
|  |  |  |  |  | Weighted- |  | Average |  |  |
|  |  |  |  |  | Average |  | Remaining |  |  |
|  | Shares |  |  |  | Exercise |  | Contractual |  | Aggregate
|  | Available |  | Options |  | Price |  | Life |  | Intrinsic
|  | For Grant |  | Outstanding |  | Per Share |  | (in years) |  | Value(a)
Balance at December 31, 2016 |  | 5 |  | 19,222 |  | $ | 0.10 |  | 9.4 |  |  |
Balance at December 31, 2017 |  | 5 |  | 19,222 |  | $ | 0.10 |  | 8.4 |  | $ | 6,639
Balance at December 31, 2018 |  | 5 |  | 19,222 |  | $ | 0.10 |  | 7.4 |  | $ | 6,956
Vested and expected to vest as of December 31, 2018 |  |  |  | 19,222 |  | $ | 0.10 |  | 7.4 |  | $ | 6,956
Exercisable at December 31, 2018 |  |  |  | 11,146 |  | $ | 0.09 |  | 7.4 |  | $ | 4,119
​
| (a) |  | The aggregate intrinsic value is calculated as the difference between the stock option exercise price and the estimated fair value of the Company’s common stock of $0.46 and $0.44 per share as of December 31, 2018 and 2017.
Share-based Payment Arrangement, Option, Exercise Price Range [Table Text Block] |
|  | Options Outstanding |  | Options Exercisable |
Range of Exercise Price |  | Weighted Average Exercise Price |  | Outstanding Number of Options |  | Weighted Average Exercise Price |  | Weighted Average Remaining Life In Years |  | Exercisable Number of Options |
$1.11 — $1.38 |  | $ 1.11 |  | 73 |  | $ 1.11 |  | 2.5 |  | 73 |
1.39 — 3.05 |  | 1.39 |  | 37 |  | 1.39 |  | 3.2 |  | 37 |
3.06 — 20.99 |  | 3.06 |  | 580 |  | 3.06 |  | 7.5 |  | 362 |
21.00 — 656.40 |  | 289.81 |  | 58 |  | 289.81 |  | 0.7 |  | 58 |
|  | $ 24.95 |  | 748 |  | $ 24.76 |  | 5.7 |  | 530 |

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- Definition Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901 + Details
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