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Share-based compensation - Summary of Stock Options Outstanding (Detail) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 shares $ / shares | Dec. 31, 2020 shares | Dec. 31, 2019 shares | Dec. 31, 2018 shares
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Number of options (in shares) | shares | 8,695,348 | 9,041,288 | 12,153,772 | 12,243,526
Weighted average remaining contractual life (years) | 2 years 8 months 12 days | 2 years 10 months 24 days | 2 years 10 months 24 days |
1.65 to 45.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Number of options (in shares) | shares | 3,533 | 195,207 | 2,130,161 |
Weighted average remaining contractual life (years) | 1 year 9 months 18 days | 3 months 18 days | 10 months 24 days |
45.01 to 90.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Number of options (in shares) | shares | 415,340 | 1,243,833 | 2,482,270 |
Weighted average remaining contractual life (years) | 2 months 12 days | 1 year 2 months 12 days | 2 years 2 months 12 days |
90.01 to 135.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Number of options (in shares) | shares | 1,659,359 | 2,234,257 | 2,946,838 |
Weighted average remaining contractual life (years) | 1 year 9 months 18 days | 2 years 8 months 12 days | 3 years 4 months 24 days |
135.01 to 180.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Number of options (in shares) | shares | 3,076,253 | 3,671,417 | 3,318,423 |
Weighted average remaining contractual life (years) | 2 years 6 months | 3 years 6 months | 4 years 1 month 6 days |
180.01 to 498.98 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Number of options (in shares) | shares | 3,540,863 | 1,696,574 | 1,276,080 |
Weighted average remaining contractual life (years) | 3 years 8 months 12 days | 3 years 7 months 6 days | 3 years 8 months 12 days |
Bottom of Range | 1.65 to 45.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | $ 1.65 |  |  |
Bottom of Range | 45.01 to 90.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 45.01 |  |  |
Bottom of Range | 90.01 to 135.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 90.01 |  |  |
Bottom of Range | 135.01 to 180.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 135.01 |  |  |
Bottom of Range | 180.01 to 498.98 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 180.01 |  |  |
Top of Range | 1.65 to 45.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 45.00 |  |  |
Top of Range | 45.01 to 90.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 90.00 |  |  |
Top of Range | 90.01 to 135.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 135.00 |  |  |
Top of Range | 135.01 to 180.00 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | 180.00 |  |  |
Top of Range | 180.01 to 498.98 |  |  |  |
Disclosure Of Share Based Payments [Line Items] |  |  |  |
Range of exercise prices (in dollars per share) | $ 498.98 |  |  |

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