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Commitments and Contingencies - Additional Information (Detail) $ in Thousands |  |  | 1 Months Ended | 3 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jul. 28, 2023 USD ($) | May 11, 2023 USD ($) | Jul. 31, 2021 | Jul. 31, 2019 agreement | Mar. 31, 2024 USD ($) | Mar. 31, 2023 USD ($) | Feb. 29, 2024 USD ($) | Jan. 31, 2024 USD ($) | Dec. 31, 2023 USD ($)
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Accounts payable and accrued expenses |  |  |  |  | $ 14,875 |  |  |  | $ 25,592
Operating lease liabilities |  |  |  |  | 7,045 |  |  |  |
Operating lease right-of-use assets |  |  |  |  | 3,826 |  |  |  | 4,864
Research and development |  |  |  |  | 21,964 | $ 24,334 |  |  |
New Corporate Headquarters Office Space |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Lease, annual fixed rent |  | $ 1,300 |  |  |  |  |  |  |
Lease, fixed rent, annual increase, percent |  | 2.50% |  |  |  |  |  |  |
Option to extend |  | true |  |  |  |  |  |  |
Operating Lease, renewable term |  | 5 years |  |  |  |  |  |  |
Discount rate - operating leases |  | 12.83% |  |  |  |  |  |  |
Operating lease liabilities | $ 6,672 |  |  |  |  |  |  |  |
Lessee, operating lease, incentives | 2,900 |  |  |  |  |  |  |  |
Operating lease right-of-use assets | $ 6,779 |  |  |  |  |  |  |  |
Lease incentives reimbursed |  |  |  |  |  |  | $ 778 | $ 947 |
Operating Lease, expense |  |  |  |  | 269 |  |  |  |
New Corporate Headquarters Office Space | Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Lessee, operating lease, discount rate, basis spread on variable rate |  | 7.75% |  |  |  |  |  |  |
Lessee, operating lease, discount rate, variable rate basis, floor |  | 2.75% |  |  |  |  |  |  |
New Corporate Headquarters Office Space | Research and Development |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating Lease, expense |  |  |  |  | 173 |  |  |  |
New Corporate Headquarters Office Space | General and Administrative |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating Lease, expense |  |  |  |  | 96 |  |  |  |
Patheon and Patheon Manufacturing Services LLC |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Reduced demand payment for manufacturing commitments |  |  |  |  |  |  |  |  | $ 1,700
Accounts payable and accrued expenses |  |  |  |  | 246 |  |  |  |
Old Stamford Operating Lease |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating lease cost |  |  |  |  | 0 | 407 |  |  |
Old Stamford Operating Lease | Research and Development |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating lease cost |  |  |  |  |  | 284 |  |  |
Old Stamford Operating Lease | General and Administrative |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Operating lease cost |  |  |  |  |  | 123 |  |  |
New Stamford Lease |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Letter of credit amount outstanding |  |  |  |  | 1,500 |  |  |  |
Non-Exclusive License Agreement | Enteris Biopharma, Inc. |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Payment of milestone payment |  |  |  |  | $ 0 | $ 0 |  |  |
MSA | Patheon and Patheon Manufacturing Services LLC |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Number of related product agreements | agreement |  |  |  | 2 |  |  |  |  |
API Commercial Supply Agreement - PPL |  |  |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |  |  |
Agreement renewal term |  |  | 5 years |  |  |  |  |  |

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