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Business - Additional Information (Detail) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2024 USD ($) item | Dec. 31, 2023 USD ($) | Mar. 31, 2023 USD ($)
Nature Of Business [Line Items] |  |  |
Date of formation | Jul. 02, 2004 |  |
Proceeds from equity and debt financing | $ 520,700 |  |
Number of follow-on public offerings | item | 4 |  |
Unrestricted cash and cash equivalents and marketable securities | $ 69,773 |  |
Accumulated deficit | 715,441 | $ 684,745 |
Net loss | (30,696) |  | $ (26,665)
Net cash used in operating activities | (30,453) |  | $ (34,618)
HCR Agreement [Member] |  |  |
Nature Of Business [Line Items] |  |  |
Net proceeds from the royalty purchase and sale agreement | $ 36,474 | $ 36,474 |
Minimum [Member] |  |  |
Nature Of Business [Line Items] |  |  |
Expected approvals and commercial launches period | 12 months |  |
Maximum [Member] |  |  |
Nature Of Business [Line Items] |  |  |
Expected approvals and commercial launches period | 18 months |  |
CSL Vifor, Maruishi and CKDP | License and supply agreements for difelikefalin |  |  |
Nature Of Business [Line Items] |  |  |
Payments received in connection with license and supply agreements | $ 288,600 |  |
Affiliated Entity [Member] | Vifor International Ltd. |  |  |
Nature Of Business [Line Items] |  |  |
Proceeds from the sale of common stock under license agreement with Vifor International | $ 98,000 |  |

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