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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Operating activities |  |  |
Net loss | $ (70,867) | $ (118,513) | $ (85,474)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation expense | 8,929 | 13,730 | 17,734
Non-cash interest expense on liability related to sales of future royalties and milestones, net of issuance costs accretion | 8,473 | 604 |
Impairment of long-lived assets | 4,274 | 0 | 0
Inventory write-down | 2,963 |  |
Depreciation and amortization | 192 | 259 | 248
Noncash lease expense | 766 | 2,075 | 1,422
(Accretion)/amortization of available-for-sale marketable securities, net | (543) | (400) | 264
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net - related party | 2,358 | 495 | (3,260)
Inventory | (1,042) | (438) | 201
Income tax receivable | 697 |  |
Other receivables | (1,034) | (59) | (41)
Prepaid expenses | 7,625 | 8,113 | (13,748)
Accounts payable and accrued expenses | (21,439) | 3,275 | 5,679
Operating lease liabilities | (4,363) | (1,918) | (1,755)
Reimbursement of lease incentive | 2,094 | 807 |
Other |  | (108) |
Net cash used in operating activities | (60,917) | (92,078) | (78,730)
Investing activities |  |  |
Proceeds from maturities of available-for-sale marketable securities | 82,000 | 155,441 | 220,435
Proceeds from redemptions of available-for-sale marketable securities, at par |  | 4,000 | 4,000
Purchases of available-for-sale marketable securities | (32,213) | (113,605) | (95,685)
Purchases of property and equipment | (1,046) | (2,375) | (43)
Net cash provided by investing activities | 48,741 | 43,461 | 128,707
Financing activities |  |  |
Payments to royalty purchase and sale agreement | (3,604) |  |
Proceeds from royalty purchase and sale agreement, net of $1.0 million of issuance costs |  | 36,474 |
Net proceeds from sales of common stock under open market sales agreement |  | 1,117 |
Proceeds from the exercise of stock options |  | 560 | 311
Net cash (used in) provided by financing activities | (3,604) | 38,151 | 311
Net (decrease) increase in cash, cash equivalents and restricted cash | (15,780) | (10,466) | 50,288
Cash, cash equivalents and restricted cash at beginning of period | 53,683 | 64,149 | 13,861
Cash, cash equivalents and restricted cash at end of period | 37,903 | 53,683 | $ 64,149
Noncash investing and financing activities |  |  |
Receivable for additional HCR financing earned | 2,500 |  |
Incremental right-of-use asset in exchange for non-cash lease liability from modification of lease | 3,417 |  |
Transfer of property and equipment per lease assignment | (3,417) |  |
Initial direct costs included as right-of-use asset from modification of lease | $ 577 |  |
Accrual for leasehold improvements |  | $ 778 |

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