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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2024
Summary of Assumptions Used in Black-Scholes Option Pricing Model | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31, | ​
​ |  | 2024 |  | 2023 |  | 2022 |
Risk-free interest rate |  | 4.12% - 4.34 | % | 3.38% - 4.65 | % | 1.70% - 4.21 | %
Expected volatility |  | 89.6% - 89.8 | % | 76.3% - 81.3 | % | 77.7% - 81.9 | %
Expected dividend yield |  | 0 | % | 0 | % | 0 | %
Expected life of employee and Board options (in years) |  | 6.25 |  | 6.25 |  | 6.25 | ​
Summary of Stock Option Activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted | ​ | Aggregate
​ | ​ | Number of | ​ | Average Exercise | ​ | Intrinsic
​ |  | Shares |  | Price |  | Value
Outstanding, December 31, 2023 |  | 658,138 | ​ | $ | 155.88 |  | ​ |
Granted |  | 253,760 | ​ |  | 10.32 |  | ​ |
Exercised |  | — | ​ |  | — |  | ​ |
Forfeited |  | (275,941) | ​ |  | 60.96 |  | ​ |
Expired |  | (295,497) | ​ |  | 176.43 |  | ​ |
Outstanding, December 31, 2024 |  | 340,460 | ​ | $ | 106.62 | ​ | $ | —
Weighted average remaining contractual life as of December 31, 2024 (in years) |  | 7.32 | ​ |  |  | ​ |  |
Options exercisable, December 31, 2024 |  | 185,602 | ​ | $ | 151.42 | ​ | $ | —
Weighted average remaining contractual life as of December 31, 2024 (in years) |  | 6.08 | ​ |  |  | ​ |  |
Options vested and expected to vest as of December 31, 2024 |  | 340,460 | ​ | $ | 106.62 | ​ | $ | —
Weighted average remaining contractual life as of December 31, 2024 (in years) |  | 7.32 | ​ |  |  | ​ |  |
Employees And Non-Employee Members Of Board Of Directors |
Summary of Restricted Stock Unit Activity | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted
​ | ​ | Number of | ​ | Average Grant
​ |  | Units |  | Date Fair Value
Outstanding, December 31, 2023 |  | 47,194 | ​ | $ | 111.24
Awarded |  | 75,323 | ​ |  | 7.92
Vested and released |  | (31,170) | ​ |  | 96.24
Forfeited |  | (11,434) | ​ |  | 126.84
Outstanding, December 31, 2024 |  | 79,913 | ​ | $ | 17.51
Restricted stock units exercisable (vested and deferred), December 31, 2024 |  | — | ​ | ​ | ​
Employee Stock Option |
Summary of Compensation Expense Recognized | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
​ |  | 2024 |  | 2023 |  | 2022
Research and development | ​ | $ | 1,016 | ​ | $ | 5,973 | ​ | $ | 7,222
General and administrative | ​ |  | 5,274 | ​ |  | 5,634 | ​ |  | 6,426
Total stock option expense | ​ | $ | 6,290 | ​ | $ | 11,607 | ​ | $ | 13,648
Restricted Stock Units |
Summary of Compensation Expense Recognized | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31,
​ |  | 2024 |  | 2023 |  | 2022
Research and development | ​ | $ | 248 | ​ | $ | 476 | ​ | $ | 765
General and administrative | ​ | ​ | 2,391 | ​ | ​ | 1,647 | ​ | ​ | 3,321
Total restricted stock unit expense | ​ | $ | 2,639 | ​ | $ | 2,123 | ​ | $ | 4,086

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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