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Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 USD ($) item | Dec. 31, 2023 USD ($) item | Dec. 31, 2022 USD ($) item
Basis of Presentation [Line Items] |  |  |
Prepaid R&D expense | $ 13 | $ 7,245 |
Expected dividend yield | 0.00% | 0.00% | 0.00%
Impairment of long-lived assets | $ 4,274 | $ 0 | $ 0
Inventory write-down | 2,963 |  |
Unrecognized tax provisions | 0 | 0 |
Unrecognized tax benefits, related interest and penalties | 0 | 0 | 0
Depreciation and amortization | $ 192 | $ 259 | $ 248
CSL Vifor and CKDP Agreements [Member] | License and milestone fees [Member] |  |  |
Basis of Presentation [Line Items] |  |  |
Number of performance obligations for revenue recognized | item | 1 | 1 | 1
Employee Stock Option |  |  |
Basis of Presentation [Line Items] |  |  |
Expected life of options (in years) | 6 years 3 months | 6 years 3 months | 6 years 3 months
Expected dividend yield | 0.00% | 0.00% | 0.00%

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