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Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Income Taxes |  |
Valuation allowance | $ (200,656) | $ (192,791)
Deferred tax assets: |  |
Net operating loss carryforwards | 122,727 | 123,739
Federal and state tax credits | 32,016 | 31,245
Stock-based compensation expense | 1,619 | 3,855
Intangible asset amortization | 34,823 | 33,162
Sales of future royalties and milestones | 8,952 |
Other | 519 | 2,101
Deferred tax assets | 200,656 | 194,102
Deferred tax liabilities: |  |
Other |  | (1,311)
Deferred tax liabilities |  | (1,311)
Net deferred tax asset | $ 0 | $ 0

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